Amino acid dipepetide frequency for Streptococcus satellite phage Javan388

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.974AlaAla: 0.974 ± 0.586
0.65AlaCys: 0.65 ± 0.415
6.171AlaAsp: 6.171 ± 1.429
3.897AlaGlu: 3.897 ± 1.209
2.273AlaPhe: 2.273 ± 0.69
1.624AlaGly: 1.624 ± 0.695
0.325AlaHis: 0.325 ± 0.318
5.521AlaIle: 5.521 ± 1.915
6.496AlaLys: 6.496 ± 2.101
4.872AlaLeu: 4.872 ± 1.237
2.273AlaMet: 2.273 ± 0.675
1.624AlaAsn: 1.624 ± 0.777
0.65AlaPro: 0.65 ± 0.421
2.273AlaGln: 2.273 ± 1.215
1.299AlaArg: 1.299 ± 0.631
3.897AlaSer: 3.897 ± 1.367
2.598AlaThr: 2.598 ± 1.219
2.923AlaVal: 2.923 ± 1.167
0.0AlaTrp: 0.0 ± 0.0
1.624AlaTyr: 1.624 ± 0.646
0.0AlaXaa: 0.0 ± 0.0
Cys
0.65CysAla: 0.65 ± 0.58
0.0CysCys: 0.0 ± 0.0
0.325CysAsp: 0.325 ± 0.352
0.974CysGlu: 0.974 ± 0.568
0.325CysPhe: 0.325 ± 0.256
0.974CysGly: 0.974 ± 0.495
0.0CysHis: 0.0 ± 0.0
1.299CysIle: 1.299 ± 0.812
0.325CysLys: 0.325 ± 0.317
0.974CysLeu: 0.974 ± 0.831
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.325CysSer: 0.325 ± 0.36
0.0CysThr: 0.0 ± 0.0
0.65CysVal: 0.65 ± 0.383
0.0CysTrp: 0.0 ± 0.0
0.325CysTyr: 0.325 ± 0.256
0.0CysXaa: 0.0 ± 0.0
Asp
2.273AspAla: 2.273 ± 0.902
0.65AspCys: 0.65 ± 0.477
5.196AspAsp: 5.196 ± 1.796
5.521AspGlu: 5.521 ± 1.468
4.547AspPhe: 4.547 ± 1.786
2.598AspGly: 2.598 ± 0.838
0.974AspHis: 0.974 ± 0.443
6.82AspIle: 6.82 ± 1.925
5.846AspLys: 5.846 ± 2.059
6.496AspLeu: 6.496 ± 2.055
0.974AspMet: 0.974 ± 0.534
5.521AspAsn: 5.521 ± 0.982
0.65AspPro: 0.65 ± 0.365
2.923AspGln: 2.923 ± 1.025
1.299AspArg: 1.299 ± 0.62
0.974AspSer: 0.974 ± 0.43
2.923AspThr: 2.923 ± 0.832
3.248AspVal: 3.248 ± 1.053
0.325AspTrp: 0.325 ± 0.335
5.196AspTyr: 5.196 ± 1.077
0.0AspXaa: 0.0 ± 0.0
Glu
5.846GluAla: 5.846 ± 1.574
0.65GluCys: 0.65 ± 0.446
5.521GluAsp: 5.521 ± 1.285
9.419GluGlu: 9.419 ± 2.269
3.573GluPhe: 3.573 ± 1.213
1.624GluGly: 1.624 ± 0.789
0.65GluHis: 0.65 ± 0.446
6.82GluIle: 6.82 ± 1.455
8.12GluLys: 8.12 ± 2.211
12.342GluLeu: 12.342 ± 2.005
3.248GluMet: 3.248 ± 0.923
7.145GluAsn: 7.145 ± 1.835
2.273GluPro: 2.273 ± 0.837
2.598GluGln: 2.598 ± 0.779
4.547GluArg: 4.547 ± 1.179
2.598GluSer: 2.598 ± 0.753
2.273GluThr: 2.273 ± 0.812
3.248GluVal: 3.248 ± 1.21
0.65GluTrp: 0.65 ± 0.436
3.573GluTyr: 3.573 ± 1.043
0.0GluXaa: 0.0 ± 0.0
Phe
1.624PheAla: 1.624 ± 0.829
0.0PheCys: 0.0 ± 0.0
2.923PheAsp: 2.923 ± 0.91
5.196PheGlu: 5.196 ± 1.114
2.923PhePhe: 2.923 ± 1.0
2.273PheGly: 2.273 ± 0.595
0.325PheHis: 0.325 ± 0.29
4.222PheIle: 4.222 ± 1.551
2.273PheLys: 2.273 ± 0.694
5.846PheLeu: 5.846 ± 2.14
0.325PheMet: 0.325 ± 0.367
2.598PheAsn: 2.598 ± 0.847
0.0PhePro: 0.0 ± 0.0
1.299PheGln: 1.299 ± 0.779
1.949PheArg: 1.949 ± 0.839
3.573PheSer: 3.573 ± 1.114
2.598PheThr: 2.598 ± 0.878
3.573PheVal: 3.573 ± 1.355
0.65PheTrp: 0.65 ± 0.391
0.974PheTyr: 0.974 ± 0.52
0.0PheXaa: 0.0 ± 0.0
Gly
2.273GlyAla: 2.273 ± 0.809
0.65GlyCys: 0.65 ± 0.512
1.624GlyAsp: 1.624 ± 1.117
3.248GlyGlu: 3.248 ± 1.297
0.65GlyPhe: 0.65 ± 0.405
2.598GlyGly: 2.598 ± 0.945
0.325GlyHis: 0.325 ± 0.29
5.196GlyIle: 5.196 ± 1.094
3.573GlyLys: 3.573 ± 1.011
5.846GlyLeu: 5.846 ± 1.558
1.299GlyMet: 1.299 ± 0.736
2.598GlyAsn: 2.598 ± 0.912
0.0GlyPro: 0.0 ± 0.0
1.299GlyGln: 1.299 ± 0.651
1.299GlyArg: 1.299 ± 0.568
2.273GlySer: 2.273 ± 0.743
2.923GlyThr: 2.923 ± 1.044
2.273GlyVal: 2.273 ± 0.761
0.65GlyTrp: 0.65 ± 0.38
1.949GlyTyr: 1.949 ± 0.727
0.0GlyXaa: 0.0 ± 0.0
His
1.299HisAla: 1.299 ± 0.87
0.0HisCys: 0.0 ± 0.0
0.65HisAsp: 0.65 ± 0.38
0.65HisGlu: 0.65 ± 0.463
0.65HisPhe: 0.65 ± 0.477
0.0HisGly: 0.0 ± 0.0
0.65HisHis: 0.65 ± 0.491
0.974HisIle: 0.974 ± 0.443
0.325HisLys: 0.325 ± 0.318
0.974HisLeu: 0.974 ± 0.525
0.974HisMet: 0.974 ± 0.721
0.65HisAsn: 0.65 ± 0.469
0.325HisPro: 0.325 ± 0.256
0.325HisGln: 0.325 ± 0.318
0.0HisArg: 0.0 ± 0.0
0.325HisSer: 0.325 ± 0.296
0.65HisThr: 0.65 ± 0.436
0.65HisVal: 0.65 ± 0.417
0.325HisTrp: 0.325 ± 0.36
0.325HisTyr: 0.325 ± 0.318
0.0HisXaa: 0.0 ± 0.0
Ile
6.496IleAla: 6.496 ± 1.658
0.974IleCys: 0.974 ± 0.528
7.145IleAsp: 7.145 ± 2.027
6.496IleGlu: 6.496 ± 1.86
4.872IlePhe: 4.872 ± 2.209
4.872IleGly: 4.872 ± 1.023
0.325IleHis: 0.325 ± 0.256
8.769IleIle: 8.769 ± 2.192
7.145IleLys: 7.145 ± 1.5
7.47IleLeu: 7.47 ± 1.711
1.299IleMet: 1.299 ± 0.614
4.222IleAsn: 4.222 ± 1.196
0.974IlePro: 0.974 ± 0.48
4.547IleGln: 4.547 ± 1.071
2.598IleArg: 2.598 ± 0.975
9.743IleSer: 9.743 ± 1.645
4.872IleThr: 4.872 ± 1.687
6.496IleVal: 6.496 ± 1.759
0.0IleTrp: 0.0 ± 0.0
1.949IleTyr: 1.949 ± 0.675
0.0IleXaa: 0.0 ± 0.0
Lys
5.196LysAla: 5.196 ± 1.296
0.325LysCys: 0.325 ± 0.36
4.872LysAsp: 4.872 ± 1.565
10.068LysGlu: 10.068 ± 1.902
3.573LysPhe: 3.573 ± 1.307
2.598LysGly: 2.598 ± 0.988
1.299LysHis: 1.299 ± 0.86
8.444LysIle: 8.444 ± 1.422
8.12LysLys: 8.12 ± 1.446
6.82LysLeu: 6.82 ± 1.611
3.573LysMet: 3.573 ± 1.164
5.521LysAsn: 5.521 ± 1.494
1.949LysPro: 1.949 ± 0.648
5.521LysGln: 5.521 ± 1.552
3.573LysArg: 3.573 ± 0.839
6.171LysSer: 6.171 ± 1.564
9.094LysThr: 9.094 ± 1.304
7.145LysVal: 7.145 ± 1.399
0.325LysTrp: 0.325 ± 0.364
1.949LysTyr: 1.949 ± 0.843
0.0LysXaa: 0.0 ± 0.0
Leu
4.872LeuAla: 4.872 ± 1.03
0.65LeuCys: 0.65 ± 0.383
7.145LeuAsp: 7.145 ± 1.389
8.444LeuGlu: 8.444 ± 2.166
5.196LeuPhe: 5.196 ± 1.319
6.496LeuGly: 6.496 ± 2.739
0.974LeuHis: 0.974 ± 0.577
10.718LeuIle: 10.718 ± 1.827
10.068LeuLys: 10.068 ± 1.746
9.743LeuLeu: 9.743 ± 2.236
2.273LeuMet: 2.273 ± 0.709
5.521LeuAsn: 5.521 ± 1.117
1.949LeuPro: 1.949 ± 0.787
6.171LeuGln: 6.171 ± 1.673
3.248LeuArg: 3.248 ± 1.115
4.872LeuSer: 4.872 ± 1.224
5.196LeuThr: 5.196 ± 1.373
5.521LeuVal: 5.521 ± 1.53
0.325LeuTrp: 0.325 ± 0.354
2.923LeuTyr: 2.923 ± 1.094
0.0LeuXaa: 0.0 ± 0.0
Met
1.299MetAla: 1.299 ± 0.57
0.325MetCys: 0.325 ± 0.29
1.299MetAsp: 1.299 ± 0.692
2.273MetGlu: 2.273 ± 0.926
0.0MetPhe: 0.0 ± 0.0
0.65MetGly: 0.65 ± 0.399
1.299MetHis: 1.299 ± 0.885
2.598MetIle: 2.598 ± 1.855
2.923MetLys: 2.923 ± 0.95
2.273MetLeu: 2.273 ± 0.832
1.299MetMet: 1.299 ± 0.534
2.598MetAsn: 2.598 ± 0.94
0.0MetPro: 0.0 ± 0.0
2.273MetGln: 2.273 ± 0.79
0.325MetArg: 0.325 ± 0.29
1.299MetSer: 1.299 ± 1.149
0.974MetThr: 0.974 ± 0.543
0.974MetVal: 0.974 ± 0.503
0.325MetTrp: 0.325 ± 0.318
0.65MetTyr: 0.65 ± 0.445
0.0MetXaa: 0.0 ± 0.0
Asn
3.897AsnAla: 3.897 ± 1.06
0.0AsnCys: 0.0 ± 0.0
2.598AsnAsp: 2.598 ± 1.0
4.872AsnGlu: 4.872 ± 1.196
2.273AsnPhe: 2.273 ± 0.963
1.949AsnGly: 1.949 ± 0.825
0.65AsnHis: 0.65 ± 0.458
5.196AsnIle: 5.196 ± 1.213
7.47AsnLys: 7.47 ± 1.363
6.496AsnLeu: 6.496 ± 1.414
1.299AsnMet: 1.299 ± 0.86
4.222AsnAsn: 4.222 ± 1.533
1.624AsnPro: 1.624 ± 0.642
2.273AsnGln: 2.273 ± 1.007
2.598AsnArg: 2.598 ± 0.982
3.248AsnSer: 3.248 ± 1.054
1.624AsnThr: 1.624 ± 0.848
2.273AsnVal: 2.273 ± 0.995
0.974AsnTrp: 0.974 ± 0.61
3.248AsnTyr: 3.248 ± 0.985
0.0AsnXaa: 0.0 ± 0.0
Pro
0.974ProAla: 0.974 ± 0.528
0.0ProCys: 0.0 ± 0.0
1.299ProAsp: 1.299 ± 0.618
2.273ProGlu: 2.273 ± 0.742
1.624ProPhe: 1.624 ± 0.58
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
0.974ProIle: 0.974 ± 0.516
0.974ProLys: 0.974 ± 0.768
2.273ProLeu: 2.273 ± 0.987
0.325ProMet: 0.325 ± 0.385
0.974ProAsn: 0.974 ± 0.708
1.299ProPro: 1.299 ± 0.602
0.325ProGln: 0.325 ± 0.317
1.949ProArg: 1.949 ± 0.944
1.949ProSer: 1.949 ± 0.515
1.624ProThr: 1.624 ± 0.75
1.299ProVal: 1.299 ± 0.849
0.0ProTrp: 0.0 ± 0.0
0.65ProTyr: 0.65 ± 0.526
0.0ProXaa: 0.0 ± 0.0
Gln
3.573GlnAla: 3.573 ± 1.011
0.974GlnCys: 0.974 ± 0.526
3.248GlnAsp: 3.248 ± 1.059
3.248GlnGlu: 3.248 ± 0.993
1.624GlnPhe: 1.624 ± 0.621
3.248GlnGly: 3.248 ± 0.908
0.0GlnHis: 0.0 ± 0.0
3.573GlnIle: 3.573 ± 1.299
5.196GlnLys: 5.196 ± 1.066
4.222GlnLeu: 4.222 ± 1.241
1.624GlnMet: 1.624 ± 0.807
1.299GlnAsn: 1.299 ± 0.696
1.299GlnPro: 1.299 ± 0.537
0.65GlnGln: 0.65 ± 0.436
1.299GlnArg: 1.299 ± 0.495
1.624GlnSer: 1.624 ± 0.898
2.273GlnThr: 2.273 ± 1.067
1.299GlnVal: 1.299 ± 0.647
0.325GlnTrp: 0.325 ± 0.308
2.923GlnTyr: 2.923 ± 1.168
0.0GlnXaa: 0.0 ± 0.0
Arg
1.299ArgAla: 1.299 ± 0.749
0.0ArgCys: 0.0 ± 0.0
2.273ArgAsp: 2.273 ± 0.94
3.573ArgGlu: 3.573 ± 1.273
1.299ArgPhe: 1.299 ± 0.577
1.299ArgGly: 1.299 ± 0.506
0.65ArgHis: 0.65 ± 0.358
2.923ArgIle: 2.923 ± 1.188
3.248ArgLys: 3.248 ± 1.144
3.248ArgLeu: 3.248 ± 0.937
0.325ArgMet: 0.325 ± 0.477
1.949ArgAsn: 1.949 ± 0.858
1.299ArgPro: 1.299 ± 0.57
3.248ArgGln: 3.248 ± 1.026
1.624ArgArg: 1.624 ± 0.601
2.273ArgSer: 2.273 ± 0.666
1.949ArgThr: 1.949 ± 0.595
1.949ArgVal: 1.949 ± 0.634
1.299ArgTrp: 1.299 ± 0.556
2.273ArgTyr: 2.273 ± 0.909
0.0ArgXaa: 0.0 ± 0.0
Ser
3.573SerAla: 3.573 ± 1.583
0.65SerCys: 0.65 ± 0.405
3.897SerAsp: 3.897 ± 0.92
3.897SerGlu: 3.897 ± 1.106
0.65SerPhe: 0.65 ± 0.38
2.598SerGly: 2.598 ± 0.747
1.624SerHis: 1.624 ± 0.688
6.171SerIle: 6.171 ± 1.319
6.171SerLys: 6.171 ± 1.655
3.573SerLeu: 3.573 ± 0.956
1.624SerMet: 1.624 ± 0.671
2.273SerAsn: 2.273 ± 0.804
1.624SerPro: 1.624 ± 0.821
1.949SerGln: 1.949 ± 0.712
3.248SerArg: 3.248 ± 1.023
3.897SerSer: 3.897 ± 1.558
2.923SerThr: 2.923 ± 0.896
1.949SerVal: 1.949 ± 0.922
1.299SerTrp: 1.299 ± 0.753
5.521SerTyr: 5.521 ± 1.338
0.0SerXaa: 0.0 ± 0.0
Thr
1.949ThrAla: 1.949 ± 0.842
0.0ThrCys: 0.0 ± 0.0
2.923ThrAsp: 2.923 ± 0.933
5.521ThrGlu: 5.521 ± 1.35
1.949ThrPhe: 1.949 ± 0.767
2.598ThrGly: 2.598 ± 0.919
0.325ThrHis: 0.325 ± 0.29
4.547ThrIle: 4.547 ± 1.234
5.521ThrLys: 5.521 ± 1.129
5.521ThrLeu: 5.521 ± 1.438
0.974ThrMet: 0.974 ± 0.746
3.573ThrAsn: 3.573 ± 1.196
1.299ThrPro: 1.299 ± 0.567
1.624ThrGln: 1.624 ± 0.775
2.273ThrArg: 2.273 ± 0.744
1.624ThrSer: 1.624 ± 0.83
3.573ThrThr: 3.573 ± 1.299
2.598ThrVal: 2.598 ± 0.905
0.325ThrTrp: 0.325 ± 0.256
2.923ThrTyr: 2.923 ± 0.923
0.0ThrXaa: 0.0 ± 0.0
Val
1.949ValAla: 1.949 ± 0.787
0.65ValCys: 0.65 ± 0.383
2.923ValAsp: 2.923 ± 1.025
2.923ValGlu: 2.923 ± 1.058
2.598ValPhe: 2.598 ± 0.992
1.624ValGly: 1.624 ± 0.569
0.0ValHis: 0.0 ± 0.0
2.598ValIle: 2.598 ± 1.193
4.547ValLys: 4.547 ± 1.491
7.795ValLeu: 7.795 ± 0.947
0.65ValMet: 0.65 ± 0.489
4.222ValAsn: 4.222 ± 0.699
2.598ValPro: 2.598 ± 1.181
1.949ValGln: 1.949 ± 0.832
1.949ValArg: 1.949 ± 0.96
4.872ValSer: 4.872 ± 1.164
2.598ValThr: 2.598 ± 0.642
1.949ValVal: 1.949 ± 0.848
0.325ValTrp: 0.325 ± 0.256
2.598ValTyr: 2.598 ± 1.226
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.949TrpGlu: 1.949 ± 0.636
0.65TrpPhe: 0.65 ± 0.514
0.974TrpGly: 0.974 ± 0.484
0.0TrpHis: 0.0 ± 0.0
0.974TrpIle: 0.974 ± 0.6
0.325TrpLys: 0.325 ± 0.324
1.299TrpLeu: 1.299 ± 0.655
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.325TrpPro: 0.325 ± 0.361
0.325TrpGln: 0.325 ± 0.36
0.325TrpArg: 0.325 ± 0.256
0.65TrpSer: 0.65 ± 0.358
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.65TrpTyr: 0.65 ± 0.365
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.949TyrAla: 1.949 ± 1.819
0.0TyrCys: 0.0 ± 0.0
2.923TyrAsp: 2.923 ± 0.899
2.273TyrGlu: 2.273 ± 0.865
3.897TyrPhe: 3.897 ± 1.308
1.949TyrGly: 1.949 ± 0.844
0.325TyrHis: 0.325 ± 0.335
2.923TyrIle: 2.923 ± 1.063
7.47TyrLys: 7.47 ± 1.399
4.222TyrLeu: 4.222 ± 1.312
0.974TyrMet: 0.974 ± 0.486
2.273TyrAsn: 2.273 ± 1.002
0.65TyrPro: 0.65 ± 0.422
1.949TyrGln: 1.949 ± 0.686
2.923TyrArg: 2.923 ± 0.999
2.923TyrSer: 2.923 ± 0.849
0.974TyrThr: 0.974 ± 0.799
1.299TyrVal: 1.299 ± 0.517
0.325TyrTrp: 0.325 ± 0.324
1.624TyrTyr: 1.624 ± 0.58
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 22 proteins (3080 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski