Amino acid dipepetide frequency for Crane-associated adenovirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.123AlaAla: 3.123 ± 0.797
1.292AlaCys: 1.292 ± 0.468
2.154AlaAsp: 2.154 ± 0.417
2.261AlaGlu: 2.261 ± 0.51
2.477AlaPhe: 2.477 ± 0.586
2.369AlaGly: 2.369 ± 0.652
0.862AlaHis: 0.862 ± 0.285
4.738AlaIle: 4.738 ± 0.744
3.015AlaLys: 3.015 ± 0.511
5.815AlaLeu: 5.815 ± 0.71
1.615AlaMet: 1.615 ± 0.679
4.092AlaAsn: 4.092 ± 0.625
3.231AlaPro: 3.231 ± 0.61
2.908AlaGln: 2.908 ± 0.667
2.477AlaArg: 2.477 ± 0.671
4.415AlaSer: 4.415 ± 0.644
2.908AlaThr: 2.908 ± 0.797
3.015AlaVal: 3.015 ± 0.5
0.431AlaTrp: 0.431 ± 0.234
2.692AlaTyr: 2.692 ± 0.505
0.0AlaXaa: 0.0 ± 0.0
Cys
0.862CysAla: 0.862 ± 0.372
0.538CysCys: 0.538 ± 0.296
0.969CysAsp: 0.969 ± 0.335
0.538CysGlu: 0.538 ± 0.23
0.862CysPhe: 0.862 ± 0.281
1.292CysGly: 1.292 ± 0.475
0.431CysHis: 0.431 ± 0.209
0.969CysIle: 0.969 ± 0.299
1.077CysLys: 1.077 ± 0.243
1.077CysLeu: 1.077 ± 0.39
0.323CysMet: 0.323 ± 0.182
1.508CysAsn: 1.508 ± 0.616
0.538CysPro: 0.538 ± 0.227
0.323CysGln: 0.323 ± 0.229
1.185CysArg: 1.185 ± 0.527
1.831CysSer: 1.831 ± 0.316
0.862CysThr: 0.862 ± 0.348
0.969CysVal: 0.969 ± 0.482
0.323CysTrp: 0.323 ± 0.15
1.508CysTyr: 1.508 ± 0.596
0.0CysXaa: 0.0 ± 0.0
Asp
2.046AspAla: 2.046 ± 0.498
0.431AspCys: 0.431 ± 0.21
4.092AspAsp: 4.092 ± 0.94
4.954AspGlu: 4.954 ± 0.96
2.8AspPhe: 2.8 ± 0.483
2.585AspGly: 2.585 ± 0.628
0.538AspHis: 0.538 ± 0.282
4.846AspIle: 4.846 ± 1.019
2.154AspLys: 2.154 ± 0.483
5.277AspLeu: 5.277 ± 0.826
1.185AspMet: 1.185 ± 0.339
3.877AspAsn: 3.877 ± 0.689
3.446AspPro: 3.446 ± 0.521
2.046AspGln: 2.046 ± 0.376
2.046AspArg: 2.046 ± 0.44
5.169AspSer: 5.169 ± 0.858
3.769AspThr: 3.769 ± 0.511
2.477AspVal: 2.477 ± 0.431
0.646AspTrp: 0.646 ± 0.237
1.723AspTyr: 1.723 ± 0.508
0.0AspXaa: 0.0 ± 0.0
Glu
2.908GluAla: 2.908 ± 0.784
1.185GluCys: 1.185 ± 0.497
3.554GluAsp: 3.554 ± 0.778
5.492GluGlu: 5.492 ± 1.237
1.615GluPhe: 1.615 ± 0.404
2.692GluGly: 2.692 ± 0.501
0.754GluHis: 0.754 ± 0.362
5.169GluIle: 5.169 ± 0.709
3.338GluLys: 3.338 ± 0.932
5.277GluLeu: 5.277 ± 0.566
1.4GluMet: 1.4 ± 0.364
3.769GluAsn: 3.769 ± 0.822
1.831GluPro: 1.831 ± 0.542
1.831GluGln: 1.831 ± 0.518
3.015GluArg: 3.015 ± 0.636
4.523GluSer: 4.523 ± 0.479
3.123GluThr: 3.123 ± 0.619
3.231GluVal: 3.231 ± 0.574
0.431GluTrp: 0.431 ± 0.253
2.261GluTyr: 2.261 ± 0.474
0.0GluXaa: 0.0 ± 0.0
Phe
1.831PheAla: 1.831 ± 0.44
0.538PheCys: 0.538 ± 0.245
3.446PheAsp: 3.446 ± 0.504
2.369PheGlu: 2.369 ± 0.395
1.508PhePhe: 1.508 ± 0.372
1.615PheGly: 1.615 ± 0.438
1.615PheHis: 1.615 ± 0.473
3.015PheIle: 3.015 ± 0.492
3.015PheLys: 3.015 ± 0.541
3.877PheLeu: 3.877 ± 0.935
1.185PheMet: 1.185 ± 0.23
3.338PheAsn: 3.338 ± 0.806
2.154PhePro: 2.154 ± 0.639
1.508PheGln: 1.508 ± 0.311
1.831PheArg: 1.831 ± 0.465
3.446PheSer: 3.446 ± 0.648
2.692PheThr: 2.692 ± 0.586
2.908PheVal: 2.908 ± 0.701
0.754PheTrp: 0.754 ± 0.327
2.046PheTyr: 2.046 ± 0.587
0.0PheXaa: 0.0 ± 0.0
Gly
3.554GlyAla: 3.554 ± 0.653
0.538GlyCys: 0.538 ± 0.303
1.723GlyAsp: 1.723 ± 0.421
2.369GlyGlu: 2.369 ± 0.34
2.692GlyPhe: 2.692 ± 0.74
3.338GlyGly: 3.338 ± 0.756
0.754GlyHis: 0.754 ± 0.39
4.2GlyIle: 4.2 ± 0.764
2.585GlyLys: 2.585 ± 0.67
3.015GlyLeu: 3.015 ± 0.797
1.831GlyMet: 1.831 ± 0.568
3.446GlyAsn: 3.446 ± 0.589
1.615GlyPro: 1.615 ± 0.526
1.077GlyGln: 1.077 ± 0.31
3.015GlyArg: 3.015 ± 0.672
3.554GlySer: 3.554 ± 0.72
2.8GlyThr: 2.8 ± 0.617
3.338GlyVal: 3.338 ± 0.628
0.969GlyTrp: 0.969 ± 0.347
1.831GlyTyr: 1.831 ± 0.502
0.0GlyXaa: 0.0 ± 0.0
His
1.077HisAla: 1.077 ± 0.304
0.754HisCys: 0.754 ± 0.271
0.862HisAsp: 0.862 ± 0.363
0.646HisGlu: 0.646 ± 0.26
0.538HisPhe: 0.538 ± 0.222
1.292HisGly: 1.292 ± 0.519
0.646HisHis: 0.646 ± 0.291
1.508HisIle: 1.508 ± 0.37
1.292HisLys: 1.292 ± 0.46
2.8HisLeu: 2.8 ± 0.737
0.323HisMet: 0.323 ± 0.173
1.077HisAsn: 1.077 ± 0.268
1.292HisPro: 1.292 ± 0.478
1.185HisGln: 1.185 ± 0.356
0.862HisArg: 0.862 ± 0.183
1.508HisSer: 1.508 ± 0.413
0.754HisThr: 0.754 ± 0.193
0.862HisVal: 0.862 ± 0.301
0.215HisTrp: 0.215 ± 0.152
0.646HisTyr: 0.646 ± 0.232
0.0HisXaa: 0.0 ± 0.0
Ile
5.277IleAla: 5.277 ± 0.816
1.292IleCys: 1.292 ± 0.396
4.092IleAsp: 4.092 ± 0.701
3.984IleGlu: 3.984 ± 0.889
2.261IlePhe: 2.261 ± 0.443
2.908IleGly: 2.908 ± 0.612
1.4IleHis: 1.4 ± 0.363
4.523IleIle: 4.523 ± 0.832
4.523IleLys: 4.523 ± 0.749
3.769IleLeu: 3.769 ± 0.685
1.185IleMet: 1.185 ± 0.409
6.784IleAsn: 6.784 ± 0.918
5.061IlePro: 5.061 ± 0.753
3.231IleGln: 3.231 ± 0.626
2.908IleArg: 2.908 ± 0.816
6.246IleSer: 6.246 ± 0.596
3.769IleThr: 3.769 ± 0.719
3.661IleVal: 3.661 ± 0.527
0.538IleTrp: 0.538 ± 0.227
2.261IleTyr: 2.261 ± 0.456
0.0IleXaa: 0.0 ± 0.0
Lys
3.231LysAla: 3.231 ± 0.701
1.938LysCys: 1.938 ± 0.575
3.984LysAsp: 3.984 ± 0.702
3.231LysGlu: 3.231 ± 0.643
2.8LysPhe: 2.8 ± 0.705
2.369LysGly: 2.369 ± 0.791
0.862LysHis: 0.862 ± 0.496
3.769LysIle: 3.769 ± 1.121
3.231LysLys: 3.231 ± 0.949
4.631LysLeu: 4.631 ± 0.858
1.292LysMet: 1.292 ± 0.377
2.692LysAsn: 2.692 ± 0.437
2.154LysPro: 2.154 ± 0.431
1.723LysGln: 1.723 ± 0.526
2.908LysArg: 2.908 ± 0.404
4.092LysSer: 4.092 ± 0.864
3.338LysThr: 3.338 ± 0.502
2.477LysVal: 2.477 ± 0.54
1.185LysTrp: 1.185 ± 0.357
3.554LysTyr: 3.554 ± 0.585
0.0LysXaa: 0.0 ± 0.0
Leu
3.984LeuAla: 3.984 ± 0.343
1.292LeuCys: 1.292 ± 0.373
3.338LeuAsp: 3.338 ± 0.745
5.061LeuGlu: 5.061 ± 1.012
3.661LeuPhe: 3.661 ± 0.925
3.231LeuGly: 3.231 ± 0.41
2.154LeuHis: 2.154 ± 0.852
4.415LeuIle: 4.415 ± 0.648
6.569LeuLys: 6.569 ± 0.818
7.538LeuLeu: 7.538 ± 1.153
2.369LeuMet: 2.369 ± 0.443
6.354LeuAsn: 6.354 ± 0.883
4.308LeuPro: 4.308 ± 0.401
4.2LeuGln: 4.2 ± 0.887
5.384LeuArg: 5.384 ± 1.019
7.538LeuSer: 7.538 ± 1.034
4.631LeuThr: 4.631 ± 0.502
3.769LeuVal: 3.769 ± 0.702
0.754LeuTrp: 0.754 ± 0.261
4.092LeuTyr: 4.092 ± 0.661
0.0LeuXaa: 0.0 ± 0.0
Met
1.938MetAla: 1.938 ± 0.556
0.862MetCys: 0.862 ± 0.507
2.261MetAsp: 2.261 ± 0.463
1.292MetGlu: 1.292 ± 0.37
1.938MetPhe: 1.938 ± 0.366
1.4MetGly: 1.4 ± 0.358
0.646MetHis: 0.646 ± 0.265
0.862MetIle: 0.862 ± 0.282
1.077MetLys: 1.077 ± 0.473
2.585MetLeu: 2.585 ± 0.499
0.754MetMet: 0.754 ± 0.318
1.077MetAsn: 1.077 ± 0.372
1.508MetPro: 1.508 ± 0.392
0.754MetGln: 0.754 ± 0.356
0.969MetArg: 0.969 ± 0.413
2.585MetSer: 2.585 ± 0.523
1.185MetThr: 1.185 ± 0.288
1.077MetVal: 1.077 ± 0.341
0.323MetTrp: 0.323 ± 0.152
1.508MetTyr: 1.508 ± 0.374
0.0MetXaa: 0.0 ± 0.0
Asn
3.661AsnAla: 3.661 ± 0.482
0.969AsnCys: 0.969 ± 0.351
3.231AsnAsp: 3.231 ± 0.565
3.338AsnGlu: 3.338 ± 0.481
2.8AsnPhe: 2.8 ± 0.531
4.2AsnGly: 4.2 ± 1.004
1.723AsnHis: 1.723 ± 0.406
6.246AsnIle: 6.246 ± 0.916
2.8AsnLys: 2.8 ± 0.658
5.815AsnLeu: 5.815 ± 0.85
1.938AsnMet: 1.938 ± 0.502
6.569AsnAsn: 6.569 ± 0.995
4.631AsnPro: 4.631 ± 0.654
2.692AsnGln: 2.692 ± 0.535
3.446AsnArg: 3.446 ± 0.611
5.492AsnSer: 5.492 ± 0.665
4.954AsnThr: 4.954 ± 1.058
3.446AsnVal: 3.446 ± 0.494
1.185AsnTrp: 1.185 ± 0.383
2.369AsnTyr: 2.369 ± 0.491
0.0AsnXaa: 0.0 ± 0.0
Pro
3.123ProAla: 3.123 ± 0.649
0.862ProCys: 0.862 ± 0.342
3.554ProAsp: 3.554 ± 0.688
2.908ProGlu: 2.908 ± 0.598
2.692ProPhe: 2.692 ± 0.621
2.369ProGly: 2.369 ± 0.573
1.508ProHis: 1.508 ± 0.502
2.585ProIle: 2.585 ± 0.67
2.261ProLys: 2.261 ± 0.536
4.523ProLeu: 4.523 ± 0.738
1.185ProMet: 1.185 ± 0.251
3.554ProAsn: 3.554 ± 0.707
5.061ProPro: 5.061 ± 1.602
2.046ProGln: 2.046 ± 0.557
1.938ProArg: 1.938 ± 0.454
6.892ProSer: 6.892 ± 1.168
2.585ProThr: 2.585 ± 0.504
2.8ProVal: 2.8 ± 0.773
0.215ProTrp: 0.215 ± 0.124
2.369ProTyr: 2.369 ± 0.412
0.0ProXaa: 0.0 ± 0.0
Gln
2.477GlnAla: 2.477 ± 0.494
0.431GlnCys: 0.431 ± 0.224
2.908GlnAsp: 2.908 ± 0.491
2.154GlnGlu: 2.154 ± 0.443
1.723GlnPhe: 1.723 ± 0.455
1.077GlnGly: 1.077 ± 0.224
0.754GlnHis: 0.754 ± 0.282
2.261GlnIle: 2.261 ± 0.642
1.723GlnLys: 1.723 ± 0.508
4.308GlnLeu: 4.308 ± 0.627
1.4GlnMet: 1.4 ± 0.348
3.661GlnAsn: 3.661 ± 0.405
1.615GlnPro: 1.615 ± 0.474
1.185GlnGln: 1.185 ± 0.342
2.154GlnArg: 2.154 ± 0.651
3.123GlnSer: 3.123 ± 0.59
3.015GlnThr: 3.015 ± 0.523
0.969GlnVal: 0.969 ± 0.199
0.215GlnTrp: 0.215 ± 0.196
1.615GlnTyr: 1.615 ± 0.327
0.0GlnXaa: 0.0 ± 0.0
Arg
3.446ArgAla: 3.446 ± 0.809
0.969ArgCys: 0.969 ± 0.4
2.046ArgAsp: 2.046 ± 0.397
2.154ArgGlu: 2.154 ± 0.398
2.585ArgPhe: 2.585 ± 0.658
2.8ArgGly: 2.8 ± 0.726
1.615ArgHis: 1.615 ± 0.367
3.015ArgIle: 3.015 ± 0.686
2.154ArgLys: 2.154 ± 0.483
3.661ArgLeu: 3.661 ± 0.628
1.615ArgMet: 1.615 ± 0.504
3.338ArgAsn: 3.338 ± 0.679
2.046ArgPro: 2.046 ± 0.378
2.8ArgGln: 2.8 ± 0.591
5.169ArgArg: 5.169 ± 1.691
3.984ArgSer: 3.984 ± 0.624
2.908ArgThr: 2.908 ± 0.714
2.908ArgVal: 2.908 ± 0.509
0.862ArgTrp: 0.862 ± 0.296
1.831ArgTyr: 1.831 ± 0.282
0.0ArgXaa: 0.0 ± 0.0
Ser
4.738SerAla: 4.738 ± 0.862
1.292SerCys: 1.292 ± 0.437
4.2SerAsp: 4.2 ± 0.681
5.708SerGlu: 5.708 ± 0.828
3.015SerPhe: 3.015 ± 0.67
5.6SerGly: 5.6 ± 1.019
0.969SerHis: 0.969 ± 0.215
6.246SerIle: 6.246 ± 0.88
5.277SerLys: 5.277 ± 1.027
7.215SerLeu: 7.215 ± 1.168
1.938SerMet: 1.938 ± 0.449
5.277SerAsn: 5.277 ± 0.625
4.631SerPro: 4.631 ± 0.978
3.231SerGln: 3.231 ± 0.54
4.738SerArg: 4.738 ± 0.91
7.107SerSer: 7.107 ± 0.961
4.954SerThr: 4.954 ± 0.719
5.277SerVal: 5.277 ± 0.85
0.646SerTrp: 0.646 ± 0.201
2.261SerTyr: 2.261 ± 0.562
0.0SerXaa: 0.0 ± 0.0
Thr
3.338ThrAla: 3.338 ± 0.649
0.754ThrCys: 0.754 ± 0.436
3.554ThrAsp: 3.554 ± 0.878
3.123ThrGlu: 3.123 ± 0.528
3.231ThrPhe: 3.231 ± 0.565
2.477ThrGly: 2.477 ± 0.322
0.969ThrHis: 0.969 ± 0.358
4.954ThrIle: 4.954 ± 0.762
2.692ThrLys: 2.692 ± 0.616
4.846ThrLeu: 4.846 ± 0.754
1.292ThrMet: 1.292 ± 0.326
3.446ThrAsn: 3.446 ± 0.567
3.231ThrPro: 3.231 ± 0.8
1.723ThrGln: 1.723 ± 0.491
2.692ThrArg: 2.692 ± 0.655
4.415ThrSer: 4.415 ± 0.541
2.8ThrThr: 2.8 ± 0.547
3.015ThrVal: 3.015 ± 0.492
0.538ThrTrp: 0.538 ± 0.178
2.692ThrTyr: 2.692 ± 0.548
0.0ThrXaa: 0.0 ± 0.0
Val
2.261ValAla: 2.261 ± 0.66
0.969ValCys: 0.969 ± 0.264
3.231ValAsp: 3.231 ± 0.742
2.8ValGlu: 2.8 ± 0.599
2.154ValPhe: 2.154 ± 0.479
2.046ValGly: 2.046 ± 0.43
0.862ValHis: 0.862 ± 0.294
2.908ValIle: 2.908 ± 0.555
3.769ValLys: 3.769 ± 0.74
4.415ValLeu: 4.415 ± 0.53
1.292ValMet: 1.292 ± 0.321
3.877ValAsn: 3.877 ± 0.595
3.446ValPro: 3.446 ± 0.651
2.477ValGln: 2.477 ± 0.563
2.369ValArg: 2.369 ± 0.592
4.415ValSer: 4.415 ± 0.714
2.585ValThr: 2.585 ± 0.367
2.585ValVal: 2.585 ± 0.569
0.646ValTrp: 0.646 ± 0.281
2.585ValTyr: 2.585 ± 0.473
0.0ValXaa: 0.0 ± 0.0
Trp
0.431TrpAla: 0.431 ± 0.228
0.108TrpCys: 0.108 ± 0.098
0.538TrpAsp: 0.538 ± 0.176
0.323TrpGlu: 0.323 ± 0.158
0.862TrpPhe: 0.862 ± 0.366
0.646TrpGly: 0.646 ± 0.197
0.215TrpHis: 0.215 ± 0.129
0.754TrpIle: 0.754 ± 0.31
0.862TrpLys: 0.862 ± 0.337
0.646TrpLeu: 0.646 ± 0.247
0.431TrpMet: 0.431 ± 0.222
0.646TrpAsn: 0.646 ± 0.223
0.646TrpPro: 0.646 ± 0.449
0.538TrpGln: 0.538 ± 0.223
0.646TrpArg: 0.646 ± 0.25
1.185TrpSer: 1.185 ± 0.288
0.538TrpThr: 0.538 ± 0.161
1.077TrpVal: 1.077 ± 0.31
0.0TrpTrp: 0.0 ± 0.0
0.431TrpTyr: 0.431 ± 0.188
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.585TyrAla: 2.585 ± 0.76
0.969TyrCys: 0.969 ± 0.339
2.369TyrAsp: 2.369 ± 0.54
2.692TyrGlu: 2.692 ± 0.486
2.477TyrPhe: 2.477 ± 0.56
1.938TyrGly: 1.938 ± 0.365
0.862TyrHis: 0.862 ± 0.33
2.692TyrIle: 2.692 ± 0.56
2.046TyrLys: 2.046 ± 0.498
3.554TyrLeu: 3.554 ± 0.637
1.938TyrMet: 1.938 ± 0.54
3.231TyrAsn: 3.231 ± 0.433
2.585TyrPro: 2.585 ± 0.432
1.292TyrGln: 1.292 ± 0.304
2.154TyrArg: 2.154 ± 0.473
2.8TyrSer: 2.8 ± 0.617
1.615TyrThr: 1.615 ± 0.462
1.831TyrVal: 1.831 ± 0.536
0.646TyrTrp: 0.646 ± 0.32
2.369TyrTyr: 2.369 ± 0.507
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 23 proteins (9287 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski