Amino acid dipepetide frequency for Pontibacillus marinus BH030004 = DSM 16465

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.463AlaAla: 4.463 ± 0.085	0.524AlaCys: 0.524 ± 0.022	3.068AlaAsp: 3.068 ± 0.056	4.293AlaGlu: 4.293 ± 0.07	3.148AlaPhe: 3.148 ± 0.057	4.625AlaGly: 4.625 ± 0.072	1.271AlaHis: 1.271 ± 0.034	5.256AlaIle: 5.256 ± 0.079	4.292AlaLys: 4.292 ± 0.072	6.635AlaLeu: 6.635 ± 0.083	1.951AlaMet: 1.951 ± 0.045	2.623AlaAsn: 2.623 ± 0.049	1.966AlaPro: 1.966 ± 0.042	2.34AlaGln: 2.34 ± 0.049	2.402AlaArg: 2.402 ± 0.048	3.94AlaSer: 3.94 ± 0.07	3.268AlaThr: 3.268 ± 0.046	4.487AlaVal: 4.487 ± 0.068	0.622AlaTrp: 0.622 ± 0.029	2.28AlaTyr: 2.28 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.356CysAla: 0.356 ± 0.02	0.075CysCys: 0.075 ± 0.008	0.402CysAsp: 0.402 ± 0.02	0.421CysGlu: 0.421 ± 0.022	0.276CysPhe: 0.276 ± 0.014	0.601CysGly: 0.601 ± 0.019	0.168CysHis: 0.168 ± 0.01	0.418CysIle: 0.418 ± 0.02	0.317CysLys: 0.317 ± 0.018	0.567CysLeu: 0.567 ± 0.024	0.167CysMet: 0.167 ± 0.012	0.275CysAsn: 0.275 ± 0.016	0.32CysPro: 0.32 ± 0.019	0.202CysGln: 0.202 ± 0.012	0.237CysArg: 0.237 ± 0.015	0.461CysSer: 0.461 ± 0.019	0.364CysThr: 0.364 ± 0.016	0.399CysVal: 0.399 ± 0.021	0.066CysTrp: 0.066 ± 0.007	0.243CysTyr: 0.243 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.242AspAla: 3.242 ± 0.057	0.376AspCys: 0.376 ± 0.018	2.794AspAsp: 2.794 ± 0.056	5.164AspGlu: 5.164 ± 0.084	2.429AspPhe: 2.429 ± 0.048	3.553AspGly: 3.553 ± 0.062	1.498AspHis: 1.498 ± 0.038	4.265AspIle: 4.265 ± 0.06	3.163AspLys: 3.163 ± 0.053	5.454AspLeu: 5.454 ± 0.069	1.514AspMet: 1.514 ± 0.035	1.902AspAsn: 1.902 ± 0.044	2.31AspPro: 2.31 ± 0.048	2.903AspGln: 2.903 ± 0.052	2.402AspArg: 2.402 ± 0.045	2.839AspSer: 2.839 ± 0.061	2.576AspThr: 2.576 ± 0.054	4.225AspVal: 4.225 ± 0.074	0.693AspTrp: 0.693 ± 0.03	2.271AspTyr: 2.271 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.434GluAla: 5.434 ± 0.074	0.353GluCys: 0.353 ± 0.023	4.927GluAsp: 4.927 ± 0.078	8.162GluGlu: 8.162 ± 0.116	2.532GluPhe: 2.532 ± 0.046	4.995GluGly: 4.995 ± 0.07	1.817GluHis: 1.817 ± 0.043	5.016GluIle: 5.016 ± 0.072	6.508GluLys: 6.508 ± 0.084	6.95GluLeu: 6.95 ± 0.077	2.47GluMet: 2.47 ± 0.047	3.94GluAsn: 3.94 ± 0.069	2.137GluPro: 2.137 ± 0.041	3.91GluGln: 3.91 ± 0.072	3.555GluArg: 3.555 ± 0.06	4.09GluSer: 4.09 ± 0.069	3.953GluThr: 3.953 ± 0.056	5.614GluVal: 5.614 ± 0.077	0.965GluTrp: 0.965 ± 0.027	2.424GluTyr: 2.424 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.709PheAla: 2.709 ± 0.059	0.315PheCys: 0.315 ± 0.017	2.433PheAsp: 2.433 ± 0.046	2.993PheGlu: 2.993 ± 0.047	2.345PhePhe: 2.345 ± 0.051	3.208PheGly: 3.208 ± 0.058	1.024PheHis: 1.024 ± 0.027	3.768PheIle: 3.768 ± 0.064	2.383PheLys: 2.383 ± 0.046	4.478PheLeu: 4.478 ± 0.078	1.3PheMet: 1.3 ± 0.035	1.882PheAsn: 1.882 ± 0.047	1.71PhePro: 1.71 ± 0.038	1.88PheGln: 1.88 ± 0.038	1.528PheArg: 1.528 ± 0.036	3.194PheSer: 3.194 ± 0.057	2.585PheThr: 2.585 ± 0.052	3.025PheVal: 3.025 ± 0.06	0.52PheTrp: 0.52 ± 0.024	1.79PheTyr: 1.79 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.536GlyAla: 4.536 ± 0.072	0.581GlyCys: 0.581 ± 0.025	3.621GlyAsp: 3.621 ± 0.06	5.076GlyGlu: 5.076 ± 0.075	3.414GlyPhe: 3.414 ± 0.061	4.783GlyGly: 4.783 ± 0.094	1.39GlyHis: 1.39 ± 0.038	5.488GlyIle: 5.488 ± 0.074	4.647GlyLys: 4.647 ± 0.069	6.25GlyLeu: 6.25 ± 0.095	2.243GlyMet: 2.243 ± 0.047	2.67GlyAsn: 2.67 ± 0.051	1.778GlyPro: 1.778 ± 0.041	2.201GlyGln: 2.201 ± 0.046	2.447GlyArg: 2.447 ± 0.046	4.089GlySer: 4.089 ± 0.062	3.864GlyThr: 3.864 ± 0.062	5.315GlyVal: 5.315 ± 0.078	0.828GlyTrp: 0.828 ± 0.03	2.869GlyTyr: 2.869 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.358HisAla: 1.358 ± 0.04	0.185HisCys: 0.185 ± 0.014	1.293HisAsp: 1.293 ± 0.035	1.739HisGlu: 1.739 ± 0.038	1.119HisPhe: 1.119 ± 0.032	1.411HisGly: 1.411 ± 0.036	0.723HisHis: 0.723 ± 0.026	1.667HisIle: 1.667 ± 0.042	1.264HisLys: 1.264 ± 0.031	2.214HisLeu: 2.214 ± 0.045	0.621HisMet: 0.621 ± 0.023	0.965HisAsn: 0.965 ± 0.028	1.143HisPro: 1.143 ± 0.033	0.948HisGln: 0.948 ± 0.029	0.895HisArg: 0.895 ± 0.029	1.264HisSer: 1.264 ± 0.033	1.149HisThr: 1.149 ± 0.026	1.567HisVal: 1.567 ± 0.036	0.265HisTrp: 0.265 ± 0.016	0.951HisTyr: 0.951 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.195IleAla: 5.195 ± 0.083	0.516IleCys: 0.516 ± 0.018	4.269IleAsp: 4.269 ± 0.065	5.496IleGlu: 5.496 ± 0.076	2.997IlePhe: 2.997 ± 0.06	5.585IleGly: 5.585 ± 0.08	1.807IleHis: 1.807 ± 0.038	5.166IleIle: 5.166 ± 0.088	4.109IleLys: 4.109 ± 0.061	6.614IleLeu: 6.614 ± 0.088	1.834IleMet: 1.834 ± 0.041	3.071IleAsn: 3.071 ± 0.047	3.316IlePro: 3.316 ± 0.055	3.418IleGln: 3.418 ± 0.058	2.783IleArg: 2.783 ± 0.049	4.853IleSer: 4.853 ± 0.074	4.229IleThr: 4.229 ± 0.057	5.181IleVal: 5.181 ± 0.073	0.641IleTrp: 0.641 ± 0.023	2.423IleTyr: 2.423 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.308LysAla: 4.308 ± 0.066	0.277LysCys: 0.277 ± 0.016	4.245LysAsp: 4.245 ± 0.064	6.924LysGlu: 6.924 ± 0.085	1.771LysPhe: 1.771 ± 0.043	4.559LysGly: 4.559 ± 0.065	1.525LysHis: 1.525 ± 0.038	3.777LysIle: 3.777 ± 0.056	5.3LysLys: 5.3 ± 0.078	5.31LysLeu: 5.31 ± 0.067	2.001LysMet: 2.001 ± 0.043	3.121LysAsn: 3.121 ± 0.058	2.343LysPro: 2.343 ± 0.046	3.554LysGln: 3.554 ± 0.068	3.277LysArg: 3.277 ± 0.058	3.65LysSer: 3.65 ± 0.063	3.301LysThr: 3.301 ± 0.053	4.653LysVal: 4.653 ± 0.069	0.855LysTrp: 0.855 ± 0.027	1.994LysTyr: 1.994 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.376LeuAla: 6.376 ± 0.086	0.544LeuCys: 0.544 ± 0.025	5.034LeuAsp: 5.034 ± 0.07	6.817LeuGlu: 6.817 ± 0.081	4.828LeuPhe: 4.828 ± 0.086	6.341LeuGly: 6.341 ± 0.086	2.081LeuHis: 2.081 ± 0.041	6.688LeuIle: 6.688 ± 0.092	6.131LeuLys: 6.131 ± 0.072	9.277LeuLeu: 9.277 ± 0.13	2.508LeuMet: 2.508 ± 0.046	4.333LeuAsn: 4.333 ± 0.063	3.747LeuPro: 3.747 ± 0.055	3.86LeuGln: 3.86 ± 0.058	3.398LeuArg: 3.398 ± 0.055	6.828LeuSer: 6.828 ± 0.078	5.31LeuThr: 5.31 ± 0.069	5.895LeuVal: 5.895 ± 0.088	0.901LeuTrp: 0.901 ± 0.032	3.268LeuTyr: 3.268 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.904MetAla: 1.904 ± 0.039	0.134MetCys: 0.134 ± 0.012	1.659MetAsp: 1.659 ± 0.04	2.031MetGlu: 2.031 ± 0.04	1.205MetPhe: 1.205 ± 0.032	1.892MetGly: 1.892 ± 0.039	0.469MetHis: 0.469 ± 0.022	2.263MetIle: 2.263 ± 0.047	2.644MetLys: 2.644 ± 0.047	2.545MetLeu: 2.545 ± 0.048	0.91MetMet: 0.91 ± 0.029	1.819MetAsn: 1.819 ± 0.038	1.025MetPro: 1.025 ± 0.031	0.979MetGln: 0.979 ± 0.029	1.153MetArg: 1.153 ± 0.036	1.797MetSer: 1.797 ± 0.037	1.588MetThr: 1.588 ± 0.035	1.897MetVal: 1.897 ± 0.036	0.22MetTrp: 0.22 ± 0.012	0.83MetTyr: 0.83 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.614AsnAla: 2.614 ± 0.042	0.242AsnCys: 0.242 ± 0.015	2.517AsnAsp: 2.517 ± 0.047	3.855AsnGlu: 3.855 ± 0.063	1.556AsnPhe: 1.556 ± 0.037	3.281AsnGly: 3.281 ± 0.051	1.179AsnHis: 1.179 ± 0.033	3.34AsnIle: 3.34 ± 0.061	2.883AsnLys: 2.883 ± 0.061	3.885AsnLeu: 3.885 ± 0.063	1.256AsnMet: 1.256 ± 0.033	2.031AsnAsn: 2.031 ± 0.051	2.122AsnPro: 2.122 ± 0.043	2.459AsnGln: 2.459 ± 0.051	2.034AsnArg: 2.034 ± 0.041	2.251AsnSer: 2.251 ± 0.044	2.235AsnThr: 2.235 ± 0.045	3.274AsnVal: 3.274 ± 0.059	0.509AsnTrp: 0.509 ± 0.022	1.533AsnTyr: 1.533 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	1.908ProAla: 1.908 ± 0.041	0.207ProCys: 0.207 ± 0.013	2.141ProAsp: 2.141 ± 0.047	3.243ProGlu: 3.243 ± 0.065	2.1ProPhe: 2.1 ± 0.049	2.279ProGly: 2.279 ± 0.049	0.905ProHis: 0.905 ± 0.028	2.845ProIle: 2.845 ± 0.045	2.285ProLys: 2.285 ± 0.043	3.358ProLeu: 3.358 ± 0.057	0.957ProMet: 0.957 ± 0.033	1.8ProAsn: 1.8 ± 0.035	1.012ProPro: 1.012 ± 0.032	1.22ProGln: 1.22 ± 0.039	1.06ProArg: 1.06 ± 0.032	2.45ProSer: 2.45 ± 0.046	1.961ProThr: 1.961 ± 0.046	2.741ProVal: 2.741 ± 0.051	0.396ProTrp: 0.396 ± 0.018	1.634ProTyr: 1.634 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.823GlnAla: 2.823 ± 0.052	0.19GlnCys: 0.19 ± 0.014	2.435GlnAsp: 2.435 ± 0.051	3.789GlnGlu: 3.789 ± 0.066	1.709GlnPhe: 1.709 ± 0.04	2.464GlnGly: 2.464 ± 0.05	0.97GlnHis: 0.97 ± 0.028	2.587GlnIle: 2.587 ± 0.047	3.282GlnLys: 3.282 ± 0.056	3.994GlnLeu: 3.994 ± 0.066	1.264GlnMet: 1.264 ± 0.036	2.166GlnAsn: 2.166 ± 0.039	1.42GlnPro: 1.42 ± 0.037	2.204GlnGln: 2.204 ± 0.06	1.51GlnArg: 1.51 ± 0.035	2.686GlnSer: 2.686 ± 0.056	2.219GlnThr: 2.219 ± 0.049	2.732GlnVal: 2.732 ± 0.053	0.489GlnTrp: 0.489 ± 0.018	1.593GlnTyr: 1.593 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.31ArgAla: 2.31 ± 0.062	0.218ArgCys: 0.218 ± 0.014	2.136ArgAsp: 2.136 ± 0.045	3.255ArgGlu: 3.255 ± 0.056	1.88ArgPhe: 1.88 ± 0.039	2.268ArgGly: 2.268 ± 0.045	0.795ArgHis: 0.795 ± 0.025	2.887ArgIle: 2.887 ± 0.056	2.998ArgLys: 2.998 ± 0.053	3.678ArgLeu: 3.678 ± 0.057	1.289ArgMet: 1.289 ± 0.036	1.854ArgAsn: 1.854 ± 0.044	1.239ArgPro: 1.239 ± 0.035	1.433ArgGln: 1.433 ± 0.04	1.685ArgArg: 1.685 ± 0.045	2.258ArgSer: 2.258 ± 0.043	2.03ArgThr: 2.03 ± 0.044	2.684ArgVal: 2.684 ± 0.058	0.415ArgTrp: 0.415 ± 0.016	1.6ArgTyr: 1.6 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.352SerAla: 3.352 ± 0.06	0.355SerCys: 0.355 ± 0.018	3.116SerAsp: 3.116 ± 0.061	4.326SerGlu: 4.326 ± 0.076	3.452SerPhe: 3.452 ± 0.057	4.354SerGly: 4.354 ± 0.065	1.332SerHis: 1.332 ± 0.035	5.078SerIle: 5.078 ± 0.075	3.879SerLys: 3.879 ± 0.053	6.272SerLeu: 6.272 ± 0.076	1.894SerMet: 1.894 ± 0.044	2.728SerAsn: 2.728 ± 0.05	2.214SerPro: 2.214 ± 0.049	2.327SerGln: 2.327 ± 0.05	2.126SerArg: 2.126 ± 0.044	4.311SerSer: 4.311 ± 0.079	3.278SerThr: 3.278 ± 0.064	4.231SerVal: 4.231 ± 0.065	0.675SerTrp: 0.675 ± 0.026	2.464SerTyr: 2.464 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	3.313ThrAla: 3.313 ± 0.051	0.343ThrCys: 0.343 ± 0.018	2.69ThrAsp: 2.69 ± 0.047	3.457ThrGlu: 3.457 ± 0.06	2.714ThrPhe: 2.714 ± 0.05	3.869ThrGly: 3.869 ± 0.064	1.096ThrHis: 1.096 ± 0.032	4.32ThrIle: 4.32 ± 0.06	3.322ThrLys: 3.322 ± 0.051	5.369ThrLeu: 5.369 ± 0.068	1.418ThrMet: 1.418 ± 0.035	2.463ThrAsn: 2.463 ± 0.049	2.322ThrPro: 2.322 ± 0.045	1.726ThrGln: 1.726 ± 0.043	1.832ThrArg: 1.832 ± 0.044	3.469ThrSer: 3.469 ± 0.052	2.922ThrThr: 2.922 ± 0.058	3.937ThrVal: 3.937 ± 0.057	0.544ThrTrp: 0.544 ± 0.021	2.165ThrTyr: 2.165 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.559ValAla: 4.559 ± 0.072	0.543ValCys: 0.543 ± 0.022	4.013ValAsp: 4.013 ± 0.062	5.139ValGlu: 5.139 ± 0.063	3.143ValPhe: 3.143 ± 0.061	4.78ValGly: 4.78 ± 0.076	1.564ValHis: 1.564 ± 0.041	5.191ValIle: 5.191 ± 0.065	4.337ValLys: 4.337 ± 0.059	6.742ValLeu: 6.742 ± 0.088	1.985ValMet: 1.985 ± 0.042	3.201ValAsn: 3.201 ± 0.054	2.652ValPro: 2.652 ± 0.049	2.824ValGln: 2.824 ± 0.049	2.637ValArg: 2.637 ± 0.055	4.593ValSer: 4.593 ± 0.066	4.151ValThr: 4.151 ± 0.061	5.103ValVal: 5.103 ± 0.076	0.653ValTrp: 0.653 ± 0.023	2.334ValTyr: 2.334 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.586TrpAla: 0.586 ± 0.023	0.067TrpCys: 0.067 ± 0.007	0.626TrpAsp: 0.626 ± 0.023	0.725TrpGlu: 0.725 ± 0.024	0.56TrpPhe: 0.56 ± 0.022	0.73TrpGly: 0.73 ± 0.025	0.203TrpHis: 0.203 ± 0.012	0.945TrpIle: 0.945 ± 0.031	0.779TrpLys: 0.779 ± 0.028	1.189TrpLeu: 1.189 ± 0.037	0.391TrpMet: 0.391 ± 0.019	0.562TrpAsn: 0.562 ± 0.022	0.262TrpPro: 0.262 ± 0.016	0.349TrpGln: 0.349 ± 0.016	0.382TrpArg: 0.382 ± 0.019	0.647TrpSer: 0.647 ± 0.024	0.536TrpThr: 0.536 ± 0.023	0.762TrpVal: 0.762 ± 0.029	0.166TrpTrp: 0.166 ± 0.012	0.379TrpTyr: 0.379 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.109TyrAla: 2.109 ± 0.042	0.292TyrCys: 0.292 ± 0.018	2.153TyrAsp: 2.153 ± 0.048	2.849TyrGlu: 2.849 ± 0.05	1.89TyrPhe: 1.89 ± 0.036	2.511TyrGly: 2.511 ± 0.046	0.923TyrHis: 0.923 ± 0.026	2.536TyrIle: 2.536 ± 0.044	2.222TyrLys: 2.222 ± 0.047	3.386TyrLeu: 3.386 ± 0.055	0.993TyrMet: 0.993 ± 0.028	1.647TyrAsn: 1.647 ± 0.043	1.463TyrPro: 1.463 ± 0.036	1.787TyrGln: 1.787 ± 0.047	1.57TyrArg: 1.57 ± 0.036	2.094TyrSer: 2.094 ± 0.047	1.773TyrThr: 1.773 ± 0.043	2.422TyrVal: 2.422 ± 0.048	0.425TyrTrp: 0.425 ± 0.02	1.531TyrTyr: 1.531 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4252 proteins (1200615 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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