Amino acid dipepetide frequency for Blastococcus sp. DSM 44272

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.086AlaAla: 23.086 ± 0.214	1.009AlaCys: 1.009 ± 0.026	8.856AlaAsp: 8.856 ± 0.08	8.878AlaGlu: 8.878 ± 0.09	3.378AlaPhe: 3.378 ± 0.051	14.31AlaGly: 14.31 ± 0.109	2.64AlaHis: 2.64 ± 0.046	3.944AlaIle: 3.944 ± 0.048	1.951AlaLys: 1.951 ± 0.051	14.909AlaLeu: 14.909 ± 0.13	2.593AlaMet: 2.593 ± 0.044	1.8AlaAsn: 1.8 ± 0.034	7.115AlaPro: 7.115 ± 0.084	3.746AlaGln: 3.746 ± 0.064	10.74AlaArg: 10.74 ± 0.116	5.756AlaSer: 5.756 ± 0.069	7.493AlaThr: 7.493 ± 0.075	13.719AlaVal: 13.719 ± 0.127	1.882AlaTrp: 1.882 ± 0.039	2.275AlaTyr: 2.275 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.923CysAla: 0.923 ± 0.028	0.096CysCys: 0.096 ± 0.009	0.463CysAsp: 0.463 ± 0.017	0.347CysGlu: 0.347 ± 0.014	0.186CysPhe: 0.186 ± 0.011	0.897CysGly: 0.897 ± 0.026	0.173CysHis: 0.173 ± 0.011	0.188CysIle: 0.188 ± 0.011	0.078CysLys: 0.078 ± 0.007	0.691CysLeu: 0.691 ± 0.024	0.118CysMet: 0.118 ± 0.008	0.11CysAsn: 0.11 ± 0.009	0.506CysPro: 0.506 ± 0.022	0.143CysGln: 0.143 ± 0.008	0.643CysArg: 0.643 ± 0.02	0.419CysSer: 0.419 ± 0.019	0.444CysThr: 0.444 ± 0.018	0.579CysVal: 0.579 ± 0.02	0.12CysTrp: 0.12 ± 0.01	0.139CysTyr: 0.139 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.043AspAla: 8.043 ± 0.071	0.357AspCys: 0.357 ± 0.015	4.181AspAsp: 4.181 ± 0.063	4.12AspGlu: 4.12 ± 0.066	1.416AspPhe: 1.416 ± 0.034	6.322AspGly: 6.322 ± 0.078	1.247AspHis: 1.247 ± 0.03	1.7AspIle: 1.7 ± 0.037	0.758AspLys: 0.758 ± 0.023	6.88AspLeu: 6.88 ± 0.073	0.826AspMet: 0.826 ± 0.022	0.738AspAsn: 0.738 ± 0.026	4.722AspPro: 4.722 ± 0.059	1.606AspGln: 1.606 ± 0.031	5.368AspArg: 5.368 ± 0.071	2.206AspSer: 2.206 ± 0.039	2.784AspThr: 2.784 ± 0.046	6.238AspVal: 6.238 ± 0.072	0.953AspTrp: 0.953 ± 0.026	1.082AspTyr: 1.082 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.169GluAla: 7.169 ± 0.078	0.335GluCys: 0.335 ± 0.014	3.074GluAsp: 3.074 ± 0.055	3.44GluGlu: 3.44 ± 0.052	1.4GluPhe: 1.4 ± 0.031	4.158GluGly: 4.158 ± 0.051	1.603GluHis: 1.603 ± 0.036	2.128GluIle: 2.128 ± 0.042	1.09GluLys: 1.09 ± 0.03	6.939GluLeu: 6.939 ± 0.081	0.858GluMet: 0.858 ± 0.024	0.942GluAsn: 0.942 ± 0.025	3.341GluPro: 3.341 ± 0.046	2.454GluGln: 2.454 ± 0.043	5.271GluArg: 5.271 ± 0.079	2.439GluSer: 2.439 ± 0.042	2.735GluThr: 2.735 ± 0.047	5.234GluVal: 5.234 ± 0.057	0.736GluTrp: 0.736 ± 0.023	0.941GluTyr: 0.941 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.657PheAla: 3.657 ± 0.053	0.253PheCys: 0.253 ± 0.012	1.931PheAsp: 1.931 ± 0.041	1.326PheGlu: 1.326 ± 0.031	0.868PhePhe: 0.868 ± 0.03	2.985PheGly: 2.985 ± 0.043	0.505PheHis: 0.505 ± 0.019	0.713PheIle: 0.713 ± 0.025	0.325PheLys: 0.325 ± 0.015	2.611PheLeu: 2.611 ± 0.048	0.319PheMet: 0.319 ± 0.015	0.446PheAsn: 0.446 ± 0.017	1.356PhePro: 1.356 ± 0.028	0.591PheGln: 0.591 ± 0.022	1.732PheArg: 1.732 ± 0.035	1.425PheSer: 1.425 ± 0.027	1.756PheThr: 1.756 ± 0.033	2.379PheVal: 2.379 ± 0.043	0.391PheTrp: 0.391 ± 0.017	0.559PheTyr: 0.559 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.432GlyAla: 11.432 ± 0.095	0.847GlyCys: 0.847 ± 0.033	5.278GlyAsp: 5.278 ± 0.068	5.159GlyGlu: 5.159 ± 0.059	2.811GlyPhe: 2.811 ± 0.049	8.873GlyGly: 8.873 ± 0.094	2.06GlyHis: 2.06 ± 0.038	3.493GlyIle: 3.493 ± 0.052	1.716GlyLys: 1.716 ± 0.039	10.005GlyLeu: 10.005 ± 0.101	2.068GlyMet: 2.068 ± 0.041	1.612GlyAsn: 1.612 ± 0.035	5.341GlyPro: 5.341 ± 0.076	2.747GlyGln: 2.747 ± 0.042	8.332GlyArg: 8.332 ± 0.089	5.358GlySer: 5.358 ± 0.066	5.896GlyThr: 5.896 ± 0.083	8.375GlyVal: 8.375 ± 0.08	1.759GlyTrp: 1.759 ± 0.039	2.122GlyTyr: 2.122 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.545HisAla: 2.545 ± 0.043	0.177HisCys: 0.177 ± 0.011	1.265HisAsp: 1.265 ± 0.03	1.092HisGlu: 1.092 ± 0.024	0.532HisPhe: 0.532 ± 0.02	2.208HisGly: 2.208 ± 0.045	0.587HisHis: 0.587 ± 0.021	0.482HisIle: 0.482 ± 0.019	0.225HisLys: 0.225 ± 0.012	2.282HisLeu: 2.282 ± 0.038	0.311HisMet: 0.311 ± 0.013	0.301HisAsn: 0.301 ± 0.014	1.754HisPro: 1.754 ± 0.035	0.552HisGln: 0.552 ± 0.022	1.943HisArg: 1.943 ± 0.039	0.879HisSer: 0.879 ± 0.025	0.974HisThr: 0.974 ± 0.028	1.933HisVal: 1.933 ± 0.037	0.31HisTrp: 0.31 ± 0.013	0.396HisTyr: 0.396 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.869IleAla: 4.869 ± 0.06	0.266IleCys: 0.266 ± 0.014	2.348IleAsp: 2.348 ± 0.047	1.971IleGlu: 1.971 ± 0.039	0.681IlePhe: 0.681 ± 0.025	3.576IleGly: 3.576 ± 0.052	0.49IleHis: 0.49 ± 0.019	0.773IleIle: 0.773 ± 0.028	0.476IleLys: 0.476 ± 0.02	2.211IleLeu: 2.211 ± 0.043	0.381IleMet: 0.381 ± 0.015	0.633IleAsn: 0.633 ± 0.021	1.728IlePro: 1.728 ± 0.035	0.653IleGln: 0.653 ± 0.022	2.192IleArg: 2.192 ± 0.046	1.708IleSer: 1.708 ± 0.036	2.082IleThr: 2.082 ± 0.036	2.955IleVal: 2.955 ± 0.048	0.369IleTrp: 0.369 ± 0.016	0.522IleTyr: 0.522 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.046LysAla: 2.046 ± 0.048	0.064LysCys: 0.064 ± 0.006	0.869LysAsp: 0.869 ± 0.027	0.753LysGlu: 0.753 ± 0.027	0.313LysPhe: 0.313 ± 0.014	1.182LysGly: 1.182 ± 0.034	0.317LysHis: 0.317 ± 0.014	0.552LysIle: 0.552 ± 0.022	0.477LysLys: 0.477 ± 0.022	1.407LysLeu: 1.407 ± 0.04	0.26LysMet: 0.26 ± 0.014	0.326LysAsn: 0.326 ± 0.014	0.905LysPro: 0.905 ± 0.027	0.497LysGln: 0.497 ± 0.021	1.158LysArg: 1.158 ± 0.033	0.766LysSer: 0.766 ± 0.022	0.928LysThr: 0.928 ± 0.028	1.379LysVal: 1.379 ± 0.039	0.201LysTrp: 0.201 ± 0.013	0.314LysTyr: 0.314 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.518LeuAla: 16.518 ± 0.135	0.712LeuCys: 0.712 ± 0.025	6.966LeuAsp: 6.966 ± 0.08	5.091LeuGlu: 5.091 ± 0.07	2.574LeuPhe: 2.574 ± 0.049	9.86LeuGly: 9.86 ± 0.096	2.1LeuHis: 2.1 ± 0.038	3.102LeuIle: 3.102 ± 0.044	1.284LeuLys: 1.284 ± 0.036	11.807LeuLeu: 11.807 ± 0.118	1.486LeuMet: 1.486 ± 0.03	1.43LeuAsn: 1.43 ± 0.031	6.717LeuPro: 6.717 ± 0.075	2.658LeuGln: 2.658 ± 0.046	8.691LeuArg: 8.691 ± 0.097	5.413LeuSer: 5.413 ± 0.067	6.705LeuThr: 6.705 ± 0.074	10.342LeuVal: 10.342 ± 0.098	1.181LeuTrp: 1.181 ± 0.03	1.529LeuTyr: 1.529 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.292MetAla: 2.292 ± 0.039	0.132MetCys: 0.132 ± 0.01	0.848MetAsp: 0.848 ± 0.025	0.687MetGlu: 0.687 ± 0.024	0.391MetPhe: 0.391 ± 0.016	1.352MetGly: 1.352 ± 0.031	0.35MetHis: 0.35 ± 0.015	0.616MetIle: 0.616 ± 0.017	0.321MetLys: 0.321 ± 0.014	1.626MetLeu: 1.626 ± 0.035	0.247MetMet: 0.247 ± 0.014	0.359MetAsn: 0.359 ± 0.016	1.084MetPro: 1.084 ± 0.025	0.471MetGln: 0.471 ± 0.017	1.376MetArg: 1.376 ± 0.034	1.347MetSer: 1.347 ± 0.03	1.744MetThr: 1.744 ± 0.037	1.367MetVal: 1.367 ± 0.034	0.186MetTrp: 0.186 ± 0.013	0.257MetTyr: 0.257 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	1.991AsnAla: 1.991 ± 0.038	0.152AsnCys: 0.152 ± 0.01	0.823AsnAsp: 0.823 ± 0.024	0.715AsnGlu: 0.715 ± 0.026	0.412AsnPhe: 0.412 ± 0.017	1.556AsnGly: 1.556 ± 0.034	0.316AsnHis: 0.316 ± 0.015	0.524AsnIle: 0.524 ± 0.019	0.258AsnLys: 0.258 ± 0.014	1.603AsnLeu: 1.603 ± 0.035	0.267AsnMet: 0.267 ± 0.013	0.333AsnAsn: 0.333 ± 0.018	1.259AsnPro: 1.259 ± 0.027	0.423AsnGln: 0.423 ± 0.017	1.194AsnArg: 1.194 ± 0.03	0.768AsnSer: 0.768 ± 0.025	0.858AsnThr: 0.858 ± 0.024	1.334AsnVal: 1.334 ± 0.027	0.24AsnTrp: 0.24 ± 0.013	0.327AsnTyr: 0.327 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.035ProAla: 9.035 ± 0.114	0.296ProCys: 0.296 ± 0.014	4.696ProAsp: 4.696 ± 0.067	4.262ProGlu: 4.262 ± 0.051	1.563ProPhe: 1.563 ± 0.034	6.729ProGly: 6.729 ± 0.084	1.2ProHis: 1.2 ± 0.029	1.537ProIle: 1.537 ± 0.037	0.824ProLys: 0.824 ± 0.029	5.475ProLeu: 5.475 ± 0.065	1.067ProMet: 1.067 ± 0.028	0.828ProAsn: 0.828 ± 0.024	3.863ProPro: 3.863 ± 0.071	1.542ProGln: 1.542 ± 0.031	4.161ProArg: 4.161 ± 0.063	3.263ProSer: 3.263 ± 0.049	3.494ProThr: 3.494 ± 0.06	6.145ProVal: 6.145 ± 0.072	0.927ProTrp: 0.927 ± 0.027	1.057ProTyr: 1.057 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.786GlnAla: 3.786 ± 0.065	0.144GlnCys: 0.144 ± 0.011	1.275GlnAsp: 1.275 ± 0.03	1.414GlnGlu: 1.414 ± 0.032	0.723GlnPhe: 0.723 ± 0.025	1.995GlnGly: 1.995 ± 0.043	0.634GlnHis: 0.634 ± 0.022	1.013GlnIle: 1.013 ± 0.029	0.446GlnLys: 0.446 ± 0.019	3.372GlnLeu: 3.372 ± 0.05	0.505GlnMet: 0.505 ± 0.02	0.44GlnAsn: 0.44 ± 0.018	1.754GlnPro: 1.754 ± 0.032	1.2GlnGln: 1.2 ± 0.036	2.53GlnArg: 2.53 ± 0.047	1.149GlnSer: 1.149 ± 0.029	1.357GlnThr: 1.357 ± 0.032	2.754GlnVal: 2.754 ± 0.044	0.442GlnTrp: 0.442 ± 0.016	0.522GlnTyr: 0.522 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.263ArgAla: 10.263 ± 0.108	0.607ArgCys: 0.607 ± 0.023	4.382ArgAsp: 4.382 ± 0.063	4.46ArgGlu: 4.46 ± 0.056	2.268ArgPhe: 2.268 ± 0.039	6.176ArgGly: 6.176 ± 0.075	1.867ArgHis: 1.867 ± 0.039	2.945ArgIle: 2.945 ± 0.045	1.25ArgLys: 1.25 ± 0.034	9.033ArgLeu: 9.033 ± 0.098	1.857ArgMet: 1.857 ± 0.034	1.283ArgAsn: 1.283 ± 0.03	5.519ArgPro: 5.519 ± 0.086	2.37ArgGln: 2.37 ± 0.036	8.597ArgArg: 8.597 ± 0.108	4.572ArgSer: 4.572 ± 0.065	5.06ArgThr: 5.06 ± 0.066	6.485ArgVal: 6.485 ± 0.075	1.508ArgTrp: 1.508 ± 0.033	1.692ArgTyr: 1.692 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.707SerAla: 6.707 ± 0.073	0.4SerCys: 0.4 ± 0.017	2.602SerAsp: 2.602 ± 0.044	2.29SerGlu: 2.29 ± 0.041	1.452SerPhe: 1.452 ± 0.034	5.654SerGly: 5.654 ± 0.064	0.868SerHis: 0.868 ± 0.027	1.619SerIle: 1.619 ± 0.035	0.682SerLys: 0.682 ± 0.023	4.861SerLeu: 4.861 ± 0.056	1.13SerMet: 1.13 ± 0.03	0.748SerAsn: 0.748 ± 0.024	3.351SerPro: 3.351 ± 0.045	1.18SerGln: 1.18 ± 0.031	3.917SerArg: 3.917 ± 0.057	3.01SerSer: 3.01 ± 0.055	3.065SerThr: 3.065 ± 0.046	4.394SerVal: 4.394 ± 0.06	0.895SerTrp: 0.895 ± 0.022	1.053SerTyr: 1.053 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.675ThrAla: 8.675 ± 0.09	0.398ThrCys: 0.398 ± 0.016	3.54ThrAsp: 3.54 ± 0.054	3.132ThrGlu: 3.132 ± 0.047	1.595ThrPhe: 1.595 ± 0.035	6.532ThrGly: 6.532 ± 0.073	1.037ThrHis: 1.037 ± 0.028	1.768ThrIle: 1.768 ± 0.038	0.836ThrLys: 0.836 ± 0.03	5.513ThrLeu: 5.513 ± 0.06	0.911ThrMet: 0.911 ± 0.027	0.878ThrAsn: 0.878 ± 0.025	3.947ThrPro: 3.947 ± 0.059	1.282ThrGln: 1.282 ± 0.031	3.977ThrArg: 3.977 ± 0.06	3.095ThrSer: 3.095 ± 0.049	3.857ThrThr: 3.857 ± 0.057	6.216ThrVal: 6.216 ± 0.073	0.88ThrTrp: 0.88 ± 0.027	1.084ThrTyr: 1.084 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	13.01ValAla: 13.01 ± 0.121	0.712ValCys: 0.712 ± 0.023	6.058ValAsp: 6.058 ± 0.068	5.441ValGlu: 5.441 ± 0.067	2.521ValPhe: 2.521 ± 0.044	7.959ValGly: 7.959 ± 0.076	2.086ValHis: 2.086 ± 0.043	2.866ValIle: 2.866 ± 0.047	1.2ValLys: 1.2 ± 0.034	11.145ValLeu: 11.145 ± 0.106	1.401ValMet: 1.401 ± 0.033	1.521ValAsn: 1.521 ± 0.034	5.941ValPro: 5.941 ± 0.072	2.352ValGln: 2.352 ± 0.04	7.379ValArg: 7.379 ± 0.084	4.459ValSer: 4.459 ± 0.063	6.006ValThr: 6.006 ± 0.067	10.514ValVal: 10.514 ± 0.104	1.068ValTrp: 1.068 ± 0.028	1.504ValTyr: 1.504 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.667TrpAla: 1.667 ± 0.038	0.141TrpCys: 0.141 ± 0.011	0.795TrpAsp: 0.795 ± 0.021	0.65TrpGlu: 0.65 ± 0.022	0.497TrpPhe: 0.497 ± 0.02	1.017TrpGly: 1.017 ± 0.025	0.362TrpHis: 0.362 ± 0.015	0.49TrpIle: 0.49 ± 0.017	0.238TrpLys: 0.238 ± 0.012	1.847TrpLeu: 1.847 ± 0.039	0.245TrpMet: 0.245 ± 0.012	0.322TrpAsn: 0.322 ± 0.015	0.82TrpPro: 0.82 ± 0.023	0.529TrpGln: 0.529 ± 0.016	1.354TrpArg: 1.354 ± 0.035	0.982TrpSer: 0.982 ± 0.028	0.941TrpThr: 0.941 ± 0.027	1.143TrpVal: 1.143 ± 0.031	0.345TrpTrp: 0.345 ± 0.013	0.281TrpTyr: 0.281 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.364TyrAla: 2.364 ± 0.044	0.165TyrCys: 0.165 ± 0.012	1.295TyrAsp: 1.295 ± 0.03	1.06TyrGlu: 1.06 ± 0.03	0.544TyrPhe: 0.544 ± 0.019	1.945TyrGly: 1.945 ± 0.036	0.307TyrHis: 0.307 ± 0.015	0.432TyrIle: 0.432 ± 0.017	0.277TyrLys: 0.277 ± 0.014	1.947TyrLeu: 1.947 ± 0.037	0.202TyrMet: 0.202 ± 0.01	0.302TyrAsn: 0.302 ± 0.015	0.941TyrPro: 0.941 ± 0.025	0.46TyrGln: 0.46 ± 0.018	1.642TyrArg: 1.642 ± 0.033	0.866TyrSer: 0.866 ± 0.024	0.975TyrThr: 0.975 ± 0.027	1.655TyrVal: 1.655 ± 0.035	0.274TyrTrp: 0.274 ± 0.015	0.375TyrTyr: 0.375 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4923 proteins (1496879 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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