Amino acid dipepetide frequency for Blastococcus sp. TF02-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.31AlaAla: 23.31 ± 0.226
0.943AlaCys: 0.943 ± 0.033
8.984AlaAsp: 8.984 ± 0.1
9.092AlaGlu: 9.092 ± 0.126
3.333AlaPhe: 3.333 ± 0.056
14.489AlaGly: 14.489 ± 0.135
2.482AlaHis: 2.482 ± 0.051
3.701AlaIle: 3.701 ± 0.069
2.039AlaLys: 2.039 ± 0.051
15.217AlaLeu: 15.217 ± 0.13
2.514AlaMet: 2.514 ± 0.044
1.852AlaAsn: 1.852 ± 0.04
7.232AlaPro: 7.232 ± 0.117
3.936AlaGln: 3.936 ± 0.072
10.673AlaArg: 10.673 ± 0.096
5.99AlaSer: 5.99 ± 0.073
7.557AlaThr: 7.557 ± 0.084
13.877AlaVal: 13.877 ± 0.129
1.932AlaTrp: 1.932 ± 0.047
2.251AlaTyr: 2.251 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.851CysAla: 0.851 ± 0.026
0.091CysCys: 0.091 ± 0.01
0.486CysAsp: 0.486 ± 0.023
0.334CysGlu: 0.334 ± 0.016
0.185CysPhe: 0.185 ± 0.013
0.853CysGly: 0.853 ± 0.031
0.147CysHis: 0.147 ± 0.012
0.175CysIle: 0.175 ± 0.012
0.078CysLys: 0.078 ± 0.009
0.654CysLeu: 0.654 ± 0.024
0.096CysMet: 0.096 ± 0.01
0.103CysAsn: 0.103 ± 0.01
0.488CysPro: 0.488 ± 0.02
0.14CysGln: 0.14 ± 0.011
0.575CysArg: 0.575 ± 0.027
0.392CysSer: 0.392 ± 0.02
0.45CysThr: 0.45 ± 0.022
0.579CysVal: 0.579 ± 0.021
0.113CysTrp: 0.113 ± 0.011
0.113CysTyr: 0.113 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
8.248AspAla: 8.248 ± 0.097
0.367AspCys: 0.367 ± 0.017
4.295AspAsp: 4.295 ± 0.067
4.235AspGlu: 4.235 ± 0.063
1.372AspPhe: 1.372 ± 0.035
6.553AspGly: 6.553 ± 0.09
1.16AspHis: 1.16 ± 0.035
1.59AspIle: 1.59 ± 0.038
0.819AspLys: 0.819 ± 0.03
6.963AspLeu: 6.963 ± 0.076
0.769AspMet: 0.769 ± 0.026
0.743AspAsn: 0.743 ± 0.029
4.773AspPro: 4.773 ± 0.078
1.662AspGln: 1.662 ± 0.037
5.443AspArg: 5.443 ± 0.088
2.307AspSer: 2.307 ± 0.046
2.734AspThr: 2.734 ± 0.057
6.268AspVal: 6.268 ± 0.067
0.926AspTrp: 0.926 ± 0.029
1.016AspTyr: 1.016 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
7.394GluAla: 7.394 ± 0.11
0.317GluCys: 0.317 ± 0.016
3.098GluAsp: 3.098 ± 0.068
3.594GluGlu: 3.594 ± 0.066
1.423GluPhe: 1.423 ± 0.036
4.353GluGly: 4.353 ± 0.067
1.544GluHis: 1.544 ± 0.037
2.063GluIle: 2.063 ± 0.043
1.174GluLys: 1.174 ± 0.035
7.251GluLeu: 7.251 ± 0.096
0.845GluMet: 0.845 ± 0.028
0.954GluAsn: 0.954 ± 0.03
3.317GluPro: 3.317 ± 0.053
2.519GluGln: 2.519 ± 0.055
5.266GluArg: 5.266 ± 0.088
2.416GluSer: 2.416 ± 0.041
2.751GluThr: 2.751 ± 0.048
5.32GluVal: 5.32 ± 0.07
0.766GluTrp: 0.766 ± 0.027
0.906GluTyr: 0.906 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.535PheAla: 3.535 ± 0.055
0.251PheCys: 0.251 ± 0.016
1.907PheAsp: 1.907 ± 0.042
1.305PheGlu: 1.305 ± 0.036
0.821PhePhe: 0.821 ± 0.031
2.925PheGly: 2.925 ± 0.06
0.45PheHis: 0.45 ± 0.018
0.625PheIle: 0.625 ± 0.022
0.343PheLys: 0.343 ± 0.019
2.525PheLeu: 2.525 ± 0.049
0.339PheMet: 0.339 ± 0.016
0.437PheAsn: 0.437 ± 0.018
1.338PhePro: 1.338 ± 0.036
0.6PheGln: 0.6 ± 0.025
1.686PheArg: 1.686 ± 0.038
1.357PheSer: 1.357 ± 0.033
1.733PheThr: 1.733 ± 0.04
2.455PheVal: 2.455 ± 0.047
0.418PheTrp: 0.418 ± 0.019
0.497PheTyr: 0.497 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
11.683GlyAla: 11.683 ± 0.124
0.791GlyCys: 0.791 ± 0.029
5.499GlyAsp: 5.499 ± 0.087
5.366GlyGlu: 5.366 ± 0.065
2.79GlyPhe: 2.79 ± 0.05
8.932GlyGly: 8.932 ± 0.129
1.994GlyHis: 1.994 ± 0.046
3.335GlyIle: 3.335 ± 0.063
1.801GlyLys: 1.801 ± 0.045
10.151GlyLeu: 10.151 ± 0.108
2.092GlyMet: 2.092 ± 0.045
1.553GlyAsn: 1.553 ± 0.041
5.152GlyPro: 5.152 ± 0.065
2.769GlyGln: 2.769 ± 0.06
8.196GlyArg: 8.196 ± 0.088
5.507GlySer: 5.507 ± 0.081
6.036GlyThr: 6.036 ± 0.097
8.381GlyVal: 8.381 ± 0.09
1.826GlyTrp: 1.826 ± 0.041
2.183GlyTyr: 2.183 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.443HisAla: 2.443 ± 0.056
0.191HisCys: 0.191 ± 0.011
1.153HisAsp: 1.153 ± 0.035
1.128HisGlu: 1.128 ± 0.039
0.498HisPhe: 0.498 ± 0.021
2.064HisGly: 2.064 ± 0.048
0.554HisHis: 0.554 ± 0.024
0.437HisIle: 0.437 ± 0.021
0.229HisLys: 0.229 ± 0.015
2.192HisLeu: 2.192 ± 0.049
0.284HisMet: 0.284 ± 0.015
0.275HisAsn: 0.275 ± 0.015
1.609HisPro: 1.609 ± 0.038
0.504HisGln: 0.504 ± 0.021
1.795HisArg: 1.795 ± 0.047
0.827HisSer: 0.827 ± 0.027
0.913HisThr: 0.913 ± 0.022
1.824HisVal: 1.824 ± 0.044
0.292HisTrp: 0.292 ± 0.017
0.352HisTyr: 0.352 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
4.612IleAla: 4.612 ± 0.071
0.236IleCys: 0.236 ± 0.013
2.271IleAsp: 2.271 ± 0.045
1.889IleGlu: 1.889 ± 0.043
0.565IlePhe: 0.565 ± 0.023
3.398IleGly: 3.398 ± 0.054
0.436IleHis: 0.436 ± 0.019
0.709IleIle: 0.709 ± 0.028
0.505IleLys: 0.505 ± 0.025
2.038IleLeu: 2.038 ± 0.054
0.354IleMet: 0.354 ± 0.019
0.579IleAsn: 0.579 ± 0.022
1.549IlePro: 1.549 ± 0.037
0.648IleGln: 0.648 ± 0.027
2.05IleArg: 2.05 ± 0.038
1.642IleSer: 1.642 ± 0.035
1.946IleThr: 1.946 ± 0.047
2.637IleVal: 2.637 ± 0.056
0.338IleTrp: 0.338 ± 0.015
0.469IleTyr: 0.469 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
2.155LysAla: 2.155 ± 0.056
0.063LysCys: 0.063 ± 0.007
0.943LysAsp: 0.943 ± 0.033
0.826LysGlu: 0.826 ± 0.032
0.318LysPhe: 0.318 ± 0.018
1.23LysGly: 1.23 ± 0.033
0.305LysHis: 0.305 ± 0.016
0.527LysIle: 0.527 ± 0.023
0.544LysLys: 0.544 ± 0.027
1.526LysLeu: 1.526 ± 0.039
0.282LysMet: 0.282 ± 0.016
0.347LysAsn: 0.347 ± 0.02
0.928LysPro: 0.928 ± 0.025
0.51LysGln: 0.51 ± 0.022
1.16LysArg: 1.16 ± 0.036
0.783LysSer: 0.783 ± 0.03
0.921LysThr: 0.921 ± 0.029
1.496LysVal: 1.496 ± 0.042
0.198LysTrp: 0.198 ± 0.012
0.331LysTyr: 0.331 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
16.792LeuAla: 16.792 ± 0.14
0.687LeuCys: 0.687 ± 0.021
7.116LeuAsp: 7.116 ± 0.093
5.137LeuGlu: 5.137 ± 0.072
2.541LeuPhe: 2.541 ± 0.054
10.019LeuGly: 10.019 ± 0.114
1.974LeuHis: 1.974 ± 0.043
2.683LeuIle: 2.683 ± 0.062
1.355LeuLys: 1.355 ± 0.039
12.176LeuLeu: 12.176 ± 0.149
1.388LeuMet: 1.388 ± 0.035
1.355LeuAsn: 1.355 ± 0.037
6.933LeuPro: 6.933 ± 0.081
2.66LeuGln: 2.66 ± 0.051
8.59LeuArg: 8.59 ± 0.101
5.339LeuSer: 5.339 ± 0.071
6.799LeuThr: 6.799 ± 0.077
10.904LeuVal: 10.904 ± 0.125
1.2LeuTrp: 1.2 ± 0.033
1.428LeuTyr: 1.428 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.25MetAla: 2.25 ± 0.045
0.115MetCys: 0.115 ± 0.011
0.869MetAsp: 0.869 ± 0.027
0.663MetGlu: 0.663 ± 0.024
0.352MetPhe: 0.352 ± 0.019
1.386MetGly: 1.386 ± 0.037
0.303MetHis: 0.303 ± 0.018
0.528MetIle: 0.528 ± 0.021
0.331MetLys: 0.331 ± 0.017
1.549MetLeu: 1.549 ± 0.034
0.241MetMet: 0.241 ± 0.014
0.331MetAsn: 0.331 ± 0.016
1.089MetPro: 1.089 ± 0.032
0.452MetGln: 0.452 ± 0.021
1.271MetArg: 1.271 ± 0.033
1.36MetSer: 1.36 ± 0.034
1.6MetThr: 1.6 ± 0.034
1.304MetVal: 1.304 ± 0.03
0.173MetTrp: 0.173 ± 0.012
0.233MetTyr: 0.233 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
1.956AsnAla: 1.956 ± 0.038
0.13AsnCys: 0.13 ± 0.011
0.797AsnAsp: 0.797 ± 0.028
0.705AsnGlu: 0.705 ± 0.026
0.406AsnPhe: 0.406 ± 0.018
1.618AsnGly: 1.618 ± 0.045
0.299AsnHis: 0.299 ± 0.016
0.482AsnIle: 0.482 ± 0.022
0.274AsnLys: 0.274 ± 0.017
1.53AsnLeu: 1.53 ± 0.037
0.248AsnMet: 0.248 ± 0.013
0.31AsnAsn: 0.31 ± 0.018
1.188AsnPro: 1.188 ± 0.039
0.422AsnGln: 0.422 ± 0.021
1.162AsnArg: 1.162 ± 0.034
0.745AsnSer: 0.745 ± 0.026
0.859AsnThr: 0.859 ± 0.031
1.311AsnVal: 1.311 ± 0.036
0.225AsnTrp: 0.225 ± 0.013
0.303AsnTyr: 0.303 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
9.175ProAla: 9.175 ± 0.107
0.332ProCys: 0.332 ± 0.018
4.555ProAsp: 4.555 ± 0.066
4.303ProGlu: 4.303 ± 0.061
1.538ProPhe: 1.538 ± 0.034
6.712ProGly: 6.712 ± 0.087
1.16ProHis: 1.16 ± 0.032
1.377ProIle: 1.377 ± 0.034
0.816ProLys: 0.816 ± 0.025
5.439ProLeu: 5.439 ± 0.075
0.982ProMet: 0.982 ± 0.026
0.759ProAsn: 0.759 ± 0.028
3.584ProPro: 3.584 ± 0.071
1.57ProGln: 1.57 ± 0.04
4.06ProArg: 4.06 ± 0.07
3.104ProSer: 3.104 ± 0.054
3.584ProThr: 3.584 ± 0.06
6.11ProVal: 6.11 ± 0.081
0.905ProTrp: 0.905 ± 0.029
0.933ProTyr: 0.933 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.841GlnAla: 3.841 ± 0.069
0.131GlnCys: 0.131 ± 0.01
1.235GlnAsp: 1.235 ± 0.034
1.402GlnGlu: 1.402 ± 0.033
0.713GlnPhe: 0.713 ± 0.025
2.123GlnGly: 2.123 ± 0.046
0.596GlnHis: 0.596 ± 0.021
1.024GlnIle: 1.024 ± 0.029
0.535GlnLys: 0.535 ± 0.023
3.417GlnLeu: 3.417 ± 0.055
0.496GlnMet: 0.496 ± 0.023
0.409GlnAsn: 0.409 ± 0.02
1.741GlnPro: 1.741 ± 0.045
1.223GlnGln: 1.223 ± 0.036
2.619GlnArg: 2.619 ± 0.056
1.123GlnSer: 1.123 ± 0.03
1.426GlnThr: 1.426 ± 0.038
2.895GlnVal: 2.895 ± 0.05
0.395GlnTrp: 0.395 ± 0.02
0.541GlnTyr: 0.541 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
10.316ArgAla: 10.316 ± 0.102
0.505ArgCys: 0.505 ± 0.021
4.438ArgAsp: 4.438 ± 0.067
4.626ArgGlu: 4.626 ± 0.076
2.261ArgPhe: 2.261 ± 0.048
6.095ArgGly: 6.095 ± 0.07
1.703ArgHis: 1.703 ± 0.041
2.814ArgIle: 2.814 ± 0.059
1.211ArgLys: 1.211 ± 0.031
8.877ArgLeu: 8.877 ± 0.098
1.768ArgMet: 1.768 ± 0.044
1.193ArgAsn: 1.193 ± 0.033
5.308ArgPro: 5.308 ± 0.071
2.332ArgGln: 2.332 ± 0.051
8.334ArgArg: 8.334 ± 0.122
4.425ArgSer: 4.425 ± 0.068
4.941ArgThr: 4.941 ± 0.066
6.603ArgVal: 6.603 ± 0.077
1.493ArgTrp: 1.493 ± 0.036
1.653ArgTyr: 1.653 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.784SerAla: 6.784 ± 0.082
0.367SerCys: 0.367 ± 0.016
2.737SerAsp: 2.737 ± 0.047
2.337SerGlu: 2.337 ± 0.047
1.474SerPhe: 1.474 ± 0.034
5.687SerGly: 5.687 ± 0.073
0.819SerHis: 0.819 ± 0.024
1.539SerIle: 1.539 ± 0.041
0.706SerLys: 0.706 ± 0.027
4.816SerLeu: 4.816 ± 0.069
1.113SerMet: 1.113 ± 0.033
0.748SerAsn: 0.748 ± 0.024
3.16SerPro: 3.16 ± 0.059
1.15SerGln: 1.15 ± 0.031
3.786SerArg: 3.786 ± 0.059
3.005SerSer: 3.005 ± 0.063
3.254SerThr: 3.254 ± 0.053
4.44SerVal: 4.44 ± 0.057
0.906SerTrp: 0.906 ± 0.027
1.075SerTyr: 1.075 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
8.662ThrAla: 8.662 ± 0.097
0.411ThrCys: 0.411 ± 0.02
3.645ThrAsp: 3.645 ± 0.053
3.139ThrGlu: 3.139 ± 0.056
1.535ThrPhe: 1.535 ± 0.038
6.573ThrGly: 6.573 ± 0.094
1.049ThrHis: 1.049 ± 0.028
1.757ThrIle: 1.757 ± 0.04
0.855ThrLys: 0.855 ± 0.027
5.516ThrLeu: 5.516 ± 0.081
0.869ThrMet: 0.869 ± 0.028
0.943ThrAsn: 0.943 ± 0.03
3.951ThrPro: 3.951 ± 0.067
1.348ThrGln: 1.348 ± 0.03
3.9ThrArg: 3.9 ± 0.054
3.128ThrSer: 3.128 ± 0.056
4.015ThrThr: 4.015 ± 0.082
6.325ThrVal: 6.325 ± 0.073
0.913ThrTrp: 0.913 ± 0.027
1.112ThrTyr: 1.112 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
13.353ValAla: 13.353 ± 0.129
0.677ValCys: 0.677 ± 0.022
6.166ValAsp: 6.166 ± 0.078
5.535ValGlu: 5.535 ± 0.084
2.407ValPhe: 2.407 ± 0.049
8.093ValGly: 8.093 ± 0.084
1.987ValHis: 1.987 ± 0.04
2.685ValIle: 2.685 ± 0.052
1.26ValLys: 1.26 ± 0.037
11.427ValLeu: 11.427 ± 0.109
1.296ValMet: 1.296 ± 0.033
1.509ValAsn: 1.509 ± 0.042
5.897ValPro: 5.897 ± 0.073
2.454ValGln: 2.454 ± 0.043
7.419ValArg: 7.419 ± 0.083
4.572ValSer: 4.572 ± 0.061
6.178ValThr: 6.178 ± 0.08
11.186ValVal: 11.186 ± 0.126
1.145ValTrp: 1.145 ± 0.03
1.461ValTyr: 1.461 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.728TrpAla: 1.728 ± 0.038
0.13TrpCys: 0.13 ± 0.01
0.789TrpAsp: 0.789 ± 0.027
0.644TrpGlu: 0.644 ± 0.027
0.509TrpPhe: 0.509 ± 0.022
1.037TrpGly: 1.037 ± 0.032
0.344TrpHis: 0.344 ± 0.02
0.454TrpIle: 0.454 ± 0.021
0.237TrpLys: 0.237 ± 0.013
1.874TrpLeu: 1.874 ± 0.043
0.257TrpMet: 0.257 ± 0.016
0.293TrpAsn: 0.293 ± 0.015
0.851TrpPro: 0.851 ± 0.029
0.548TrpGln: 0.548 ± 0.022
1.324TrpArg: 1.324 ± 0.033
1.007TrpSer: 1.007 ± 0.031
0.957TrpThr: 0.957 ± 0.03
1.202TrpVal: 1.202 ± 0.033
0.366TrpTrp: 0.366 ± 0.02
0.264TrpTyr: 0.264 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.313TyrAla: 2.313 ± 0.041
0.167TyrCys: 0.167 ± 0.012
1.264TyrAsp: 1.264 ± 0.039
1.013TyrGlu: 1.013 ± 0.033
0.507TyrPhe: 0.507 ± 0.021
1.892TyrGly: 1.892 ± 0.047
0.258TyrHis: 0.258 ± 0.015
0.367TyrIle: 0.367 ± 0.018
0.282TyrLys: 0.282 ± 0.015
1.936TyrLeu: 1.936 ± 0.04
0.166TyrMet: 0.166 ± 0.011
0.276TyrAsn: 0.276 ± 0.017
0.912TyrPro: 0.912 ± 0.027
0.437TyrGln: 0.437 ± 0.021
1.589TyrArg: 1.589 ± 0.037
0.874TyrSer: 0.874 ± 0.029
0.993TyrThr: 0.993 ± 0.03
1.591TyrVal: 1.591 ± 0.035
0.284TyrTrp: 0.284 ± 0.015
0.351TyrTyr: 0.351 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3726 proteins (1181205 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski