Amino acid dipepetide frequency for Trypanosoma conorhini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.62AlaAla: 17.62 ± 0.144	1.871AlaCys: 1.871 ± 0.025	4.218AlaAsp: 4.218 ± 0.031	7.676AlaGlu: 7.676 ± 0.056	3.286AlaPhe: 3.286 ± 0.032	7.39AlaGly: 7.39 ± 0.06	2.176AlaHis: 2.176 ± 0.023	2.844AlaIle: 2.844 ± 0.027	3.944AlaLys: 3.944 ± 0.035	10.728AlaLeu: 10.728 ± 0.061	2.424AlaMet: 2.424 ± 0.022	2.515AlaAsn: 2.515 ± 0.024	6.052AlaPro: 6.052 ± 0.052	3.688AlaGln: 3.688 ± 0.035	6.866AlaArg: 6.866 ± 0.047	8.301AlaSer: 8.301 ± 0.048	6.345AlaThr: 6.345 ± 0.041	8.419AlaVal: 8.419 ± 0.054	1.209AlaTrp: 1.209 ± 0.018	1.98AlaTyr: 1.98 ± 0.021	0.011AlaXaa: 0.011 ± 0.001
Cys	2.026CysAla: 2.026 ± 0.024	0.648CysCys: 0.648 ± 0.014	0.94CysAsp: 0.94 ± 0.014	1.066CysGlu: 1.066 ± 0.013	0.857CysPhe: 0.857 ± 0.016	1.906CysGly: 1.906 ± 0.024	0.48CysHis: 0.48 ± 0.009	0.771CysIle: 0.771 ± 0.014	0.537CysLys: 0.537 ± 0.011	1.851CysLeu: 1.851 ± 0.02	0.409CysMet: 0.409 ± 0.009	0.505CysAsn: 0.505 ± 0.011	0.993CysPro: 0.993 ± 0.017	0.537CysGln: 0.537 ± 0.011	1.545CysArg: 1.545 ± 0.02	1.468CysSer: 1.468 ± 0.021	1.048CysThr: 1.048 ± 0.016	1.777CysVal: 1.777 ± 0.024	0.231CysTrp: 0.231 ± 0.007	0.448CysTyr: 0.448 ± 0.013	0.002CysXaa: 0.002 ± 0.001
Asp	6.579AspAla: 6.579 ± 0.047	0.753AspCys: 0.753 ± 0.012	3.204AspAsp: 3.204 ± 0.042	3.743AspGlu: 3.743 ± 0.034	1.554AspPhe: 1.554 ± 0.018	4.057AspGly: 4.057 ± 0.033	0.804AspHis: 0.804 ± 0.013	1.664AspIle: 1.664 ± 0.021	1.5AspLys: 1.5 ± 0.02	3.456AspLeu: 3.456 ± 0.028	0.941AspMet: 0.941 ± 0.014	1.267AspAsn: 1.267 ± 0.018	2.317AspPro: 2.317 ± 0.024	0.902AspGln: 0.902 ± 0.016	2.48AspArg: 2.48 ± 0.024	2.756AspSer: 2.756 ± 0.024	2.365AspThr: 2.365 ± 0.023	4.159AspVal: 4.159 ± 0.028	0.526AspTrp: 0.526 ± 0.011	1.081AspTyr: 1.081 ± 0.018	0.002AspXaa: 0.002 ± 0.001
Glu	8.179GluAla: 8.179 ± 0.055	1.008GluCys: 1.008 ± 0.015	3.612GluAsp: 3.612 ± 0.034	7.977GluGlu: 7.977 ± 0.074	1.886GluPhe: 1.886 ± 0.021	4.77GluGly: 4.77 ± 0.035	1.455GluHis: 1.455 ± 0.019	1.834GluIle: 1.834 ± 0.021	3.489GluLys: 3.489 ± 0.034	6.714GluLeu: 6.714 ± 0.05	1.616GluMet: 1.616 ± 0.022	1.952GluAsn: 1.952 ± 0.026	2.45GluPro: 2.45 ± 0.025	2.775GluGln: 2.775 ± 0.031	5.598GluArg: 5.598 ± 0.048	3.698GluSer: 3.698 ± 0.029	3.18GluThr: 3.18 ± 0.03	4.999GluVal: 4.999 ± 0.041	0.792GluTrp: 0.792 ± 0.015	1.456GluTyr: 1.456 ± 0.021	0.003GluXaa: 0.003 ± 0.001
Phe	3.353PheAla: 3.353 ± 0.03	0.859PheCys: 0.859 ± 0.012	1.71PheAsp: 1.71 ± 0.022	1.697PheGlu: 1.697 ± 0.021	1.852PhePhe: 1.852 ± 0.024	2.199PheGly: 2.199 ± 0.026	0.874PheHis: 0.874 ± 0.013	1.296PheIle: 1.296 ± 0.019	0.94PheLys: 0.94 ± 0.016	3.998PheLeu: 3.998 ± 0.038	0.758PheMet: 0.758 ± 0.013	0.996PheAsn: 0.996 ± 0.015	1.843PhePro: 1.843 ± 0.021	0.998PheGln: 0.998 ± 0.013	2.066PheArg: 2.066 ± 0.023	2.776PheSer: 2.776 ± 0.028	1.883PheThr: 1.883 ± 0.02	2.809PheVal: 2.809 ± 0.027	0.397PheTrp: 0.397 ± 0.009	0.981PheTyr: 0.981 ± 0.015	0.002PheXaa: 0.002 ± 0.001
Gly	7.745GlyAla: 7.745 ± 0.061	1.394GlyCys: 1.394 ± 0.019	3.846GlyAsp: 3.846 ± 0.032	4.893GlyGlu: 4.893 ± 0.04	2.143GlyPhe: 2.143 ± 0.027	7.957GlyGly: 7.957 ± 0.077	1.48GlyHis: 1.48 ± 0.02	2.174GlyIle: 2.174 ± 0.026	2.945GlyLys: 2.945 ± 0.029	4.998GlyLeu: 4.998 ± 0.036	1.392GlyMet: 1.392 ± 0.019	2.22GlyAsn: 2.22 ± 0.025	2.862GlyPro: 2.862 ± 0.032	1.9GlyGln: 1.9 ± 0.022	5.206GlyArg: 5.206 ± 0.044	5.263GlySer: 5.263 ± 0.04	3.787GlyThr: 3.787 ± 0.033	5.633GlyVal: 5.633 ± 0.038	0.777GlyTrp: 0.777 ± 0.014	1.408GlyTyr: 1.408 ± 0.019	0.007GlyXaa: 0.007 ± 0.001
His	2.666HisAla: 2.666 ± 0.025	0.592HisCys: 0.592 ± 0.011	1.196HisAsp: 1.196 ± 0.016	1.451HisGlu: 1.451 ± 0.018	0.974HisPhe: 0.974 ± 0.015	1.834HisGly: 1.834 ± 0.021	0.843HisHis: 0.843 ± 0.018	0.845HisIle: 0.845 ± 0.013	0.734HisLys: 0.734 ± 0.015	2.398HisLeu: 2.398 ± 0.025	0.487HisMet: 0.487 ± 0.01	0.716HisAsn: 0.716 ± 0.014	1.498HisPro: 1.498 ± 0.015	0.85HisGln: 0.85 ± 0.016	2.033HisArg: 2.033 ± 0.024	1.719HisSer: 1.719 ± 0.021	1.283HisThr: 1.283 ± 0.017	1.925HisVal: 1.925 ± 0.023	0.333HisTrp: 0.333 ± 0.009	0.679HisTyr: 0.679 ± 0.013	0.001HisXaa: 0.001 ± 0.001
Ile	3.073IleAla: 3.073 ± 0.028	0.635IleCys: 0.635 ± 0.013	1.611IleAsp: 1.611 ± 0.023	1.872IleGlu: 1.872 ± 0.025	1.207IlePhe: 1.207 ± 0.018	1.845IleGly: 1.845 ± 0.024	0.84IleHis: 0.84 ± 0.013	1.233IleIle: 1.233 ± 0.019	1.078IleLys: 1.078 ± 0.018	3.02IleLeu: 3.02 ± 0.029	0.654IleMet: 0.654 ± 0.013	0.946IleAsn: 0.946 ± 0.015	1.792IlePro: 1.792 ± 0.022	1.056IleGln: 1.056 ± 0.016	2.091IleArg: 2.091 ± 0.022	2.161IleSer: 2.161 ± 0.023	1.641IleThr: 1.641 ± 0.022	2.473IleVal: 2.473 ± 0.025	0.288IleTrp: 0.288 ± 0.007	0.777IleTyr: 0.777 ± 0.012	0.002IleXaa: 0.002 ± 0.001
Lys	3.49LysAla: 3.49 ± 0.03	0.61LysCys: 0.61 ± 0.012	1.797LysAsp: 1.797 ± 0.023	3.297LysGlu: 3.297 ± 0.032	0.974LysPhe: 0.974 ± 0.017	2.487LysGly: 2.487 ± 0.025	0.881LysHis: 0.881 ± 0.016	1.096LysIle: 1.096 ± 0.019	2.552LysLys: 2.552 ± 0.038	3.581LysLeu: 3.581 ± 0.03	0.916LysMet: 0.916 ± 0.017	1.234LysAsn: 1.234 ± 0.018	1.691LysPro: 1.691 ± 0.022	1.598LysGln: 1.598 ± 0.024	3.213LysArg: 3.213 ± 0.031	2.376LysSer: 2.376 ± 0.026	2.002LysThr: 2.002 ± 0.023	2.285LysVal: 2.285 ± 0.026	0.446LysTrp: 0.446 ± 0.01	1.01LysTyr: 1.01 ± 0.017	0.002LysXaa: 0.002 ± 0.001
Leu	8.923LeuAla: 8.923 ± 0.05	2.295LeuCys: 2.295 ± 0.023	4.175LeuAsp: 4.175 ± 0.034	6.236LeuGlu: 6.236 ± 0.049	3.77LeuPhe: 3.77 ± 0.029	5.397LeuGly: 5.397 ± 0.035	3.076LeuHis: 3.076 ± 0.031	2.637LeuIle: 2.637 ± 0.03	3.355LeuLys: 3.355 ± 0.032	12.706LeuLeu: 12.706 ± 0.096	2.084LeuMet: 2.084 ± 0.022	2.493LeuAsn: 2.493 ± 0.028	5.952LeuPro: 5.952 ± 0.044	5.384LeuGln: 5.384 ± 0.042	9.506LeuArg: 9.506 ± 0.054	7.319LeuSer: 7.319 ± 0.042	4.896LeuThr: 4.896 ± 0.039	6.175LeuVal: 6.175 ± 0.043	1.263LeuTrp: 1.263 ± 0.019	2.348LeuTyr: 2.348 ± 0.023	0.005LeuXaa: 0.005 ± 0.001
Met	1.87MetAla: 1.87 ± 0.021	0.409MetCys: 0.409 ± 0.01	1.067MetAsp: 1.067 ± 0.014	1.683MetGlu: 1.683 ± 0.02	0.662MetPhe: 0.662 ± 0.013	1.267MetGly: 1.267 ± 0.018	0.604MetHis: 0.604 ± 0.01	0.596MetIle: 0.596 ± 0.013	0.906MetLys: 0.906 ± 0.016	2.262MetLeu: 2.262 ± 0.024	0.599MetMet: 0.599 ± 0.013	0.732MetAsn: 0.732 ± 0.013	1.138MetPro: 1.138 ± 0.017	1.122MetGln: 1.122 ± 0.016	1.966MetArg: 1.966 ± 0.021	1.537MetSer: 1.537 ± 0.02	1.17MetThr: 1.17 ± 0.016	1.206MetVal: 1.206 ± 0.016	0.288MetTrp: 0.288 ± 0.008	0.567MetTyr: 0.567 ± 0.013	0.001MetXaa: 0.001 ± 0.001
Asn	3.209AsnAla: 3.209 ± 0.026	0.568AsnCys: 0.568 ± 0.013	1.464AsnAsp: 1.464 ± 0.02	1.868AsnGlu: 1.868 ± 0.024	1.02AsnPhe: 1.02 ± 0.016	2.199AsnGly: 2.199 ± 0.024	0.579AsnHis: 0.579 ± 0.012	1.084AsnIle: 1.084 ± 0.016	1.106AsnLys: 1.106 ± 0.017	2.145AsnLeu: 2.145 ± 0.024	0.595AsnMet: 0.595 ± 0.012	1.104AsnAsn: 1.104 ± 0.019	1.488AsnPro: 1.488 ± 0.02	0.689AsnGln: 0.689 ± 0.012	1.671AsnArg: 1.671 ± 0.021	2.061AsnSer: 2.061 ± 0.022	1.65AsnThr: 1.65 ± 0.019	2.124AsnVal: 2.124 ± 0.02	0.316AsnTrp: 0.316 ± 0.008	0.776AsnTyr: 0.776 ± 0.015	0.001AsnXaa: 0.001 ± 0.001
Pro	5.871ProAla: 5.871 ± 0.044	0.998ProCys: 0.998 ± 0.016	1.939ProAsp: 1.939 ± 0.022	2.964ProGlu: 2.964 ± 0.028	1.962ProPhe: 1.962 ± 0.022	3.027ProGly: 3.027 ± 0.035	1.605ProHis: 1.605 ± 0.021	1.472ProIle: 1.472 ± 0.018	1.718ProLys: 1.718 ± 0.021	5.776ProLeu: 5.776 ± 0.039	1.004ProMet: 1.004 ± 0.014	1.435ProAsn: 1.435 ± 0.018	5.721ProPro: 5.721 ± 0.063	2.545ProGln: 2.545 ± 0.032	4.202ProArg: 4.202 ± 0.038	4.905ProSer: 4.905 ± 0.039	3.284ProThr: 3.284 ± 0.03	3.616ProVal: 3.616 ± 0.028	0.603ProTrp: 0.603 ± 0.011	1.119ProTyr: 1.119 ± 0.015	0.007ProXaa: 0.007 ± 0.001
Gln	3.239GlnAla: 3.239 ± 0.028	0.687GlnCys: 0.687 ± 0.012	1.294GlnAsp: 1.294 ± 0.017	2.87GlnGlu: 2.87 ± 0.035	1.088GlnPhe: 1.088 ± 0.016	2.136GlnGly: 2.136 ± 0.021	1.238GlnHis: 1.238 ± 0.019	0.935GlnIle: 0.935 ± 0.016	1.708GlnLys: 1.708 ± 0.021	4.733GlnLeu: 4.733 ± 0.039	0.887GlnMet: 0.887 ± 0.012	0.97GlnAsn: 0.97 ± 0.014	2.142GlnPro: 2.142 ± 0.024	3.525GlnGln: 3.525 ± 0.056	4.409GlnArg: 4.409 ± 0.038	2.3GlnSer: 2.3 ± 0.023	1.757GlnThr: 1.757 ± 0.017	2.042GlnVal: 2.042 ± 0.022	0.544GlnTrp: 0.544 ± 0.01	0.877GlnTyr: 0.877 ± 0.013	0.002GlnXaa: 0.002 ± 0.001
Arg	6.946ArgAla: 6.946 ± 0.046	1.839ArgCys: 1.839 ± 0.021	3.392ArgAsp: 3.392 ± 0.028	5.754ArgGlu: 5.754 ± 0.047	2.429ArgPhe: 2.429 ± 0.026	5.772ArgGly: 5.772 ± 0.047	2.435ArgHis: 2.435 ± 0.025	2.387ArgIle: 2.387 ± 0.027	2.94ArgLys: 2.94 ± 0.032	7.966ArgLeu: 7.966 ± 0.048	1.669ArgMet: 1.669 ± 0.021	2.075ArgAsn: 2.075 ± 0.02	3.756ArgPro: 3.756 ± 0.028	3.803ArgGln: 3.803 ± 0.032	9.292ArgArg: 9.292 ± 0.067	5.108ArgSer: 5.108 ± 0.042	3.345ArgThr: 3.345 ± 0.028	5.334ArgVal: 5.334 ± 0.041	1.121ArgTrp: 1.121 ± 0.017	1.832ArgTyr: 1.832 ± 0.018	0.007ArgXaa: 0.007 ± 0.001
Ser	7.509SerAla: 7.509 ± 0.046	1.54SerCys: 1.54 ± 0.018	3.049SerAsp: 3.049 ± 0.023	3.803SerGlu: 3.803 ± 0.032	2.71SerPhe: 2.71 ± 0.026	5.235SerGly: 5.235 ± 0.039	1.815SerHis: 1.815 ± 0.019	2.322SerIle: 2.322 ± 0.028	2.307SerLys: 2.307 ± 0.026	7.534SerLeu: 7.534 ± 0.045	1.532SerMet: 1.532 ± 0.018	1.971SerAsn: 1.971 ± 0.022	4.84SerPro: 4.84 ± 0.039	2.354SerGln: 2.354 ± 0.024	5.11SerArg: 5.11 ± 0.037	7.229SerSer: 7.229 ± 0.051	4.093SerThr: 4.093 ± 0.031	5.274SerVal: 5.274 ± 0.038	0.832SerTrp: 0.832 ± 0.014	1.468SerTyr: 1.468 ± 0.018	0.005SerXaa: 0.005 ± 0.001
Thr	6.269ThrAla: 6.269 ± 0.042	0.886ThrCys: 0.886 ± 0.014	2.212ThrAsp: 2.212 ± 0.022	3.249ThrGlu: 3.249 ± 0.029	1.722ThrPhe: 1.722 ± 0.021	3.405ThrGly: 3.405 ± 0.028	1.286ThrHis: 1.286 ± 0.019	1.719ThrIle: 1.719 ± 0.022	1.741ThrLys: 1.741 ± 0.023	5.376ThrLeu: 5.376 ± 0.036	1.133ThrMet: 1.133 ± 0.016	1.449ThrAsn: 1.449 ± 0.019	3.726ThrPro: 3.726 ± 0.035	1.9ThrGln: 1.9 ± 0.021	3.611ThrArg: 3.611 ± 0.03	4.091ThrSer: 4.091 ± 0.032	3.623ThrThr: 3.623 ± 0.036	4.002ThrVal: 4.002 ± 0.037	0.564ThrTrp: 0.564 ± 0.011	1.064ThrTyr: 1.064 ± 0.016	0.006ThrXaa: 0.006 ± 0.001
Val	7.918ValAla: 7.918 ± 0.045	1.608ValCys: 1.608 ± 0.022	3.538ValAsp: 3.538 ± 0.027	5.113ValGlu: 5.113 ± 0.041	2.78ValPhe: 2.78 ± 0.028	4.739ValGly: 4.739 ± 0.036	1.697ValHis: 1.697 ± 0.021	2.187ValIle: 2.187 ± 0.027	2.684ValLys: 2.684 ± 0.031	7.416ValLeu: 7.416 ± 0.043	1.66ValMet: 1.66 ± 0.017	1.941ValAsn: 1.941 ± 0.023	4.068ValPro: 4.068 ± 0.036	2.572ValGln: 2.572 ± 0.024	5.325ValArg: 5.325 ± 0.033	5.155ValSer: 5.155 ± 0.039	3.868ValThr: 3.868 ± 0.037	6.271ValVal: 6.271 ± 0.047	0.848ValTrp: 0.848 ± 0.016	1.735ValTyr: 1.735 ± 0.022	0.005ValXaa: 0.005 ± 0.001
Trp	0.912TrpAla: 0.912 ± 0.017	0.309TrpCys: 0.309 ± 0.009	0.591TrpAsp: 0.591 ± 0.012	0.837TrpGlu: 0.837 ± 0.014	0.375TrpPhe: 0.375 ± 0.01	0.848TrpGly: 0.848 ± 0.017	0.282TrpHis: 0.282 ± 0.008	0.363TrpIle: 0.363 ± 0.01	0.575TrpLys: 0.575 ± 0.011	1.122TrpLeu: 1.122 ± 0.017	0.344TrpMet: 0.344 ± 0.008	0.409TrpAsn: 0.409 ± 0.01	0.461TrpPro: 0.461 ± 0.01	0.45TrpGln: 0.45 ± 0.01	1.327TrpArg: 1.327 ± 0.018	0.852TrpSer: 0.852 ± 0.014	0.56TrpThr: 0.56 ± 0.011	0.758TrpVal: 0.758 ± 0.013	0.231TrpTrp: 0.231 ± 0.008	0.294TrpTyr: 0.294 ± 0.007	0.001TrpXaa: 0.001 ± 0.0
Tyr	2.156TyrAla: 2.156 ± 0.026	0.535TyrCys: 0.535 ± 0.01	1.253TyrAsp: 1.253 ± 0.017	1.389TyrGlu: 1.389 ± 0.019	1.031TyrPhe: 1.031 ± 0.016	1.556TyrGly: 1.556 ± 0.019	0.609TyrHis: 0.609 ± 0.013	0.834TyrIle: 0.834 ± 0.015	0.778TyrLys: 0.778 ± 0.014	2.207TyrLeu: 2.207 ± 0.021	0.547TyrMet: 0.547 ± 0.01	0.788TyrAsn: 0.788 ± 0.015	0.973TyrPro: 0.973 ± 0.015	0.733TyrGln: 0.733 ± 0.014	1.673TyrArg: 1.673 ± 0.019	1.454TyrSer: 1.454 ± 0.018	1.25TyrThr: 1.25 ± 0.017	1.844TyrVal: 1.844 ± 0.024	0.291TyrTrp: 0.291 ± 0.009	0.786TyrTyr: 0.786 ± 0.015	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.011XaaAla: 0.011 ± 0.001	0.003XaaCys: 0.003 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.004XaaGlu: 0.004 ± 0.001	0.003XaaPhe: 0.003 ± 0.001	0.006XaaGly: 0.006 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.006XaaLeu: 0.006 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.005XaaPro: 0.005 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.011XaaArg: 0.011 ± 0.002	0.005XaaSer: 0.005 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.004XaaVal: 0.004 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.544XaaXaa: 0.544 ± 0.03

Statistics based on 10134 proteins (4735071 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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