Onchocerca volvulus

Taxonomy: cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca

Average proteome isoelectric point is 6.98

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 12227 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A044SD50|A0A044SD50_ONCVO 80 kDa nuclear cap-binding protein OS=Onchocerca volvulus OX=6282 PE=3 SV=1
MM1 pKa = 7.43IVLSNVAAPTDD12 pKa = 4.82GIRR15 pKa = 11.84LIQGQVTAYY24 pKa = 9.66IEE26 pKa = 4.28SEE28 pKa = 4.25SAGEE32 pKa = 4.29GEE34 pKa = 4.43LTVSEE39 pKa = 5.32SSVTWISNISGQGFSLTYY57 pKa = 9.77PSIILHH63 pKa = 5.76AVSRR67 pKa = 11.84DD68 pKa = 3.2PSVFPEE74 pKa = 3.73EE75 pKa = 4.69CIYY78 pKa = 11.3VLADD82 pKa = 3.74AKK84 pKa = 11.09GSDD87 pKa = 3.25IGIQSTEE94 pKa = 3.86EE95 pKa = 4.26SVSSVQNVTANGIDD109 pKa = 3.44VEE111 pKa = 4.27AAEE114 pKa = 4.83NGCDD118 pKa = 5.72DD119 pKa = 5.96DD120 pKa = 7.56DD121 pKa = 6.62DD122 pKa = 6.87GNDD125 pKa = 3.91DD126 pKa = 5.62DD127 pKa = 6.38DD128 pKa = 5.88DD129 pKa = 4.28KK130 pKa = 12.07AHH132 pKa = 6.42LAIRR136 pKa = 11.84FAPQDD141 pKa = 3.04IMQNIYY147 pKa = 9.8QQMCEE152 pKa = 4.16CQEE155 pKa = 4.15LNPDD159 pKa = 3.79EE160 pKa = 6.04GDD162 pKa = 3.92DD163 pKa = 4.08FSDD166 pKa = 4.58DD167 pKa = 3.57FTMGPDD173 pKa = 3.93DD174 pKa = 5.98DD175 pKa = 4.91EE176 pKa = 5.35EE177 pKa = 6.25DD178 pKa = 4.02YY179 pKa = 11.57EE180 pKa = 5.83GDD182 pKa = 3.7GGEE185 pKa = 4.22GDD187 pKa = 4.49HH188 pKa = 7.18PNILHH193 pKa = 6.13FQNISSDD200 pKa = 3.54MHH202 pKa = 6.71RR203 pKa = 11.84HH204 pKa = 4.73EE205 pKa = 4.69TNGDD209 pKa = 2.87QRR211 pKa = 11.84YY212 pKa = 7.04TFDD215 pKa = 4.22SEE217 pKa = 4.95QMDD220 pKa = 3.7EE221 pKa = 4.25GG222 pKa = 4.02

Molecular weight: 24.23 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A044V351|A0A044V351_ONCVO Uncharacterized protein OS=Onchocerca volvulus OX=6282 PE=4 SV=1
MM1 pKa = 8.08PYY3 pKa = 9.73RR4 pKa = 11.84RR5 pKa = 11.84SRR7 pKa = 11.84SRR9 pKa = 11.84TRR11 pKa = 11.84RR12 pKa = 11.84TRR14 pKa = 11.84SRR16 pKa = 11.84SRR18 pKa = 11.84TPRR21 pKa = 11.84RR22 pKa = 11.84SVMSLSVVPVRR33 pKa = 11.84RR34 pKa = 11.84RR35 pKa = 11.84RR36 pKa = 11.84RR37 pKa = 11.84LRR39 pKa = 11.84SRR41 pKa = 11.84TRR43 pKa = 11.84SRR45 pKa = 11.84SLADD49 pKa = 3.85FDD51 pKa = 5.59LLGLVPSRR59 pKa = 11.84RR60 pKa = 11.84RR61 pKa = 11.84RR62 pKa = 11.84RR63 pKa = 11.84YY64 pKa = 7.82RR65 pKa = 11.84SRR67 pKa = 11.84SRR69 pKa = 11.84RR70 pKa = 11.84SLYY73 pKa = 10.03RR74 pKa = 11.84PRR76 pKa = 11.84LRR78 pKa = 11.84RR79 pKa = 11.84SLRR82 pKa = 11.84RR83 pKa = 11.84RR84 pKa = 11.84RR85 pKa = 11.84SPSLRR90 pKa = 11.84RR91 pKa = 11.84RR92 pKa = 11.84RR93 pKa = 11.84RR94 pKa = 11.84RR95 pKa = 11.84SSSRR99 pKa = 11.84RR100 pKa = 11.84RR101 pKa = 11.84RR102 pKa = 11.84RR103 pKa = 11.84SRR105 pKa = 11.84SPRR108 pKa = 11.84RR109 pKa = 11.84LRR111 pKa = 11.84SRR113 pKa = 11.84RR114 pKa = 11.84TLSRR118 pKa = 11.84RR119 pKa = 11.84RR120 pKa = 11.84PSRR123 pKa = 11.84SRR125 pKa = 11.84PRR127 pKa = 11.84SRR129 pKa = 11.84SRR131 pKa = 11.84SRR133 pKa = 11.84IYY135 pKa = 10.12RR136 pKa = 11.84YY137 pKa = 9.38GVRR140 pKa = 11.84RR141 pKa = 3.51

Molecular weight: 17.94 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

12119

108

12227

5048635

15

12628

412.9

46.89

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.039 ± 0.017

2.202 ± 0.017

5.39 ± 0.018

6.578 ± 0.031

4.355 ± 0.016

4.879 ± 0.026

2.401 ± 0.009

6.907 ± 0.019

6.317 ± 0.025

9.312 ± 0.028

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.536 ± 0.01

5.276 ± 0.017

4.218 ± 0.021

4.139 ± 0.02

5.635 ± 0.017

8.194 ± 0.027

5.557 ± 0.018

5.717 ± 0.017

1.108 ± 0.007

3.24 ± 0.015
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski