Amino acid dipepetide frequency for Onchocerca volvulus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.878AlaAla: 4.878 ± 0.056	1.167AlaCys: 1.167 ± 0.019	3.029AlaAsp: 3.029 ± 0.024	4.066AlaGlu: 4.066 ± 0.038	2.54AlaPhe: 2.54 ± 0.026	2.842AlaGly: 2.842 ± 0.029	1.317AlaHis: 1.317 ± 0.017	4.235AlaIle: 4.235 ± 0.036	3.652AlaLys: 3.652 ± 0.034	5.749AlaLeu: 5.749 ± 0.046	1.544AlaMet: 1.544 ± 0.019	2.859AlaAsn: 2.859 ± 0.025	2.222AlaPro: 2.222 ± 0.027	2.322AlaGln: 2.322 ± 0.029	2.991AlaArg: 2.991 ± 0.029	4.686AlaSer: 4.686 ± 0.036	3.59AlaThr: 3.59 ± 0.027	4.357AlaVal: 4.357 ± 0.033	0.556AlaTrp: 0.556 ± 0.012	1.785AlaTyr: 1.785 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	1.261CysAla: 1.261 ± 0.019	0.668CysCys: 0.668 ± 0.016	1.258CysAsp: 1.258 ± 0.024	1.249CysGlu: 1.249 ± 0.021	1.028CysPhe: 1.028 ± 0.016	1.293CysGly: 1.293 ± 0.021	0.575CysHis: 0.575 ± 0.012	1.513CysIle: 1.513 ± 0.023	1.25CysLys: 1.25 ± 0.02	1.924CysLeu: 1.924 ± 0.024	0.502CysMet: 0.502 ± 0.011	1.123CysAsn: 1.123 ± 0.02	1.05CysPro: 1.05 ± 0.027	0.81CysGln: 0.81 ± 0.015	1.267CysArg: 1.267 ± 0.02	1.945CysSer: 1.945 ± 0.024	1.121CysThr: 1.121 ± 0.018	1.195CysVal: 1.195 ± 0.02	0.251CysTrp: 0.251 ± 0.007	0.738CysTyr: 0.738 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.12AspAla: 3.12 ± 0.026	1.115AspCys: 1.115 ± 0.021	4.132AspAsp: 4.132 ± 0.041	4.692AspGlu: 4.692 ± 0.035	2.418AspPhe: 2.418 ± 0.025	3.256AspGly: 3.256 ± 0.037	1.115AspHis: 1.115 ± 0.018	3.676AspIle: 3.676 ± 0.029	2.943AspLys: 2.943 ± 0.031	4.759AspLeu: 4.759 ± 0.031	1.248AspMet: 1.248 ± 0.018	2.632AspAsn: 2.632 ± 0.028	1.994AspPro: 1.994 ± 0.021	1.826AspGln: 1.826 ± 0.02	2.748AspArg: 2.748 ± 0.027	4.071AspSer: 4.071 ± 0.034	2.444AspThr: 2.444 ± 0.025	3.261AspVal: 3.261 ± 0.03	0.634AspTrp: 0.634 ± 0.011	1.819AspTyr: 1.819 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	3.8GluAla: 3.8 ± 0.043	1.264GluCys: 1.264 ± 0.024	3.285GluAsp: 3.285 ± 0.035	5.438GluGlu: 5.438 ± 0.062	2.315GluPhe: 2.315 ± 0.024	2.58GluGly: 2.58 ± 0.029	1.457GluHis: 1.457 ± 0.019	4.687GluIle: 4.687 ± 0.037	5.589GluLys: 5.589 ± 0.055	5.898GluLeu: 5.898 ± 0.053	2.078GluMet: 2.078 ± 0.023	4.074GluAsn: 4.074 ± 0.032	2.045GluPro: 2.045 ± 0.026	3.123GluGln: 3.123 ± 0.03	4.033GluArg: 4.033 ± 0.04	4.473GluSer: 4.473 ± 0.033	3.514GluThr: 3.514 ± 0.032	3.382GluVal: 3.382 ± 0.039	0.763GluTrp: 0.763 ± 0.017	1.98GluTyr: 1.98 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.746PheAla: 2.746 ± 0.025	1.147PheCys: 1.147 ± 0.017	2.556PheAsp: 2.556 ± 0.024	2.556PheGlu: 2.556 ± 0.027	2.074PhePhe: 2.074 ± 0.029	2.659PheGly: 2.659 ± 0.03	1.143PheHis: 1.143 ± 0.014	3.07PheIle: 3.07 ± 0.035	2.04PheLys: 2.04 ± 0.024	4.237PheLeu: 4.237 ± 0.041	1.072PheMet: 1.072 ± 0.015	1.912PheAsn: 1.912 ± 0.021	1.816PhePro: 1.816 ± 0.023	1.493PheGln: 1.493 ± 0.017	2.28PheArg: 2.28 ± 0.024	3.511PheSer: 3.511 ± 0.034	2.332PheThr: 2.332 ± 0.022	2.769PheVal: 2.769 ± 0.029	0.533PheTrp: 0.533 ± 0.011	1.599PheTyr: 1.599 ± 0.022	0.001PheXaa: 0.001 ± 0.0
Gly	2.729GlyAla: 2.729 ± 0.033	1.033GlyCys: 1.033 ± 0.018	2.6GlyAsp: 2.6 ± 0.025	2.94GlyGlu: 2.94 ± 0.032	2.193GlyPhe: 2.193 ± 0.026	2.938GlyGly: 2.938 ± 0.044	1.195GlyHis: 1.195 ± 0.018	3.583GlyIle: 3.583 ± 0.029	3.23GlyLys: 3.23 ± 0.028	3.919GlyLeu: 3.919 ± 0.04	1.229GlyMet: 1.229 ± 0.022	2.646GlyAsn: 2.646 ± 0.027	1.821GlyPro: 1.821 ± 0.043	1.881GlyGln: 1.881 ± 0.024	2.925GlyArg: 2.925 ± 0.029	3.971GlySer: 3.971 ± 0.037	3.002GlyThr: 3.002 ± 0.031	2.597GlyVal: 2.597 ± 0.023	0.602GlyTrp: 0.602 ± 0.012	1.758GlyTyr: 1.758 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.339HisAla: 1.339 ± 0.015	0.655HisCys: 0.655 ± 0.012	1.135HisAsp: 1.135 ± 0.016	1.392HisGlu: 1.392 ± 0.019	1.281HisPhe: 1.281 ± 0.017	1.215HisGly: 1.215 ± 0.019	0.804HisHis: 0.804 ± 0.018	1.597HisIle: 1.597 ± 0.021	1.117HisLys: 1.117 ± 0.015	2.467HisLeu: 2.467 ± 0.02	0.575HisMet: 0.575 ± 0.011	1.095HisAsn: 1.095 ± 0.016	1.146HisPro: 1.146 ± 0.015	1.052HisGln: 1.052 ± 0.016	1.465HisArg: 1.465 ± 0.018	2.013HisSer: 2.013 ± 0.027	1.105HisThr: 1.105 ± 0.016	1.325HisVal: 1.325 ± 0.014	0.322HisTrp: 0.322 ± 0.009	0.907HisTyr: 0.907 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.581IleAla: 4.581 ± 0.037	1.751IleCys: 1.751 ± 0.021	3.997IleAsp: 3.997 ± 0.031	4.152IleGlu: 4.152 ± 0.04	3.22IlePhe: 3.22 ± 0.033	3.443IleGly: 3.443 ± 0.032	1.626IleHis: 1.626 ± 0.019	4.9IleIle: 4.9 ± 0.041	3.583IleLys: 3.583 ± 0.029	6.219IleLeu: 6.219 ± 0.042	1.569IleMet: 1.569 ± 0.018	3.417IleAsn: 3.417 ± 0.03	3.203IlePro: 3.203 ± 0.03	2.474IleGln: 2.474 ± 0.023	3.825IleArg: 3.825 ± 0.03	6.048IleSer: 6.048 ± 0.037	3.951IleThr: 3.951 ± 0.028	4.08IleVal: 4.08 ± 0.034	0.757IleTrp: 0.757 ± 0.012	2.269IleTyr: 2.269 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.32LysAla: 3.32 ± 0.034	1.398LysCys: 1.398 ± 0.022	2.987LysAsp: 2.987 ± 0.029	4.567LysGlu: 4.567 ± 0.052	2.453LysPhe: 2.453 ± 0.023	2.501LysGly: 2.501 ± 0.029	1.509LysHis: 1.509 ± 0.019	4.418LysIle: 4.418 ± 0.04	5.462LysLys: 5.462 ± 0.057	5.92LysLeu: 5.92 ± 0.044	1.826LysMet: 1.826 ± 0.02	3.684LysAsn: 3.684 ± 0.032	2.297LysPro: 2.297 ± 0.028	2.899LysGln: 2.899 ± 0.029	4.096LysArg: 4.096 ± 0.036	4.406LysSer: 4.406 ± 0.033	3.403LysThr: 3.403 ± 0.03	3.112LysVal: 3.112 ± 0.027	0.769LysTrp: 0.769 ± 0.012	2.145LysTyr: 2.145 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	5.642LeuAla: 5.642 ± 0.041	2.114LeuCys: 2.114 ± 0.024	4.578LeuAsp: 4.578 ± 0.033	5.732LeuGlu: 5.732 ± 0.055	4.238LeuPhe: 4.238 ± 0.037	3.659LeuGly: 3.659 ± 0.027	2.511LeuHis: 2.511 ± 0.028	6.224LeuIle: 6.224 ± 0.053	6.072LeuLys: 6.072 ± 0.043	9.91LeuLeu: 9.91 ± 0.073	2.338LeuMet: 2.338 ± 0.022	4.707LeuAsn: 4.707 ± 0.036	4.566LeuPro: 4.566 ± 0.04	4.226LeuGln: 4.226 ± 0.032	5.508LeuArg: 5.508 ± 0.039	7.766LeuSer: 7.766 ± 0.047	4.843LeuThr: 4.843 ± 0.032	4.612LeuVal: 4.612 ± 0.04	1.009LeuTrp: 1.009 ± 0.017	2.863LeuTyr: 2.863 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.587MetAla: 1.587 ± 0.018	0.459MetCys: 0.459 ± 0.01	1.485MetAsp: 1.485 ± 0.017	1.919MetGlu: 1.919 ± 0.024	0.942MetPhe: 0.942 ± 0.015	1.034MetGly: 1.034 ± 0.015	0.657MetHis: 0.657 ± 0.013	1.737MetIle: 1.737 ± 0.02	1.941MetLys: 1.941 ± 0.02	2.387MetLeu: 2.387 ± 0.027	0.73MetMet: 0.73 ± 0.013	1.474MetAsn: 1.474 ± 0.017	1.08MetPro: 1.08 ± 0.015	1.214MetGln: 1.214 ± 0.016	1.409MetArg: 1.409 ± 0.015	1.768MetSer: 1.768 ± 0.02	1.35MetThr: 1.35 ± 0.018	1.288MetVal: 1.288 ± 0.018	0.235MetTrp: 0.235 ± 0.006	0.665MetTyr: 0.665 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.21AsnAla: 3.21 ± 0.027	1.171AsnCys: 1.171 ± 0.019	3.43AsnAsp: 3.43 ± 0.032	3.958AsnGlu: 3.958 ± 0.034	2.331AsnPhe: 2.331 ± 0.022	3.173AsnGly: 3.173 ± 0.034	1.165AsnHis: 1.165 ± 0.016	3.784AsnIle: 3.784 ± 0.028	2.819AsnLys: 2.819 ± 0.025	4.536AsnLeu: 4.536 ± 0.035	1.273AsnMet: 1.273 ± 0.016	3.004AsnAsn: 3.004 ± 0.035	1.972AsnPro: 1.972 ± 0.021	1.88AsnGln: 1.88 ± 0.019	2.761AsnArg: 2.761 ± 0.026	4.302AsnSer: 4.302 ± 0.034	2.517AsnThr: 2.517 ± 0.024	3.111AsnVal: 3.111 ± 0.027	0.561AsnTrp: 0.561 ± 0.012	1.806AsnTyr: 1.806 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	2.262ProAla: 2.262 ± 0.025	0.762ProCys: 0.762 ± 0.019	2.091ProAsp: 2.091 ± 0.025	2.743ProGlu: 2.743 ± 0.032	1.866ProPhe: 1.866 ± 0.021	2.173ProGly: 2.173 ± 0.081	0.905ProHis: 0.905 ± 0.015	2.689ProIle: 2.689 ± 0.028	2.419ProLys: 2.419 ± 0.026	3.782ProLeu: 3.782 ± 0.033	0.883ProMet: 0.883 ± 0.012	2.108ProAsn: 2.108 ± 0.024	2.887ProPro: 2.887 ± 0.057	1.654ProGln: 1.654 ± 0.021	1.944ProArg: 1.944 ± 0.023	3.93ProSer: 3.93 ± 0.04	2.551ProThr: 2.551 ± 0.029	2.7ProVal: 2.7 ± 0.027	0.402ProTrp: 0.402 ± 0.01	1.424ProTyr: 1.424 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	2.125GlnAla: 2.125 ± 0.023	0.944GlnCys: 0.944 ± 0.019	1.447GlnAsp: 1.447 ± 0.017	2.342GlnGlu: 2.342 ± 0.027	1.767GlnPhe: 1.767 ± 0.02	1.374GlnGly: 1.374 ± 0.021	1.116GlnHis: 1.116 ± 0.017	2.939GlnIle: 2.939 ± 0.023	2.966GlnLys: 2.966 ± 0.032	4.394GlnLeu: 4.394 ± 0.032	1.276GlnMet: 1.276 ± 0.017	2.317GlnAsn: 2.317 ± 0.023	1.662GlnPro: 1.662 ± 0.023	3.286GlnGln: 3.286 ± 0.077	2.471GlnArg: 2.471 ± 0.027	3.002GlnSer: 3.002 ± 0.031	2.169GlnThr: 2.169 ± 0.022	1.906GlnVal: 1.906 ± 0.021	0.504GlnTrp: 0.504 ± 0.011	1.386GlnTyr: 1.386 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	2.888ArgAla: 2.888 ± 0.026	1.313ArgCys: 1.313 ± 0.022	2.607ArgAsp: 2.607 ± 0.026	3.431ArgGlu: 3.431 ± 0.036	2.429ArgPhe: 2.429 ± 0.022	2.358ArgGly: 2.358 ± 0.032	1.452ArgHis: 1.452 ± 0.019	4.022ArgIle: 4.022 ± 0.031	4.344ArgLys: 4.344 ± 0.038	5.295ArgLeu: 5.295 ± 0.04	1.456ArgMet: 1.456 ± 0.017	3.366ArgAsn: 3.366 ± 0.031	2.111ArgPro: 2.111 ± 0.023	2.451ArgGln: 2.451 ± 0.026	4.261ArgArg: 4.261 ± 0.043	4.441ArgSer: 4.441 ± 0.044	2.951ArgThr: 2.951 ± 0.027	2.584ArgVal: 2.584 ± 0.023	0.664ArgTrp: 0.664 ± 0.013	1.929ArgTyr: 1.929 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	4.899SerAla: 4.899 ± 0.033	1.647SerCys: 1.647 ± 0.023	4.546SerAsp: 4.546 ± 0.032	4.817SerGlu: 4.817 ± 0.039	3.565SerPhe: 3.565 ± 0.03	4.333SerGly: 4.333 ± 0.034	1.751SerHis: 1.751 ± 0.023	5.17SerIle: 5.17 ± 0.038	4.617SerLys: 4.617 ± 0.037	7.435SerLeu: 7.435 ± 0.048	1.883SerMet: 1.883 ± 0.02	4.338SerAsn: 4.338 ± 0.034	3.471SerPro: 3.471 ± 0.047	2.934SerGln: 2.934 ± 0.029	4.238SerArg: 4.238 ± 0.035	9.12SerSer: 9.12 ± 0.082	5.184SerThr: 5.184 ± 0.044	4.9SerVal: 4.9 ± 0.034	0.808SerTrp: 0.808 ± 0.014	2.278SerTyr: 2.278 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	3.784ThrAla: 3.784 ± 0.031	1.119ThrCys: 1.119 ± 0.02	2.998ThrAsp: 2.998 ± 0.029	3.424ThrGlu: 3.424 ± 0.031	2.376ThrPhe: 2.376 ± 0.024	2.89ThrGly: 2.89 ± 0.028	1.117ThrHis: 1.117 ± 0.016	3.917ThrIle: 3.917 ± 0.032	3.129ThrLys: 3.129 ± 0.027	4.802ThrLeu: 4.802 ± 0.033	1.3ThrMet: 1.3 ± 0.018	2.911ThrAsn: 2.911 ± 0.025	2.41ThrPro: 2.41 ± 0.03	1.771ThrGln: 1.771 ± 0.022	2.467ThrArg: 2.467 ± 0.022	4.95ThrSer: 4.95 ± 0.042	4.075ThrThr: 4.075 ± 0.053	3.992ThrVal: 3.992 ± 0.031	0.518ThrTrp: 0.518 ± 0.01	1.62ThrTyr: 1.62 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	3.778ValAla: 3.778 ± 0.031	1.208ValCys: 1.208 ± 0.021	3.316ValAsp: 3.316 ± 0.025	3.827ValGlu: 3.827 ± 0.037	2.364ValPhe: 2.364 ± 0.028	2.716ValGly: 2.716 ± 0.029	1.394ValHis: 1.394 ± 0.019	4.025ValIle: 4.025 ± 0.032	3.422ValLys: 3.422 ± 0.028	5.322ValLeu: 5.322 ± 0.037	1.416ValMet: 1.416 ± 0.019	2.779ValAsn: 2.779 ± 0.027	2.641ValPro: 2.641 ± 0.025	2.339ValGln: 2.339 ± 0.023	3.004ValArg: 3.004 ± 0.029	4.259ValSer: 4.259 ± 0.028	3.318ValThr: 3.318 ± 0.029	3.706ValVal: 3.706 ± 0.042	0.607ValTrp: 0.607 ± 0.012	1.727ValTyr: 1.727 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.538TrpAla: 0.538 ± 0.011	0.226TrpCys: 0.226 ± 0.007	0.551TrpAsp: 0.551 ± 0.013	0.582TrpGlu: 0.582 ± 0.011	0.504TrpPhe: 0.504 ± 0.011	0.401TrpGly: 0.401 ± 0.01	0.296TrpHis: 0.296 ± 0.009	0.829TrpIle: 0.829 ± 0.014	0.877TrpLys: 0.877 ± 0.014	1.148TrpLeu: 1.148 ± 0.017	0.347TrpMet: 0.347 ± 0.009	0.738TrpAsn: 0.738 ± 0.017	0.431TrpPro: 0.431 ± 0.009	0.465TrpGln: 0.465 ± 0.009	0.68TrpArg: 0.68 ± 0.013	0.832TrpSer: 0.832 ± 0.016	0.641TrpThr: 0.641 ± 0.012	0.445TrpVal: 0.445 ± 0.01	0.17TrpTrp: 0.17 ± 0.006	0.38TrpTyr: 0.38 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.899TyrAla: 1.899 ± 0.02	0.858TyrCys: 0.858 ± 0.017	1.875TyrAsp: 1.875 ± 0.019	1.955TyrGlu: 1.955 ± 0.021	1.642TyrPhe: 1.642 ± 0.023	1.952TyrGly: 1.952 ± 0.023	0.901TyrHis: 0.901 ± 0.015	2.052TyrIle: 2.052 ± 0.022	1.701TyrLys: 1.701 ± 0.02	3.016TyrLeu: 3.016 ± 0.029	0.815TyrMet: 0.815 ± 0.014	1.577TyrAsn: 1.577 ± 0.017	1.351TyrPro: 1.351 ± 0.022	1.292TyrGln: 1.292 ± 0.017	1.983TyrArg: 1.983 ± 0.021	2.441TyrSer: 2.441 ± 0.023	1.506TyrThr: 1.506 ± 0.018	1.845TyrVal: 1.845 ± 0.02	0.416TyrTrp: 0.416 ± 0.01	1.321TyrTyr: 1.321 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.004

Statistics based on 12227 proteins (5048635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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