Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA261G05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.225AlaAla: 5.225 ± 0.241
0.721AlaCys: 0.721 ± 0.066
3.619AlaAsp: 3.619 ± 0.166
5.918AlaGlu: 5.918 ± 0.189
2.641AlaPhe: 2.641 ± 0.147
5.789AlaGly: 5.789 ± 0.244
1.321AlaHis: 1.321 ± 0.093
4.947AlaIle: 4.947 ± 0.239
4.761AlaLys: 4.761 ± 0.175
7.067AlaLeu: 7.067 ± 0.241
1.556AlaMet: 1.556 ± 0.111
1.835AlaAsn: 1.835 ± 0.11
2.349AlaPro: 2.349 ± 0.118
1.578AlaGln: 1.578 ± 0.1
4.376AlaArg: 4.376 ± 0.222
4.333AlaSer: 4.333 ± 0.191
3.319AlaThr: 3.319 ± 0.161
4.683AlaVal: 4.683 ± 0.206
0.721AlaTrp: 0.721 ± 0.08
2.034AlaTyr: 2.034 ± 0.138
0.0AlaXaa: 0.0 ± 0.0
Cys
0.528CysAla: 0.528 ± 0.062
0.114CysCys: 0.114 ± 0.03
0.578CysAsp: 0.578 ± 0.067
0.892CysGlu: 0.892 ± 0.081
0.385CysPhe: 0.385 ± 0.055
1.306CysGly: 1.306 ± 0.106
0.221CysHis: 0.221 ± 0.047
0.585CysIle: 0.585 ± 0.062
0.507CysLys: 0.507 ± 0.065
0.771CysLeu: 0.771 ± 0.064
0.178CysMet: 0.178 ± 0.031
0.25CysAsn: 0.25 ± 0.041
0.764CysPro: 0.764 ± 0.075
0.25CysGln: 0.25 ± 0.047
0.521CysArg: 0.521 ± 0.051
0.628CysSer: 0.628 ± 0.068
0.435CysThr: 0.435 ± 0.051
0.585CysVal: 0.585 ± 0.068
0.15CysTrp: 0.15 ± 0.032
0.257CysTyr: 0.257 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
3.555AspAla: 3.555 ± 0.149
0.628AspCys: 0.628 ± 0.065
2.563AspAsp: 2.563 ± 0.136
5.118AspGlu: 5.118 ± 0.201
2.484AspPhe: 2.484 ± 0.137
3.791AspGly: 3.791 ± 0.176
0.992AspHis: 0.992 ± 0.089
3.569AspIle: 3.569 ± 0.172
3.105AspLys: 3.105 ± 0.155
6.432AspLeu: 6.432 ± 0.214
1.242AspMet: 1.242 ± 0.076
1.585AspAsn: 1.585 ± 0.145
2.827AspPro: 2.827 ± 0.144
1.306AspGln: 1.306 ± 0.099
2.884AspArg: 2.884 ± 0.153
2.813AspSer: 2.813 ± 0.133
2.277AspThr: 2.277 ± 0.131
4.347AspVal: 4.347 ± 0.175
0.821AspTrp: 0.821 ± 0.086
2.027AspTyr: 2.027 ± 0.144
0.0AspXaa: 0.0 ± 0.0
Glu
5.875GluAla: 5.875 ± 0.216
0.778GluCys: 0.778 ± 0.08
5.725GluAsp: 5.725 ± 0.197
10.608GluGlu: 10.608 ± 0.35
3.198GluPhe: 3.198 ± 0.186
6.196GluGly: 6.196 ± 0.199
1.385GluHis: 1.385 ± 0.11
7.303GluIle: 7.303 ± 0.247
8.316GluLys: 8.316 ± 0.286
9.023GluLeu: 9.023 ± 0.249
2.049GluMet: 2.049 ± 0.132
3.94GluAsn: 3.94 ± 0.225
2.77GluPro: 2.77 ± 0.17
1.685GluGln: 1.685 ± 0.095
5.611GluArg: 5.611 ± 0.209
4.476GluSer: 4.476 ± 0.177
3.848GluThr: 3.848 ± 0.167
6.653GluVal: 6.653 ± 0.216
0.792GluTrp: 0.792 ± 0.078
2.32GluTyr: 2.32 ± 0.11
0.0GluXaa: 0.0 ± 0.0
Phe
2.506PheAla: 2.506 ± 0.124
0.45PheCys: 0.45 ± 0.058
1.877PheAsp: 1.877 ± 0.115
3.155PheGlu: 3.155 ± 0.153
1.642PhePhe: 1.642 ± 0.127
3.248PheGly: 3.248 ± 0.167
0.764PheHis: 0.764 ± 0.072
2.256PheIle: 2.256 ± 0.165
2.184PheLys: 2.184 ± 0.142
3.99PheLeu: 3.99 ± 0.207
0.871PheMet: 0.871 ± 0.082
1.199PheAsn: 1.199 ± 0.104
1.449PhePro: 1.449 ± 0.104
0.992PheGln: 0.992 ± 0.08
1.942PheArg: 1.942 ± 0.118
2.656PheSer: 2.656 ± 0.15
1.977PheThr: 1.977 ± 0.123
2.584PheVal: 2.584 ± 0.128
0.471PheTrp: 0.471 ± 0.065
1.114PheTyr: 1.114 ± 0.096
0.0PheXaa: 0.0 ± 0.0
Gly
5.225GlyAla: 5.225 ± 0.225
0.871GlyCys: 0.871 ± 0.087
3.805GlyAsp: 3.805 ± 0.166
7.474GlyGlu: 7.474 ± 0.241
3.177GlyPhe: 3.177 ± 0.151
5.839GlyGly: 5.839 ± 0.237
1.178GlyHis: 1.178 ± 0.09
5.939GlyIle: 5.939 ± 0.249
5.939GlyLys: 5.939 ± 0.197
7.424GlyLeu: 7.424 ± 0.283
2.156GlyMet: 2.156 ± 0.128
2.12GlyAsn: 2.12 ± 0.127
2.327GlyPro: 2.327 ± 0.145
1.349GlyGln: 1.349 ± 0.092
4.69GlyArg: 4.69 ± 0.183
4.454GlySer: 4.454 ± 0.187
3.733GlyThr: 3.733 ± 0.176
6.353GlyVal: 6.353 ± 0.187
1.014GlyTrp: 1.014 ± 0.071
2.591GlyTyr: 2.591 ± 0.142
0.0GlyXaa: 0.0 ± 0.0
His
1.271HisAla: 1.271 ± 0.091
0.25HisCys: 0.25 ± 0.044
1.064HisAsp: 1.064 ± 0.099
1.613HisGlu: 1.613 ± 0.113
0.685HisPhe: 0.685 ± 0.069
1.342HisGly: 1.342 ± 0.102
0.4HisHis: 0.4 ± 0.054
1.071HisIle: 1.071 ± 0.081
0.978HisLys: 0.978 ± 0.086
1.82HisLeu: 1.82 ± 0.101
0.228HisMet: 0.228 ± 0.036
0.514HisAsn: 0.514 ± 0.06
1.278HisPro: 1.278 ± 0.097
0.6HisGln: 0.6 ± 0.068
1.106HisArg: 1.106 ± 0.097
0.935HisSer: 0.935 ± 0.083
0.728HisThr: 0.728 ± 0.075
1.299HisVal: 1.299 ± 0.097
0.243HisTrp: 0.243 ± 0.048
0.557HisTyr: 0.557 ± 0.065
0.0HisXaa: 0.0 ± 0.0
Ile
5.368IleAla: 5.368 ± 0.223
0.621IleCys: 0.621 ± 0.073
4.005IleAsp: 4.005 ± 0.191
5.739IleGlu: 5.739 ± 0.202
2.67IlePhe: 2.67 ± 0.161
5.911IleGly: 5.911 ± 0.276
1.292IleHis: 1.292 ± 0.098
4.676IleIle: 4.676 ± 0.209
4.376IleLys: 4.376 ± 0.172
6.953IleLeu: 6.953 ± 0.27
1.521IleMet: 1.521 ± 0.097
2.291IleAsn: 2.291 ± 0.122
3.512IlePro: 3.512 ± 0.171
1.927IleGln: 1.927 ± 0.127
4.033IleArg: 4.033 ± 0.16
4.819IleSer: 4.819 ± 0.192
3.519IleThr: 3.519 ± 0.158
4.861IleVal: 4.861 ± 0.198
0.528IleTrp: 0.528 ± 0.063
1.935IleTyr: 1.935 ± 0.11
0.0IleXaa: 0.0 ± 0.0
Lys
5.04LysAla: 5.04 ± 0.211
0.6LysCys: 0.6 ± 0.085
3.748LysAsp: 3.748 ± 0.167
6.303LysGlu: 6.303 ± 0.256
2.577LysPhe: 2.577 ± 0.142
4.769LysGly: 4.769 ± 0.189
1.228LysHis: 1.228 ± 0.092
6.082LysIle: 6.082 ± 0.198
5.882LysLys: 5.882 ± 0.299
7.031LysLeu: 7.031 ± 0.248
1.642LysMet: 1.642 ± 0.108
2.684LysAsn: 2.684 ± 0.14
2.634LysPro: 2.634 ± 0.143
1.599LysGln: 1.599 ± 0.1
4.426LysArg: 4.426 ± 0.193
4.205LysSer: 4.205 ± 0.188
3.641LysThr: 3.641 ± 0.156
5.711LysVal: 5.711 ± 0.225
0.821LysTrp: 0.821 ± 0.077
1.963LysTyr: 1.963 ± 0.111
0.0LysXaa: 0.0 ± 0.0
Leu
8.038LeuAla: 8.038 ± 0.232
0.757LeuCys: 0.757 ± 0.066
6.061LeuAsp: 6.061 ± 0.213
9.451LeuGlu: 9.451 ± 0.271
3.148LeuPhe: 3.148 ± 0.168
8.002LeuGly: 8.002 ± 0.285
1.613LeuHis: 1.613 ± 0.111
6.396LeuIle: 6.396 ± 0.253
7.181LeuLys: 7.181 ± 0.204
8.473LeuLeu: 8.473 ± 0.332
1.892LeuMet: 1.892 ± 0.137
3.284LeuAsn: 3.284 ± 0.156
4.048LeuPro: 4.048 ± 0.204
2.134LeuGln: 2.134 ± 0.111
5.832LeuArg: 5.832 ± 0.24
6.617LeuSer: 6.617 ± 0.212
4.833LeuThr: 4.833 ± 0.212
6.753LeuVal: 6.753 ± 0.231
0.928LeuTrp: 0.928 ± 0.096
2.106LeuTyr: 2.106 ± 0.137
0.0LeuXaa: 0.0 ± 0.0
Met
1.513MetAla: 1.513 ± 0.11
0.136MetCys: 0.136 ± 0.031
1.135MetAsp: 1.135 ± 0.089
1.799MetGlu: 1.799 ± 0.103
0.571MetPhe: 0.571 ± 0.068
1.899MetGly: 1.899 ± 0.12
0.278MetHis: 0.278 ± 0.036
1.62MetIle: 1.62 ± 0.117
1.856MetLys: 1.856 ± 0.111
1.942MetLeu: 1.942 ± 0.104
0.564MetMet: 0.564 ± 0.066
0.892MetAsn: 0.892 ± 0.073
1.028MetPro: 1.028 ± 0.09
0.357MetGln: 0.357 ± 0.046
1.428MetArg: 1.428 ± 0.103
1.463MetSer: 1.463 ± 0.102
1.392MetThr: 1.392 ± 0.093
1.378MetVal: 1.378 ± 0.092
0.164MetTrp: 0.164 ± 0.035
0.407MetTyr: 0.407 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
2.12AsnAla: 2.12 ± 0.129
0.457AsnCys: 0.457 ± 0.059
1.221AsnAsp: 1.221 ± 0.097
2.327AsnGlu: 2.327 ± 0.148
1.606AsnPhe: 1.606 ± 0.103
2.027AsnGly: 2.027 ± 0.133
0.592AsnHis: 0.592 ± 0.064
2.256AsnIle: 2.256 ± 0.135
1.763AsnLys: 1.763 ± 0.113
3.969AsnLeu: 3.969 ± 0.162
0.621AsnMet: 0.621 ± 0.073
0.842AsnAsn: 0.842 ± 0.085
2.399AsnPro: 2.399 ± 0.123
0.999AsnGln: 0.999 ± 0.094
1.842AsnArg: 1.842 ± 0.115
2.013AsnSer: 2.013 ± 0.133
1.521AsnThr: 1.521 ± 0.11
2.613AsnVal: 2.613 ± 0.136
0.435AsnTrp: 0.435 ± 0.06
1.042AsnTyr: 1.042 ± 0.084
0.0AsnXaa: 0.0 ± 0.0
Pro
2.213ProAla: 2.213 ± 0.133
0.393ProCys: 0.393 ± 0.055
2.577ProAsp: 2.577 ± 0.127
4.526ProGlu: 4.526 ± 0.176
1.578ProPhe: 1.578 ± 0.117
2.977ProGly: 2.977 ± 0.173
0.921ProHis: 0.921 ± 0.083
2.977ProIle: 2.977 ± 0.166
2.706ProLys: 2.706 ± 0.132
3.398ProLeu: 3.398 ± 0.165
0.692ProMet: 0.692 ± 0.075
1.356ProAsn: 1.356 ± 0.108
1.899ProPro: 1.899 ± 0.135
1.313ProGln: 1.313 ± 0.096
2.356ProArg: 2.356 ± 0.139
3.005ProSer: 3.005 ± 0.138
2.413ProThr: 2.413 ± 0.131
2.955ProVal: 2.955 ± 0.16
0.385ProTrp: 0.385 ± 0.052
1.521ProTyr: 1.521 ± 0.105
0.0ProXaa: 0.0 ± 0.0
Gln
1.806GlnAla: 1.806 ± 0.118
0.164GlnCys: 0.164 ± 0.034
1.221GlnAsp: 1.221 ± 0.108
2.441GlnGlu: 2.441 ± 0.14
0.721GlnPhe: 0.721 ± 0.064
1.62GlnGly: 1.62 ± 0.102
0.457GlnHis: 0.457 ± 0.058
1.927GlnIle: 1.927 ± 0.119
2.027GlnLys: 2.027 ± 0.11
2.127GlnLeu: 2.127 ± 0.123
0.664GlnMet: 0.664 ± 0.065
0.864GlnAsn: 0.864 ± 0.078
0.871GlnPro: 0.871 ± 0.066
0.628GlnGln: 0.628 ± 0.071
1.371GlnArg: 1.371 ± 0.111
1.142GlnSer: 1.142 ± 0.097
1.156GlnThr: 1.156 ± 0.09
1.877GlnVal: 1.877 ± 0.119
0.2GlnTrp: 0.2 ± 0.036
0.585GlnTyr: 0.585 ± 0.061
0.0GlnXaa: 0.0 ± 0.0
Arg
3.876ArgAla: 3.876 ± 0.157
0.607ArgCys: 0.607 ± 0.063
3.055ArgAsp: 3.055 ± 0.172
6.675ArgGlu: 6.675 ± 0.215
1.999ArgPhe: 1.999 ± 0.13
4.569ArgGly: 4.569 ± 0.185
0.878ArgHis: 0.878 ± 0.087
3.833ArgIle: 3.833 ± 0.192
5.375ArgLys: 5.375 ± 0.22
5.454ArgLeu: 5.454 ± 0.186
1.506ArgMet: 1.506 ± 0.088
1.813ArgAsn: 1.813 ± 0.112
1.87ArgPro: 1.87 ± 0.114
1.406ArgGln: 1.406 ± 0.096
4.147ArgArg: 4.147 ± 0.206
2.962ArgSer: 2.962 ± 0.147
2.848ArgThr: 2.848 ± 0.145
4.462ArgVal: 4.462 ± 0.208
0.671ArgTrp: 0.671 ± 0.079
1.585ArgTyr: 1.585 ± 0.109
0.0ArgXaa: 0.0 ± 0.0
Ser
4.076SerAla: 4.076 ± 0.179
0.585SerCys: 0.585 ± 0.069
3.355SerAsp: 3.355 ± 0.173
5.518SerGlu: 5.518 ± 0.201
2.463SerPhe: 2.463 ± 0.15
5.018SerGly: 5.018 ± 0.189
1.264SerHis: 1.264 ± 0.095
4.14SerIle: 4.14 ± 0.153
4.44SerLys: 4.44 ± 0.198
5.754SerLeu: 5.754 ± 0.245
1.363SerMet: 1.363 ± 0.1
1.792SerAsn: 1.792 ± 0.12
2.884SerPro: 2.884 ± 0.167
1.763SerGln: 1.763 ± 0.124
3.455SerArg: 3.455 ± 0.15
3.898SerSer: 3.898 ± 0.182
3.098SerThr: 3.098 ± 0.132
3.89SerVal: 3.89 ± 0.154
0.664SerTrp: 0.664 ± 0.071
1.528SerTyr: 1.528 ± 0.105
0.0SerXaa: 0.0 ± 0.0
Thr
3.198ThrAla: 3.198 ± 0.158
0.55ThrCys: 0.55 ± 0.059
2.263ThrAsp: 2.263 ± 0.138
3.305ThrGlu: 3.305 ± 0.148
1.763ThrPhe: 1.763 ± 0.12
4.283ThrGly: 4.283 ± 0.189
1.192ThrHis: 1.192 ± 0.087
3.541ThrIle: 3.541 ± 0.175
2.898ThrLys: 2.898 ± 0.154
5.147ThrLeu: 5.147 ± 0.188
0.892ThrMet: 0.892 ± 0.083
1.57ThrAsn: 1.57 ± 0.111
2.884ThrPro: 2.884 ± 0.136
1.221ThrGln: 1.221 ± 0.084
2.934ThrArg: 2.934 ± 0.146
3.191ThrSer: 3.191 ± 0.15
2.713ThrThr: 2.713 ± 0.15
3.469ThrVal: 3.469 ± 0.17
0.478ThrTrp: 0.478 ± 0.058
1.521ThrTyr: 1.521 ± 0.12
0.0ThrXaa: 0.0 ± 0.0
Val
4.74ValAla: 4.74 ± 0.191
0.75ValCys: 0.75 ± 0.077
4.333ValAsp: 4.333 ± 0.174
6.853ValGlu: 6.853 ± 0.225
2.541ValPhe: 2.541 ± 0.146
5.854ValGly: 5.854 ± 0.249
1.185ValHis: 1.185 ± 0.103
5.218ValIle: 5.218 ± 0.215
5.689ValLys: 5.689 ± 0.205
6.839ValLeu: 6.839 ± 0.223
1.413ValMet: 1.413 ± 0.108
2.491ValAsn: 2.491 ± 0.144
2.741ValPro: 2.741 ± 0.144
1.506ValGln: 1.506 ± 0.094
4.276ValArg: 4.276 ± 0.19
4.44ValSer: 4.44 ± 0.167
3.655ValThr: 3.655 ± 0.141
4.84ValVal: 4.84 ± 0.215
0.607ValTrp: 0.607 ± 0.064
1.827ValTyr: 1.827 ± 0.112
0.0ValXaa: 0.0 ± 0.0
Trp
0.7TrpAla: 0.7 ± 0.07
0.1TrpCys: 0.1 ± 0.027
0.571TrpAsp: 0.571 ± 0.065
0.778TrpGlu: 0.778 ± 0.074
0.371TrpPhe: 0.371 ± 0.058
0.771TrpGly: 0.771 ± 0.085
0.193TrpHis: 0.193 ± 0.037
0.814TrpIle: 0.814 ± 0.063
0.885TrpLys: 0.885 ± 0.094
0.949TrpLeu: 0.949 ± 0.076
0.257TrpMet: 0.257 ± 0.038
0.457TrpAsn: 0.457 ± 0.052
0.314TrpPro: 0.314 ± 0.053
0.393TrpGln: 0.393 ± 0.065
0.757TrpArg: 0.757 ± 0.081
0.771TrpSer: 0.771 ± 0.065
0.514TrpThr: 0.514 ± 0.053
0.607TrpVal: 0.607 ± 0.073
0.186TrpTrp: 0.186 ± 0.044
0.307TrpTyr: 0.307 ± 0.051
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.92TyrAla: 1.92 ± 0.126
0.378TyrCys: 0.378 ± 0.05
1.592TyrAsp: 1.592 ± 0.111
2.056TyrGlu: 2.056 ± 0.141
1.106TyrPhe: 1.106 ± 0.091
2.449TyrGly: 2.449 ± 0.135
0.628TyrHis: 0.628 ± 0.062
1.406TyrIle: 1.406 ± 0.109
1.713TyrLys: 1.713 ± 0.108
2.984TyrLeu: 2.984 ± 0.136
0.507TyrMet: 0.507 ± 0.054
0.885TyrAsn: 0.885 ± 0.09
1.313TyrPro: 1.313 ± 0.118
0.864TyrGln: 0.864 ± 0.082
1.613TyrArg: 1.613 ± 0.1
2.127TyrSer: 2.127 ± 0.129
1.392TyrThr: 1.392 ± 0.107
1.877TyrVal: 1.877 ± 0.137
0.414TyrTrp: 0.414 ± 0.051
0.928TyrTyr: 0.928 ± 0.096
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 601 proteins (140086 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski