Amino acid dipepetide frequency for Notoacmeibacter marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.115AlaAla: 15.115 ± 0.163	0.986AlaCys: 0.986 ± 0.032	7.505AlaAsp: 7.505 ± 0.085	8.148AlaGlu: 8.148 ± 0.098	4.685AlaPhe: 4.685 ± 0.066	10.041AlaGly: 10.041 ± 0.102	2.092AlaHis: 2.092 ± 0.05	7.152AlaIle: 7.152 ± 0.097	3.879AlaLys: 3.879 ± 0.078	12.801AlaLeu: 12.801 ± 0.139	3.904AlaMet: 3.904 ± 0.072	2.958AlaAsn: 2.958 ± 0.058	4.794AlaPro: 4.794 ± 0.078	3.386AlaGln: 3.386 ± 0.054	7.81AlaArg: 7.81 ± 0.102	6.293AlaSer: 6.293 ± 0.078	5.764AlaThr: 5.764 ± 0.082	8.263AlaVal: 8.263 ± 0.104	1.303AlaTrp: 1.303 ± 0.037	2.492AlaTyr: 2.492 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.968CysAla: 0.968 ± 0.028	0.104CysCys: 0.104 ± 0.01	0.588CysAsp: 0.588 ± 0.024	0.482CysGlu: 0.482 ± 0.024	0.338CysPhe: 0.338 ± 0.02	0.939CysGly: 0.939 ± 0.034	0.272CysHis: 0.272 ± 0.015	0.405CysIle: 0.405 ± 0.018	0.196CysLys: 0.196 ± 0.016	0.757CysLeu: 0.757 ± 0.031	0.156CysMet: 0.156 ± 0.013	0.176CysAsn: 0.176 ± 0.014	0.476CysPro: 0.476 ± 0.026	0.253CysGln: 0.253 ± 0.016	0.627CysArg: 0.627 ± 0.032	0.424CysSer: 0.424 ± 0.02	0.424CysThr: 0.424 ± 0.021	0.578CysVal: 0.578 ± 0.029	0.116CysTrp: 0.116 ± 0.01	0.197CysTyr: 0.197 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.16AspAla: 7.16 ± 0.09	0.532AspCys: 0.532 ± 0.022	4.303AspAsp: 4.303 ± 0.085	4.741AspGlu: 4.741 ± 0.074	2.203AspPhe: 2.203 ± 0.047	6.012AspGly: 6.012 ± 0.086	1.44AspHis: 1.44 ± 0.041	3.347AspIle: 3.347 ± 0.066	1.815AspLys: 1.815 ± 0.051	6.325AspLeu: 6.325 ± 0.084	1.596AspMet: 1.596 ± 0.04	1.507AspAsn: 1.507 ± 0.042	3.532AspPro: 3.532 ± 0.065	1.702AspGln: 1.702 ± 0.046	5.133AspArg: 5.133 ± 0.078	2.488AspSer: 2.488 ± 0.051	2.872AspThr: 2.872 ± 0.057	4.147AspVal: 4.147 ± 0.069	0.995AspTrp: 0.995 ± 0.033	1.618AspTyr: 1.618 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.17GluAla: 8.17 ± 0.096	0.387GluCys: 0.387 ± 0.021	3.342GluAsp: 3.342 ± 0.064	4.16GluGlu: 4.16 ± 0.08	1.673GluPhe: 1.673 ± 0.041	4.858GluGly: 4.858 ± 0.069	1.187GluHis: 1.187 ± 0.037	3.622GluIle: 3.622 ± 0.063	2.754GluLys: 2.754 ± 0.06	5.425GluLeu: 5.425 ± 0.08	1.818GluMet: 1.818 ± 0.04	1.912GluAsn: 1.912 ± 0.044	3.161GluPro: 3.161 ± 0.07	2.206GluGln: 2.206 ± 0.054	5.733GluArg: 5.733 ± 0.093	2.725GluSer: 2.725 ± 0.053	4.326GluThr: 4.326 ± 0.074	3.796GluVal: 3.796 ± 0.06	0.764GluTrp: 0.764 ± 0.028	0.988GluTyr: 0.988 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.666PheAla: 4.666 ± 0.075	0.419PheCys: 0.419 ± 0.017	2.911PheAsp: 2.911 ± 0.062	2.36PheGlu: 2.36 ± 0.045	1.541PhePhe: 1.541 ± 0.042	3.825PheGly: 3.825 ± 0.073	0.782PheHis: 0.782 ± 0.031	1.817PheIle: 1.817 ± 0.04	0.872PheLys: 0.872 ± 0.034	3.481PheLeu: 3.481 ± 0.061	0.895PheMet: 0.895 ± 0.03	0.951PheAsn: 0.951 ± 0.03	1.422PhePro: 1.422 ± 0.04	0.99PheGln: 0.99 ± 0.034	2.358PheArg: 2.358 ± 0.047	2.326PheSer: 2.326 ± 0.046	1.949PheThr: 1.949 ± 0.044	2.815PheVal: 2.815 ± 0.053	0.528PheTrp: 0.528 ± 0.024	0.938PheTyr: 0.938 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.962GlyAla: 8.962 ± 0.108	0.838GlyCys: 0.838 ± 0.034	4.855GlyAsp: 4.855 ± 0.083	5.592GlyGlu: 5.592 ± 0.082	3.549GlyPhe: 3.549 ± 0.065	7.263GlyGly: 7.263 ± 0.134	1.942GlyHis: 1.942 ± 0.043	4.546GlyIle: 4.546 ± 0.078	3.198GlyLys: 3.198 ± 0.073	8.609GlyLeu: 8.609 ± 0.111	2.352GlyMet: 2.352 ± 0.05	2.109GlyAsn: 2.109 ± 0.05	3.441GlyPro: 3.441 ± 0.062	3.002GlyGln: 3.002 ± 0.057	6.292GlyArg: 6.292 ± 0.091	4.53GlySer: 4.53 ± 0.073	4.515GlyThr: 4.515 ± 0.066	5.81GlyVal: 5.81 ± 0.082	1.335GlyTrp: 1.335 ± 0.039	2.197GlyTyr: 2.197 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.21HisAla: 2.21 ± 0.056	0.264HisCys: 0.264 ± 0.016	1.335HisAsp: 1.335 ± 0.04	1.188HisGlu: 1.188 ± 0.04	0.934HisPhe: 0.934 ± 0.035	1.984HisGly: 1.984 ± 0.044	0.568HisHis: 0.568 ± 0.029	1.022HisIle: 1.022 ± 0.029	0.48HisLys: 0.48 ± 0.021	2.088HisLeu: 2.088 ± 0.047	0.501HisMet: 0.501 ± 0.025	0.459HisAsn: 0.459 ± 0.025	1.241HisPro: 1.241 ± 0.039	0.527HisGln: 0.527 ± 0.024	1.518HisArg: 1.518 ± 0.044	0.984HisSer: 0.984 ± 0.031	0.802HisThr: 0.802 ± 0.03	1.392HisVal: 1.392 ± 0.044	0.294HisTrp: 0.294 ± 0.018	0.537HisTyr: 0.537 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.858IleAla: 7.858 ± 0.101	0.549IleCys: 0.549 ± 0.021	4.176IleAsp: 4.176 ± 0.06	4.135IleGlu: 4.135 ± 0.067	1.95IlePhe: 1.95 ± 0.047	5.58IleGly: 5.58 ± 0.089	0.995IleHis: 0.995 ± 0.035	2.385IleIle: 2.385 ± 0.055	1.235IleLys: 1.235 ± 0.042	4.781IleLeu: 4.781 ± 0.078	1.091IleMet: 1.091 ± 0.028	1.285IleAsn: 1.285 ± 0.037	2.079IlePro: 2.079 ± 0.046	1.131IleGln: 1.131 ± 0.036	3.536IleArg: 3.536 ± 0.065	2.761IleSer: 2.761 ± 0.055	2.497IleThr: 2.497 ± 0.051	4.959IleVal: 4.959 ± 0.074	0.625IleTrp: 0.625 ± 0.028	1.115IleTyr: 1.115 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.204LysAla: 4.204 ± 0.068	0.185LysCys: 0.185 ± 0.013	1.834LysAsp: 1.834 ± 0.053	1.812LysGlu: 1.812 ± 0.05	0.849LysPhe: 0.849 ± 0.029	2.722LysGly: 2.722 ± 0.059	0.562LysHis: 0.562 ± 0.022	1.701LysIle: 1.701 ± 0.042	1.434LysLys: 1.434 ± 0.051	3.045LysLeu: 3.045 ± 0.061	0.855LysMet: 0.855 ± 0.033	0.937LysAsn: 0.937 ± 0.03	1.986LysPro: 1.986 ± 0.049	0.906LysGln: 0.906 ± 0.031	2.681LysArg: 2.681 ± 0.059	1.926LysSer: 1.926 ± 0.042	2.025LysThr: 2.025 ± 0.047	2.157LysVal: 2.157 ± 0.05	0.344LysTrp: 0.344 ± 0.018	0.548LysTyr: 0.548 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.556LeuAla: 12.556 ± 0.126	0.934LeuCys: 0.934 ± 0.032	6.09LeuAsp: 6.09 ± 0.088	5.198LeuGlu: 5.198 ± 0.083	3.848LeuPhe: 3.848 ± 0.06	7.713LeuGly: 7.713 ± 0.099	1.818LeuHis: 1.818 ± 0.044	5.359LeuIle: 5.359 ± 0.082	3.462LeuLys: 3.462 ± 0.064	9.234LeuLeu: 9.234 ± 0.126	2.373LeuMet: 2.373 ± 0.049	2.599LeuAsn: 2.599 ± 0.056	5.548LeuPro: 5.548 ± 0.09	2.739LeuGln: 2.739 ± 0.054	6.522LeuArg: 6.522 ± 0.103	6.901LeuSer: 6.901 ± 0.091	5.575LeuThr: 5.575 ± 0.071	6.726LeuVal: 6.726 ± 0.103	1.093LeuTrp: 1.093 ± 0.034	2.001LeuTyr: 2.001 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.591MetAla: 3.591 ± 0.058	0.138MetCys: 0.138 ± 0.013	1.413MetAsp: 1.413 ± 0.041	1.428MetGlu: 1.428 ± 0.042	0.68MetPhe: 0.68 ± 0.024	2.032MetGly: 2.032 ± 0.051	0.411MetHis: 0.411 ± 0.021	1.529MetIle: 1.529 ± 0.041	1.09MetLys: 1.09 ± 0.033	2.386MetLeu: 2.386 ± 0.052	0.761MetMet: 0.761 ± 0.032	0.941MetAsn: 0.941 ± 0.033	1.534MetPro: 1.534 ± 0.038	0.836MetGln: 0.836 ± 0.028	1.98MetArg: 1.98 ± 0.05	1.663MetSer: 1.663 ± 0.038	1.863MetThr: 1.863 ± 0.04	1.829MetVal: 1.829 ± 0.041	0.202MetTrp: 0.202 ± 0.015	0.266MetTyr: 0.266 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.253AsnAla: 3.253 ± 0.06	0.222AsnCys: 0.222 ± 0.015	1.683AsnAsp: 1.683 ± 0.042	1.508AsnGlu: 1.508 ± 0.035	0.958AsnPhe: 0.958 ± 0.038	2.608AsnGly: 2.608 ± 0.053	0.529AsnHis: 0.529 ± 0.019	1.421AsnIle: 1.421 ± 0.048	0.673AsnLys: 0.673 ± 0.026	2.352AsnLeu: 2.352 ± 0.053	0.697AsnMet: 0.697 ± 0.028	0.604AsnAsn: 0.604 ± 0.026	1.668AsnPro: 1.668 ± 0.047	0.711AsnGln: 0.711 ± 0.028	2.048AsnArg: 2.048 ± 0.048	1.224AsnSer: 1.224 ± 0.036	1.156AsnThr: 1.156 ± 0.034	1.968AsnVal: 1.968 ± 0.052	0.432AsnTrp: 0.432 ± 0.021	0.637AsnTyr: 0.637 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.589ProAla: 5.589 ± 0.087	0.3ProCys: 0.3 ± 0.016	4.062ProAsp: 4.062 ± 0.067	3.434ProGlu: 3.434 ± 0.064	2.08ProPhe: 2.08 ± 0.054	3.856ProGly: 3.856 ± 0.073	0.973ProHis: 0.973 ± 0.032	2.455ProIle: 2.455 ± 0.049	1.689ProLys: 1.689 ± 0.04	4.648ProLeu: 4.648 ± 0.081	1.175ProMet: 1.175 ± 0.043	1.368ProAsn: 1.368 ± 0.044	2.194ProPro: 2.194 ± 0.052	1.54ProGln: 1.54 ± 0.045	2.615ProArg: 2.615 ± 0.056	2.859ProSer: 2.859 ± 0.054	2.382ProThr: 2.382 ± 0.056	4.181ProVal: 4.181 ± 0.065	0.579ProTrp: 0.579 ± 0.025	1.147ProTyr: 1.147 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.598GlnAla: 3.598 ± 0.064	0.23GlnCys: 0.23 ± 0.018	1.505GlnAsp: 1.505 ± 0.042	1.457GlnGlu: 1.457 ± 0.044	1.076GlnPhe: 1.076 ± 0.034	2.107GlnGly: 2.107 ± 0.051	0.573GlnHis: 0.573 ± 0.022	1.978GlnIle: 1.978 ± 0.047	1.197GlnLys: 1.197 ± 0.033	2.648GlnLeu: 2.648 ± 0.055	0.999GlnMet: 0.999 ± 0.031	0.968GlnAsn: 0.968 ± 0.031	1.687GlnPro: 1.687 ± 0.046	1.146GlnGln: 1.146 ± 0.04	2.385GlnArg: 2.385 ± 0.048	2.028GlnSer: 2.028 ± 0.044	2.039GlnThr: 2.039 ± 0.048	1.754GlnVal: 1.754 ± 0.047	0.396GlnTrp: 0.396 ± 0.019	0.547GlnTyr: 0.547 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.352ArgAla: 7.352 ± 0.093	0.496ArgCys: 0.496 ± 0.024	4.267ArgAsp: 4.267 ± 0.082	4.054ArgGlu: 4.054 ± 0.068	3.139ArgPhe: 3.139 ± 0.063	4.621ArgGly: 4.621 ± 0.071	1.876ArgHis: 1.876 ± 0.039	4.357ArgIle: 4.357 ± 0.067	2.541ArgLys: 2.541 ± 0.055	7.928ArgLeu: 7.928 ± 0.108	2.012ArgMet: 2.012 ± 0.045	2.025ArgAsn: 2.025 ± 0.047	3.475ArgPro: 3.475 ± 0.072	3.123ArgGln: 3.123 ± 0.059	5.897ArgArg: 5.897 ± 0.097	4.039ArgSer: 4.039 ± 0.072	3.566ArgThr: 3.566 ± 0.052	4.196ArgVal: 4.196 ± 0.062	0.982ArgTrp: 0.982 ± 0.033	1.722ArgTyr: 1.722 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.218SerAla: 6.218 ± 0.096	0.471SerCys: 0.471 ± 0.027	3.697SerAsp: 3.697 ± 0.064	3.463SerGlu: 3.463 ± 0.061	2.194SerPhe: 2.194 ± 0.046	5.437SerGly: 5.437 ± 0.079	1.192SerHis: 1.192 ± 0.038	3.029SerIle: 3.029 ± 0.065	1.58SerLys: 1.58 ± 0.041	5.46SerLeu: 5.46 ± 0.084	1.394SerMet: 1.394 ± 0.039	1.391SerAsn: 1.391 ± 0.04	2.537SerPro: 2.537 ± 0.049	1.641SerGln: 1.641 ± 0.046	3.846SerArg: 3.846 ± 0.066	3.099SerSer: 3.099 ± 0.082	2.645SerThr: 2.645 ± 0.054	3.955SerVal: 3.955 ± 0.067	0.707SerTrp: 0.707 ± 0.027	1.266SerTyr: 1.266 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.007ThrAla: 6.007 ± 0.085	0.414ThrCys: 0.414 ± 0.023	3.404ThrAsp: 3.404 ± 0.071	3.103ThrGlu: 3.103 ± 0.056	1.986ThrPhe: 1.986 ± 0.044	5.15ThrGly: 5.15 ± 0.076	1.02ThrHis: 1.02 ± 0.035	3.218ThrIle: 3.218 ± 0.055	1.494ThrLys: 1.494 ± 0.042	5.644ThrLeu: 5.644 ± 0.082	1.335ThrMet: 1.335 ± 0.039	1.336ThrAsn: 1.336 ± 0.04	2.96ThrPro: 2.96 ± 0.063	1.345ThrGln: 1.345 ± 0.034	3.08ThrArg: 3.08 ± 0.06	2.609ThrSer: 2.609 ± 0.054	2.719ThrThr: 2.719 ± 0.058	4.625ThrVal: 4.625 ± 0.067	0.489ThrTrp: 0.489 ± 0.025	1.139ThrTyr: 1.139 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.435ValAla: 8.435 ± 0.097	0.618ValCys: 0.618 ± 0.023	4.339ValAsp: 4.339 ± 0.072	4.837ValGlu: 4.837 ± 0.082	2.708ValPhe: 2.708 ± 0.059	5.367ValGly: 5.367 ± 0.092	1.302ValHis: 1.302 ± 0.038	3.838ValIle: 3.838 ± 0.056	2.141ValLys: 2.141 ± 0.052	7.029ValLeu: 7.029 ± 0.095	1.814ValMet: 1.814 ± 0.046	1.829ValAsn: 1.829 ± 0.052	3.69ValPro: 3.69 ± 0.056	1.873ValGln: 1.873 ± 0.048	4.693ValArg: 4.693 ± 0.071	4.361ValSer: 4.361 ± 0.077	4.265ValThr: 4.265 ± 0.078	5.098ValVal: 5.098 ± 0.076	0.842ValTrp: 0.842 ± 0.029	1.331ValTyr: 1.331 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.151TrpAla: 1.151 ± 0.038	0.14TrpCys: 0.14 ± 0.013	0.624TrpAsp: 0.624 ± 0.023	0.513TrpGlu: 0.513 ± 0.026	0.537TrpPhe: 0.537 ± 0.022	0.75TrpGly: 0.75 ± 0.032	0.291TrpHis: 0.291 ± 0.018	0.648TrpIle: 0.648 ± 0.029	0.452TrpLys: 0.452 ± 0.023	1.494TrpLeu: 1.494 ± 0.048	0.401TrpMet: 0.401 ± 0.022	0.447TrpAsn: 0.447 ± 0.022	0.698TrpPro: 0.698 ± 0.027	0.604TrpGln: 0.604 ± 0.026	1.073TrpArg: 1.073 ± 0.039	0.812TrpSer: 0.812 ± 0.028	0.723TrpThr: 0.723 ± 0.028	0.731TrpVal: 0.731 ± 0.03	0.215TrpTrp: 0.215 ± 0.015	0.278TrpTyr: 0.278 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.311TyrAla: 2.311 ± 0.055	0.248TyrCys: 0.248 ± 0.016	1.535TyrAsp: 1.535 ± 0.039	1.395TyrGlu: 1.395 ± 0.036	0.916TyrPhe: 0.916 ± 0.032	2.075TyrGly: 2.075 ± 0.048	0.501TyrHis: 0.501 ± 0.023	0.892TyrIle: 0.892 ± 0.03	0.531TyrLys: 0.531 ± 0.022	2.156TyrLeu: 2.156 ± 0.048	0.442TyrMet: 0.442 ± 0.022	0.553TyrAsn: 0.553 ± 0.024	1.003TyrPro: 1.003 ± 0.03	0.656TyrGln: 0.656 ± 0.024	1.842TyrArg: 1.842 ± 0.045	1.169TyrSer: 1.169 ± 0.041	0.97TyrThr: 0.97 ± 0.033	1.431TyrVal: 1.431 ± 0.042	0.338TyrTrp: 0.338 ± 0.019	0.552TyrTyr: 0.552 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3077 proteins (985364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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