Amino acid dipepetide frequency for Bacteroides sp. OM08-11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.453AlaAla: 5.453 ± 0.086
1.024AlaCys: 1.024 ± 0.03
4.114AlaAsp: 4.114 ± 0.07
4.6AlaGlu: 4.6 ± 0.083
3.167AlaPhe: 3.167 ± 0.052
5.034AlaGly: 5.034 ± 0.077
1.193AlaHis: 1.193 ± 0.033
4.749AlaIle: 4.749 ± 0.076
4.042AlaLys: 4.042 ± 0.064
6.488AlaLeu: 6.488 ± 0.079
1.942AlaMet: 1.942 ± 0.045
3.149AlaAsn: 3.149 ± 0.055
2.146AlaPro: 2.146 ± 0.052
2.518AlaGln: 2.518 ± 0.053
3.057AlaArg: 3.057 ± 0.055
4.012AlaSer: 4.012 ± 0.061
3.971AlaThr: 3.971 ± 0.066
4.66AlaVal: 4.66 ± 0.074
0.781AlaTrp: 0.781 ± 0.026
2.879AlaTyr: 2.879 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.727CysAla: 0.727 ± 0.027
0.212CysCys: 0.212 ± 0.014
0.67CysAsp: 0.67 ± 0.022
0.692CysGlu: 0.692 ± 0.023
0.628CysPhe: 0.628 ± 0.026
1.05CysGly: 1.05 ± 0.033
0.311CysHis: 0.311 ± 0.016
1.023CysIle: 1.023 ± 0.035
0.694CysLys: 0.694 ± 0.022
1.111CysLeu: 1.111 ± 0.035
0.344CysMet: 0.344 ± 0.017
0.608CysAsn: 0.608 ± 0.023
0.519CysPro: 0.519 ± 0.022
0.35CysGln: 0.35 ± 0.018
0.636CysArg: 0.636 ± 0.022
0.767CysSer: 0.767 ± 0.023
0.752CysThr: 0.752 ± 0.027
0.774CysVal: 0.774 ± 0.027
0.136CysTrp: 0.136 ± 0.011
0.529CysTyr: 0.529 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.811AspAla: 3.811 ± 0.068
0.618AspCys: 0.618 ± 0.023
2.681AspAsp: 2.681 ± 0.057
3.889AspGlu: 3.889 ± 0.055
2.952AspPhe: 2.952 ± 0.05
4.062AspGly: 4.062 ± 0.079
0.83AspHis: 0.83 ± 0.026
4.334AspIle: 4.334 ± 0.068
4.131AspLys: 4.131 ± 0.062
4.491AspLeu: 4.491 ± 0.069
1.649AspMet: 1.649 ± 0.038
2.887AspAsn: 2.887 ± 0.055
1.74AspPro: 1.74 ± 0.041
1.113AspGln: 1.113 ± 0.037
2.394AspArg: 2.394 ± 0.054
2.794AspSer: 2.794 ± 0.053
2.976AspThr: 2.976 ± 0.052
3.589AspVal: 3.589 ± 0.058
0.898AspTrp: 0.898 ± 0.03
2.907AspTyr: 2.907 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.639GluAla: 4.639 ± 0.071
0.61GluCys: 0.61 ± 0.025
3.317GluAsp: 3.317 ± 0.058
5.22GluGlu: 5.22 ± 0.081
2.469GluPhe: 2.469 ± 0.049
4.173GluGly: 4.173 ± 0.06
1.284GluHis: 1.284 ± 0.034
4.759GluIle: 4.759 ± 0.06
5.268GluLys: 5.268 ± 0.071
6.227GluLeu: 6.227 ± 0.092
2.025GluMet: 2.025 ± 0.045
3.59GluAsn: 3.59 ± 0.059
1.727GluPro: 1.727 ± 0.041
2.627GluGln: 2.627 ± 0.046
3.257GluArg: 3.257 ± 0.073
2.799GluSer: 2.799 ± 0.048
3.599GluThr: 3.599 ± 0.053
4.359GluVal: 4.359 ± 0.073
0.85GluTrp: 0.85 ± 0.024
2.908GluTyr: 2.908 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
2.942PheAla: 2.942 ± 0.053
0.695PheCys: 0.695 ± 0.026
2.683PheAsp: 2.683 ± 0.051
2.45PheGlu: 2.45 ± 0.05
2.212PhePhe: 2.212 ± 0.055
3.155PheGly: 3.155 ± 0.066
0.895PheHis: 0.895 ± 0.028
3.365PheIle: 3.365 ± 0.07
2.462PheLys: 2.462 ± 0.056
4.127PheLeu: 4.127 ± 0.071
1.264PheMet: 1.264 ± 0.033
2.393PheAsn: 2.393 ± 0.052
1.764PhePro: 1.764 ± 0.036
1.252PheGln: 1.252 ± 0.032
2.195PheArg: 2.195 ± 0.042
3.455PheSer: 3.455 ± 0.062
2.754PheThr: 2.754 ± 0.054
2.887PheVal: 2.887 ± 0.057
0.618PheTrp: 0.618 ± 0.026
2.022PheTyr: 2.022 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.346GlyAla: 4.346 ± 0.067
0.916GlyCys: 0.916 ± 0.029
3.554GlyAsp: 3.554 ± 0.056
4.2GlyGlu: 4.2 ± 0.072
3.149GlyPhe: 3.149 ± 0.054
4.809GlyGly: 4.809 ± 0.086
1.24GlyHis: 1.24 ± 0.034
5.585GlyIle: 5.585 ± 0.076
5.447GlyLys: 5.447 ± 0.076
5.777GlyLeu: 5.777 ± 0.084
2.207GlyMet: 2.207 ± 0.045
3.742GlyAsn: 3.742 ± 0.074
1.229GlyPro: 1.229 ± 0.033
2.025GlyGln: 2.025 ± 0.049
2.867GlyArg: 2.867 ± 0.054
4.018GlySer: 4.018 ± 0.068
4.299GlyThr: 4.299 ± 0.074
4.738GlyVal: 4.738 ± 0.059
1.03GlyTrp: 1.03 ± 0.035
3.45GlyTyr: 3.45 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.187HisAla: 1.187 ± 0.032
0.321HisCys: 0.321 ± 0.019
0.937HisAsp: 0.937 ± 0.03
0.988HisGlu: 0.988 ± 0.03
1.026HisPhe: 1.026 ± 0.031
1.24HisGly: 1.24 ± 0.031
0.485HisHis: 0.485 ± 0.025
1.442HisIle: 1.442 ± 0.04
1.072HisLys: 1.072 ± 0.031
1.793HisLeu: 1.793 ± 0.047
0.342HisMet: 0.342 ± 0.017
0.972HisAsn: 0.972 ± 0.03
1.098HisPro: 1.098 ± 0.031
0.609HisGln: 0.609 ± 0.026
0.929HisArg: 0.929 ± 0.028
1.141HisSer: 1.141 ± 0.037
1.072HisThr: 1.072 ± 0.031
1.066HisVal: 1.066 ± 0.032
0.261HisTrp: 0.261 ± 0.015
0.933HisTyr: 0.933 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.249IleAla: 5.249 ± 0.077
1.021IleCys: 1.021 ± 0.032
4.204IleAsp: 4.204 ± 0.06
4.511IleGlu: 4.511 ± 0.062
2.947IlePhe: 2.947 ± 0.057
4.875IleGly: 4.875 ± 0.074
1.386IleHis: 1.386 ± 0.036
4.883IleIle: 4.883 ± 0.086
4.18IleLys: 4.18 ± 0.067
6.296IleLeu: 6.296 ± 0.098
1.574IleMet: 1.574 ± 0.042
3.608IleAsn: 3.608 ± 0.057
3.267IlePro: 3.267 ± 0.057
2.252IleGln: 2.252 ± 0.046
3.554IleArg: 3.554 ± 0.058
4.752IleSer: 4.752 ± 0.069
4.21IleThr: 4.21 ± 0.062
4.554IleVal: 4.554 ± 0.065
0.755IleTrp: 0.755 ± 0.031
2.927IleTyr: 2.927 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.661LysAla: 4.661 ± 0.069
0.563LysCys: 0.563 ± 0.022
4.002LysAsp: 4.002 ± 0.069
5.876LysGlu: 5.876 ± 0.08
2.241LysPhe: 2.241 ± 0.044
4.578LysGly: 4.578 ± 0.076
1.245LysHis: 1.245 ± 0.03
4.306LysIle: 4.306 ± 0.066
5.29LysLys: 5.29 ± 0.075
5.449LysLeu: 5.449 ± 0.068
2.099LysMet: 2.099 ± 0.042
3.689LysAsn: 3.689 ± 0.063
2.174LysPro: 2.174 ± 0.046
2.65LysGln: 2.65 ± 0.049
3.158LysArg: 3.158 ± 0.061
3.311LysSer: 3.311 ± 0.06
3.484LysThr: 3.484 ± 0.053
4.507LysVal: 4.507 ± 0.066
0.802LysTrp: 0.802 ± 0.028
3.11LysTyr: 3.11 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
6.283LeuAla: 6.283 ± 0.087
1.366LeuCys: 1.366 ± 0.035
4.585LeuAsp: 4.585 ± 0.058
5.184LeuGlu: 5.184 ± 0.062
4.476LeuPhe: 4.476 ± 0.079
5.612LeuGly: 5.612 ± 0.088
1.799LeuHis: 1.799 ± 0.042
5.691LeuIle: 5.691 ± 0.092
6.465LeuLys: 6.465 ± 0.077
9.187LeuLeu: 9.187 ± 0.134
2.484LeuMet: 2.484 ± 0.045
4.726LeuAsn: 4.726 ± 0.061
4.104LeuPro: 4.104 ± 0.059
3.443LeuGln: 3.443 ± 0.06
4.12LeuArg: 4.12 ± 0.063
6.474LeuSer: 6.474 ± 0.082
5.176LeuThr: 5.176 ± 0.075
5.205LeuVal: 5.205 ± 0.07
1.111LeuTrp: 1.111 ± 0.03
3.71LeuTyr: 3.71 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.06MetAla: 2.06 ± 0.042
0.252MetCys: 0.252 ± 0.016
1.487MetAsp: 1.487 ± 0.04
1.832MetGlu: 1.832 ± 0.037
1.056MetPhe: 1.056 ± 0.029
1.921MetGly: 1.921 ± 0.044
0.427MetHis: 0.427 ± 0.018
1.658MetIle: 1.658 ± 0.039
2.683MetLys: 2.683 ± 0.045
2.507MetLeu: 2.507 ± 0.052
0.834MetMet: 0.834 ± 0.027
1.675MetAsn: 1.675 ± 0.039
1.148MetPro: 1.148 ± 0.037
1.134MetGln: 1.134 ± 0.034
1.336MetArg: 1.336 ± 0.035
1.496MetSer: 1.496 ± 0.039
1.49MetThr: 1.49 ± 0.038
1.58MetVal: 1.58 ± 0.041
0.258MetTrp: 0.258 ± 0.014
0.89MetTyr: 0.89 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.396AsnAla: 3.396 ± 0.05
0.557AsnCys: 0.557 ± 0.025
2.689AsnAsp: 2.689 ± 0.05
3.112AsnGlu: 3.112 ± 0.046
2.318AsnPhe: 2.318 ± 0.048
4.067AsnGly: 4.067 ± 0.07
1.005AsnHis: 1.005 ± 0.031
4.03AsnIle: 4.03 ± 0.074
3.29AsnLys: 3.29 ± 0.054
4.584AsnLeu: 4.584 ± 0.071
1.379AsnMet: 1.379 ± 0.033
2.822AsnAsn: 2.822 ± 0.057
2.456AsnPro: 2.456 ± 0.044
1.623AsnGln: 1.623 ± 0.04
2.445AsnArg: 2.445 ± 0.051
2.917AsnSer: 2.917 ± 0.048
2.808AsnThr: 2.808 ± 0.049
3.323AsnVal: 3.323 ± 0.057
0.682AsnTrp: 0.682 ± 0.024
2.483AsnTyr: 2.483 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.678ProAla: 2.678 ± 0.049
0.403ProCys: 0.403 ± 0.02
2.507ProAsp: 2.507 ± 0.047
3.312ProGlu: 3.312 ± 0.058
1.875ProPhe: 1.875 ± 0.04
2.488ProGly: 2.488 ± 0.049
0.753ProHis: 0.753 ± 0.027
2.351ProIle: 2.351 ± 0.049
1.989ProLys: 1.989 ± 0.043
3.251ProLeu: 3.251 ± 0.056
0.942ProMet: 0.942 ± 0.028
1.71ProAsn: 1.71 ± 0.047
0.775ProPro: 0.775 ± 0.025
1.439ProGln: 1.439 ± 0.042
1.306ProArg: 1.306 ± 0.035
2.069ProSer: 2.069 ± 0.044
1.967ProThr: 1.967 ± 0.04
3.0ProVal: 3.0 ± 0.053
0.459ProTrp: 0.459 ± 0.021
1.715ProTyr: 1.715 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.429GlnAla: 2.429 ± 0.05
0.321GlnCys: 0.321 ± 0.015
1.573GlnAsp: 1.573 ± 0.037
2.463GlnGlu: 2.463 ± 0.05
1.309GlnPhe: 1.309 ± 0.034
2.004GlnGly: 2.004 ± 0.045
0.611GlnHis: 0.611 ± 0.027
2.398GlnIle: 2.398 ± 0.054
2.455GlnLys: 2.455 ± 0.052
3.261GlnLeu: 3.261 ± 0.058
0.998GlnMet: 0.998 ± 0.028
1.688GlnAsn: 1.688 ± 0.044
1.293GlnPro: 1.293 ± 0.031
1.504GlnGln: 1.504 ± 0.044
1.708GlnArg: 1.708 ± 0.036
1.886GlnSer: 1.886 ± 0.042
2.021GlnThr: 2.021 ± 0.042
2.173GlnVal: 2.173 ± 0.048
0.5GlnTrp: 0.5 ± 0.024
1.472GlnTyr: 1.472 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.791ArgAla: 2.791 ± 0.051
0.472ArgCys: 0.472 ± 0.02
2.177ArgAsp: 2.177 ± 0.044
3.116ArgGlu: 3.116 ± 0.061
2.291ArgPhe: 2.291 ± 0.04
2.501ArgGly: 2.501 ± 0.049
0.923ArgHis: 0.923 ± 0.033
3.672ArgIle: 3.672 ± 0.06
3.404ArgLys: 3.404 ± 0.057
4.454ArgLeu: 4.454 ± 0.064
1.563ArgMet: 1.563 ± 0.037
2.464ArgAsn: 2.464 ± 0.049
1.624ArgPro: 1.624 ± 0.041
1.817ArgGln: 1.817 ± 0.045
2.313ArgArg: 2.313 ± 0.049
2.426ArgSer: 2.426 ± 0.049
2.502ArgThr: 2.502 ± 0.046
2.627ArgVal: 2.627 ± 0.054
0.628ArgTrp: 0.628 ± 0.025
2.193ArgTyr: 2.193 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.994SerAla: 3.994 ± 0.064
0.823SerCys: 0.823 ± 0.026
3.251SerAsp: 3.251 ± 0.056
3.365SerGlu: 3.365 ± 0.053
3.099SerPhe: 3.099 ± 0.053
4.473SerGly: 4.473 ± 0.069
1.128SerHis: 1.128 ± 0.035
4.39SerIle: 4.39 ± 0.065
3.338SerLys: 3.338 ± 0.056
5.678SerLeu: 5.678 ± 0.069
1.546SerMet: 1.546 ± 0.041
2.718SerAsn: 2.718 ± 0.058
2.265SerPro: 2.265 ± 0.042
1.813SerGln: 1.813 ± 0.043
2.589SerArg: 2.589 ± 0.047
3.85SerSer: 3.85 ± 0.072
3.208SerThr: 3.208 ± 0.055
4.295SerVal: 4.295 ± 0.063
0.793SerTrp: 0.793 ± 0.031
2.74SerTyr: 2.74 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.013ThrAla: 4.013 ± 0.057
0.621ThrCys: 0.621 ± 0.027
3.445ThrAsp: 3.445 ± 0.055
3.481ThrGlu: 3.481 ± 0.056
2.776ThrPhe: 2.776 ± 0.045
4.419ThrGly: 4.419 ± 0.073
1.054ThrHis: 1.054 ± 0.03
3.98ThrIle: 3.98 ± 0.06
2.894ThrLys: 2.894 ± 0.053
5.56ThrLeu: 5.56 ± 0.069
1.281ThrMet: 1.281 ± 0.032
2.655ThrAsn: 2.655 ± 0.058
2.763ThrPro: 2.763 ± 0.05
1.771ThrGln: 1.771 ± 0.04
2.231ThrArg: 2.231 ± 0.047
3.362ThrSer: 3.362 ± 0.057
3.225ThrThr: 3.225 ± 0.059
4.159ThrVal: 4.159 ± 0.062
0.665ThrTrp: 0.665 ± 0.025
2.497ThrTyr: 2.497 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
4.629ValAla: 4.629 ± 0.067
0.993ValCys: 0.993 ± 0.032
3.659ValAsp: 3.659 ± 0.052
4.126ValGlu: 4.126 ± 0.068
2.867ValPhe: 2.867 ± 0.053
4.137ValGly: 4.137 ± 0.067
1.134ValHis: 1.134 ± 0.036
4.53ValIle: 4.53 ± 0.07
4.366ValLys: 4.366 ± 0.071
5.763ValLeu: 5.763 ± 0.074
1.68ValMet: 1.68 ± 0.044
3.476ValAsn: 3.476 ± 0.058
2.606ValPro: 2.606 ± 0.048
2.014ValGln: 2.014 ± 0.042
2.987ValArg: 2.987 ± 0.055
4.408ValSer: 4.408 ± 0.069
3.91ValThr: 3.91 ± 0.058
4.376ValVal: 4.376 ± 0.079
0.712ValTrp: 0.712 ± 0.024
2.673ValTyr: 2.673 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.752TrpAla: 0.752 ± 0.026
0.174TrpCys: 0.174 ± 0.013
0.689TrpAsp: 0.689 ± 0.031
0.8TrpGlu: 0.8 ± 0.025
0.568TrpPhe: 0.568 ± 0.026
0.976TrpGly: 0.976 ± 0.029
0.266TrpHis: 0.266 ± 0.015
0.872TrpIle: 0.872 ± 0.032
0.929TrpLys: 0.929 ± 0.036
1.169TrpLeu: 1.169 ± 0.031
0.46TrpMet: 0.46 ± 0.021
0.841TrpAsn: 0.841 ± 0.029
0.27TrpPro: 0.27 ± 0.015
0.537TrpGln: 0.537 ± 0.023
0.587TrpArg: 0.587 ± 0.024
0.651TrpSer: 0.651 ± 0.026
0.682TrpThr: 0.682 ± 0.025
0.711TrpVal: 0.711 ± 0.027
0.199TrpTrp: 0.199 ± 0.015
0.576TrpTyr: 0.576 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.937TyrAla: 2.937 ± 0.054
0.574TyrCys: 0.574 ± 0.024
2.522TyrAsp: 2.522 ± 0.051
2.49TyrGlu: 2.49 ± 0.048
2.166TyrPhe: 2.166 ± 0.045
3.055TyrGly: 3.055 ± 0.06
0.946TyrHis: 0.946 ± 0.026
2.984TyrIle: 2.984 ± 0.047
2.795TyrLys: 2.795 ± 0.052
4.03TyrLeu: 4.03 ± 0.058
1.111TyrMet: 1.111 ± 0.034
2.57TyrAsn: 2.57 ± 0.058
2.021TyrPro: 2.021 ± 0.042
1.577TyrGln: 1.577 ± 0.042
2.287TyrArg: 2.287 ± 0.049
2.767TyrSer: 2.767 ± 0.055
2.748TyrThr: 2.748 ± 0.049
2.46TyrVal: 2.46 ± 0.046
0.572TyrTrp: 0.572 ± 0.024
2.203TyrTyr: 2.203 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3094 proteins (1151197 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski