Amino acid dipepetide frequency for Streptococcus satellite phage Javan339

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.899AlaAla: 0.899 ± 0.413
0.599AlaCys: 0.599 ± 0.327
4.495AlaAsp: 4.495 ± 1.202
4.495AlaGlu: 4.495 ± 1.245
3.596AlaPhe: 3.596 ± 1.111
3.296AlaGly: 3.296 ± 0.809
0.3AlaHis: 0.3 ± 0.361
5.094AlaIle: 5.094 ± 1.093
5.993AlaLys: 5.993 ± 1.279
6.593AlaLeu: 6.593 ± 1.617
2.697AlaMet: 2.697 ± 0.781
2.997AlaAsn: 2.997 ± 0.967
0.599AlaPro: 0.599 ± 0.401
3.296AlaGln: 3.296 ± 1.048
3.296AlaArg: 3.296 ± 0.873
2.997AlaSer: 2.997 ± 0.918
2.697AlaThr: 2.697 ± 0.822
2.397AlaVal: 2.397 ± 0.763
0.899AlaTrp: 0.899 ± 0.425
3.896AlaTyr: 3.896 ± 1.244
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.3CysAsp: 0.3 ± 0.288
0.599CysGlu: 0.599 ± 0.337
0.0CysPhe: 0.0 ± 0.0
0.3CysGly: 0.3 ± 0.288
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.3CysLys: 0.3 ± 0.237
0.3CysLeu: 0.3 ± 0.313
0.0CysMet: 0.0 ± 0.0
0.3CysAsn: 0.3 ± 0.305
0.3CysPro: 0.3 ± 0.288
0.3CysGln: 0.3 ± 0.31
0.599CysArg: 0.599 ± 0.334
0.3CysSer: 0.3 ± 0.28
0.0CysThr: 0.0 ± 0.0
0.3CysVal: 0.3 ± 0.23
0.0CysTrp: 0.0 ± 0.0
0.599CysTyr: 0.599 ± 0.409
0.0CysXaa: 0.0 ± 0.0
Asp
1.498AspAla: 1.498 ± 0.721
0.0AspCys: 0.0 ± 0.0
5.094AspAsp: 5.094 ± 1.156
5.993AspGlu: 5.993 ± 1.337
2.098AspPhe: 2.098 ± 0.629
3.896AspGly: 3.896 ± 1.173
0.899AspHis: 0.899 ± 0.418
5.394AspIle: 5.394 ± 1.144
8.99AspLys: 8.99 ± 1.988
8.091AspLeu: 8.091 ± 1.675
1.498AspMet: 1.498 ± 0.583
2.397AspAsn: 2.397 ± 0.615
0.599AspPro: 0.599 ± 0.46
1.498AspGln: 1.498 ± 0.643
2.397AspArg: 2.397 ± 0.581
5.394AspSer: 5.394 ± 1.327
3.896AspThr: 3.896 ± 1.166
3.896AspVal: 3.896 ± 0.988
0.3AspTrp: 0.3 ± 0.288
2.997AspTyr: 2.997 ± 0.939
0.0AspXaa: 0.0 ± 0.0
Glu
4.495GluAla: 4.495 ± 1.177
0.3GluCys: 0.3 ± 0.313
5.094GluAsp: 5.094 ± 0.941
6.593GluGlu: 6.593 ± 1.378
4.195GluPhe: 4.195 ± 1.099
2.397GluGly: 2.397 ± 0.83
1.798GluHis: 1.798 ± 0.678
7.791GluIle: 7.791 ± 1.327
8.69GluLys: 8.69 ± 1.252
12.286GluLeu: 12.286 ± 2.285
2.697GluMet: 2.697 ± 0.585
6.892GluAsn: 6.892 ± 1.136
1.498GluPro: 1.498 ± 0.735
2.697GluGln: 2.697 ± 0.666
3.296GluArg: 3.296 ± 0.846
3.296GluSer: 3.296 ± 1.061
5.094GluThr: 5.094 ± 0.841
6.593GluVal: 6.593 ± 1.674
0.599GluTrp: 0.599 ± 0.364
3.296GluTyr: 3.296 ± 0.795
0.0GluXaa: 0.0 ± 0.0
Phe
2.098PheAla: 2.098 ± 0.766
0.0PheCys: 0.0 ± 0.0
2.997PheAsp: 2.997 ± 0.93
3.296PheGlu: 3.296 ± 0.976
1.498PhePhe: 1.498 ± 0.735
2.397PheGly: 2.397 ± 0.65
0.3PheHis: 0.3 ± 0.237
2.997PheIle: 2.997 ± 0.69
3.296PheLys: 3.296 ± 1.195
4.495PheLeu: 4.495 ± 1.011
0.599PheMet: 0.599 ± 0.357
1.798PheAsn: 1.798 ± 0.763
1.199PhePro: 1.199 ± 0.572
1.199PheGln: 1.199 ± 0.562
1.498PheArg: 1.498 ± 0.477
2.697PheSer: 2.697 ± 0.595
2.997PheThr: 2.997 ± 0.896
2.397PheVal: 2.397 ± 0.882
0.3PheTrp: 0.3 ± 0.23
0.599PheTyr: 0.599 ± 0.397
0.0PheXaa: 0.0 ± 0.0
Gly
2.397GlyAla: 2.397 ± 0.91
0.3GlyCys: 0.3 ± 0.237
2.098GlyAsp: 2.098 ± 0.728
3.896GlyGlu: 3.896 ± 1.04
2.997GlyPhe: 2.997 ± 1.084
1.798GlyGly: 1.798 ± 0.787
1.199GlyHis: 1.199 ± 0.516
2.697GlyIle: 2.697 ± 1.112
4.795GlyLys: 4.795 ± 1.159
5.694GlyLeu: 5.694 ± 1.376
0.3GlyMet: 0.3 ± 0.304
2.098GlyAsn: 2.098 ± 0.686
0.599GlyPro: 0.599 ± 0.38
1.498GlyGln: 1.498 ± 0.689
1.798GlyArg: 1.798 ± 0.687
1.199GlySer: 1.199 ± 0.523
2.997GlyThr: 2.997 ± 0.9
4.795GlyVal: 4.795 ± 1.221
1.498GlyTrp: 1.498 ± 0.8
2.697GlyTyr: 2.697 ± 0.77
0.0GlyXaa: 0.0 ± 0.0
His
0.599HisAla: 0.599 ± 0.369
0.0HisCys: 0.0 ± 0.0
2.098HisAsp: 2.098 ± 0.648
0.599HisGlu: 0.599 ± 0.407
0.899HisPhe: 0.899 ± 0.464
1.798HisGly: 1.798 ± 0.732
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.199HisLys: 1.199 ± 0.447
0.899HisLeu: 0.899 ± 0.445
0.599HisMet: 0.599 ± 0.348
1.498HisAsn: 1.498 ± 0.528
0.899HisPro: 0.899 ± 0.537
0.899HisGln: 0.899 ± 0.616
0.599HisArg: 0.599 ± 0.409
0.899HisSer: 0.899 ± 0.364
1.798HisThr: 1.798 ± 0.837
0.3HisVal: 0.3 ± 0.26
0.3HisTrp: 0.3 ± 0.26
1.498HisTyr: 1.498 ± 0.619
0.0HisXaa: 0.0 ± 0.0
Ile
4.195IleAla: 4.195 ± 1.026
1.199IleCys: 1.199 ± 0.579
5.094IleAsp: 5.094 ± 1.125
5.694IleGlu: 5.694 ± 1.158
1.498IlePhe: 1.498 ± 0.765
2.098IleGly: 2.098 ± 0.886
1.498IleHis: 1.498 ± 0.741
5.094IleIle: 5.094 ± 0.926
5.993IleLys: 5.993 ± 0.927
5.394IleLeu: 5.394 ± 1.305
0.599IleMet: 0.599 ± 0.33
4.195IleAsn: 4.195 ± 1.297
1.498IlePro: 1.498 ± 0.537
2.997IleGln: 2.997 ± 0.776
2.098IleArg: 2.098 ± 0.745
3.896IleSer: 3.896 ± 1.026
5.094IleThr: 5.094 ± 0.99
3.596IleVal: 3.596 ± 0.935
0.0IleTrp: 0.0 ± 0.0
1.498IleTyr: 1.498 ± 0.603
0.0IleXaa: 0.0 ± 0.0
Lys
7.492LysAla: 7.492 ± 1.513
0.0LysCys: 0.0 ± 0.0
6.593LysAsp: 6.593 ± 1.257
10.189LysGlu: 10.189 ± 1.62
2.997LysPhe: 2.997 ± 0.829
5.094LysGly: 5.094 ± 1.132
1.798LysHis: 1.798 ± 0.605
5.094LysIle: 5.094 ± 1.229
10.788LysLys: 10.788 ± 1.71
10.488LysLeu: 10.488 ± 1.078
2.397LysMet: 2.397 ± 0.633
5.094LysAsn: 5.094 ± 0.707
3.596LysPro: 3.596 ± 1.138
2.997LysGln: 2.997 ± 0.782
4.495LysArg: 4.495 ± 0.714
5.694LysSer: 5.694 ± 1.059
4.495LysThr: 4.495 ± 1.005
5.394LysVal: 5.394 ± 1.132
0.599LysTrp: 0.599 ± 0.321
4.195LysTyr: 4.195 ± 0.99
0.0LysXaa: 0.0 ± 0.0
Leu
5.993LeuAla: 5.993 ± 1.863
0.0LeuCys: 0.0 ± 0.0
10.189LeuAsp: 10.189 ± 1.353
10.488LeuGlu: 10.488 ± 1.882
3.896LeuPhe: 3.896 ± 1.334
4.795LeuGly: 4.795 ± 1.314
1.199LeuHis: 1.199 ± 0.522
4.795LeuIle: 4.795 ± 1.086
9.29LeuLys: 9.29 ± 1.337
10.189LeuLeu: 10.189 ± 2.238
0.599LeuMet: 0.599 ± 0.323
5.094LeuAsn: 5.094 ± 1.103
1.498LeuPro: 1.498 ± 0.511
1.199LeuGln: 1.199 ± 0.68
4.195LeuArg: 4.195 ± 1.041
3.896LeuSer: 3.896 ± 1.035
7.791LeuThr: 7.791 ± 1.472
5.993LeuVal: 5.993 ± 0.899
1.199LeuTrp: 1.199 ± 0.618
4.795LeuTyr: 4.795 ± 1.086
0.0LeuXaa: 0.0 ± 0.0
Met
2.397MetAla: 2.397 ± 0.889
0.0MetCys: 0.0 ± 0.0
1.498MetAsp: 1.498 ± 0.674
1.798MetGlu: 1.798 ± 0.759
0.3MetPhe: 0.3 ± 0.28
0.599MetGly: 0.599 ± 0.329
0.0MetHis: 0.0 ± 0.0
0.899MetIle: 0.899 ± 0.546
0.899MetLys: 0.899 ± 0.415
0.599MetLeu: 0.599 ± 0.349
0.899MetMet: 0.899 ± 0.405
3.896MetAsn: 3.896 ± 1.11
0.3MetPro: 0.3 ± 0.305
0.599MetGln: 0.599 ± 0.402
1.199MetArg: 1.199 ± 0.614
0.899MetSer: 0.899 ± 0.381
2.098MetThr: 2.098 ± 0.855
1.199MetVal: 1.199 ± 0.681
0.0MetTrp: 0.0 ± 0.0
0.3MetTyr: 0.3 ± 0.23
0.0MetXaa: 0.0 ± 0.0
Asn
4.195AsnAla: 4.195 ± 1.686
0.3AsnCys: 0.3 ± 0.288
3.296AsnAsp: 3.296 ± 0.545
5.394AsnGlu: 5.394 ± 1.153
2.098AsnPhe: 2.098 ± 0.839
4.495AsnGly: 4.495 ± 1.12
1.498AsnHis: 1.498 ± 0.617
2.997AsnIle: 2.997 ± 0.802
5.694AsnLys: 5.694 ± 1.218
3.896AsnLeu: 3.896 ± 0.88
1.199AsnMet: 1.199 ± 0.516
4.495AsnAsn: 4.495 ± 0.988
3.296AsnPro: 3.296 ± 0.757
2.397AsnGln: 2.397 ± 0.683
2.397AsnArg: 2.397 ± 0.71
3.296AsnSer: 3.296 ± 0.63
3.896AsnThr: 3.896 ± 1.015
3.296AsnVal: 3.296 ± 0.94
0.899AsnTrp: 0.899 ± 0.718
2.397AsnTyr: 2.397 ± 0.879
0.0AsnXaa: 0.0 ± 0.0
Pro
2.098ProAla: 2.098 ± 0.706
0.3ProCys: 0.3 ± 0.26
1.199ProAsp: 1.199 ± 0.648
1.199ProGlu: 1.199 ± 0.488
1.498ProPhe: 1.498 ± 0.499
0.899ProGly: 0.899 ± 0.546
0.0ProHis: 0.0 ± 0.0
1.199ProIle: 1.199 ± 0.556
3.596ProLys: 3.596 ± 1.068
1.798ProLeu: 1.798 ± 0.541
0.899ProMet: 0.899 ± 0.445
0.899ProAsn: 0.899 ± 0.398
1.199ProPro: 1.199 ± 0.497
0.899ProGln: 0.899 ± 0.671
0.899ProArg: 0.899 ± 0.399
2.098ProSer: 2.098 ± 0.675
0.899ProThr: 0.899 ± 0.378
2.397ProVal: 2.397 ± 0.704
0.0ProTrp: 0.0 ± 0.0
0.899ProTyr: 0.899 ± 0.517
0.0ProXaa: 0.0 ± 0.0
Gln
3.596GlnAla: 3.596 ± 1.092
0.0GlnCys: 0.0 ± 0.0
1.498GlnAsp: 1.498 ± 0.795
2.697GlnGlu: 2.697 ± 0.95
1.498GlnPhe: 1.498 ± 0.543
1.498GlnGly: 1.498 ± 0.493
0.0GlnHis: 0.0 ± 0.0
2.098GlnIle: 2.098 ± 0.773
3.596GlnLys: 3.596 ± 0.879
2.697GlnLeu: 2.697 ± 1.087
0.0GlnMet: 0.0 ± 0.0
2.397GlnAsn: 2.397 ± 0.76
0.3GlnPro: 0.3 ± 0.29
3.296GlnGln: 3.296 ± 1.072
2.397GlnArg: 2.397 ± 0.861
1.798GlnSer: 1.798 ± 0.703
1.798GlnThr: 1.798 ± 0.552
2.397GlnVal: 2.397 ± 0.736
0.3GlnTrp: 0.3 ± 0.313
2.397GlnTyr: 2.397 ± 0.93
0.0GlnXaa: 0.0 ± 0.0
Arg
4.495ArgAla: 4.495 ± 1.079
0.0ArgCys: 0.0 ± 0.0
2.098ArgAsp: 2.098 ± 0.627
4.795ArgGlu: 4.795 ± 1.295
1.498ArgPhe: 1.498 ± 0.709
1.498ArgGly: 1.498 ± 0.595
1.498ArgHis: 1.498 ± 0.631
3.896ArgIle: 3.896 ± 0.76
4.495ArgLys: 4.495 ± 0.932
2.997ArgLeu: 2.997 ± 0.823
1.498ArgMet: 1.498 ± 0.73
0.899ArgAsn: 0.899 ± 0.407
1.199ArgPro: 1.199 ± 0.626
2.697ArgGln: 2.697 ± 0.8
1.498ArgArg: 1.498 ± 0.764
1.798ArgSer: 1.798 ± 0.631
1.498ArgThr: 1.498 ± 0.755
1.498ArgVal: 1.498 ± 0.627
1.199ArgTrp: 1.199 ± 0.497
3.296ArgTyr: 3.296 ± 0.718
0.0ArgXaa: 0.0 ± 0.0
Ser
3.596SerAla: 3.596 ± 1.252
0.3SerCys: 0.3 ± 0.23
3.296SerAsp: 3.296 ± 0.672
5.694SerGlu: 5.694 ± 1.362
1.498SerPhe: 1.498 ± 0.558
2.697SerGly: 2.697 ± 0.801
0.3SerHis: 0.3 ± 0.26
2.697SerIle: 2.697 ± 1.253
4.195SerLys: 4.195 ± 1.147
3.296SerLeu: 3.296 ± 0.855
0.599SerMet: 0.599 ± 0.313
4.495SerAsn: 4.495 ± 1.056
2.098SerPro: 2.098 ± 0.57
0.899SerGln: 0.899 ± 0.545
2.397SerArg: 2.397 ± 0.904
3.296SerSer: 3.296 ± 0.788
2.098SerThr: 2.098 ± 0.693
3.896SerVal: 3.896 ± 0.728
0.599SerTrp: 0.599 ± 0.405
2.098SerTyr: 2.098 ± 0.545
0.0SerXaa: 0.0 ± 0.0
Thr
3.596ThrAla: 3.596 ± 0.661
0.0ThrCys: 0.0 ± 0.0
3.896ThrAsp: 3.896 ± 0.874
3.896ThrGlu: 3.896 ± 0.997
2.098ThrPhe: 2.098 ± 0.573
2.997ThrGly: 2.997 ± 0.717
1.199ThrHis: 1.199 ± 0.545
3.896ThrIle: 3.896 ± 1.51
4.195ThrLys: 4.195 ± 0.855
5.694ThrLeu: 5.694 ± 1.358
0.899ThrMet: 0.899 ± 0.461
4.195ThrAsn: 4.195 ± 1.481
1.798ThrPro: 1.798 ± 0.649
2.997ThrGln: 2.997 ± 0.957
2.697ThrArg: 2.697 ± 0.61
2.697ThrSer: 2.697 ± 0.811
4.495ThrThr: 4.495 ± 1.479
4.195ThrVal: 4.195 ± 1.036
0.599ThrTrp: 0.599 ± 0.412
2.697ThrTyr: 2.697 ± 0.68
0.0ThrXaa: 0.0 ± 0.0
Val
4.795ValAla: 4.795 ± 1.327
0.599ValCys: 0.599 ± 0.577
3.596ValAsp: 3.596 ± 1.147
5.094ValGlu: 5.094 ± 1.284
2.697ValPhe: 2.697 ± 0.994
1.798ValGly: 1.798 ± 0.62
2.098ValHis: 2.098 ± 0.535
2.697ValIle: 2.697 ± 0.772
4.195ValLys: 4.195 ± 1.129
5.094ValLeu: 5.094 ± 1.031
1.199ValMet: 1.199 ± 0.515
3.896ValAsn: 3.896 ± 0.877
2.098ValPro: 2.098 ± 0.755
1.199ValGln: 1.199 ± 0.521
3.596ValArg: 3.596 ± 0.864
1.798ValSer: 1.798 ± 0.651
2.997ValThr: 2.997 ± 0.881
4.195ValVal: 4.195 ± 1.258
0.899ValTrp: 0.899 ± 0.408
5.394ValTyr: 5.394 ± 1.103
0.0ValXaa: 0.0 ± 0.0
Trp
0.3TrpAla: 0.3 ± 0.237
0.3TrpCys: 0.3 ± 0.23
0.899TrpAsp: 0.899 ± 0.463
1.798TrpGlu: 1.798 ± 0.658
0.599TrpPhe: 0.599 ± 0.358
0.599TrpGly: 0.599 ± 0.353
0.3TrpHis: 0.3 ± 0.237
0.899TrpIle: 0.899 ± 0.49
1.199TrpLys: 1.199 ± 0.419
1.798TrpLeu: 1.798 ± 0.691
0.0TrpMet: 0.0 ± 0.0
0.599TrpAsn: 0.599 ± 0.409
0.0TrpPro: 0.0 ± 0.0
0.599TrpGln: 0.599 ± 0.405
0.3TrpArg: 0.3 ± 0.29
0.599TrpSer: 0.599 ± 0.364
0.3TrpThr: 0.3 ± 0.23
0.0TrpVal: 0.0 ± 0.0
0.3TrpTrp: 0.3 ± 0.237
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.397TyrAla: 2.397 ± 0.942
0.3TyrCys: 0.3 ± 0.313
1.498TyrAsp: 1.498 ± 0.599
5.394TyrGlu: 5.394 ± 0.885
1.199TyrPhe: 1.199 ± 0.721
2.397TyrGly: 2.397 ± 0.593
1.498TyrHis: 1.498 ± 0.537
2.997TyrIle: 2.997 ± 0.966
8.091TyrLys: 8.091 ± 1.373
4.795TyrLeu: 4.795 ± 1.269
0.899TyrMet: 0.899 ± 0.593
3.296TyrAsn: 3.296 ± 0.952
0.3TyrPro: 0.3 ± 0.23
2.098TyrGln: 2.098 ± 0.75
2.697TyrArg: 2.697 ± 1.0
1.498TyrSer: 1.498 ± 0.58
1.798TyrThr: 1.798 ± 0.577
1.199TyrVal: 1.199 ± 0.531
0.899TyrTrp: 0.899 ± 0.382
2.098TyrTyr: 2.098 ± 0.733
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (3338 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski