Amino acid dipepetide frequency for Verticiella sediminum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.989AlaAla: 19.989 ± 0.178
1.59AlaCys: 1.59 ± 0.033
7.196AlaAsp: 7.196 ± 0.074
7.218AlaGlu: 7.218 ± 0.07
4.181AlaPhe: 4.181 ± 0.049
12.753AlaGly: 12.753 ± 0.094
2.982AlaHis: 2.982 ± 0.044
5.419AlaIle: 5.419 ± 0.059
2.686AlaLys: 2.686 ± 0.048
15.261AlaLeu: 15.261 ± 0.119
3.585AlaMet: 3.585 ± 0.049
2.671AlaAsn: 2.671 ± 0.042
6.896AlaPro: 6.896 ± 0.08
5.875AlaGln: 5.875 ± 0.066
11.055AlaArg: 11.055 ± 0.105
6.784AlaSer: 6.784 ± 0.063
5.839AlaThr: 5.839 ± 0.059
9.62AlaVal: 9.62 ± 0.074
2.136AlaTrp: 2.136 ± 0.04
2.788AlaTyr: 2.788 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.401CysAla: 1.401 ± 0.031
0.158CysCys: 0.158 ± 0.01
0.486CysAsp: 0.486 ± 0.017
0.517CysGlu: 0.517 ± 0.017
0.276CysPhe: 0.276 ± 0.012
0.986CysGly: 0.986 ± 0.025
0.242CysHis: 0.242 ± 0.013
0.398CysIle: 0.398 ± 0.016
0.16CysLys: 0.16 ± 0.009
0.911CysLeu: 0.911 ± 0.023
0.212CysMet: 0.212 ± 0.011
0.213CysAsn: 0.213 ± 0.012
0.492CysPro: 0.492 ± 0.018
0.249CysGln: 0.249 ± 0.011
0.721CysArg: 0.721 ± 0.021
0.484CysSer: 0.484 ± 0.018
0.502CysThr: 0.502 ± 0.017
0.769CysVal: 0.769 ± 0.02
0.127CysTrp: 0.127 ± 0.008
0.211CysTyr: 0.211 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.926AspAla: 7.926 ± 0.082
0.448AspCys: 0.448 ± 0.017
2.895AspAsp: 2.895 ± 0.048
3.334AspGlu: 3.334 ± 0.052
1.961AspPhe: 1.961 ± 0.033
4.983AspGly: 4.983 ± 0.073
0.968AspHis: 0.968 ± 0.026
2.544AspIle: 2.544 ± 0.041
1.19AspLys: 1.19 ± 0.027
5.254AspLeu: 5.254 ± 0.054
1.348AspMet: 1.348 ± 0.028
1.088AspAsn: 1.088 ± 0.025
3.162AspPro: 3.162 ± 0.043
1.34AspGln: 1.34 ± 0.028
3.244AspArg: 3.244 ± 0.048
2.054AspSer: 2.054 ± 0.034
2.86AspThr: 2.86 ± 0.038
4.547AspVal: 4.547 ± 0.05
0.911AspTrp: 0.911 ± 0.023
1.429AspTyr: 1.429 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
7.005GluAla: 7.005 ± 0.079
0.383GluCys: 0.383 ± 0.014
2.449GluAsp: 2.449 ± 0.043
2.307GluGlu: 2.307 ± 0.046
1.646GluPhe: 1.646 ± 0.027
3.834GluGly: 3.834 ± 0.058
1.615GluHis: 1.615 ± 0.032
2.614GluIle: 2.614 ± 0.041
1.363GluLys: 1.363 ± 0.031
5.915GluLeu: 5.915 ± 0.063
1.154GluMet: 1.154 ± 0.027
1.362GluAsn: 1.362 ± 0.029
2.925GluPro: 2.925 ± 0.046
2.534GluGln: 2.534 ± 0.039
5.693GluArg: 5.693 ± 0.059
2.385GluSer: 2.385 ± 0.034
2.54GluThr: 2.54 ± 0.041
3.817GluVal: 3.817 ± 0.05
0.631GluTrp: 0.631 ± 0.017
1.139GluTyr: 1.139 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.227PheAla: 4.227 ± 0.053
0.413PheCys: 0.413 ± 0.015
2.268PheAsp: 2.268 ± 0.037
1.875PheGlu: 1.875 ± 0.032
1.215PhePhe: 1.215 ± 0.028
3.344PheGly: 3.344 ± 0.045
0.72PheHis: 0.72 ± 0.019
1.329PheIle: 1.329 ± 0.027
0.771PheLys: 0.771 ± 0.024
2.916PheLeu: 2.916 ± 0.043
0.701PheMet: 0.701 ± 0.022
0.906PheAsn: 0.906 ± 0.023
1.467PhePro: 1.467 ± 0.028
0.953PheGln: 0.953 ± 0.026
1.959PheArg: 1.959 ± 0.032
1.885PheSer: 1.885 ± 0.035
1.737PheThr: 1.737 ± 0.03
2.707PheVal: 2.707 ± 0.04
0.419PheTrp: 0.419 ± 0.017
0.767PheTyr: 0.767 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.273GlyAla: 10.273 ± 0.084
0.884GlyCys: 0.884 ± 0.024
4.01GlyAsp: 4.01 ± 0.061
4.807GlyGlu: 4.807 ± 0.055
3.189GlyPhe: 3.189 ± 0.046
7.494GlyGly: 7.494 ± 0.103
1.935GlyHis: 1.935 ± 0.034
4.142GlyIle: 4.142 ± 0.051
2.68GlyLys: 2.68 ± 0.047
9.301GlyLeu: 9.301 ± 0.079
2.652GlyMet: 2.652 ± 0.037
2.045GlyAsn: 2.045 ± 0.043
3.653GlyPro: 3.653 ± 0.052
3.349GlyGln: 3.349 ± 0.041
6.555GlyArg: 6.555 ± 0.069
4.682GlySer: 4.682 ± 0.064
4.676GlyThr: 4.676 ± 0.064
7.084GlyVal: 7.084 ± 0.067
1.498GlyTrp: 1.498 ± 0.033
2.587GlyTyr: 2.587 ± 0.037
0.0GlyXaa: 0.0 ± 0.0
His
3.319HisAla: 3.319 ± 0.046
0.258HisCys: 0.258 ± 0.012
1.287HisAsp: 1.287 ± 0.028
1.191HisGlu: 1.191 ± 0.023
0.781HisPhe: 0.781 ± 0.023
2.217HisGly: 2.217 ± 0.039
0.584HisHis: 0.584 ± 0.02
0.986HisIle: 0.986 ± 0.025
0.358HisLys: 0.358 ± 0.013
2.293HisLeu: 2.293 ± 0.033
0.504HisMet: 0.504 ± 0.014
0.444HisAsn: 0.444 ± 0.015
1.605HisPro: 1.605 ± 0.034
0.624HisGln: 0.624 ± 0.018
1.654HisArg: 1.654 ± 0.027
0.932HisSer: 0.932 ± 0.025
1.169HisThr: 1.169 ± 0.029
1.821HisVal: 1.821 ± 0.03
0.366HisTrp: 0.366 ± 0.014
0.611HisTyr: 0.611 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.325IleAla: 6.325 ± 0.055
0.38IleCys: 0.38 ± 0.015
2.993IleAsp: 2.993 ± 0.042
3.028IleGlu: 3.028 ± 0.042
1.128IlePhe: 1.128 ± 0.025
4.261IleGly: 4.261 ± 0.052
0.86IleHis: 0.86 ± 0.023
1.389IleIle: 1.389 ± 0.028
0.957IleLys: 0.957 ± 0.025
3.445IleLeu: 3.445 ± 0.042
0.725IleMet: 0.725 ± 0.021
1.12IleAsn: 1.12 ± 0.024
2.049IlePro: 2.049 ± 0.035
1.29IleGln: 1.29 ± 0.025
2.697IleArg: 2.697 ± 0.042
2.098IleSer: 2.098 ± 0.038
2.265IleThr: 2.265 ± 0.039
3.862IleVal: 3.862 ± 0.047
0.446IleTrp: 0.446 ± 0.016
0.873IleTyr: 0.873 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.89LysAla: 2.89 ± 0.044
0.118LysCys: 0.118 ± 0.008
1.128LysAsp: 1.128 ± 0.027
1.09LysGlu: 1.09 ± 0.03
0.62LysPhe: 0.62 ± 0.019
1.777LysGly: 1.777 ± 0.034
0.479LysHis: 0.479 ± 0.018
0.913LysIle: 0.913 ± 0.024
0.681LysLys: 0.681 ± 0.029
2.425LysLeu: 2.425 ± 0.044
0.479LysMet: 0.479 ± 0.016
0.542LysAsn: 0.542 ± 0.019
1.618LysPro: 1.618 ± 0.032
0.854LysGln: 0.854 ± 0.024
1.732LysArg: 1.732 ± 0.032
1.253LysSer: 1.253 ± 0.027
1.267LysThr: 1.267 ± 0.029
1.841LysVal: 1.841 ± 0.033
0.26LysTrp: 0.26 ± 0.012
0.48LysTyr: 0.48 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
16.726LeuAla: 16.726 ± 0.124
1.102LeuCys: 1.102 ± 0.024
6.153LeuAsp: 6.153 ± 0.068
5.321LeuGlu: 5.321 ± 0.057
3.174LeuPhe: 3.174 ± 0.049
9.261LeuGly: 9.261 ± 0.094
2.339LeuHis: 2.339 ± 0.039
4.036LeuIle: 4.036 ± 0.048
2.345LeuLys: 2.345 ± 0.039
10.914LeuLeu: 10.914 ± 0.12
2.259LeuMet: 2.259 ± 0.033
2.463LeuAsn: 2.463 ± 0.042
6.359LeuPro: 6.359 ± 0.065
3.645LeuGln: 3.645 ± 0.052
8.432LeuArg: 8.432 ± 0.081
5.714LeuSer: 5.714 ± 0.058
4.992LeuThr: 4.992 ± 0.052
7.903LeuVal: 7.903 ± 0.086
1.104LeuTrp: 1.104 ± 0.028
2.218LeuTyr: 2.218 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
2.998MetAla: 2.998 ± 0.04
0.192MetCys: 0.192 ± 0.01
1.034MetAsp: 1.034 ± 0.024
0.919MetGlu: 0.919 ± 0.024
0.665MetPhe: 0.665 ± 0.017
1.746MetGly: 1.746 ± 0.032
0.568MetHis: 0.568 ± 0.019
0.956MetIle: 0.956 ± 0.024
0.737MetLys: 0.737 ± 0.021
2.787MetLeu: 2.787 ± 0.042
0.542MetMet: 0.542 ± 0.017
0.761MetAsn: 0.761 ± 0.021
1.559MetPro: 1.559 ± 0.031
1.131MetGln: 1.131 ± 0.024
1.95MetArg: 1.95 ± 0.033
1.639MetSer: 1.639 ± 0.029
1.523MetThr: 1.523 ± 0.027
1.653MetVal: 1.653 ± 0.032
0.189MetTrp: 0.189 ± 0.009
0.414MetTyr: 0.414 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.97AsnAla: 2.97 ± 0.037
0.206AsnCys: 0.206 ± 0.011
1.172AsnAsp: 1.172 ± 0.025
1.065AsnGlu: 1.065 ± 0.027
0.771AsnPhe: 0.771 ± 0.021
1.975AsnGly: 1.975 ± 0.038
0.49AsnHis: 0.49 ± 0.019
1.028AsnIle: 1.028 ± 0.024
0.531AsnLys: 0.531 ± 0.017
2.438AsnLeu: 2.438 ± 0.036
0.503AsnMet: 0.503 ± 0.018
0.591AsnAsn: 0.591 ± 0.02
1.787AsnPro: 1.787 ± 0.03
0.745AsnGln: 0.745 ± 0.021
1.712AsnArg: 1.712 ± 0.032
0.907AsnSer: 0.907 ± 0.027
1.205AsnThr: 1.205 ± 0.027
1.909AsnVal: 1.909 ± 0.031
0.337AsnTrp: 0.337 ± 0.016
0.66AsnTyr: 0.66 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
8.359ProAla: 8.359 ± 0.086
0.386ProCys: 0.386 ± 0.016
3.617ProAsp: 3.617 ± 0.039
3.538ProGlu: 3.538 ± 0.044
1.782ProPhe: 1.782 ± 0.032
5.505ProGly: 5.505 ± 0.063
1.265ProHis: 1.265 ± 0.027
2.043ProIle: 2.043 ± 0.033
1.055ProLys: 1.055 ± 0.023
5.383ProLeu: 5.383 ± 0.059
1.327ProMet: 1.327 ± 0.029
1.105ProAsn: 1.105 ± 0.025
2.964ProPro: 2.964 ± 0.054
2.083ProGln: 2.083 ± 0.034
3.663ProArg: 3.663 ± 0.048
2.741ProSer: 2.741 ± 0.04
2.502ProThr: 2.502 ± 0.034
4.524ProVal: 4.524 ± 0.048
0.812ProTrp: 0.812 ± 0.022
1.492ProTyr: 1.492 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
6.068GlnAla: 6.068 ± 0.067
0.266GlnCys: 0.266 ± 0.012
1.713GlnAsp: 1.713 ± 0.035
1.637GlnGlu: 1.637 ± 0.033
1.034GlnPhe: 1.034 ± 0.026
3.135GlnGly: 3.135 ± 0.039
0.865GlnHis: 0.865 ± 0.026
1.617GlnIle: 1.617 ± 0.032
0.775GlnLys: 0.775 ± 0.021
3.323GlnLeu: 3.323 ± 0.052
0.865GlnMet: 0.865 ± 0.021
0.739GlnAsn: 0.739 ± 0.023
2.318GlnPro: 2.318 ± 0.034
1.564GlnGln: 1.564 ± 0.035
3.46GlnArg: 3.46 ± 0.047
1.737GlnSer: 1.737 ± 0.036
1.795GlnThr: 1.795 ± 0.032
2.825GlnVal: 2.825 ± 0.044
0.547GlnTrp: 0.547 ± 0.019
0.785GlnTyr: 0.785 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
9.386ArgAla: 9.386 ± 0.082
0.681ArgCys: 0.681 ± 0.02
3.886ArgAsp: 3.886 ± 0.048
4.927ArgGlu: 4.927 ± 0.065
2.634ArgPhe: 2.634 ± 0.04
5.292ArgGly: 5.292 ± 0.061
2.164ArgHis: 2.164 ± 0.031
3.887ArgIle: 3.887 ± 0.046
1.82ArgLys: 1.82 ± 0.035
9.22ArgLeu: 9.22 ± 0.086
2.1ArgMet: 2.1 ± 0.037
1.808ArgAsn: 1.808 ± 0.031
3.873ArgPro: 3.873 ± 0.055
3.131ArgGln: 3.131 ± 0.049
6.403ArgArg: 6.403 ± 0.074
3.697ArgSer: 3.697 ± 0.041
3.734ArgThr: 3.734 ± 0.049
5.741ArgVal: 5.741 ± 0.063
1.223ArgTrp: 1.223 ± 0.028
2.156ArgTyr: 2.156 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.357SerAla: 6.357 ± 0.065
0.432SerCys: 0.432 ± 0.016
2.408SerAsp: 2.408 ± 0.041
2.338SerGlu: 2.338 ± 0.039
1.862SerPhe: 1.862 ± 0.032
5.165SerGly: 5.165 ± 0.063
1.138SerHis: 1.138 ± 0.024
2.246SerIle: 2.246 ± 0.039
0.933SerLys: 0.933 ± 0.025
5.383SerLeu: 5.383 ± 0.062
1.273SerMet: 1.273 ± 0.025
1.139SerAsn: 1.139 ± 0.028
2.983SerPro: 2.983 ± 0.042
1.593SerGln: 1.593 ± 0.032
3.73SerArg: 3.73 ± 0.048
2.804SerSer: 2.804 ± 0.044
2.647SerThr: 2.647 ± 0.039
3.944SerVal: 3.944 ± 0.052
0.692SerTrp: 0.692 ± 0.021
1.244SerTyr: 1.244 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
5.84ThrAla: 5.84 ± 0.057
0.39ThrCys: 0.39 ± 0.016
2.486ThrAsp: 2.486 ± 0.039
2.257ThrGlu: 2.257 ± 0.035
1.645ThrPhe: 1.645 ± 0.035
4.694ThrGly: 4.694 ± 0.054
1.204ThrHis: 1.204 ± 0.027
1.955ThrIle: 1.955 ± 0.034
0.77ThrLys: 0.77 ± 0.021
6.284ThrLeu: 6.284 ± 0.064
1.092ThrMet: 1.092 ± 0.024
1.01ThrAsn: 1.01 ± 0.027
3.644ThrPro: 3.644 ± 0.049
1.742ThrGln: 1.742 ± 0.034
3.657ThrArg: 3.657 ± 0.045
2.528ThrSer: 2.528 ± 0.04
2.47ThrThr: 2.47 ± 0.038
4.139ThrVal: 4.139 ± 0.048
0.658ThrTrp: 0.658 ± 0.025
1.119ThrTyr: 1.119 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
10.002ValAla: 10.002 ± 0.076
0.814ValCys: 0.814 ± 0.02
4.258ValAsp: 4.258 ± 0.05
4.152ValGlu: 4.152 ± 0.049
2.708ValPhe: 2.708 ± 0.037
5.873ValGly: 5.873 ± 0.062
1.708ValHis: 1.708 ± 0.029
3.374ValIle: 3.374 ± 0.047
1.792ValLys: 1.792 ± 0.037
8.651ValLeu: 8.651 ± 0.085
1.844ValMet: 1.844 ± 0.032
2.085ValAsn: 2.085 ± 0.034
4.681ValPro: 4.681 ± 0.055
2.881ValGln: 2.881 ± 0.04
6.083ValArg: 6.083 ± 0.056
4.159ValSer: 4.159 ± 0.048
3.861ValThr: 3.861 ± 0.047
6.38ValVal: 6.38 ± 0.077
0.916ValTrp: 0.916 ± 0.026
1.613ValTyr: 1.613 ± 0.024
0.0ValXaa: 0.0 ± 0.0
Trp
1.326TrpAla: 1.326 ± 0.025
0.154TrpCys: 0.154 ± 0.011
0.589TrpAsp: 0.589 ± 0.019
0.553TrpGlu: 0.553 ± 0.019
0.498TrpPhe: 0.498 ± 0.016
0.948TrpGly: 0.948 ± 0.022
0.415TrpHis: 0.415 ± 0.017
0.556TrpIle: 0.556 ± 0.017
0.311TrpLys: 0.311 ± 0.013
1.994TrpLeu: 1.994 ± 0.04
0.348TrpMet: 0.348 ± 0.013
0.38TrpAsn: 0.38 ± 0.015
0.794TrpPro: 0.794 ± 0.021
0.71TrpGln: 0.71 ± 0.021
1.409TrpArg: 1.409 ± 0.031
0.756TrpSer: 0.756 ± 0.024
0.638TrpThr: 0.638 ± 0.021
0.948TrpVal: 0.948 ± 0.022
0.23TrpTrp: 0.23 ± 0.012
0.307TrpTyr: 0.307 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.137TyrAla: 3.137 ± 0.042
0.26TyrCys: 0.26 ± 0.012
1.457TyrAsp: 1.457 ± 0.029
1.24TyrGlu: 1.24 ± 0.026
0.808TyrPhe: 0.808 ± 0.021
2.252TyrGly: 2.252 ± 0.038
0.465TyrHis: 0.465 ± 0.015
0.76TyrIle: 0.76 ± 0.02
0.531TyrLys: 0.531 ± 0.018
2.362TyrLeu: 2.362 ± 0.037
0.45TyrMet: 0.45 ± 0.014
0.529TyrAsn: 0.529 ± 0.017
1.318TyrPro: 1.318 ± 0.029
0.775TyrGln: 0.775 ± 0.023
1.952TyrArg: 1.952 ± 0.034
1.072TyrSer: 1.072 ± 0.026
1.363TyrThr: 1.363 ± 0.032
1.801TyrVal: 1.801 ± 0.034
0.361TyrTrp: 0.361 ± 0.014
0.56TyrTyr: 0.56 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5320 proteins (1790601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski