Amino acid dipepetide frequency for Pseudoxanthobacter soli DSM 19599

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.055AlaAla: 22.055 ± 0.205	1.028AlaCys: 1.028 ± 0.027	7.656AlaAsp: 7.656 ± 0.07	8.031AlaGlu: 8.031 ± 0.102	4.917AlaPhe: 4.917 ± 0.07	13.495AlaGly: 13.495 ± 0.136	2.235AlaHis: 2.235 ± 0.043	6.684AlaIle: 6.684 ± 0.072	3.335AlaLys: 3.335 ± 0.06	14.333AlaLeu: 14.333 ± 0.131	3.5AlaMet: 3.5 ± 0.056	2.714AlaAsn: 2.714 ± 0.057	6.511AlaPro: 6.511 ± 0.094	3.172AlaGln: 3.172 ± 0.055	9.903AlaArg: 9.903 ± 0.116	7.073AlaSer: 7.073 ± 0.095	6.911AlaThr: 6.911 ± 0.084	11.103AlaVal: 11.103 ± 0.096	1.48AlaTrp: 1.48 ± 0.032	2.506AlaTyr: 2.506 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.891CysAla: 0.891 ± 0.023	0.095CysCys: 0.095 ± 0.009	0.468CysAsp: 0.468 ± 0.019	0.357CysGlu: 0.357 ± 0.016	0.295CysPhe: 0.295 ± 0.015	0.861CysGly: 0.861 ± 0.023	0.18CysHis: 0.18 ± 0.012	0.307CysIle: 0.307 ± 0.013	0.134CysLys: 0.134 ± 0.009	0.773CysLeu: 0.773 ± 0.027	0.112CysMet: 0.112 ± 0.008	0.163CysAsn: 0.163 ± 0.01	0.353CysPro: 0.353 ± 0.016	0.169CysGln: 0.169 ± 0.01	0.59CysArg: 0.59 ± 0.021	0.388CysSer: 0.388 ± 0.014	0.383CysThr: 0.383 ± 0.017	0.569CysVal: 0.569 ± 0.022	0.102CysTrp: 0.102 ± 0.009	0.161CysTyr: 0.161 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.502AspAla: 7.502 ± 0.087	0.413AspCys: 0.413 ± 0.018	3.205AspAsp: 3.205 ± 0.06	3.362AspGlu: 3.362 ± 0.057	1.931AspPhe: 1.931 ± 0.044	5.689AspGly: 5.689 ± 0.079	1.215AspHis: 1.215 ± 0.032	2.959AspIle: 2.959 ± 0.051	1.292AspLys: 1.292 ± 0.033	6.29AspLeu: 6.29 ± 0.076	1.151AspMet: 1.151 ± 0.028	1.103AspAsn: 1.103 ± 0.028	3.624AspPro: 3.624 ± 0.051	1.314AspGln: 1.314 ± 0.033	4.583AspArg: 4.583 ± 0.057	2.126AspSer: 2.126 ± 0.042	2.413AspThr: 2.413 ± 0.046	4.36AspVal: 4.36 ± 0.051	0.827AspTrp: 0.827 ± 0.023	1.333AspTyr: 1.333 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.495GluAla: 8.495 ± 0.115	0.295GluCys: 0.295 ± 0.015	2.654GluAsp: 2.654 ± 0.052	2.829GluGlu: 2.829 ± 0.063	1.443GluPhe: 1.443 ± 0.036	4.238GluGly: 4.238 ± 0.059	1.078GluHis: 1.078 ± 0.027	3.474GluIle: 3.474 ± 0.052	1.671GluLys: 1.671 ± 0.047	4.409GluLeu: 4.409 ± 0.059	1.289GluMet: 1.289 ± 0.032	1.317GluAsn: 1.317 ± 0.032	2.952GluPro: 2.952 ± 0.055	1.603GluGln: 1.603 ± 0.039	5.051GluArg: 5.051 ± 0.077	2.1GluSer: 2.1 ± 0.033	3.474GluThr: 3.474 ± 0.053	3.72GluVal: 3.72 ± 0.054	0.572GluTrp: 0.572 ± 0.021	0.788GluTyr: 0.788 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.939PheAla: 4.939 ± 0.055	0.352PheCys: 0.352 ± 0.014	2.541PheAsp: 2.541 ± 0.035	2.03PheGlu: 2.03 ± 0.043	1.291PhePhe: 1.291 ± 0.034	3.774PheGly: 3.774 ± 0.053	0.73PheHis: 0.73 ± 0.022	1.482PheIle: 1.482 ± 0.034	0.81PheLys: 0.81 ± 0.024	3.374PheLeu: 3.374 ± 0.063	0.722PheMet: 0.722 ± 0.024	0.936PheAsn: 0.936 ± 0.029	1.58PhePro: 1.58 ± 0.034	0.905PheGln: 0.905 ± 0.026	2.335PheArg: 2.335 ± 0.042	2.167PheSer: 2.167 ± 0.05	1.992PheThr: 1.992 ± 0.04	3.07PheVal: 3.07 ± 0.049	0.49PheTrp: 0.49 ± 0.018	0.801PheTyr: 0.801 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.99GlyAla: 10.99 ± 0.14	0.798GlyCys: 0.798 ± 0.026	4.664GlyAsp: 4.664 ± 0.062	4.898GlyGlu: 4.898 ± 0.068	3.805GlyPhe: 3.805 ± 0.063	9.238GlyGly: 9.238 ± 0.3	1.934GlyHis: 1.934 ± 0.042	4.985GlyIle: 4.985 ± 0.064	2.805GlyLys: 2.805 ± 0.053	9.707GlyLeu: 9.707 ± 0.104	2.084GlyMet: 2.084 ± 0.044	2.185GlyAsn: 2.185 ± 0.064	4.025GlyPro: 4.025 ± 0.06	2.445GlyGln: 2.445 ± 0.046	7.364GlyArg: 7.364 ± 0.089	5.141GlySer: 5.141 ± 0.114	5.929GlyThr: 5.929 ± 0.259	6.869GlyVal: 6.869 ± 0.077	1.395GlyTrp: 1.395 ± 0.035	2.219GlyTyr: 2.219 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.312HisAla: 2.312 ± 0.045	0.193HisCys: 0.193 ± 0.011	1.187HisAsp: 1.187 ± 0.033	0.948HisGlu: 0.948 ± 0.025	0.753HisPhe: 0.753 ± 0.023	2.0HisGly: 2.0 ± 0.04	0.529HisHis: 0.529 ± 0.026	0.856HisIle: 0.856 ± 0.023	0.381HisLys: 0.381 ± 0.017	1.931HisLeu: 1.931 ± 0.035	0.445HisMet: 0.445 ± 0.015	0.387HisAsn: 0.387 ± 0.017	1.348HisPro: 1.348 ± 0.032	0.447HisGln: 0.447 ± 0.02	1.408HisArg: 1.408 ± 0.036	0.773HisSer: 0.773 ± 0.022	0.774HisThr: 0.774 ± 0.026	1.492HisVal: 1.492 ± 0.031	0.283HisTrp: 0.283 ± 0.012	0.478HisTyr: 0.478 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.911IleAla: 7.911 ± 0.076	0.415IleCys: 0.415 ± 0.019	3.59IleAsp: 3.59 ± 0.046	3.417IleGlu: 3.417 ± 0.055	1.401IlePhe: 1.401 ± 0.036	5.371IleGly: 5.371 ± 0.072	0.843IleHis: 0.843 ± 0.023	1.817IleIle: 1.817 ± 0.047	1.07IleLys: 1.07 ± 0.034	4.113IleLeu: 4.113 ± 0.059	0.798IleMet: 0.798 ± 0.024	1.207IleAsn: 1.207 ± 0.028	2.16IlePro: 2.16 ± 0.043	1.002IleGln: 1.002 ± 0.027	3.166IleArg: 3.166 ± 0.054	2.76IleSer: 2.76 ± 0.063	2.501IleThr: 2.501 ± 0.047	4.673IleVal: 4.673 ± 0.062	0.498IleTrp: 0.498 ± 0.018	1.033IleTyr: 1.033 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.875LysAla: 3.875 ± 0.068	0.116LysCys: 0.116 ± 0.008	1.311LysAsp: 1.311 ± 0.036	1.172LysGlu: 1.172 ± 0.03	0.667LysPhe: 0.667 ± 0.024	2.147LysGly: 2.147 ± 0.046	0.398LysHis: 0.398 ± 0.019	1.336LysIle: 1.336 ± 0.037	0.812LysLys: 0.812 ± 0.031	2.525LysLeu: 2.525 ± 0.054	0.552LysMet: 0.552 ± 0.023	0.608LysAsn: 0.608 ± 0.022	1.854LysPro: 1.854 ± 0.041	0.709LysGln: 0.709 ± 0.023	1.899LysArg: 1.899 ± 0.039	1.422LysSer: 1.422 ± 0.036	1.679LysThr: 1.679 ± 0.033	2.115LysVal: 2.115 ± 0.043	0.281LysTrp: 0.281 ± 0.015	0.429LysTyr: 0.429 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.902LeuAla: 14.902 ± 0.133	0.8LeuCys: 0.8 ± 0.023	6.224LeuAsp: 6.224 ± 0.078	4.726LeuGlu: 4.726 ± 0.068	3.549LeuPhe: 3.549 ± 0.059	8.731LeuGly: 8.731 ± 0.094	1.71LeuHis: 1.71 ± 0.036	4.762LeuIle: 4.762 ± 0.068	3.115LeuLys: 3.115 ± 0.048	8.39LeuLeu: 8.39 ± 0.108	2.241LeuMet: 2.241 ± 0.041	2.249LeuAsn: 2.249 ± 0.044	5.627LeuPro: 5.627 ± 0.072	2.418LeuGln: 2.418 ± 0.04	6.3LeuArg: 6.3 ± 0.089	6.559LeuSer: 6.559 ± 0.086	5.572LeuThr: 5.572 ± 0.105	8.464LeuVal: 8.464 ± 0.087	1.083LeuTrp: 1.083 ± 0.028	2.027LeuTyr: 2.027 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.996MetAla: 2.996 ± 0.042	0.123MetCys: 0.123 ± 0.009	0.937MetAsp: 0.937 ± 0.027	0.976MetGlu: 0.976 ± 0.026	0.691MetPhe: 0.691 ± 0.023	1.558MetGly: 1.558 ± 0.034	0.342MetHis: 0.342 ± 0.015	1.201MetIle: 1.201 ± 0.028	0.804MetLys: 0.804 ± 0.026	2.212MetLeu: 2.212 ± 0.041	0.596MetMet: 0.596 ± 0.022	0.65MetAsn: 0.65 ± 0.02	1.478MetPro: 1.478 ± 0.033	0.591MetGln: 0.591 ± 0.019	1.657MetArg: 1.657 ± 0.035	1.586MetSer: 1.586 ± 0.035	1.816MetThr: 1.816 ± 0.035	1.704MetVal: 1.704 ± 0.037	0.19MetTrp: 0.19 ± 0.013	0.227MetTyr: 0.227 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.107AsnAla: 3.107 ± 0.05	0.174AsnCys: 0.174 ± 0.011	1.206AsnAsp: 1.206 ± 0.03	0.966AsnGlu: 0.966 ± 0.027	0.803AsnPhe: 0.803 ± 0.025	2.389AsnGly: 2.389 ± 0.068	0.418AsnHis: 0.418 ± 0.016	1.169AsnIle: 1.169 ± 0.026	0.492AsnLys: 0.492 ± 0.018	2.24AsnLeu: 2.24 ± 0.045	0.5AsnMet: 0.5 ± 0.02	0.616AsnAsn: 0.616 ± 0.029	1.674AsnPro: 1.674 ± 0.033	0.617AsnGln: 0.617 ± 0.019	1.611AsnArg: 1.611 ± 0.035	0.983AsnSer: 0.983 ± 0.034	1.226AsnThr: 1.226 ± 0.049	1.841AsnVal: 1.841 ± 0.039	0.383AsnTrp: 0.383 ± 0.015	0.554AsnTyr: 0.554 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.935ProAla: 7.935 ± 0.102	0.262ProCys: 0.262 ± 0.014	3.732ProAsp: 3.732 ± 0.051	3.534ProGlu: 3.534 ± 0.057	2.133ProPhe: 2.133 ± 0.039	5.176ProGly: 5.176 ± 0.07	1.038ProHis: 1.038 ± 0.024	2.189ProIle: 2.189 ± 0.042	1.406ProLys: 1.406 ± 0.036	4.861ProLeu: 4.861 ± 0.07	1.147ProMet: 1.147 ± 0.028	1.235ProAsn: 1.235 ± 0.025	3.162ProPro: 3.162 ± 0.078	1.457ProGln: 1.457 ± 0.041	3.059ProArg: 3.059 ± 0.051	2.932ProSer: 2.932 ± 0.04	2.559ProThr: 2.559 ± 0.042	4.746ProVal: 4.746 ± 0.066	0.743ProTrp: 0.743 ± 0.025	1.11ProTyr: 1.11 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.608GlnAla: 3.608 ± 0.06	0.134GlnCys: 0.134 ± 0.01	1.211GlnAsp: 1.211 ± 0.031	1.154GlnGlu: 1.154 ± 0.028	0.878GlnPhe: 0.878 ± 0.022	2.042GlnGly: 2.042 ± 0.04	0.454GlnHis: 0.454 ± 0.017	1.548GlnIle: 1.548 ± 0.032	0.765GlnLys: 0.765 ± 0.027	2.121GlnLeu: 2.121 ± 0.047	0.688GlnMet: 0.688 ± 0.024	0.712GlnAsn: 0.712 ± 0.025	1.559GlnPro: 1.559 ± 0.032	0.925GlnGln: 0.925 ± 0.038	1.918GlnArg: 1.918 ± 0.04	1.599GlnSer: 1.599 ± 0.048	1.478GlnThr: 1.478 ± 0.034	1.956GlnVal: 1.956 ± 0.041	0.306GlnTrp: 0.306 ± 0.018	0.47GlnTyr: 0.47 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	8.702ArgAla: 8.702 ± 0.1	0.477ArgCys: 0.477 ± 0.021	3.997ArgAsp: 3.997 ± 0.064	3.944ArgGlu: 3.944 ± 0.06	3.081ArgPhe: 3.081 ± 0.053	5.206ArgGly: 5.206 ± 0.067	1.734ArgHis: 1.734 ± 0.041	4.032ArgIle: 4.032 ± 0.058	1.792ArgLys: 1.792 ± 0.04	8.565ArgLeu: 8.565 ± 0.104	1.765ArgMet: 1.765 ± 0.035	1.544ArgAsn: 1.544 ± 0.031	4.103ArgPro: 4.103 ± 0.065	2.229ArgGln: 2.229 ± 0.043	6.805ArgArg: 6.805 ± 0.094	3.616ArgSer: 3.616 ± 0.053	3.708ArgThr: 3.708 ± 0.057	4.988ArgVal: 4.988 ± 0.073	0.968ArgTrp: 0.968 ± 0.025	1.597ArgTyr: 1.597 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.668SerAla: 6.668 ± 0.082	0.346SerCys: 0.346 ± 0.016	2.914SerAsp: 2.914 ± 0.044	2.538SerGlu: 2.538 ± 0.051	2.254SerPhe: 2.254 ± 0.043	6.348SerGly: 6.348 ± 0.216	1.046SerHis: 1.046 ± 0.029	2.64SerIle: 2.64 ± 0.052	1.21SerLys: 1.21 ± 0.033	5.344SerLeu: 5.344 ± 0.065	1.166SerMet: 1.166 ± 0.031	1.282SerAsn: 1.282 ± 0.038	2.93SerPro: 2.93 ± 0.046	1.341SerGln: 1.341 ± 0.035	3.587SerArg: 3.587 ± 0.053	3.031SerSer: 3.031 ± 0.077	2.769SerThr: 2.769 ± 0.056	4.273SerVal: 4.273 ± 0.067	0.673SerTrp: 0.673 ± 0.022	1.194SerTyr: 1.194 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.052ThrAla: 7.052 ± 0.079	0.375ThrCys: 0.375 ± 0.018	2.745ThrAsp: 2.745 ± 0.043	2.512ThrGlu: 2.512 ± 0.041	2.124ThrPhe: 2.124 ± 0.052	5.734ThrGly: 5.734 ± 0.15	0.956ThrHis: 0.956 ± 0.025	2.863ThrIle: 2.863 ± 0.063	1.133ThrLys: 1.133 ± 0.03	6.35ThrLeu: 6.35 ± 0.165	1.128ThrMet: 1.128 ± 0.029	1.254ThrAsn: 1.254 ± 0.043	3.355ThrPro: 3.355 ± 0.054	1.211ThrGln: 1.211 ± 0.03	3.304ThrArg: 3.304 ± 0.047	2.755ThrSer: 2.755 ± 0.064	3.063ThrThr: 3.063 ± 0.092	5.103ThrVal: 5.103 ± 0.07	0.604ThrTrp: 0.604 ± 0.021	1.19ThrTyr: 1.19 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	11.226ValAla: 11.226 ± 0.111	0.632ValCys: 0.632 ± 0.02	4.52ValAsp: 4.52 ± 0.06	4.546ValGlu: 4.546 ± 0.06	3.004ValPhe: 3.004 ± 0.054	6.512ValGly: 6.512 ± 0.083	1.404ValHis: 1.404 ± 0.033	3.99ValIle: 3.99 ± 0.063	1.995ValLys: 1.995 ± 0.044	8.332ValLeu: 8.332 ± 0.089	1.789ValMet: 1.789 ± 0.035	1.876ValAsn: 1.876 ± 0.036	4.421ValPro: 4.421 ± 0.055	1.878ValGln: 1.878 ± 0.035	5.485ValArg: 5.485 ± 0.065	4.653ValSer: 4.653 ± 0.072	4.79ValThr: 4.79 ± 0.079	7.457ValVal: 7.457 ± 0.073	0.871ValTrp: 0.871 ± 0.022	1.498ValTyr: 1.498 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.11TrpAla: 1.11 ± 0.029	0.12TrpCys: 0.12 ± 0.009	0.582TrpAsp: 0.582 ± 0.019	0.467TrpGlu: 0.467 ± 0.016	0.501TrpPhe: 0.501 ± 0.02	0.874TrpGly: 0.874 ± 0.027	0.282TrpHis: 0.282 ± 0.014	0.63TrpIle: 0.63 ± 0.019	0.377TrpLys: 0.377 ± 0.017	1.489TrpLeu: 1.489 ± 0.039	0.293TrpMet: 0.293 ± 0.014	0.428TrpAsn: 0.428 ± 0.02	0.673TrpPro: 0.673 ± 0.022	0.496TrpGln: 0.496 ± 0.017	1.125TrpArg: 1.125 ± 0.03	0.786TrpSer: 0.786 ± 0.025	0.761TrpThr: 0.761 ± 0.022	0.791TrpVal: 0.791 ± 0.023	0.228TrpTrp: 0.228 ± 0.013	0.253TrpTyr: 0.253 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.364TyrAla: 2.364 ± 0.047	0.203TyrCys: 0.203 ± 0.012	1.35TyrAsp: 1.35 ± 0.031	1.043TyrGlu: 1.043 ± 0.03	0.802TyrPhe: 0.802 ± 0.024	2.096TyrGly: 2.096 ± 0.046	0.402TyrHis: 0.402 ± 0.02	0.819TyrIle: 0.819 ± 0.025	0.507TyrLys: 0.507 ± 0.021	2.089TyrLeu: 2.089 ± 0.042	0.369TyrMet: 0.369 ± 0.016	0.503TyrAsn: 0.503 ± 0.018	1.026TyrPro: 1.026 ± 0.026	0.595TyrGln: 0.595 ± 0.02	1.703TyrArg: 1.703 ± 0.036	1.106TyrSer: 1.106 ± 0.027	1.016TyrThr: 1.016 ± 0.033	1.587TyrVal: 1.587 ± 0.036	0.289TyrTrp: 0.289 ± 0.015	0.555TyrTyr: 0.555 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4320 proteins (1486866 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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