Amino acid dipepetide frequency for Cephalotus follicularis (Albany pitcher plant)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.734AlaAla: 4.734 ± 0.036	1.191AlaCys: 1.191 ± 0.013	2.889AlaAsp: 2.889 ± 0.018	3.444AlaGlu: 3.444 ± 0.019	2.699AlaPhe: 2.699 ± 0.014	3.475AlaGly: 3.475 ± 0.021	1.23AlaHis: 1.23 ± 0.011	3.745AlaIle: 3.745 ± 0.018	4.042AlaLys: 4.042 ± 0.021	6.359AlaLeu: 6.359 ± 0.029	1.697AlaMet: 1.697 ± 0.012	2.526AlaAsn: 2.526 ± 0.014	2.718AlaPro: 2.718 ± 0.021	2.081AlaGln: 2.081 ± 0.016	3.22AlaArg: 3.22 ± 0.016	5.419AlaSer: 5.419 ± 0.025	3.423AlaThr: 3.423 ± 0.017	3.819AlaVal: 3.819 ± 0.025	0.767AlaTrp: 0.767 ± 0.008	1.743AlaTyr: 1.743 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	0.977CysAla: 0.977 ± 0.009	0.444CysCys: 0.444 ± 0.007	0.87CysAsp: 0.87 ± 0.01	0.856CysGlu: 0.856 ± 0.009	1.029CysPhe: 1.029 ± 0.01	1.369CysGly: 1.369 ± 0.013	0.485CysHis: 0.485 ± 0.007	1.259CysIle: 1.259 ± 0.011	1.126CysLys: 1.126 ± 0.012	1.98CysLeu: 1.98 ± 0.016	0.426CysMet: 0.426 ± 0.006	1.016CysAsn: 1.016 ± 0.011	1.021CysPro: 1.021 ± 0.011	0.561CysGln: 0.561 ± 0.007	1.028CysArg: 1.028 ± 0.011	1.668CysSer: 1.668 ± 0.012	0.868CysThr: 0.868 ± 0.009	1.153CysVal: 1.153 ± 0.009	0.25CysTrp: 0.25 ± 0.005	0.665CysTyr: 0.665 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.15AspAla: 3.15 ± 0.018	1.016AspCys: 1.016 ± 0.01	3.794AspAsp: 3.794 ± 0.027	4.001AspGlu: 4.001 ± 0.023	2.413AspPhe: 2.413 ± 0.013	3.36AspGly: 3.36 ± 0.023	1.44AspHis: 1.44 ± 0.011	3.228AspIle: 3.228 ± 0.018	2.831AspLys: 2.831 ± 0.017	5.198AspLeu: 5.198 ± 0.022	1.307AspMet: 1.307 ± 0.012	2.247AspAsn: 2.247 ± 0.012	2.561AspPro: 2.561 ± 0.014	1.769AspGln: 1.769 ± 0.013	2.378AspArg: 2.378 ± 0.015	4.153AspSer: 4.153 ± 0.02	2.4AspThr: 2.4 ± 0.014	3.231AspVal: 3.231 ± 0.019	0.666AspTrp: 0.666 ± 0.007	1.675AspTyr: 1.675 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	4.426GluAla: 4.426 ± 0.025	1.042GluCys: 1.042 ± 0.011	4.177GluAsp: 4.177 ± 0.023	6.672GluGlu: 6.672 ± 0.043	2.58GluPhe: 2.58 ± 0.015	4.016GluGly: 4.016 ± 0.023	1.405GluHis: 1.405 ± 0.01	3.638GluIle: 3.638 ± 0.017	4.516GluLys: 4.516 ± 0.024	5.567GluLeu: 5.567 ± 0.028	1.98GluMet: 1.98 ± 0.016	3.279GluAsn: 3.279 ± 0.02	1.901GluPro: 1.901 ± 0.015	2.341GluGln: 2.341 ± 0.017	3.248GluArg: 3.248 ± 0.021	4.287GluSer: 4.287 ± 0.021	2.886GluThr: 2.886 ± 0.019	4.386GluVal: 4.386 ± 0.02	0.732GluTrp: 0.732 ± 0.008	1.804GluTyr: 1.804 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	2.433PheAla: 2.433 ± 0.015	1.109PheCys: 1.109 ± 0.01	2.598PheAsp: 2.598 ± 0.015	2.369PheGlu: 2.369 ± 0.016	1.808PhePhe: 1.808 ± 0.015	2.795PheGly: 2.795 ± 0.018	1.246PheHis: 1.246 ± 0.012	2.122PheIle: 2.122 ± 0.015	2.558PheLys: 2.558 ± 0.018	4.309PheLeu: 4.309 ± 0.023	1.005PheMet: 1.005 ± 0.009	1.963PheAsn: 1.963 ± 0.013	1.915PhePro: 1.915 ± 0.014	1.522PheGln: 1.522 ± 0.011	1.731PheArg: 1.731 ± 0.014	3.928PheSer: 3.928 ± 0.019	2.289PheThr: 2.289 ± 0.013	2.695PheVal: 2.695 ± 0.017	0.548PheTrp: 0.548 ± 0.007	1.457PheTyr: 1.457 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	3.155GlyAla: 3.155 ± 0.019	1.121GlyCys: 1.121 ± 0.01	3.269GlyAsp: 3.269 ± 0.02	3.525GlyGlu: 3.525 ± 0.017	2.837GlyPhe: 2.837 ± 0.016	4.699GlyGly: 4.699 ± 0.038	1.744GlyHis: 1.744 ± 0.014	3.543GlyIle: 3.543 ± 0.02	3.867GlyLys: 3.867 ± 0.021	5.545GlyLeu: 5.545 ± 0.025	1.431GlyMet: 1.431 ± 0.01	2.783GlyAsn: 2.783 ± 0.019	2.251GlyPro: 2.251 ± 0.015	2.024GlyGln: 2.024 ± 0.013	3.518GlyArg: 3.518 ± 0.022	5.482GlySer: 5.482 ± 0.024	3.157GlyThr: 3.157 ± 0.015	3.728GlyVal: 3.728 ± 0.02	1.031GlyTrp: 1.031 ± 0.011	2.011GlyTyr: 2.011 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	1.39HisAla: 1.39 ± 0.01	0.607HisCys: 0.607 ± 0.008	1.255HisAsp: 1.255 ± 0.011	1.499HisGlu: 1.499 ± 0.014	1.276HisPhe: 1.276 ± 0.011	1.532HisGly: 1.532 ± 0.014	1.098HisHis: 1.098 ± 0.014	1.787HisIle: 1.787 ± 0.013	1.424HisLys: 1.424 ± 0.011	2.862HisLeu: 2.862 ± 0.016	0.616HisMet: 0.616 ± 0.007	1.014HisAsn: 1.014 ± 0.01	1.514HisPro: 1.514 ± 0.012	1.096HisGln: 1.096 ± 0.011	1.502HisArg: 1.502 ± 0.013	1.99HisSer: 1.99 ± 0.015	1.289HisThr: 1.289 ± 0.012	1.542HisVal: 1.542 ± 0.01	0.331HisTrp: 0.331 ± 0.006	0.742HisTyr: 0.742 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.593IleAla: 3.593 ± 0.02	1.273IleCys: 1.273 ± 0.011	3.049IleAsp: 3.049 ± 0.016	3.706IleGlu: 3.706 ± 0.018	2.376IlePhe: 2.376 ± 0.015	3.139IleGly: 3.139 ± 0.02	1.412IleHis: 1.412 ± 0.011	3.322IleIle: 3.322 ± 0.018	3.331IleLys: 3.331 ± 0.021	6.466IleLeu: 6.466 ± 0.029	1.3IleMet: 1.3 ± 0.011	2.589IleAsn: 2.589 ± 0.015	3.068IlePro: 3.068 ± 0.02	1.959IleGln: 1.959 ± 0.016	2.704IleArg: 2.704 ± 0.016	5.002IleSer: 5.002 ± 0.02	3.02IleThr: 3.02 ± 0.018	3.591IleVal: 3.591 ± 0.019	0.823IleTrp: 0.823 ± 0.008	1.724IleTyr: 1.724 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.982LysAla: 3.982 ± 0.02	0.968LysCys: 0.968 ± 0.01	3.249LysAsp: 3.249 ± 0.019	4.992LysGlu: 4.992 ± 0.027	2.467LysPhe: 2.467 ± 0.017	3.715LysGly: 3.715 ± 0.018	1.557LysHis: 1.557 ± 0.012	3.781LysIle: 3.781 ± 0.021	6.399LysLys: 6.399 ± 0.049	6.395LysLeu: 6.395 ± 0.027	1.608LysMet: 1.608 ± 0.012	3.303LysAsn: 3.303 ± 0.021	2.828LysPro: 2.828 ± 0.018	2.343LysGln: 2.343 ± 0.015	3.688LysArg: 3.688 ± 0.024	4.766LysSer: 4.766 ± 0.022	3.244LysThr: 3.244 ± 0.02	3.977LysVal: 3.977 ± 0.019	1.001LysTrp: 1.001 ± 0.009	1.78LysTyr: 1.78 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	5.965LeuAla: 5.965 ± 0.024	1.849LeuCys: 1.849 ± 0.015	4.886LeuAsp: 4.886 ± 0.022	6.207LeuGlu: 6.207 ± 0.026	3.718LeuPhe: 3.718 ± 0.019	5.747LeuGly: 5.747 ± 0.026	2.83LeuHis: 2.83 ± 0.02	5.141LeuIle: 5.141 ± 0.022	6.884LeuLys: 6.884 ± 0.026	9.718LeuLeu: 9.718 ± 0.038	2.394LeuMet: 2.394 ± 0.016	4.296LeuAsn: 4.296 ± 0.018	5.478LeuPro: 5.478 ± 0.026	4.108LeuGln: 4.108 ± 0.025	5.489LeuArg: 5.489 ± 0.023	8.524LeuSer: 8.524 ± 0.037	4.344LeuThr: 4.344 ± 0.021	6.583LeuVal: 6.583 ± 0.027	1.317LeuTrp: 1.317 ± 0.013	2.657LeuTyr: 2.657 ± 0.016	0.0LeuXaa: 0.0 ± 0.0
Met	2.097MetAla: 2.097 ± 0.015	0.333MetCys: 0.333 ± 0.006	1.43MetAsp: 1.43 ± 0.01	1.972MetGlu: 1.972 ± 0.014	0.99MetPhe: 0.99 ± 0.009	1.663MetGly: 1.663 ± 0.013	0.609MetHis: 0.609 ± 0.007	1.204MetIle: 1.204 ± 0.011	1.764MetLys: 1.764 ± 0.012	2.248MetLeu: 2.248 ± 0.013	0.674MetMet: 0.674 ± 0.008	1.117MetAsn: 1.117 ± 0.011	0.989MetPro: 0.989 ± 0.01	1.144MetGln: 1.144 ± 0.011	1.189MetArg: 1.189 ± 0.011	1.643MetSer: 1.643 ± 0.011	1.345MetThr: 1.345 ± 0.011	1.887MetVal: 1.887 ± 0.012	0.527MetTrp: 0.527 ± 0.006	0.611MetTyr: 0.611 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.814AsnAla: 2.814 ± 0.014	0.841AsnCys: 0.841 ± 0.009	2.363AsnAsp: 2.363 ± 0.016	3.194AsnGlu: 3.194 ± 0.021	1.929AsnPhe: 1.929 ± 0.014	3.064AsnGly: 3.064 ± 0.017	1.323AsnHis: 1.323 ± 0.012	2.898AsnIle: 2.898 ± 0.018	2.852AsnLys: 2.852 ± 0.02	4.989AsnLeu: 4.989 ± 0.025	1.224AsnMet: 1.224 ± 0.011	2.307AsnAsn: 2.307 ± 0.019	2.342AsnPro: 2.342 ± 0.013	1.96AsnGln: 1.96 ± 0.015	2.279AsnArg: 2.279 ± 0.013	3.943AsnSer: 3.943 ± 0.021	2.0AsnThr: 2.0 ± 0.015	3.081AsnVal: 3.081 ± 0.015	0.569AsnTrp: 0.569 ± 0.007	1.293AsnTyr: 1.293 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	2.559ProAla: 2.559 ± 0.021	0.685ProCys: 0.685 ± 0.009	2.252ProAsp: 2.252 ± 0.016	2.676ProGlu: 2.676 ± 0.017	1.974ProPhe: 1.974 ± 0.013	2.313ProGly: 2.313 ± 0.016	1.265ProHis: 1.265 ± 0.01	2.431ProIle: 2.431 ± 0.016	2.927ProLys: 2.927 ± 0.018	4.425ProLeu: 4.425 ± 0.021	0.958ProMet: 0.958 ± 0.009	2.836ProAsn: 2.836 ± 0.019	3.357ProPro: 3.357 ± 0.05	1.76ProGln: 1.76 ± 0.013	2.569ProArg: 2.569 ± 0.017	4.481ProSer: 4.481 ± 0.025	2.801ProThr: 2.801 ± 0.018	2.794ProVal: 2.794 ± 0.02	0.736ProTrp: 0.736 ± 0.009	1.541ProTyr: 1.541 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	2.544GlnAla: 2.544 ± 0.018	0.565GlnCys: 0.565 ± 0.007	1.535GlnAsp: 1.535 ± 0.012	2.385GlnGlu: 2.385 ± 0.017	1.452GlnPhe: 1.452 ± 0.01	2.116GlnGly: 2.116 ± 0.014	0.875GlnHis: 0.875 ± 0.009	2.313GlnIle: 2.313 ± 0.017	2.326GlnLys: 2.326 ± 0.018	3.673GlnLeu: 3.673 ± 0.021	0.962GlnMet: 0.962 ± 0.011	1.826GlnAsn: 1.826 ± 0.016	1.619GlnPro: 1.619 ± 0.014	2.228GlnGln: 2.228 ± 0.03	2.159GlnArg: 2.159 ± 0.014	2.729GlnSer: 2.729 ± 0.018	1.653GlnThr: 1.653 ± 0.012	2.587GlnVal: 2.587 ± 0.014	0.501GlnTrp: 0.501 ± 0.007	0.89GlnTyr: 0.89 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	3.055ArgAla: 3.055 ± 0.018	1.095ArgCys: 1.095 ± 0.01	2.607ArgAsp: 2.607 ± 0.019	3.385ArgGlu: 3.385 ± 0.022	2.318ArgPhe: 2.318 ± 0.015	2.978ArgGly: 2.978 ± 0.02	1.246ArgHis: 1.246 ± 0.011	3.447ArgIle: 3.447 ± 0.018	3.885ArgLys: 3.885 ± 0.02	5.051ArgLeu: 5.051 ± 0.021	1.73ArgMet: 1.73 ± 0.016	2.425ArgAsn: 2.425 ± 0.017	2.367ArgPro: 2.367 ± 0.015	1.885ArgGln: 1.885 ± 0.015	3.546ArgArg: 3.546 ± 0.023	3.709ArgSer: 3.709 ± 0.024	2.256ArgThr: 2.256 ± 0.014	3.266ArgVal: 3.266 ± 0.019	0.635ArgTrp: 0.635 ± 0.008	1.428ArgTyr: 1.428 ± 0.012	0.0ArgXaa: 0.0 ± 0.0
Ser	4.472SerAla: 4.472 ± 0.021	1.684SerCys: 1.684 ± 0.014	4.263SerAsp: 4.263 ± 0.023	4.332SerGlu: 4.332 ± 0.024	3.752SerPhe: 3.752 ± 0.018	5.097SerGly: 5.097 ± 0.027	2.147SerHis: 2.147 ± 0.017	4.814SerIle: 4.814 ± 0.022	5.067SerLys: 5.067 ± 0.024	8.396SerLeu: 8.396 ± 0.034	2.191SerMet: 2.191 ± 0.013	4.066SerAsn: 4.066 ± 0.019	3.905SerPro: 3.905 ± 0.03	2.982SerGln: 2.982 ± 0.016	4.263SerArg: 4.263 ± 0.025	10.209SerSer: 10.209 ± 0.045	4.664SerThr: 4.664 ± 0.024	4.96SerVal: 4.96 ± 0.024	1.322SerTrp: 1.322 ± 0.011	2.165SerTyr: 2.165 ± 0.015	0.0SerXaa: 0.0 ± 0.0
Thr	3.054ThrAla: 3.054 ± 0.016	0.964ThrCys: 0.964 ± 0.01	2.127ThrAsp: 2.127 ± 0.014	2.536ThrGlu: 2.536 ± 0.016	2.195ThrPhe: 2.195 ± 0.014	3.151ThrGly: 3.151 ± 0.018	1.309ThrHis: 1.309 ± 0.009	3.201ThrIle: 3.201 ± 0.017	3.127ThrLys: 3.127 ± 0.02	4.842ThrLeu: 4.842 ± 0.019	1.415ThrMet: 1.415 ± 0.011	2.598ThrAsn: 2.598 ± 0.017	2.682ThrPro: 2.682 ± 0.018	1.573ThrGln: 1.573 ± 0.013	2.512ThrArg: 2.512 ± 0.015	4.502ThrSer: 4.502 ± 0.022	3.237ThrThr: 3.237 ± 0.022	2.968ThrVal: 2.968 ± 0.018	0.722ThrTrp: 0.722 ± 0.008	1.722ThrTyr: 1.722 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	4.378ValAla: 4.378 ± 0.021	1.118ValCys: 1.118 ± 0.011	3.791ValAsp: 3.791 ± 0.019	4.33ValGlu: 4.33 ± 0.023	2.815ValPhe: 2.815 ± 0.018	3.871ValGly: 3.871 ± 0.021	1.813ValHis: 1.813 ± 0.013	3.289ValIle: 3.289 ± 0.017	4.399ValLys: 4.399 ± 0.02	5.942ValLeu: 5.942 ± 0.023	1.435ValMet: 1.435 ± 0.011	2.698ValAsn: 2.698 ± 0.015	2.819ValPro: 2.819 ± 0.021	2.148ValGln: 2.148 ± 0.016	3.128ValArg: 3.128 ± 0.017	5.054ValSer: 5.054 ± 0.023	3.483ValThr: 3.483 ± 0.017	4.644ValVal: 4.644 ± 0.027	0.809ValTrp: 0.809 ± 0.009	1.683ValTyr: 1.683 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	0.682TrpAla: 0.682 ± 0.009	0.394TrpCys: 0.394 ± 0.006	0.9TrpAsp: 0.9 ± 0.008	0.858TrpGlu: 0.858 ± 0.009	0.57TrpPhe: 0.57 ± 0.008	0.722TrpGly: 0.722 ± 0.009	0.435TrpHis: 0.435 ± 0.007	0.694TrpIle: 0.694 ± 0.008	1.087TrpLys: 1.087 ± 0.009	1.331TrpLeu: 1.331 ± 0.012	0.417TrpMet: 0.417 ± 0.007	0.712TrpAsn: 0.712 ± 0.009	0.567TrpPro: 0.567 ± 0.007	0.462TrpGln: 0.462 ± 0.007	0.765TrpArg: 0.765 ± 0.008	1.045TrpSer: 1.045 ± 0.008	0.751TrpThr: 0.751 ± 0.009	0.965TrpVal: 0.965 ± 0.01	0.223TrpTrp: 0.223 ± 0.006	0.327TrpTyr: 0.327 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.763TyrAla: 1.763 ± 0.013	0.751TyrCys: 0.751 ± 0.008	1.514TyrAsp: 1.514 ± 0.011	1.944TyrGlu: 1.944 ± 0.014	1.202TyrPhe: 1.202 ± 0.01	1.897TyrGly: 1.897 ± 0.016	0.897TyrHis: 0.897 ± 0.008	1.589TyrIle: 1.589 ± 0.011	1.63TyrLys: 1.63 ± 0.015	2.841TyrLeu: 2.841 ± 0.015	0.664TyrMet: 0.664 ± 0.008	1.664TyrAsn: 1.664 ± 0.013	1.439TyrPro: 1.439 ± 0.012	0.991TyrGln: 0.991 ± 0.009	1.396TyrArg: 1.396 ± 0.012	2.219TyrSer: 2.219 ± 0.015	1.327TyrThr: 1.327 ± 0.011	1.794TyrVal: 1.794 ± 0.013	0.394TyrTrp: 0.394 ± 0.006	0.967TyrTyr: 0.967 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 36397 proteins (11578339 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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