Amino acid dipepetide frequency for Hubei picorna-like virus 55

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.275AlaAla: 4.275 ± 1.116
1.315AlaCys: 1.315 ± 0.639
1.644AlaAsp: 1.644 ± 0.266
1.644AlaGlu: 1.644 ± 0.799
3.946AlaPhe: 3.946 ± 0.853
3.946AlaGly: 3.946 ± 0.211
1.315AlaHis: 1.315 ± 0.639
4.933AlaIle: 4.933 ± 0.268
3.946AlaLys: 3.946 ± 1.918
4.933AlaLeu: 4.933 ± 0.797
2.631AlaMet: 2.631 ± 0.214
3.946AlaAsn: 3.946 ± 1.276
0.987AlaPro: 0.987 ± 1.65
2.631AlaGln: 2.631 ± 4.045
1.973AlaArg: 1.973 ± 0.106
5.59AlaSer: 5.59 ± 2.606
3.617AlaThr: 3.617 ± 0.371
3.617AlaVal: 3.617 ± 0.693
0.329AlaTrp: 0.329 ± 0.16
2.302AlaTyr: 2.302 ± 1.119
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.658CysAsp: 0.658 ± 0.32
1.973CysGlu: 1.973 ± 0.959
0.658CysPhe: 0.658 ± 0.32
0.658CysGly: 0.658 ± 0.32
0.0CysHis: 0.0 ± 0.0
0.658CysIle: 0.658 ± 0.32
1.315CysLys: 1.315 ± 0.639
1.644CysLeu: 1.644 ± 0.266
0.329CysMet: 0.329 ± 0.16
1.315CysAsn: 1.315 ± 0.639
1.315CysPro: 1.315 ± 0.425
0.0CysGln: 0.0 ± 0.0
0.658CysArg: 0.658 ± 0.32
2.96CysSer: 2.96 ± 0.691
1.315CysThr: 1.315 ± 0.639
1.315CysVal: 1.315 ± 0.639
0.329CysTrp: 0.329 ± 0.16
1.315CysTyr: 1.315 ± 0.639
0.0CysXaa: 0.0 ± 0.0
Asp
2.631AspAla: 2.631 ± 0.851
0.987AspCys: 0.987 ± 0.585
2.631AspAsp: 2.631 ± 0.851
3.617AspGlu: 3.617 ± 0.693
3.946AspPhe: 3.946 ± 0.853
1.973AspGly: 1.973 ± 0.959
0.329AspHis: 0.329 ± 0.16
4.933AspIle: 4.933 ± 0.797
3.617AspLys: 3.617 ± 0.693
3.288AspLeu: 3.288 ± 0.531
0.658AspMet: 0.658 ± 0.32
2.96AspAsn: 2.96 ± 0.691
3.617AspPro: 3.617 ± 1.758
0.658AspGln: 0.658 ± 0.32
2.302AspArg: 2.302 ± 0.054
4.933AspSer: 4.933 ± 0.268
1.973AspThr: 1.973 ± 1.17
1.315AspVal: 1.315 ± 0.425
1.315AspTrp: 1.315 ± 0.425
0.987AspTyr: 0.987 ± 0.479
0.0AspXaa: 0.0 ± 0.0
Glu
3.617GluAla: 3.617 ± 1.758
0.987GluCys: 0.987 ± 0.479
4.604GluAsp: 4.604 ± 1.173
6.577GluGlu: 6.577 ± 2.132
4.604GluPhe: 4.604 ± 2.021
1.973GluGly: 1.973 ± 0.959
1.315GluHis: 1.315 ± 0.639
5.261GluIle: 5.261 ± 0.428
4.933GluLys: 4.933 ± 1.333
6.577GluLeu: 6.577 ± 1.067
1.644GluMet: 1.644 ± 0.799
2.96GluAsn: 2.96 ± 1.438
1.644GluPro: 1.644 ± 0.266
3.946GluGln: 3.946 ± 1.276
2.96GluArg: 2.96 ± 1.755
2.96GluSer: 2.96 ± 0.691
4.604GluThr: 4.604 ± 1.173
3.617GluVal: 3.617 ± 0.693
0.658GluTrp: 0.658 ± 0.32
4.275GluTyr: 4.275 ± 1.013
0.0GluXaa: 0.0 ± 0.0
Phe
2.302PheAla: 2.302 ± 1.011
1.973PheCys: 1.973 ± 0.959
2.96PheAsp: 2.96 ± 0.691
2.96PheGlu: 2.96 ± 0.374
0.987PhePhe: 0.987 ± 0.479
2.631PheGly: 2.631 ± 0.851
0.658PheHis: 0.658 ± 0.32
2.302PheIle: 2.302 ± 1.119
4.275PheLys: 4.275 ± 1.013
4.275PheLeu: 4.275 ± 0.052
0.987PheMet: 0.987 ± 0.413
2.96PheAsn: 2.96 ± 1.438
1.315PhePro: 1.315 ± 1.49
1.644PheGln: 1.644 ± 1.33
3.288PheArg: 3.288 ± 1.596
4.604PheSer: 4.604 ± 0.108
3.617PheThr: 3.617 ± 0.693
3.288PheVal: 3.288 ± 0.531
0.329PheTrp: 0.329 ± 0.16
1.973PheTyr: 1.973 ± 0.106
0.0PheXaa: 0.0 ± 0.0
Gly
2.96GlyAla: 2.96 ± 0.691
0.329GlyCys: 0.329 ± 0.16
1.973GlyAsp: 1.973 ± 0.959
2.631GlyGlu: 2.631 ± 1.279
2.96GlyPhe: 2.96 ± 1.755
2.96GlyGly: 2.96 ± 1.755
0.658GlyHis: 0.658 ± 0.745
3.946GlyIle: 3.946 ± 0.853
4.604GlyLys: 4.604 ± 2.237
3.617GlyLeu: 3.617 ± 1.436
0.987GlyMet: 0.987 ± 0.479
1.973GlyAsn: 1.973 ± 0.959
2.302GlyPro: 2.302 ± 1.011
1.315GlyGln: 1.315 ± 1.49
3.946GlyArg: 3.946 ± 2.341
2.96GlySer: 2.96 ± 1.438
2.302GlyThr: 2.302 ± 0.054
4.275GlyVal: 4.275 ± 1.013
0.658GlyTrp: 0.658 ± 0.32
2.96GlyTyr: 2.96 ± 1.755
0.0GlyXaa: 0.0 ± 0.0
His
1.644HisAla: 1.644 ± 0.799
0.329HisCys: 0.329 ± 0.16
1.315HisAsp: 1.315 ± 0.639
1.644HisGlu: 1.644 ± 0.799
0.0HisPhe: 0.0 ± 0.0
0.329HisGly: 0.329 ± 0.16
0.0HisHis: 0.0 ± 0.0
1.315HisIle: 1.315 ± 0.639
0.658HisLys: 0.658 ± 0.32
1.644HisLeu: 1.644 ± 0.799
0.329HisMet: 0.329 ± 0.905
1.644HisAsn: 1.644 ± 0.799
0.987HisPro: 0.987 ± 0.585
0.658HisGln: 0.658 ± 0.32
1.973HisArg: 1.973 ± 0.959
0.987HisSer: 0.987 ± 0.479
1.315HisThr: 1.315 ± 0.425
0.987HisVal: 0.987 ± 0.479
0.0HisTrp: 0.0 ± 0.0
0.987HisTyr: 0.987 ± 0.479
0.0HisXaa: 0.0 ± 0.0
Ile
3.288IleAla: 3.288 ± 0.534
1.644IleCys: 1.644 ± 0.266
3.288IleAsp: 3.288 ± 0.534
3.617IleGlu: 3.617 ± 1.758
2.302IlePhe: 2.302 ± 1.011
3.946IleGly: 3.946 ± 0.211
1.973IleHis: 1.973 ± 0.959
3.946IleIle: 3.946 ± 0.211
5.919IleLys: 5.919 ± 2.877
4.275IleLeu: 4.275 ± 1.013
2.302IleMet: 2.302 ± 0.411
3.288IleAsn: 3.288 ± 1.596
4.275IlePro: 4.275 ± 0.052
1.973IleGln: 1.973 ± 0.106
3.288IleArg: 3.288 ± 0.531
3.946IleSer: 3.946 ± 0.211
4.604IleThr: 4.604 ± 2.237
6.577IleVal: 6.577 ± 1.067
0.329IleTrp: 0.329 ± 0.16
2.302IleTyr: 2.302 ± 1.011
0.0IleXaa: 0.0 ± 0.0
Lys
3.617LysAla: 3.617 ± 0.371
0.658LysCys: 0.658 ± 0.32
3.288LysAsp: 3.288 ± 1.598
5.59LysGlu: 5.59 ± 0.588
3.288LysPhe: 3.288 ± 0.531
2.96LysGly: 2.96 ± 1.438
1.315LysHis: 1.315 ± 0.639
3.946LysIle: 3.946 ± 1.918
5.59LysLys: 5.59 ± 0.588
6.906LysLeu: 6.906 ± 3.356
1.644LysMet: 1.644 ± 0.799
2.302LysAsn: 2.302 ± 1.119
2.96LysPro: 2.96 ± 0.374
3.288LysGln: 3.288 ± 0.531
3.946LysArg: 3.946 ± 1.918
5.59LysSer: 5.59 ± 2.717
5.919LysThr: 5.919 ± 0.747
4.604LysVal: 4.604 ± 1.173
0.329LysTrp: 0.329 ± 0.16
2.96LysTyr: 2.96 ± 0.374
0.0LysXaa: 0.0 ± 0.0
Leu
4.604LeuAla: 4.604 ± 1.173
2.302LeuCys: 2.302 ± 1.119
2.631LeuAsp: 2.631 ± 2.98
7.563LeuGlu: 7.563 ± 2.611
2.96LeuPhe: 2.96 ± 1.438
3.946LeuGly: 3.946 ± 0.211
1.644LeuHis: 1.644 ± 0.799
4.604LeuIle: 4.604 ± 2.237
5.59LeuLys: 5.59 ± 2.717
6.906LeuLeu: 6.906 ± 1.227
1.973LeuMet: 1.973 ± 0.106
5.919LeuAsn: 5.919 ± 1.812
3.288LeuPro: 3.288 ± 2.66
2.631LeuGln: 2.631 ± 1.915
4.275LeuArg: 4.275 ± 2.181
5.261LeuSer: 5.261 ± 0.637
7.563LeuThr: 7.563 ± 0.583
4.933LeuVal: 4.933 ± 0.268
0.329LeuTrp: 0.329 ± 0.16
2.96LeuTyr: 2.96 ± 2.82
0.0LeuXaa: 0.0 ± 0.0
Met
1.644MetAla: 1.644 ± 0.799
0.658MetCys: 0.658 ± 0.32
0.987MetAsp: 0.987 ± 0.585
2.302MetGlu: 2.302 ± 0.054
1.644MetPhe: 1.644 ± 1.33
0.658MetGly: 0.658 ± 0.32
0.329MetHis: 0.329 ± 0.905
1.644MetIle: 1.644 ± 1.33
1.315MetLys: 1.315 ± 0.425
2.96MetLeu: 2.96 ± 0.691
0.329MetMet: 0.329 ± 0.16
1.644MetAsn: 1.644 ± 0.799
2.302MetPro: 2.302 ± 0.054
1.315MetGln: 1.315 ± 0.425
1.315MetArg: 1.315 ± 0.639
0.987MetSer: 0.987 ± 0.479
1.973MetThr: 1.973 ± 0.106
1.315MetVal: 1.315 ± 0.639
0.0MetTrp: 0.0 ± 0.0
0.329MetTyr: 0.329 ± 0.16
0.0MetXaa: 0.0 ± 0.0
Asn
5.261AsnAla: 5.261 ± 0.637
0.987AsnCys: 0.987 ± 0.479
0.987AsnAsp: 0.987 ± 0.479
5.261AsnGlu: 5.261 ± 0.637
3.617AsnPhe: 3.617 ± 0.371
3.288AsnGly: 3.288 ± 1.598
0.658AsnHis: 0.658 ± 0.32
3.288AsnIle: 3.288 ± 0.531
3.617AsnLys: 3.617 ± 0.693
3.288AsnLeu: 3.288 ± 1.596
1.973AsnMet: 1.973 ± 0.959
2.631AsnAsn: 2.631 ± 1.279
3.946AsnPro: 3.946 ± 0.211
1.973AsnGln: 1.973 ± 1.17
1.644AsnArg: 1.644 ± 0.799
2.96AsnSer: 2.96 ± 1.755
1.973AsnThr: 1.973 ± 0.106
3.288AsnVal: 3.288 ± 0.534
0.658AsnTrp: 0.658 ± 0.745
2.302AsnTyr: 2.302 ± 1.119
0.0AsnXaa: 0.0 ± 0.0
Pro
1.644ProAla: 1.644 ± 0.266
0.987ProCys: 0.987 ± 0.585
1.973ProAsp: 1.973 ± 0.106
2.96ProGlu: 2.96 ± 0.691
2.302ProPhe: 2.302 ± 1.119
2.302ProGly: 2.302 ± 1.119
1.315ProHis: 1.315 ± 0.639
2.96ProIle: 2.96 ± 0.374
1.973ProLys: 1.973 ± 0.106
2.631ProLeu: 2.631 ± 0.851
1.973ProMet: 1.973 ± 0.106
3.288ProAsn: 3.288 ± 0.534
1.315ProPro: 1.315 ± 0.425
1.973ProGln: 1.973 ± 0.106
0.987ProArg: 0.987 ± 2.714
3.946ProSer: 3.946 ± 1.918
3.946ProThr: 3.946 ± 5.534
2.302ProVal: 2.302 ± 2.075
0.329ProTrp: 0.329 ± 0.16
1.973ProTyr: 1.973 ± 0.959
0.0ProXaa: 0.0 ± 0.0
Gln
2.96GlnAla: 2.96 ± 0.691
0.658GlnCys: 0.658 ± 0.32
1.644GlnAsp: 1.644 ± 0.266
1.973GlnGlu: 1.973 ± 0.106
0.329GlnPhe: 0.329 ± 0.16
2.302GlnGly: 2.302 ± 2.075
0.658GlnHis: 0.658 ± 0.32
2.96GlnIle: 2.96 ± 0.374
0.987GlnLys: 0.987 ± 1.65
3.617GlnLeu: 3.617 ± 0.371
0.987GlnMet: 0.987 ± 2.714
1.644GlnAsn: 1.644 ± 1.33
1.644GlnPro: 1.644 ± 0.799
2.302GlnGln: 2.302 ± 4.204
2.302GlnArg: 2.302 ± 1.011
2.96GlnSer: 2.96 ± 2.82
1.973GlnThr: 1.973 ± 2.235
2.631GlnVal: 2.631 ± 1.279
0.0GlnTrp: 0.0 ± 0.0
2.302GlnTyr: 2.302 ± 3.14
0.0GlnXaa: 0.0 ± 0.0
Arg
1.644ArgAla: 1.644 ± 0.266
0.329ArgCys: 0.329 ± 0.16
2.96ArgAsp: 2.96 ± 0.374
3.288ArgGlu: 3.288 ± 1.596
2.302ArgPhe: 2.302 ± 1.011
2.631ArgGly: 2.631 ± 2.98
0.658ArgHis: 0.658 ± 0.32
3.288ArgIle: 3.288 ± 1.596
3.617ArgLys: 3.617 ± 0.693
5.59ArgLeu: 5.59 ± 1.542
1.315ArgMet: 1.315 ± 0.425
1.973ArgAsn: 1.973 ± 1.17
1.315ArgPro: 1.315 ± 0.425
0.987ArgGln: 0.987 ± 0.585
2.302ArgArg: 2.302 ± 0.054
2.96ArgSer: 2.96 ± 0.374
3.617ArgThr: 3.617 ± 0.693
3.946ArgVal: 3.946 ± 0.211
0.0ArgTrp: 0.0 ± 0.0
2.96ArgTyr: 2.96 ± 0.374
0.0ArgXaa: 0.0 ± 0.0
Ser
4.933SerAla: 4.933 ± 1.861
1.644SerCys: 1.644 ± 0.799
3.946SerAsp: 3.946 ± 0.853
4.933SerGlu: 4.933 ± 0.268
3.617SerPhe: 3.617 ± 0.371
3.946SerGly: 3.946 ± 2.341
1.973SerHis: 1.973 ± 0.959
5.261SerIle: 5.261 ± 2.557
5.261SerLys: 5.261 ± 2.557
5.59SerLeu: 5.59 ± 1.652
1.315SerMet: 1.315 ± 0.425
4.933SerAsn: 4.933 ± 1.861
2.631SerPro: 2.631 ± 0.851
1.973SerGln: 1.973 ± 0.106
3.288SerArg: 3.288 ± 0.531
4.604SerSer: 4.604 ± 0.108
5.59SerThr: 5.59 ± 0.588
2.631SerVal: 2.631 ± 0.214
0.658SerTrp: 0.658 ± 0.32
2.302SerTyr: 2.302 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.261ThrAla: 5.261 ± 0.637
0.329ThrCys: 0.329 ± 0.16
3.946ThrAsp: 3.946 ± 1.276
4.604ThrGlu: 4.604 ± 2.237
2.96ThrPhe: 2.96 ± 0.374
3.617ThrGly: 3.617 ± 0.371
1.315ThrHis: 1.315 ± 0.639
4.933ThrIle: 4.933 ± 0.797
6.906ThrLys: 6.906 ± 0.162
5.261ThrLeu: 5.261 ± 0.428
0.658ThrMet: 0.658 ± 0.32
2.631ThrAsn: 2.631 ± 0.851
3.946ThrPro: 3.946 ± 1.276
2.302ThrGln: 2.302 ± 2.075
2.631ThrArg: 2.631 ± 0.214
4.275ThrSer: 4.275 ± 2.078
5.59ThrThr: 5.59 ± 1.652
4.933ThrVal: 4.933 ± 1.861
0.329ThrTrp: 0.329 ± 0.16
3.617ThrTyr: 3.617 ± 1.436
0.0ThrXaa: 0.0 ± 0.0
Val
2.302ValAla: 2.302 ± 1.119
0.987ValCys: 0.987 ± 0.585
3.617ValAsp: 3.617 ± 0.693
4.933ValGlu: 4.933 ± 0.797
3.946ValPhe: 3.946 ± 0.853
3.946ValGly: 3.946 ± 1.918
1.315ValHis: 1.315 ± 0.425
3.946ValIle: 3.946 ± 2.341
2.96ValLys: 2.96 ± 1.438
5.261ValLeu: 5.261 ± 1.492
2.302ValMet: 2.302 ± 0.054
2.631ValAsn: 2.631 ± 1.915
1.315ValPro: 1.315 ± 0.639
2.96ValGln: 2.96 ± 0.374
3.288ValArg: 3.288 ± 0.531
5.919ValSer: 5.919 ± 0.747
5.919ValThr: 5.919 ± 1.812
5.919ValVal: 5.919 ± 0.317
0.0ValTrp: 0.0 ± 0.0
3.288ValTyr: 3.288 ± 0.531
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.329TrpCys: 0.329 ± 0.16
0.329TrpAsp: 0.329 ± 0.16
0.0TrpGlu: 0.0 ± 0.0
0.987TrpPhe: 0.987 ± 0.479
0.329TrpGly: 0.329 ± 0.905
0.329TrpHis: 0.329 ± 0.16
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.658TrpLeu: 0.658 ± 0.32
0.329TrpMet: 0.329 ± 0.16
0.987TrpAsn: 0.987 ± 0.585
0.0TrpPro: 0.0 ± 0.0
0.658TrpGln: 0.658 ± 0.745
0.329TrpArg: 0.329 ± 0.16
0.329TrpSer: 0.329 ± 0.16
0.329TrpThr: 0.329 ± 0.16
1.315TrpVal: 1.315 ± 0.639
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.933TyrAla: 4.933 ± 2.926
0.987TyrCys: 0.987 ± 0.479
3.288TyrAsp: 3.288 ± 0.531
1.644TyrGlu: 1.644 ± 1.33
1.973TyrPhe: 1.973 ± 0.959
1.973TyrGly: 1.973 ± 0.106
0.987TyrHis: 0.987 ± 0.479
3.288TyrIle: 3.288 ± 1.598
3.617TyrLys: 3.617 ± 0.693
2.96TyrLeu: 2.96 ± 1.755
0.658TyrMet: 0.658 ± 0.745
1.973TyrAsn: 1.973 ± 0.959
1.973TyrPro: 1.973 ± 0.959
1.644TyrGln: 1.644 ± 0.266
0.987TyrArg: 0.987 ± 0.585
2.302TyrSer: 2.302 ± 1.119
2.302TyrThr: 2.302 ± 2.075
3.946TyrVal: 3.946 ± 0.211
0.658TyrTrp: 0.658 ± 0.745
1.644TyrTyr: 1.644 ± 1.33
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3042 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski