Amino acid dipepetide frequency for Hubei tombus-like virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.414AlaAla: 7.414 ± 3.161
0.927AlaCys: 0.927 ± 0.62
3.707AlaAsp: 3.707 ± 1.707
3.707AlaGlu: 3.707 ± 1.707
5.561AlaPhe: 5.561 ± 1.108
3.707AlaGly: 3.707 ± 2.095
2.78AlaHis: 2.78 ± 1.243
0.927AlaIle: 0.927 ± 0.829
7.414AlaLys: 7.414 ± 2.094
6.487AlaLeu: 6.487 ± 2.259
0.0AlaMet: 0.0 ± 0.0
3.707AlaAsn: 3.707 ± 1.944
5.561AlaPro: 5.561 ± 2.577
2.78AlaGln: 2.78 ± 1.633
3.707AlaArg: 3.707 ± 2.959
5.561AlaSer: 5.561 ± 2.577
7.414AlaThr: 7.414 ± 3.361
7.414AlaVal: 7.414 ± 3.161
2.78AlaTrp: 2.78 ± 1.633
2.78AlaTyr: 2.78 ± 1.297
0.0AlaXaa: 0.0 ± 0.0
Cys
1.854CysAla: 1.854 ± 1.24
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.854CysGlu: 1.854 ± 0.972
1.854CysPhe: 1.854 ± 2.112
3.707CysGly: 3.707 ± 1.404
0.0CysHis: 0.0 ± 0.0
0.927CysIle: 0.927 ± 1.056
0.927CysLys: 0.927 ± 0.62
0.927CysLeu: 0.927 ± 0.62
0.927CysMet: 0.927 ± 0.62
0.0CysAsn: 0.0 ± 0.0
0.927CysPro: 0.927 ± 0.829
0.927CysGln: 0.927 ± 0.62
1.854CysArg: 1.854 ± 0.588
0.927CysSer: 0.927 ± 1.056
0.927CysThr: 0.927 ± 0.829
2.78CysVal: 2.78 ± 0.879
0.927CysTrp: 0.927 ± 1.056
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.487AspAla: 6.487 ± 2.284
3.707AspCys: 3.707 ± 1.404
3.707AspAsp: 3.707 ± 0.424
2.78AspGlu: 2.78 ± 1.243
4.634AspPhe: 4.634 ± 0.907
3.707AspGly: 3.707 ± 1.404
0.0AspHis: 0.0 ± 0.0
1.854AspIle: 1.854 ± 1.658
1.854AspLys: 1.854 ± 1.24
3.707AspLeu: 3.707 ± 2.346
0.0AspMet: 0.0 ± 0.0
0.927AspAsn: 0.927 ± 1.056
2.78AspPro: 2.78 ± 0.554
1.854AspGln: 1.854 ± 0.972
2.78AspArg: 2.78 ± 1.861
0.927AspSer: 0.927 ± 0.829
0.927AspThr: 0.927 ± 0.62
2.78AspVal: 2.78 ± 1.633
0.0AspTrp: 0.0 ± 0.0
0.927AspTyr: 0.927 ± 0.829
0.0AspXaa: 0.0 ± 0.0
Glu
1.854GluAla: 1.854 ± 1.24
0.927GluCys: 0.927 ± 0.62
2.78GluAsp: 2.78 ± 1.933
1.854GluGlu: 1.854 ± 2.112
4.634GluPhe: 4.634 ± 1.984
0.927GluGly: 0.927 ± 0.62
2.78GluHis: 2.78 ± 1.933
1.854GluIle: 1.854 ± 1.097
2.78GluLys: 2.78 ± 1.861
6.487GluLeu: 6.487 ± 1.661
0.927GluMet: 0.927 ± 0.62
0.0GluAsn: 0.0 ± 0.0
0.0GluPro: 0.0 ± 0.0
1.854GluGln: 1.854 ± 1.24
10.195GluArg: 10.195 ± 4.619
0.927GluSer: 0.927 ± 0.62
0.0GluThr: 0.0 ± 0.0
0.927GluVal: 0.927 ± 0.62
0.0GluTrp: 0.0 ± 0.0
0.927GluTyr: 0.927 ± 0.62
0.0GluXaa: 0.0 ± 0.0
Phe
5.561PheAla: 5.561 ± 3.291
0.927PheCys: 0.927 ± 0.62
4.634PheAsp: 4.634 ± 0.907
2.78PheGlu: 2.78 ± 1.933
1.854PhePhe: 1.854 ± 2.112
3.707PheGly: 3.707 ± 1.021
0.0PheHis: 0.0 ± 0.0
0.927PheIle: 0.927 ± 0.62
1.854PheLys: 1.854 ± 0.588
4.634PheLeu: 4.634 ± 1.835
0.927PheMet: 0.927 ± 0.829
1.854PheAsn: 1.854 ± 1.658
2.78PhePro: 2.78 ± 1.861
0.927PheGln: 0.927 ± 0.829
2.78PheArg: 2.78 ± 0.879
3.707PheSer: 3.707 ± 0.424
3.707PheThr: 3.707 ± 1.404
8.341PheVal: 8.341 ± 1.696
0.927PheTrp: 0.927 ± 0.62
2.78PheTyr: 2.78 ± 0.554
0.0PheXaa: 0.0 ± 0.0
Gly
7.414GlyAla: 7.414 ± 0.805
0.927GlyCys: 0.927 ± 0.829
2.78GlyAsp: 2.78 ± 0.879
1.854GlyGlu: 1.854 ± 1.24
3.707GlyPhe: 3.707 ± 1.404
5.561GlyGly: 5.561 ± 1.759
0.0GlyHis: 0.0 ± 0.0
3.707GlyIle: 3.707 ± 1.404
0.927GlyLys: 0.927 ± 0.62
4.634GlyLeu: 4.634 ± 1.835
0.927GlyMet: 0.927 ± 0.62
4.634GlyAsn: 4.634 ± 0.436
3.707GlyPro: 3.707 ± 1.176
0.0GlyGln: 0.0 ± 0.0
8.341GlyArg: 8.341 ± 3.728
11.121GlySer: 11.121 ± 5.186
2.78GlyThr: 2.78 ± 1.633
8.341GlyVal: 8.341 ± 1.425
1.854GlyTrp: 1.854 ± 1.097
1.854GlyTyr: 1.854 ± 1.24
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.854HisGlu: 1.854 ± 1.24
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.927HisLys: 0.927 ± 0.829
1.854HisLeu: 1.854 ± 0.972
0.0HisMet: 0.0 ± 0.0
1.854HisAsn: 1.854 ± 0.972
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.854HisArg: 1.854 ± 0.972
2.78HisSer: 2.78 ± 1.861
0.0HisThr: 0.0 ± 0.0
1.854HisVal: 1.854 ± 0.588
0.927HisTrp: 0.927 ± 0.62
1.854HisTyr: 1.854 ± 0.972
0.0HisXaa: 0.0 ± 0.0
Ile
2.78IleAla: 2.78 ± 0.554
0.0IleCys: 0.0 ± 0.0
1.854IleAsp: 1.854 ± 0.588
1.854IleGlu: 1.854 ± 0.588
3.707IlePhe: 3.707 ± 0.424
2.78IleGly: 2.78 ± 1.297
0.0IleHis: 0.0 ± 0.0
0.927IleIle: 0.927 ± 0.62
0.0IleLys: 0.0 ± 0.0
0.927IleLeu: 0.927 ± 1.056
3.707IleMet: 3.707 ± 1.602
0.0IleAsn: 0.0 ± 0.0
2.78IlePro: 2.78 ± 1.297
0.927IleGln: 0.927 ± 0.829
2.78IleArg: 2.78 ± 1.243
3.707IleSer: 3.707 ± 2.481
1.854IleThr: 1.854 ± 0.972
1.854IleVal: 1.854 ± 1.097
0.0IleTrp: 0.0 ± 0.0
0.927IleTyr: 0.927 ± 1.056
0.0IleXaa: 0.0 ± 0.0
Lys
2.78LysAla: 2.78 ± 1.243
0.0LysCys: 0.0 ± 0.0
2.78LysAsp: 2.78 ± 1.861
2.78LysGlu: 2.78 ± 0.879
1.854LysPhe: 1.854 ± 0.588
6.487LysGly: 6.487 ± 2.101
0.927LysHis: 0.927 ± 0.62
0.0LysIle: 0.0 ± 0.0
3.707LysLys: 3.707 ± 1.176
2.78LysLeu: 2.78 ± 1.297
1.854LysMet: 1.854 ± 1.658
0.927LysAsn: 0.927 ± 0.829
2.78LysPro: 2.78 ± 1.861
0.927LysGln: 0.927 ± 0.62
3.707LysArg: 3.707 ± 2.481
2.78LysSer: 2.78 ± 1.297
0.0LysThr: 0.0 ± 0.0
1.854LysVal: 1.854 ± 1.097
0.927LysTrp: 0.927 ± 0.62
1.854LysTyr: 1.854 ± 0.972
0.0LysXaa: 0.0 ± 0.0
Leu
8.341LeuAla: 8.341 ± 2.604
2.78LeuCys: 2.78 ± 1.987
6.487LeuAsp: 6.487 ± 1.661
5.561LeuGlu: 5.561 ± 3.721
1.854LeuPhe: 1.854 ± 1.097
4.634LeuGly: 4.634 ± 1.835
0.927LeuHis: 0.927 ± 0.62
4.634LeuIle: 4.634 ± 2.247
1.854LeuLys: 1.854 ± 0.588
2.78LeuLeu: 2.78 ± 0.879
3.707LeuMet: 3.707 ± 1.627
5.561LeuAsn: 5.561 ± 3.733
4.634LeuPro: 4.634 ± 2.631
1.854LeuGln: 1.854 ± 0.588
3.707LeuArg: 3.707 ± 1.176
6.487LeuSer: 6.487 ± 0.874
6.487LeuThr: 6.487 ± 2.082
4.634LeuVal: 4.634 ± 1.623
0.0LeuTrp: 0.0 ± 0.0
2.78LeuTyr: 2.78 ± 0.554
0.0LeuXaa: 0.0 ± 0.0
Met
5.561MetAla: 5.561 ± 1.255
0.927MetCys: 0.927 ± 0.62
0.0MetAsp: 0.0 ± 0.0
1.854MetGlu: 1.854 ± 0.972
0.927MetPhe: 0.927 ± 0.62
0.927MetGly: 0.927 ± 1.056
0.0MetHis: 0.0 ± 0.0
0.927MetIle: 0.927 ± 1.056
0.0MetLys: 0.0 ± 0.0
0.927MetLeu: 0.927 ± 0.829
0.0MetMet: 0.0 ± 0.0
0.927MetAsn: 0.927 ± 0.829
1.854MetPro: 1.854 ± 1.658
1.854MetGln: 1.854 ± 1.24
1.854MetArg: 1.854 ± 0.588
3.707MetSer: 3.707 ± 1.176
0.927MetThr: 0.927 ± 0.62
4.634MetVal: 4.634 ± 3.101
0.0MetTrp: 0.0 ± 0.0
0.927MetTyr: 0.927 ± 0.62
0.0MetXaa: 0.0 ± 0.0
Asn
5.561AsnAla: 5.561 ± 2.036
0.0AsnCys: 0.0 ± 0.0
0.927AsnAsp: 0.927 ± 0.62
0.0AsnGlu: 0.0 ± 0.0
0.0AsnPhe: 0.0 ± 0.0
2.78AsnGly: 2.78 ± 0.554
0.0AsnHis: 0.0 ± 0.0
0.927AsnIle: 0.927 ± 0.62
2.78AsnLys: 2.78 ± 2.487
1.854AsnLeu: 1.854 ± 0.588
0.0AsnMet: 0.0 ± 0.0
1.854AsnAsn: 1.854 ± 1.658
0.927AsnPro: 0.927 ± 0.62
0.0AsnGln: 0.0 ± 0.0
2.78AsnArg: 2.78 ± 1.297
3.707AsnSer: 3.707 ± 1.176
5.561AsnThr: 5.561 ± 1.255
2.78AsnVal: 2.78 ± 1.987
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
0.927ProAla: 0.927 ± 0.829
0.927ProCys: 0.927 ± 0.62
0.927ProAsp: 0.927 ± 0.62
0.0ProGlu: 0.0 ± 0.0
3.707ProPhe: 3.707 ± 2.346
2.78ProGly: 2.78 ± 1.297
0.927ProHis: 0.927 ± 0.62
2.78ProIle: 2.78 ± 0.879
2.78ProLys: 2.78 ± 1.297
3.707ProLeu: 3.707 ± 1.021
0.0ProMet: 0.0 ± 0.0
0.927ProAsn: 0.927 ± 0.62
2.78ProPro: 2.78 ± 0.879
1.854ProGln: 1.854 ± 1.24
4.634ProArg: 4.634 ± 1.776
4.634ProSer: 4.634 ± 0.907
0.927ProThr: 0.927 ± 1.056
7.414ProVal: 7.414 ± 2.215
0.0ProTrp: 0.0 ± 0.0
1.854ProTyr: 1.854 ± 1.097
0.0ProXaa: 0.0 ± 0.0
Gln
0.927GlnAla: 0.927 ± 0.62
0.927GlnCys: 0.927 ± 1.056
0.927GlnAsp: 0.927 ± 0.62
2.78GlnGlu: 2.78 ± 1.243
0.0GlnPhe: 0.0 ± 0.0
1.854GlnGly: 1.854 ± 0.588
1.854GlnHis: 1.854 ± 0.588
0.927GlnIle: 0.927 ± 1.056
0.0GlnLys: 0.0 ± 0.0
3.707GlnLeu: 3.707 ± 1.581
0.0GlnMet: 0.0 ± 0.0
0.927GlnAsn: 0.927 ± 0.829
0.0GlnPro: 0.0 ± 0.0
0.927GlnGln: 0.927 ± 1.056
0.927GlnArg: 0.927 ± 0.829
3.707GlnSer: 3.707 ± 0.424
0.927GlnThr: 0.927 ± 0.62
3.707GlnVal: 3.707 ± 0.424
0.927GlnTrp: 0.927 ± 0.829
1.854GlnTyr: 1.854 ± 0.588
0.0GlnXaa: 0.0 ± 0.0
Arg
7.414ArgAla: 7.414 ± 3.122
1.854ArgCys: 1.854 ± 1.24
2.78ArgAsp: 2.78 ± 0.554
3.707ArgGlu: 3.707 ± 1.404
4.634ArgPhe: 4.634 ± 2.247
3.707ArgGly: 3.707 ± 1.021
1.854ArgHis: 1.854 ± 0.972
1.854ArgIle: 1.854 ± 1.24
5.561ArgLys: 5.561 ± 2.821
6.487ArgLeu: 6.487 ± 2.101
0.927ArgMet: 0.927 ± 1.056
1.854ArgAsn: 1.854 ± 0.588
1.854ArgPro: 1.854 ± 0.972
0.0ArgGln: 0.0 ± 0.0
4.634ArgArg: 4.634 ± 2.872
9.268ArgSer: 9.268 ± 5.342
5.561ArgThr: 5.561 ± 1.38
5.561ArgVal: 5.561 ± 0.325
1.854ArgTrp: 1.854 ± 1.24
3.707ArgTyr: 3.707 ± 1.707
0.0ArgXaa: 0.0 ± 0.0
Ser
7.414SerAla: 7.414 ± 4.27
1.854SerCys: 1.854 ± 1.658
4.634SerAsp: 4.634 ± 1.776
2.78SerGlu: 2.78 ± 1.243
6.487SerPhe: 6.487 ± 1.419
4.634SerGly: 4.634 ± 2.247
1.854SerHis: 1.854 ± 0.588
1.854SerIle: 1.854 ± 1.097
0.0SerLys: 0.0 ± 0.0
9.268SerLeu: 9.268 ± 2.732
5.561SerMet: 5.561 ± 0.763
0.927SerAsn: 0.927 ± 0.829
1.854SerPro: 1.854 ± 0.588
1.854SerGln: 1.854 ± 0.972
7.414SerArg: 7.414 ± 0.848
6.487SerSer: 6.487 ± 2.082
8.341SerThr: 8.341 ± 2.491
10.195SerVal: 10.195 ± 2.961
2.78SerTrp: 2.78 ± 1.297
4.634SerTyr: 4.634 ± 1.361
0.0SerXaa: 0.0 ± 0.0
Thr
3.707ThrAla: 3.707 ± 2.346
1.854ThrCys: 1.854 ± 1.24
1.854ThrAsp: 1.854 ± 2.112
0.927ThrGlu: 0.927 ± 1.056
1.854ThrPhe: 1.854 ± 1.658
4.634ThrGly: 4.634 ± 1.835
0.0ThrHis: 0.0 ± 0.0
6.487ThrIle: 6.487 ± 0.767
1.854ThrLys: 1.854 ± 0.972
5.561ThrLeu: 5.561 ± 0.325
4.634ThrMet: 4.634 ± 0.436
1.854ThrAsn: 1.854 ± 0.588
1.854ThrPro: 1.854 ± 1.24
1.854ThrGln: 1.854 ± 1.097
3.707ThrArg: 3.707 ± 1.581
6.487ThrSer: 6.487 ± 4.557
0.927ThrThr: 0.927 ± 1.056
4.634ThrVal: 4.634 ± 2.911
1.854ThrTrp: 1.854 ± 1.097
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
2.78ValAla: 2.78 ± 1.861
2.78ValCys: 2.78 ± 1.933
2.78ValAsp: 2.78 ± 2.487
3.707ValGlu: 3.707 ± 1.707
4.634ValPhe: 4.634 ± 1.835
12.048ValGly: 12.048 ± 2.462
1.854ValHis: 1.854 ± 1.24
0.0ValIle: 0.0 ± 0.0
3.707ValLys: 3.707 ± 1.404
7.414ValLeu: 7.414 ± 3.108
2.78ValMet: 2.78 ± 1.861
2.78ValAsn: 2.78 ± 0.879
6.487ValPro: 6.487 ± 2.396
4.634ValGln: 4.634 ± 2.655
6.487ValArg: 6.487 ± 2.92
9.268ValSer: 9.268 ± 2.696
6.487ValThr: 6.487 ± 3.956
6.487ValVal: 6.487 ± 0.767
3.707ValTrp: 3.707 ± 0.424
1.854ValTyr: 1.854 ± 0.588
0.0ValXaa: 0.0 ± 0.0
Trp
0.927TrpAla: 0.927 ± 0.829
0.927TrpCys: 0.927 ± 1.056
0.927TrpAsp: 0.927 ± 0.829
0.0TrpGlu: 0.0 ± 0.0
0.927TrpPhe: 0.927 ± 1.056
2.78TrpGly: 2.78 ± 1.861
0.0TrpHis: 0.0 ± 0.0
0.927TrpIle: 0.927 ± 0.829
1.854TrpLys: 1.854 ± 0.588
1.854TrpLeu: 1.854 ± 0.972
0.927TrpMet: 0.927 ± 0.62
0.927TrpAsn: 0.927 ± 1.056
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.927TrpSer: 0.927 ± 0.829
0.927TrpThr: 0.927 ± 0.62
2.78TrpVal: 2.78 ± 0.554
0.927TrpTrp: 0.927 ± 1.056
1.854TrpTyr: 1.854 ± 1.658
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.634TyrAla: 4.634 ± 2.872
0.0TyrCys: 0.0 ± 0.0
1.854TyrAsp: 1.854 ± 1.658
0.0TyrGlu: 0.0 ± 0.0
2.78TyrPhe: 2.78 ± 0.879
3.707TyrGly: 3.707 ± 1.404
0.0TyrHis: 0.0 ± 0.0
0.927TyrIle: 0.927 ± 0.62
0.927TyrLys: 0.927 ± 0.62
4.634TyrLeu: 4.634 ± 0.436
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
0.927TyrPro: 0.927 ± 0.829
2.78TyrGln: 2.78 ± 1.243
0.927TyrArg: 0.927 ± 0.829
3.707TyrSer: 3.707 ± 2.095
1.854TyrThr: 1.854 ± 1.097
3.707TyrVal: 3.707 ± 1.707
0.0TyrTrp: 0.0 ± 0.0
0.927TyrTyr: 0.927 ± 0.62
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1080 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski