Amino acid dipepetide frequency for Schlegelella thermodepolymerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.951AlaAla: 18.951 ± 0.208	1.48AlaCys: 1.48 ± 0.038	6.099AlaAsp: 6.099 ± 0.075	7.272AlaGlu: 7.272 ± 0.083	3.846AlaPhe: 3.846 ± 0.062	11.084AlaGly: 11.084 ± 0.114	2.743AlaHis: 2.743 ± 0.046	4.713AlaIle: 4.713 ± 0.072	3.026AlaLys: 3.026 ± 0.078	15.369AlaLeu: 15.369 ± 0.143	3.296AlaMet: 3.296 ± 0.058	2.228AlaAsn: 2.228 ± 0.049	7.014AlaPro: 7.014 ± 0.115	5.905AlaGln: 5.905 ± 0.08	10.697AlaArg: 10.697 ± 0.12	5.85AlaSer: 5.85 ± 0.088	5.782AlaThr: 5.782 ± 0.074	9.667AlaVal: 9.667 ± 0.098	2.194AlaTrp: 2.194 ± 0.057	2.541AlaTyr: 2.541 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.211CysAla: 1.211 ± 0.034	0.141CysCys: 0.141 ± 0.011	0.517CysAsp: 0.517 ± 0.022	0.585CysGlu: 0.585 ± 0.026	0.313CysPhe: 0.313 ± 0.016	1.055CysGly: 1.055 ± 0.033	0.253CysHis: 0.253 ± 0.017	0.418CysIle: 0.418 ± 0.022	0.196CysLys: 0.196 ± 0.015	0.864CysLeu: 0.864 ± 0.028	0.201CysMet: 0.201 ± 0.014	0.211CysAsn: 0.211 ± 0.014	0.517CysPro: 0.517 ± 0.024	0.256CysGln: 0.256 ± 0.015	0.753CysArg: 0.753 ± 0.026	0.478CysSer: 0.478 ± 0.021	0.527CysThr: 0.527 ± 0.023	0.72CysVal: 0.72 ± 0.024	0.145CysTrp: 0.145 ± 0.01	0.233CysTyr: 0.233 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.135AspAla: 7.135 ± 0.092	0.405AspCys: 0.405 ± 0.02	2.734AspAsp: 2.734 ± 0.059	3.742AspGlu: 3.742 ± 0.067	1.898AspPhe: 1.898 ± 0.041	4.647AspGly: 4.647 ± 0.071	1.172AspHis: 1.172 ± 0.035	2.034AspIle: 2.034 ± 0.045	1.301AspLys: 1.301 ± 0.037	5.271AspLeu: 5.271 ± 0.069	0.994AspMet: 0.994 ± 0.033	0.992AspAsn: 0.992 ± 0.032	3.354AspPro: 3.354 ± 0.063	1.42AspGln: 1.42 ± 0.034	3.777AspArg: 3.777 ± 0.063	1.718AspSer: 1.718 ± 0.038	2.344AspThr: 2.344 ± 0.041	4.037AspVal: 4.037 ± 0.062	0.921AspTrp: 0.921 ± 0.027	1.333AspTyr: 1.333 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.162GluAla: 8.162 ± 0.107	0.417GluCys: 0.417 ± 0.019	2.581GluAsp: 2.581 ± 0.043	3.011GluGlu: 3.011 ± 0.058	1.858GluPhe: 1.858 ± 0.041	4.001GluGly: 4.001 ± 0.065	1.552GluHis: 1.552 ± 0.045	2.712GluIle: 2.712 ± 0.052	1.69GluLys: 1.69 ± 0.049	6.676GluLeu: 6.676 ± 0.075	1.285GluMet: 1.285 ± 0.036	1.082GluAsn: 1.082 ± 0.035	3.031GluPro: 3.031 ± 0.055	2.968GluGln: 2.968 ± 0.053	5.812GluArg: 5.812 ± 0.079	2.162GluSer: 2.162 ± 0.043	2.544GluThr: 2.544 ± 0.048	4.81GluVal: 4.81 ± 0.067	0.746GluTrp: 0.746 ± 0.024	1.187GluTyr: 1.187 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.916PheAla: 3.916 ± 0.066	0.369PheCys: 0.369 ± 0.019	2.28PheAsp: 2.28 ± 0.043	2.236PheGlu: 2.236 ± 0.049	1.295PhePhe: 1.295 ± 0.036	3.239PheGly: 3.239 ± 0.059	0.781PheHis: 0.781 ± 0.026	1.36PheIle: 1.36 ± 0.037	0.956PheLys: 0.956 ± 0.032	2.933PheLeu: 2.933 ± 0.06	0.708PheMet: 0.708 ± 0.025	0.892PheAsn: 0.892 ± 0.032	1.466PhePro: 1.466 ± 0.035	0.995PheGln: 0.995 ± 0.029	2.253PheArg: 2.253 ± 0.041	1.733PheSer: 1.733 ± 0.034	1.744PheThr: 1.744 ± 0.034	2.754PheVal: 2.754 ± 0.052	0.508PheTrp: 0.508 ± 0.02	0.8PheTyr: 0.8 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.186GlyAla: 9.186 ± 0.107	0.975GlyCys: 0.975 ± 0.032	3.812GlyAsp: 3.812 ± 0.057	4.725GlyGlu: 4.725 ± 0.064	3.012GlyPhe: 3.012 ± 0.05	6.909GlyGly: 6.909 ± 0.107	2.082GlyHis: 2.082 ± 0.039	3.858GlyIle: 3.858 ± 0.071	2.671GlyLys: 2.671 ± 0.056	9.153GlyLeu: 9.153 ± 0.108	2.195GlyMet: 2.195 ± 0.049	1.825GlyAsn: 1.825 ± 0.046	3.586GlyPro: 3.586 ± 0.056	3.211GlyGln: 3.211 ± 0.054	6.696GlyArg: 6.696 ± 0.088	4.16GlySer: 4.16 ± 0.063	4.503GlyThr: 4.503 ± 0.061	6.607GlyVal: 6.607 ± 0.078	1.617GlyTrp: 1.617 ± 0.039	2.302GlyTyr: 2.302 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	3.116HisAla: 3.116 ± 0.053	0.288HisCys: 0.288 ± 0.018	1.273HisAsp: 1.273 ± 0.037	1.408HisGlu: 1.408 ± 0.033	0.878HisPhe: 0.878 ± 0.03	2.384HisGly: 2.384 ± 0.049	0.709HisHis: 0.709 ± 0.034	0.828HisIle: 0.828 ± 0.027	0.515HisLys: 0.515 ± 0.02	2.496HisLeu: 2.496 ± 0.057	0.439HisMet: 0.439 ± 0.02	0.454HisAsn: 0.454 ± 0.02	1.74HisPro: 1.74 ± 0.038	0.758HisGln: 0.758 ± 0.024	1.838HisArg: 1.838 ± 0.042	0.854HisSer: 0.854 ± 0.028	1.033HisThr: 1.033 ± 0.031	1.851HisVal: 1.851 ± 0.037	0.431HisTrp: 0.431 ± 0.02	0.662HisTyr: 0.662 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.608IleAla: 5.608 ± 0.087	0.362IleCys: 0.362 ± 0.018	2.773IleAsp: 2.773 ± 0.047	3.229IleGlu: 3.229 ± 0.058	1.143IlePhe: 1.143 ± 0.032	3.903IleGly: 3.903 ± 0.074	0.827IleHis: 0.827 ± 0.028	1.348IleIle: 1.348 ± 0.045	1.199IleLys: 1.199 ± 0.042	3.069IleLeu: 3.069 ± 0.059	0.662IleMet: 0.662 ± 0.026	1.13IleAsn: 1.13 ± 0.035	1.91IlePro: 1.91 ± 0.04	1.101IleGln: 1.101 ± 0.029	2.683IleArg: 2.683 ± 0.053	1.87IleSer: 1.87 ± 0.048	2.171IleThr: 2.171 ± 0.039	3.436IleVal: 3.436 ± 0.066	0.389IleTrp: 0.389 ± 0.019	0.897IleTyr: 0.897 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.404LysAla: 3.404 ± 0.064	0.152LysCys: 0.152 ± 0.011	1.38LysAsp: 1.38 ± 0.04	1.497LysGlu: 1.497 ± 0.042	0.748LysPhe: 0.748 ± 0.029	2.061LysGly: 2.061 ± 0.049	0.607LysHis: 0.607 ± 0.026	1.117LysIle: 1.117 ± 0.04	1.092LysLys: 1.092 ± 0.051	2.991LysLeu: 2.991 ± 0.055	0.615LysMet: 0.615 ± 0.026	0.658LysAsn: 0.658 ± 0.026	1.735LysPro: 1.735 ± 0.047	1.059LysGln: 1.059 ± 0.028	2.09LysArg: 2.09 ± 0.049	1.305LysSer: 1.305 ± 0.041	1.383LysThr: 1.383 ± 0.04	2.365LysVal: 2.365 ± 0.058	0.301LysTrp: 0.301 ± 0.017	0.625LysTyr: 0.625 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	15.481LeuAla: 15.481 ± 0.145	1.043LeuCys: 1.043 ± 0.028	6.038LeuAsp: 6.038 ± 0.086	5.995LeuGlu: 5.995 ± 0.082	3.311LeuPhe: 3.311 ± 0.059	8.916LeuGly: 8.916 ± 0.097	2.627LeuHis: 2.627 ± 0.062	3.767LeuIle: 3.767 ± 0.068	3.426LeuLys: 3.426 ± 0.057	11.761LeuLeu: 11.761 ± 0.163	2.482LeuMet: 2.482 ± 0.05	2.35LeuAsn: 2.35 ± 0.049	6.704LeuPro: 6.704 ± 0.082	4.596LeuGln: 4.596 ± 0.062	8.871LeuArg: 8.871 ± 0.096	5.461LeuSer: 5.461 ± 0.072	4.972LeuThr: 4.972 ± 0.067	8.494LeuVal: 8.494 ± 0.095	1.454LeuTrp: 1.454 ± 0.04	2.251LeuTyr: 2.251 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.676MetAla: 2.676 ± 0.052	0.174MetCys: 0.174 ± 0.012	1.079MetAsp: 1.079 ± 0.033	1.067MetGlu: 1.067 ± 0.031	0.683MetPhe: 0.683 ± 0.026	1.641MetGly: 1.641 ± 0.044	0.534MetHis: 0.534 ± 0.022	0.875MetIle: 0.875 ± 0.027	0.894MetLys: 0.894 ± 0.029	2.607MetLeu: 2.607 ± 0.05	0.532MetMet: 0.532 ± 0.022	0.716MetAsn: 0.716 ± 0.026	1.34MetPro: 1.34 ± 0.031	1.041MetGln: 1.041 ± 0.035	1.851MetArg: 1.851 ± 0.045	1.535MetSer: 1.535 ± 0.036	1.335MetThr: 1.335 ± 0.037	1.636MetVal: 1.636 ± 0.041	0.204MetTrp: 0.204 ± 0.014	0.385MetTyr: 0.385 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.645AsnAla: 2.645 ± 0.043	0.237AsnCys: 0.237 ± 0.016	1.071AsnAsp: 1.071 ± 0.028	1.144AsnGlu: 1.144 ± 0.036	0.822AsnPhe: 0.822 ± 0.024	1.821AsnGly: 1.821 ± 0.049	0.437AsnHis: 0.437 ± 0.018	0.91AsnIle: 0.91 ± 0.029	0.609AsnLys: 0.609 ± 0.026	2.258AsnLeu: 2.258 ± 0.04	0.457AsnMet: 0.457 ± 0.021	0.564AsnAsn: 0.564 ± 0.025	1.635AsnPro: 1.635 ± 0.041	0.67AsnGln: 0.67 ± 0.023	1.538AsnArg: 1.538 ± 0.037	0.788AsnSer: 0.788 ± 0.024	1.098AsnThr: 1.098 ± 0.034	1.798AsnVal: 1.798 ± 0.043	0.329AsnTrp: 0.329 ± 0.019	0.591AsnTyr: 0.591 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	8.175ProAla: 8.175 ± 0.125	0.45ProCys: 0.45 ± 0.021	3.518ProAsp: 3.518 ± 0.059	3.872ProGlu: 3.872 ± 0.06	1.748ProPhe: 1.748 ± 0.039	5.282ProGly: 5.282 ± 0.074	1.301ProHis: 1.301 ± 0.032	1.7ProIle: 1.7 ± 0.038	1.319ProLys: 1.319 ± 0.043	5.598ProLeu: 5.598 ± 0.081	1.208ProMet: 1.208 ± 0.032	1.102ProAsn: 1.102 ± 0.033	3.444ProPro: 3.444 ± 0.082	2.584ProGln: 2.584 ± 0.043	3.744ProArg: 3.744 ± 0.065	2.513ProSer: 2.513 ± 0.049	2.391ProThr: 2.391 ± 0.04	5.06ProVal: 5.06 ± 0.077	0.9ProTrp: 0.9 ± 0.03	1.264ProTyr: 1.264 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	6.117GlnAla: 6.117 ± 0.094	0.284GlnCys: 0.284 ± 0.016	1.691GlnAsp: 1.691 ± 0.041	1.846GlnGlu: 1.846 ± 0.041	1.143GlnPhe: 1.143 ± 0.032	3.242GlnGly: 3.242 ± 0.06	0.983GlnHis: 0.983 ± 0.032	1.486GlnIle: 1.486 ± 0.037	0.897GlnLys: 0.897 ± 0.032	4.382GlnLeu: 4.382 ± 0.065	0.903GlnMet: 0.903 ± 0.023	0.599GlnAsn: 0.599 ± 0.023	2.573GlnPro: 2.573 ± 0.051	2.038GlnGln: 2.038 ± 0.047	3.87GlnArg: 3.87 ± 0.071	1.526GlnSer: 1.526 ± 0.042	1.518GlnThr: 1.518 ± 0.038	3.464GlnVal: 3.464 ± 0.062	0.674GlnTrp: 0.674 ± 0.028	0.724GlnTyr: 0.724 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.014ArgAla: 9.014 ± 0.102	0.764ArgCys: 0.764 ± 0.026	3.924ArgAsp: 3.924 ± 0.07	5.312ArgGlu: 5.312 ± 0.074	3.009ArgPhe: 3.009 ± 0.056	5.234ArgGly: 5.234 ± 0.065	2.419ArgHis: 2.419 ± 0.05	3.686ArgIle: 3.686 ± 0.056	2.076ArgLys: 2.076 ± 0.044	9.557ArgLeu: 9.557 ± 0.116	2.038ArgMet: 2.038 ± 0.039	1.723ArgAsn: 1.723 ± 0.038	4.323ArgPro: 4.323 ± 0.067	3.315ArgGln: 3.315 ± 0.053	7.052ArgArg: 7.052 ± 0.104	3.545ArgSer: 3.545 ± 0.061	3.753ArgThr: 3.753 ± 0.062	5.816ArgVal: 5.816 ± 0.069	1.435ArgTrp: 1.435 ± 0.037	2.187ArgTyr: 2.187 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.367SerAla: 5.367 ± 0.084	0.417SerCys: 0.417 ± 0.022	2.167SerAsp: 2.167 ± 0.048	2.258SerGlu: 2.258 ± 0.043	1.8SerPhe: 1.8 ± 0.044	4.437SerGly: 4.437 ± 0.068	1.03SerHis: 1.03 ± 0.029	1.983SerIle: 1.983 ± 0.043	1.117SerLys: 1.117 ± 0.032	5.014SerLeu: 5.014 ± 0.072	1.13SerMet: 1.13 ± 0.031	1.074SerAsn: 1.074 ± 0.032	2.685SerPro: 2.685 ± 0.048	1.536SerGln: 1.536 ± 0.036	3.527SerArg: 3.527 ± 0.061	2.4SerSer: 2.4 ± 0.049	2.392SerThr: 2.392 ± 0.046	3.539SerVal: 3.539 ± 0.063	0.695SerTrp: 0.695 ± 0.026	1.169SerTyr: 1.169 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.355ThrAla: 5.355 ± 0.084	0.452ThrCys: 0.452 ± 0.021	2.27ThrAsp: 2.27 ± 0.043	2.361ThrGlu: 2.361 ± 0.048	1.574ThrPhe: 1.574 ± 0.036	4.467ThrGly: 4.467 ± 0.075	1.098ThrHis: 1.098 ± 0.031	1.932ThrIle: 1.932 ± 0.038	0.972ThrLys: 0.972 ± 0.028	6.209ThrLeu: 6.209 ± 0.082	0.961ThrMet: 0.961 ± 0.032	0.978ThrAsn: 0.978 ± 0.029	3.547ThrPro: 3.547 ± 0.06	1.698ThrGln: 1.698 ± 0.039	3.488ThrArg: 3.488 ± 0.053	2.229ThrSer: 2.229 ± 0.057	2.52ThrThr: 2.52 ± 0.055	4.197ThrVal: 4.197 ± 0.061	0.697ThrTrp: 0.697 ± 0.024	1.128ThrTyr: 1.128 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	10.003ValAla: 10.003 ± 0.124	0.725ValCys: 0.725 ± 0.029	4.135ValAsp: 4.135 ± 0.064	4.773ValGlu: 4.773 ± 0.064	2.646ValPhe: 2.646 ± 0.05	5.718ValGly: 5.718 ± 0.081	1.875ValHis: 1.875 ± 0.039	3.486ValIle: 3.486 ± 0.057	2.217ValLys: 2.217 ± 0.047	9.155ValLeu: 9.155 ± 0.111	1.865ValMet: 1.865 ± 0.042	1.893ValAsn: 1.893 ± 0.041	4.62ValPro: 4.62 ± 0.067	3.207ValGln: 3.207 ± 0.054	6.245ValArg: 6.245 ± 0.089	3.858ValSer: 3.858 ± 0.062	4.136ValThr: 4.136 ± 0.06	6.947ValVal: 6.947 ± 0.093	1.037ValTrp: 1.037 ± 0.028	1.676ValTyr: 1.676 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.45TrpAla: 1.45 ± 0.043	0.205TrpCys: 0.205 ± 0.013	0.634TrpAsp: 0.634 ± 0.024	0.626TrpGlu: 0.626 ± 0.023	0.59TrpPhe: 0.59 ± 0.025	0.988TrpGly: 0.988 ± 0.036	0.419TrpHis: 0.419 ± 0.02	0.707TrpIle: 0.707 ± 0.03	0.425TrpLys: 0.425 ± 0.019	2.181TrpLeu: 2.181 ± 0.044	0.424TrpMet: 0.424 ± 0.02	0.412TrpAsn: 0.412 ± 0.02	0.813TrpPro: 0.813 ± 0.029	0.783TrpGln: 0.783 ± 0.031	1.441TrpArg: 1.441 ± 0.039	0.746TrpSer: 0.746 ± 0.025	0.769TrpThr: 0.769 ± 0.026	1.129TrpVal: 1.129 ± 0.031	0.348TrpTrp: 0.348 ± 0.019	0.332TrpTyr: 0.332 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.788TyrAla: 2.788 ± 0.045	0.249TyrCys: 0.249 ± 0.014	1.255TyrAsp: 1.255 ± 0.037	1.326TyrGlu: 1.326 ± 0.038	0.898TyrPhe: 0.898 ± 0.026	2.057TyrGly: 2.057 ± 0.044	0.505TyrHis: 0.505 ± 0.023	0.793TyrIle: 0.793 ± 0.024	0.587TyrLys: 0.587 ± 0.027	2.456TyrLeu: 2.456 ± 0.056	0.409TyrMet: 0.409 ± 0.022	0.541TyrAsn: 0.541 ± 0.022	1.137TyrPro: 1.137 ± 0.033	0.82TyrGln: 0.82 ± 0.027	1.958TyrArg: 1.958 ± 0.045	1.006TyrSer: 1.006 ± 0.032	1.216TyrThr: 1.216 ± 0.035	1.889TyrVal: 1.889 ± 0.039	0.398TyrTrp: 0.398 ± 0.017	0.633TyrTyr: 0.633 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3542 proteins (1154366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---