Amino acid dipepetide frequency for Streptococcus phage Javan11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.781AlaAla: 3.781 ± 1.604
0.176AlaCys: 0.176 ± 0.125
4.66AlaAsp: 4.66 ± 0.971
4.924AlaGlu: 4.924 ± 0.641
3.693AlaPhe: 3.693 ± 0.896
5.364AlaGly: 5.364 ± 1.449
0.44AlaHis: 0.44 ± 0.24
7.298AlaIle: 7.298 ± 1.049
5.803AlaLys: 5.803 ± 0.75
5.715AlaLeu: 5.715 ± 1.283
2.638AlaMet: 2.638 ± 0.848
3.781AlaAsn: 3.781 ± 0.862
2.286AlaPro: 2.286 ± 0.496
4.221AlaGln: 4.221 ± 1.061
2.374AlaArg: 2.374 ± 0.55
5.276AlaSer: 5.276 ± 1.22
5.1AlaThr: 5.1 ± 1.159
4.221AlaVal: 4.221 ± 1.13
1.143AlaTrp: 1.143 ± 0.208
2.286AlaTyr: 2.286 ± 0.454
0.0AlaXaa: 0.0 ± 0.0
Cys
0.088CysAla: 0.088 ± 0.077
0.0CysCys: 0.0 ± 0.0
0.264CysAsp: 0.264 ± 0.169
0.528CysGlu: 0.528 ± 0.193
0.0CysPhe: 0.0 ± 0.0
0.528CysGly: 0.528 ± 0.23
0.088CysHis: 0.088 ± 0.095
0.352CysIle: 0.352 ± 0.187
0.176CysLys: 0.176 ± 0.134
0.264CysLeu: 0.264 ± 0.147
0.088CysMet: 0.088 ± 0.071
0.176CysAsn: 0.176 ± 0.144
0.0CysPro: 0.0 ± 0.0
0.088CysGln: 0.088 ± 0.099
0.088CysArg: 0.088 ± 0.087
0.176CysSer: 0.176 ± 0.107
0.176CysThr: 0.176 ± 0.133
0.791CysVal: 0.791 ± 0.236
0.176CysTrp: 0.176 ± 0.139
0.352CysTyr: 0.352 ± 0.195
0.0CysXaa: 0.0 ± 0.0
Asp
2.55AspAla: 2.55 ± 0.431
0.0AspCys: 0.0 ± 0.0
4.133AspAsp: 4.133 ± 0.902
5.1AspGlu: 5.1 ± 0.766
3.605AspPhe: 3.605 ± 0.623
4.836AspGly: 4.836 ± 0.661
0.703AspHis: 0.703 ± 0.216
4.396AspIle: 4.396 ± 0.791
6.419AspLys: 6.419 ± 1.095
5.012AspLeu: 5.012 ± 0.609
1.583AspMet: 1.583 ± 0.331
3.693AspAsn: 3.693 ± 0.64
1.583AspPro: 1.583 ± 0.555
1.143AspGln: 1.143 ± 0.216
2.99AspArg: 2.99 ± 0.532
2.99AspSer: 2.99 ± 0.539
4.572AspThr: 4.572 ± 0.787
2.638AspVal: 2.638 ± 0.402
0.703AspTrp: 0.703 ± 0.218
3.781AspTyr: 3.781 ± 0.771
0.0AspXaa: 0.0 ± 0.0
Glu
3.781GluAla: 3.781 ± 0.662
0.352GluCys: 0.352 ± 0.168
3.253GluAsp: 3.253 ± 0.662
5.1GluGlu: 5.1 ± 0.927
3.341GluPhe: 3.341 ± 0.663
2.814GluGly: 2.814 ± 0.456
0.967GluHis: 0.967 ± 0.259
5.1GluIle: 5.1 ± 0.725
5.276GluLys: 5.276 ± 0.968
7.562GluLeu: 7.562 ± 0.987
2.198GluMet: 2.198 ± 0.421
4.045GluAsn: 4.045 ± 0.655
2.286GluPro: 2.286 ± 0.577
3.605GluGln: 3.605 ± 0.698
3.605GluArg: 3.605 ± 0.665
3.429GluSer: 3.429 ± 0.52
3.869GluThr: 3.869 ± 0.682
5.188GluVal: 5.188 ± 0.865
0.615GluTrp: 0.615 ± 0.222
3.341GluTyr: 3.341 ± 0.802
0.0GluXaa: 0.0 ± 0.0
Phe
2.902PheAla: 2.902 ± 0.498
0.088PheCys: 0.088 ± 0.075
4.308PheAsp: 4.308 ± 0.582
3.957PheGlu: 3.957 ± 0.776
1.143PhePhe: 1.143 ± 0.281
3.429PheGly: 3.429 ± 0.596
0.264PheHis: 0.264 ± 0.146
3.253PheIle: 3.253 ± 0.44
3.077PheLys: 3.077 ± 0.587
2.726PheLeu: 2.726 ± 0.389
0.967PheMet: 0.967 ± 0.296
2.638PheAsn: 2.638 ± 0.479
0.44PhePro: 0.44 ± 0.228
1.319PheGln: 1.319 ± 0.354
0.967PheArg: 0.967 ± 0.236
2.55PheSer: 2.55 ± 0.594
3.165PheThr: 3.165 ± 0.452
2.374PheVal: 2.374 ± 0.474
0.352PheTrp: 0.352 ± 0.18
1.934PheTyr: 1.934 ± 0.519
0.0PheXaa: 0.0 ± 0.0
Gly
4.221GlyAla: 4.221 ± 1.19
0.176GlyCys: 0.176 ± 0.099
3.781GlyAsp: 3.781 ± 0.749
4.133GlyGlu: 4.133 ± 0.432
2.638GlyPhe: 2.638 ± 0.459
4.045GlyGly: 4.045 ± 0.644
0.703GlyHis: 0.703 ± 0.242
5.276GlyIle: 5.276 ± 0.788
4.66GlyLys: 4.66 ± 0.608
5.364GlyLeu: 5.364 ± 0.911
1.846GlyMet: 1.846 ± 0.565
4.221GlyAsn: 4.221 ± 0.737
0.44GlyPro: 0.44 ± 0.191
2.726GlyGln: 2.726 ± 0.495
3.429GlyArg: 3.429 ± 0.586
4.221GlySer: 4.221 ± 0.899
3.869GlyThr: 3.869 ± 0.59
4.66GlyVal: 4.66 ± 0.755
1.231GlyTrp: 1.231 ± 0.326
3.077GlyTyr: 3.077 ± 0.729
0.0GlyXaa: 0.0 ± 0.0
His
0.352HisAla: 0.352 ± 0.171
0.0HisCys: 0.0 ± 0.0
0.703HisAsp: 0.703 ± 0.234
0.967HisGlu: 0.967 ± 0.296
0.44HisPhe: 0.44 ± 0.225
0.615HisGly: 0.615 ± 0.234
0.264HisHis: 0.264 ± 0.135
0.879HisIle: 0.879 ± 0.229
1.231HisLys: 1.231 ± 0.303
0.44HisLeu: 0.44 ± 0.174
0.264HisMet: 0.264 ± 0.171
0.528HisAsn: 0.528 ± 0.234
0.791HisPro: 0.791 ± 0.248
0.791HisGln: 0.791 ± 0.234
0.352HisArg: 0.352 ± 0.171
0.44HisSer: 0.44 ± 0.186
0.528HisThr: 0.528 ± 0.208
1.055HisVal: 1.055 ± 0.264
0.352HisTrp: 0.352 ± 0.147
0.264HisTyr: 0.264 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
5.715IleAla: 5.715 ± 1.0
0.176IleCys: 0.176 ± 0.144
5.188IleAsp: 5.188 ± 0.621
5.012IleGlu: 5.012 ± 0.88
2.198IlePhe: 2.198 ± 0.473
4.396IleGly: 4.396 ± 0.736
1.055IleHis: 1.055 ± 0.316
3.957IleIle: 3.957 ± 0.613
6.507IleLys: 6.507 ± 1.016
3.781IleLeu: 3.781 ± 0.534
1.231IleMet: 1.231 ± 0.321
5.012IleAsn: 5.012 ± 0.848
1.934IlePro: 1.934 ± 0.383
2.462IleGln: 2.462 ± 0.496
3.077IleArg: 3.077 ± 0.435
5.012IleSer: 5.012 ± 0.803
5.627IleThr: 5.627 ± 0.638
3.693IleVal: 3.693 ± 0.59
0.528IleTrp: 0.528 ± 0.226
2.55IleTyr: 2.55 ± 0.464
0.0IleXaa: 0.0 ± 0.0
Lys
6.77LysAla: 6.77 ± 0.874
0.264LysCys: 0.264 ± 0.165
4.396LysAsp: 4.396 ± 0.86
6.067LysGlu: 6.067 ± 0.681
2.286LysPhe: 2.286 ± 0.389
4.308LysGly: 4.308 ± 0.697
0.703LysHis: 0.703 ± 0.222
5.188LysIle: 5.188 ± 0.842
6.858LysLys: 6.858 ± 1.119
5.979LysLeu: 5.979 ± 0.907
2.726LysMet: 2.726 ± 0.445
4.045LysAsn: 4.045 ± 0.652
2.374LysPro: 2.374 ± 0.642
4.572LysGln: 4.572 ± 0.895
3.429LysArg: 3.429 ± 0.71
5.803LysSer: 5.803 ± 0.616
4.924LysThr: 4.924 ± 0.801
7.298LysVal: 7.298 ± 0.646
1.143LysTrp: 1.143 ± 0.386
3.253LysTyr: 3.253 ± 0.545
0.0LysXaa: 0.0 ± 0.0
Leu
6.946LeuAla: 6.946 ± 1.022
0.264LeuCys: 0.264 ± 0.163
5.627LeuAsp: 5.627 ± 0.671
5.803LeuGlu: 5.803 ± 0.827
3.957LeuPhe: 3.957 ± 0.566
5.803LeuGly: 5.803 ± 0.736
0.967LeuHis: 0.967 ± 0.314
4.133LeuIle: 4.133 ± 0.615
6.507LeuLys: 6.507 ± 0.96
3.957LeuLeu: 3.957 ± 0.573
1.583LeuMet: 1.583 ± 0.463
4.396LeuAsn: 4.396 ± 0.482
3.605LeuPro: 3.605 ± 0.516
3.693LeuGln: 3.693 ± 0.608
3.077LeuArg: 3.077 ± 0.561
5.452LeuSer: 5.452 ± 0.577
4.572LeuThr: 4.572 ± 0.576
4.748LeuVal: 4.748 ± 0.935
0.615LeuTrp: 0.615 ± 0.219
1.846LeuTyr: 1.846 ± 0.442
0.0LeuXaa: 0.0 ± 0.0
Met
2.638MetAla: 2.638 ± 0.925
0.264MetCys: 0.264 ± 0.118
1.583MetAsp: 1.583 ± 0.315
0.879MetGlu: 0.879 ± 0.292
0.967MetPhe: 0.967 ± 0.259
1.319MetGly: 1.319 ± 0.311
0.088MetHis: 0.088 ± 0.071
1.671MetIle: 1.671 ± 0.343
2.286MetLys: 2.286 ± 0.417
2.198MetLeu: 2.198 ± 0.379
0.44MetMet: 0.44 ± 0.139
1.583MetAsn: 1.583 ± 0.371
0.528MetPro: 0.528 ± 0.144
1.143MetGln: 1.143 ± 0.253
0.967MetArg: 0.967 ± 0.272
2.814MetSer: 2.814 ± 0.599
2.198MetThr: 2.198 ± 0.43
1.319MetVal: 1.319 ± 0.317
0.264MetTrp: 0.264 ± 0.149
0.44MetTyr: 0.44 ± 0.235
0.0MetXaa: 0.0 ± 0.0
Asn
4.045AsnAla: 4.045 ± 0.65
0.44AsnCys: 0.44 ± 0.166
3.429AsnAsp: 3.429 ± 0.715
2.726AsnGlu: 2.726 ± 0.558
2.11AsnPhe: 2.11 ± 0.377
5.364AsnGly: 5.364 ± 0.683
1.055AsnHis: 1.055 ± 0.265
2.462AsnIle: 2.462 ± 0.492
4.572AsnLys: 4.572 ± 0.674
4.484AsnLeu: 4.484 ± 0.665
1.055AsnMet: 1.055 ± 0.305
3.429AsnAsn: 3.429 ± 0.607
2.198AsnPro: 2.198 ± 0.443
2.638AsnGln: 2.638 ± 0.582
2.022AsnArg: 2.022 ± 0.443
4.045AsnSer: 4.045 ± 0.501
4.045AsnThr: 4.045 ± 0.578
3.341AsnVal: 3.341 ± 0.446
0.352AsnTrp: 0.352 ± 0.191
1.583AsnTyr: 1.583 ± 0.421
0.0AsnXaa: 0.0 ± 0.0
Pro
1.846ProAla: 1.846 ± 0.425
0.088ProCys: 0.088 ± 0.087
0.967ProAsp: 0.967 ± 0.281
1.846ProGlu: 1.846 ± 0.489
1.934ProPhe: 1.934 ± 0.358
1.319ProGly: 1.319 ± 0.371
0.088ProHis: 0.088 ± 0.091
2.022ProIle: 2.022 ± 0.424
2.902ProLys: 2.902 ± 0.481
2.902ProLeu: 2.902 ± 0.446
0.703ProMet: 0.703 ± 0.229
1.583ProAsn: 1.583 ± 0.437
0.615ProPro: 0.615 ± 0.186
1.231ProGln: 1.231 ± 0.424
1.143ProArg: 1.143 ± 0.372
1.759ProSer: 1.759 ± 0.403
1.143ProThr: 1.143 ± 0.355
2.11ProVal: 2.11 ± 0.435
0.176ProTrp: 0.176 ± 0.119
1.495ProTyr: 1.495 ± 0.433
0.0ProXaa: 0.0 ± 0.0
Gln
5.1GlnAla: 5.1 ± 1.515
0.264GlnCys: 0.264 ± 0.15
2.022GlnAsp: 2.022 ± 0.429
2.814GlnGlu: 2.814 ± 0.577
1.143GlnPhe: 1.143 ± 0.232
2.198GlnGly: 2.198 ± 0.671
0.264GlnHis: 0.264 ± 0.18
2.638GlnIle: 2.638 ± 0.471
3.781GlnLys: 3.781 ± 0.478
3.869GlnLeu: 3.869 ± 0.551
1.055GlnMet: 1.055 ± 0.286
3.517GlnAsn: 3.517 ± 0.675
0.879GlnPro: 0.879 ± 0.223
2.638GlnGln: 2.638 ± 0.572
2.374GlnArg: 2.374 ± 0.573
3.429GlnSer: 3.429 ± 0.534
1.407GlnThr: 1.407 ± 0.269
3.341GlnVal: 3.341 ± 0.492
0.352GlnTrp: 0.352 ± 0.165
1.055GlnTyr: 1.055 ± 0.345
0.0GlnXaa: 0.0 ± 0.0
Arg
2.902ArgAla: 2.902 ± 0.425
0.088ArgCys: 0.088 ± 0.083
1.934ArgAsp: 1.934 ± 0.426
3.253ArgGlu: 3.253 ± 0.596
1.407ArgPhe: 1.407 ± 0.456
2.55ArgGly: 2.55 ± 0.482
0.791ArgHis: 0.791 ± 0.299
2.638ArgIle: 2.638 ± 0.553
3.341ArgLys: 3.341 ± 0.712
3.253ArgLeu: 3.253 ± 0.639
1.055ArgMet: 1.055 ± 0.282
1.759ArgAsn: 1.759 ± 0.478
0.879ArgPro: 0.879 ± 0.315
2.11ArgGln: 2.11 ± 0.461
0.879ArgArg: 0.879 ± 0.289
2.99ArgSer: 2.99 ± 0.575
2.022ArgThr: 2.022 ± 0.526
1.759ArgVal: 1.759 ± 0.423
0.791ArgTrp: 0.791 ± 0.319
2.286ArgTyr: 2.286 ± 0.432
0.0ArgXaa: 0.0 ± 0.0
Ser
6.419SerAla: 6.419 ± 2.032
0.352SerCys: 0.352 ± 0.169
5.188SerAsp: 5.188 ± 0.647
4.748SerGlu: 4.748 ± 0.637
2.638SerPhe: 2.638 ± 0.368
4.221SerGly: 4.221 ± 0.672
0.703SerHis: 0.703 ± 0.272
4.484SerIle: 4.484 ± 0.694
4.924SerLys: 4.924 ± 0.673
5.891SerLeu: 5.891 ± 0.951
1.846SerMet: 1.846 ± 0.358
3.341SerAsn: 3.341 ± 0.619
1.846SerPro: 1.846 ± 0.446
2.814SerGln: 2.814 ± 0.716
2.374SerArg: 2.374 ± 0.389
5.188SerSer: 5.188 ± 1.213
4.396SerThr: 4.396 ± 0.688
4.484SerVal: 4.484 ± 1.291
0.967SerTrp: 0.967 ± 0.292
3.077SerTyr: 3.077 ± 0.659
0.0SerXaa: 0.0 ± 0.0
Thr
6.331ThrAla: 6.331 ± 1.076
0.352ThrCys: 0.352 ± 0.177
3.165ThrAsp: 3.165 ± 0.491
3.605ThrGlu: 3.605 ± 0.657
3.165ThrPhe: 3.165 ± 0.478
4.396ThrGly: 4.396 ± 0.579
0.615ThrHis: 0.615 ± 0.198
5.979ThrIle: 5.979 ± 0.943
3.957ThrLys: 3.957 ± 0.413
4.836ThrLeu: 4.836 ± 0.512
1.407ThrMet: 1.407 ± 0.245
2.638ThrAsn: 2.638 ± 0.392
2.11ThrPro: 2.11 ± 0.407
2.902ThrGln: 2.902 ± 0.518
1.407ThrArg: 1.407 ± 0.344
5.276ThrSer: 5.276 ± 0.77
3.957ThrThr: 3.957 ± 0.716
3.957ThrVal: 3.957 ± 0.48
0.44ThrTrp: 0.44 ± 0.19
2.99ThrTyr: 2.99 ± 0.584
0.0ThrXaa: 0.0 ± 0.0
Val
5.364ValAla: 5.364 ± 1.092
0.264ValCys: 0.264 ± 0.126
3.341ValAsp: 3.341 ± 0.608
5.188ValGlu: 5.188 ± 0.616
2.198ValPhe: 2.198 ± 0.493
4.396ValGly: 4.396 ± 1.172
0.528ValHis: 0.528 ± 0.154
3.957ValIle: 3.957 ± 0.594
5.452ValLys: 5.452 ± 0.619
4.924ValLeu: 4.924 ± 0.696
1.495ValMet: 1.495 ± 0.361
2.374ValAsn: 2.374 ± 0.358
1.407ValPro: 1.407 ± 0.341
1.759ValGln: 1.759 ± 0.573
2.462ValArg: 2.462 ± 0.504
6.155ValSer: 6.155 ± 0.706
5.276ValThr: 5.276 ± 0.515
4.66ValVal: 4.66 ± 0.691
0.703ValTrp: 0.703 ± 0.241
2.462ValTyr: 2.462 ± 0.558
0.0ValXaa: 0.0 ± 0.0
Trp
1.055TrpAla: 1.055 ± 0.279
0.088TrpCys: 0.088 ± 0.117
0.703TrpAsp: 0.703 ± 0.236
0.791TrpGlu: 0.791 ± 0.296
0.791TrpPhe: 0.791 ± 0.268
0.352TrpGly: 0.352 ± 0.155
0.176TrpHis: 0.176 ± 0.126
0.791TrpIle: 0.791 ± 0.259
1.495TrpLys: 1.495 ± 0.434
0.879TrpLeu: 0.879 ± 0.208
0.352TrpMet: 0.352 ± 0.16
0.528TrpAsn: 0.528 ± 0.218
0.0TrpPro: 0.0 ± 0.0
0.615TrpGln: 0.615 ± 0.194
0.528TrpArg: 0.528 ± 0.182
0.879TrpSer: 0.879 ± 0.444
0.703TrpThr: 0.703 ± 0.259
0.528TrpVal: 0.528 ± 0.214
0.264TrpTrp: 0.264 ± 0.143
0.264TrpTyr: 0.264 ± 0.179
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.374TyrAla: 2.374 ± 0.48
0.703TyrCys: 0.703 ± 0.344
3.781TyrAsp: 3.781 ± 0.55
2.286TyrGlu: 2.286 ± 0.516
2.198TyrPhe: 2.198 ± 0.609
2.462TyrGly: 2.462 ± 0.455
0.791TyrHis: 0.791 ± 0.269
2.638TyrIle: 2.638 ± 0.51
3.165TyrLys: 3.165 ± 0.608
3.517TyrLeu: 3.517 ± 0.683
0.967TyrMet: 0.967 ± 0.311
2.11TyrAsn: 2.11 ± 0.526
1.671TyrPro: 1.671 ± 0.429
1.759TyrGln: 1.759 ± 0.477
1.143TyrArg: 1.143 ± 0.372
2.022TyrSer: 2.022 ± 0.367
1.934TyrThr: 1.934 ± 0.471
2.198TyrVal: 2.198 ± 0.457
0.615TyrTrp: 0.615 ± 0.295
1.846TyrTyr: 1.846 ± 0.563
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (11374 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski