Amino acid dipepetide frequency for Muricauda alvinocaridis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.412AlaAla: 4.412 ± 0.08	0.613AlaCys: 0.613 ± 0.024	3.401AlaAsp: 3.401 ± 0.063	4.212AlaGlu: 4.212 ± 0.064	3.405AlaPhe: 3.405 ± 0.048	4.35AlaGly: 4.35 ± 0.074	1.333AlaHis: 1.333 ± 0.042	5.171AlaIle: 5.171 ± 0.076	4.565AlaLys: 4.565 ± 0.079	6.818AlaLeu: 6.818 ± 0.088	1.834AlaMet: 1.834 ± 0.04	3.204AlaAsn: 3.204 ± 0.057	2.119AlaPro: 2.119 ± 0.052	2.788AlaGln: 2.788 ± 0.05	2.149AlaArg: 2.149 ± 0.041	4.309AlaSer: 4.309 ± 0.064	3.672AlaThr: 3.672 ± 0.073	4.248AlaVal: 4.248 ± 0.067	0.681AlaTrp: 0.681 ± 0.022	2.526AlaTyr: 2.526 ± 0.05	0.005AlaXaa: 0.005 ± 0.003
Cys	0.473CysAla: 0.473 ± 0.021	0.1CysCys: 0.1 ± 0.009	0.427CysAsp: 0.427 ± 0.024	0.434CysGlu: 0.434 ± 0.019	0.426CysPhe: 0.426 ± 0.02	0.618CysGly: 0.618 ± 0.025	0.213CysHis: 0.213 ± 0.017	0.529CysIle: 0.529 ± 0.023	0.435CysLys: 0.435 ± 0.019	0.635CysLeu: 0.635 ± 0.025	0.178CysMet: 0.178 ± 0.013	0.379CysAsn: 0.379 ± 0.018	0.345CysPro: 0.345 ± 0.023	0.208CysGln: 0.208 ± 0.012	0.214CysArg: 0.214 ± 0.012	0.529CysSer: 0.529 ± 0.025	0.488CysThr: 0.488 ± 0.028	0.447CysVal: 0.447 ± 0.021	0.074CysTrp: 0.074 ± 0.008	0.285CysTyr: 0.285 ± 0.017	0.004CysXaa: 0.004 ± 0.002
Asp	3.9AspAla: 3.9 ± 0.073	0.436AspCys: 0.436 ± 0.022	3.147AspAsp: 3.147 ± 0.087	3.847AspGlu: 3.847 ± 0.065	3.647AspPhe: 3.647 ± 0.06	4.46AspGly: 4.46 ± 0.106	1.136AspHis: 1.136 ± 0.032	4.263AspIle: 4.263 ± 0.071	3.624AspLys: 3.624 ± 0.067	5.212AspLeu: 5.212 ± 0.072	1.323AspMet: 1.323 ± 0.039	2.822AspAsn: 2.822 ± 0.069	2.038AspPro: 2.038 ± 0.052	1.78AspGln: 1.78 ± 0.04	2.252AspArg: 2.252 ± 0.047	3.382AspSer: 3.382 ± 0.07	2.977AspThr: 2.977 ± 0.074	3.752AspVal: 3.752 ± 0.053	0.849AspTrp: 0.849 ± 0.028	2.727AspTyr: 2.727 ± 0.061	0.01AspXaa: 0.01 ± 0.003
Glu	4.603GluAla: 4.603 ± 0.075	0.358GluCys: 0.358 ± 0.018	3.779GluAsp: 3.779 ± 0.07	5.414GluGlu: 5.414 ± 0.092	2.807GluPhe: 2.807 ± 0.049	4.242GluGly: 4.242 ± 0.072	1.461GluHis: 1.461 ± 0.042	5.016GluIle: 5.016 ± 0.072	5.713GluLys: 5.713 ± 0.083	6.435GluLeu: 6.435 ± 0.086	1.768GluMet: 1.768 ± 0.041	4.251GluAsn: 4.251 ± 0.069	1.826GluPro: 1.826 ± 0.044	2.58GluGln: 2.58 ± 0.048	2.916GluArg: 2.916 ± 0.053	3.547GluSer: 3.547 ± 0.058	3.678GluThr: 3.678 ± 0.059	4.875GluVal: 4.875 ± 0.068	0.714GluTrp: 0.714 ± 0.025	2.409GluTyr: 2.409 ± 0.047	0.014GluXaa: 0.014 ± 0.005
Phe	3.037PheAla: 3.037 ± 0.055	0.43PheCys: 0.43 ± 0.021	3.273PheAsp: 3.273 ± 0.054	3.345PheGlu: 3.345 ± 0.054	2.828PhePhe: 2.828 ± 0.06	3.884PheGly: 3.884 ± 0.068	0.905PheHis: 0.905 ± 0.03	3.225PheIle: 3.225 ± 0.069	3.28PheLys: 3.28 ± 0.059	4.982PheLeu: 4.982 ± 0.081	1.246PheMet: 1.246 ± 0.035	2.797PheAsn: 2.797 ± 0.062	1.826PhePro: 1.826 ± 0.038	1.664PheGln: 1.664 ± 0.041	1.763PheArg: 1.763 ± 0.038	3.758PheSer: 3.758 ± 0.059	2.887PheThr: 2.887 ± 0.06	3.234PheVal: 3.234 ± 0.056	0.609PheTrp: 0.609 ± 0.021	2.035PheTyr: 2.035 ± 0.043	0.004PheXaa: 0.004 ± 0.002
Gly	4.46GlyAla: 4.46 ± 0.078	0.661GlyCys: 0.661 ± 0.034	3.83GlyAsp: 3.83 ± 0.075	4.173GlyGlu: 4.173 ± 0.062	3.859GlyPhe: 3.859 ± 0.068	5.046GlyGly: 5.046 ± 0.104	1.48GlyHis: 1.48 ± 0.044	5.507GlyIle: 5.507 ± 0.078	5.178GlyLys: 5.178 ± 0.079	6.425GlyLeu: 6.425 ± 0.084	1.99GlyMet: 1.99 ± 0.043	3.792GlyAsn: 3.792 ± 0.074	1.637GlyPro: 1.637 ± 0.045	2.222GlyGln: 2.222 ± 0.041	2.486GlyArg: 2.486 ± 0.054	4.294GlySer: 4.294 ± 0.075	4.307GlyThr: 4.307 ± 0.082	4.726GlyVal: 4.726 ± 0.082	0.882GlyTrp: 0.882 ± 0.028	2.904GlyTyr: 2.904 ± 0.056	0.007GlyXaa: 0.007 ± 0.003
His	1.071HisAla: 1.071 ± 0.035	0.197HisCys: 0.197 ± 0.014	0.918HisAsp: 0.918 ± 0.029	1.099HisGlu: 1.099 ± 0.03	1.269HisPhe: 1.269 ± 0.039	1.324HisGly: 1.324 ± 0.041	0.527HisHis: 0.527 ± 0.024	1.448HisIle: 1.448 ± 0.039	1.232HisLys: 1.232 ± 0.037	2.033HisLeu: 2.033 ± 0.05	0.442HisMet: 0.442 ± 0.019	0.928HisAsn: 0.928 ± 0.029	1.016HisPro: 1.016 ± 0.037	0.828HisGln: 0.828 ± 0.028	0.808HisArg: 0.808 ± 0.026	1.097HisSer: 1.097 ± 0.036	1.085HisThr: 1.085 ± 0.038	1.132HisVal: 1.132 ± 0.031	0.282HisTrp: 0.282 ± 0.019	0.852HisTyr: 0.852 ± 0.027	0.004HisXaa: 0.004 ± 0.002
Ile	5.251IleAla: 5.251 ± 0.072	0.581IleCys: 0.581 ± 0.02	4.191IleAsp: 4.191 ± 0.062	4.546IleGlu: 4.546 ± 0.075	3.413IlePhe: 3.413 ± 0.064	4.96IleGly: 4.96 ± 0.072	1.355IleHis: 1.355 ± 0.036	4.576IleIle: 4.576 ± 0.086	4.847IleLys: 4.847 ± 0.068	6.771IleLeu: 6.771 ± 0.089	1.429IleMet: 1.429 ± 0.042	3.799IleAsn: 3.799 ± 0.064	3.196IlePro: 3.196 ± 0.049	2.529IleGln: 2.529 ± 0.043	2.62IleArg: 2.62 ± 0.052	5.061IleSer: 5.061 ± 0.072	4.202IleThr: 4.202 ± 0.08	4.381IleVal: 4.381 ± 0.076	0.678IleTrp: 0.678 ± 0.022	2.449IleTyr: 2.449 ± 0.046	0.012IleXaa: 0.012 ± 0.004
Lys	4.853LysAla: 4.853 ± 0.075	0.297LysCys: 0.297 ± 0.016	4.171LysAsp: 4.171 ± 0.065	6.029LysGlu: 6.029 ± 0.096	2.507LysPhe: 2.507 ± 0.045	4.545LysGly: 4.545 ± 0.063	1.231LysHis: 1.231 ± 0.034	5.08LysIle: 5.08 ± 0.081	6.305LysLys: 6.305 ± 0.082	6.06LysLeu: 6.06 ± 0.066	1.94LysMet: 1.94 ± 0.041	4.226LysAsn: 4.226 ± 0.06	2.294LysPro: 2.294 ± 0.051	2.511LysGln: 2.511 ± 0.045	3.003LysArg: 3.003 ± 0.057	4.127LysSer: 4.127 ± 0.062	4.019LysThr: 4.019 ± 0.066	4.741LysVal: 4.741 ± 0.079	0.762LysTrp: 0.762 ± 0.027	2.581LysTyr: 2.581 ± 0.053	0.011LysXaa: 0.011 ± 0.003
Leu	6.345LeuAla: 6.345 ± 0.079	0.683LeuCys: 0.683 ± 0.023	5.78LeuAsp: 5.78 ± 0.079	6.819LeuGlu: 6.819 ± 0.087	4.877LeuPhe: 4.877 ± 0.078	6.794LeuGly: 6.794 ± 0.09	1.69LeuHis: 1.69 ± 0.04	5.96LeuIle: 5.96 ± 0.084	7.038LeuLys: 7.038 ± 0.096	8.965LeuLeu: 8.965 ± 0.105	2.27LeuMet: 2.27 ± 0.051	4.931LeuAsn: 4.931 ± 0.07	3.795LeuPro: 3.795 ± 0.06	3.425LeuGln: 3.425 ± 0.06	3.516LeuArg: 3.516 ± 0.063	6.53LeuSer: 6.53 ± 0.085	5.032LeuThr: 5.032 ± 0.085	6.175LeuVal: 6.175 ± 0.085	0.949LeuTrp: 0.949 ± 0.032	3.254LeuTyr: 3.254 ± 0.056	0.017LeuXaa: 0.017 ± 0.005
Met	2.106MetAla: 2.106 ± 0.043	0.141MetCys: 0.141 ± 0.012	1.718MetAsp: 1.718 ± 0.045	1.972MetGlu: 1.972 ± 0.046	0.891MetPhe: 0.891 ± 0.028	1.952MetGly: 1.952 ± 0.049	0.464MetHis: 0.464 ± 0.018	1.352MetIle: 1.352 ± 0.033	2.013MetLys: 2.013 ± 0.042	2.042MetLeu: 2.042 ± 0.048	0.604MetMet: 0.604 ± 0.027	1.185MetAsn: 1.185 ± 0.031	0.95MetPro: 0.95 ± 0.03	0.891MetGln: 0.891 ± 0.025	0.943MetArg: 0.943 ± 0.031	1.303MetSer: 1.303 ± 0.036	1.189MetThr: 1.189 ± 0.034	1.766MetVal: 1.766 ± 0.04	0.187MetTrp: 0.187 ± 0.013	0.683MetTyr: 0.683 ± 0.026	0.005MetXaa: 0.005 ± 0.002
Asn	3.662AsnAla: 3.662 ± 0.065	0.413AsnCys: 0.413 ± 0.02	2.874AsnAsp: 2.874 ± 0.078	3.204AsnGlu: 3.204 ± 0.06	2.674AsnPhe: 2.674 ± 0.055	4.197AsnGly: 4.197 ± 0.085	1.037AsnHis: 1.037 ± 0.029	3.88AsnIle: 3.88 ± 0.067	3.173AsnLys: 3.173 ± 0.057	4.936AsnLeu: 4.936 ± 0.068	1.229AsnMet: 1.229 ± 0.034	2.876AsnAsn: 2.876 ± 0.071	2.884AsnPro: 2.884 ± 0.056	2.075AsnGln: 2.075 ± 0.043	2.253AsnArg: 2.253 ± 0.047	3.14AsnSer: 3.14 ± 0.058	3.282AsnThr: 3.282 ± 0.062	3.293AsnVal: 3.293 ± 0.067	0.683AsnTrp: 0.683 ± 0.025	2.175AsnTyr: 2.175 ± 0.051	0.007AsnXaa: 0.007 ± 0.002
Pro	1.94ProAla: 1.94 ± 0.049	0.23ProCys: 0.23 ± 0.017	2.276ProAsp: 2.276 ± 0.05	3.069ProGlu: 3.069 ± 0.053	1.979ProPhe: 1.979 ± 0.04	2.209ProGly: 2.209 ± 0.055	0.711ProHis: 0.711 ± 0.029	2.686ProIle: 2.686 ± 0.052	2.854ProLys: 2.854 ± 0.058	3.249ProLeu: 3.249 ± 0.056	0.944ProMet: 0.944 ± 0.031	2.32ProAsn: 2.32 ± 0.052	0.982ProPro: 0.982 ± 0.032	1.278ProGln: 1.278 ± 0.033	1.097ProArg: 1.097 ± 0.032	2.414ProSer: 2.414 ± 0.046	2.082ProThr: 2.082 ± 0.051	2.431ProVal: 2.431 ± 0.043	0.406ProTrp: 0.406 ± 0.02	1.44ProTyr: 1.44 ± 0.036	0.004ProXaa: 0.004 ± 0.001
Gln	2.092GlnAla: 2.092 ± 0.044	0.199GlnCys: 0.199 ± 0.014	1.854GlnAsp: 1.854 ± 0.044	2.634GlnGlu: 2.634 ± 0.049	1.673GlnPhe: 1.673 ± 0.035	2.166GlnGly: 2.166 ± 0.048	0.691GlnHis: 0.691 ± 0.026	2.564GlnIle: 2.564 ± 0.05	2.999GlnLys: 2.999 ± 0.058	3.753GlnLeu: 3.753 ± 0.067	0.995GlnMet: 0.995 ± 0.032	2.064GlnAsn: 2.064 ± 0.048	1.21GlnPro: 1.21 ± 0.028	1.625GlnGln: 1.625 ± 0.045	1.581GlnArg: 1.581 ± 0.039	1.94GlnSer: 1.94 ± 0.042	1.874GlnThr: 1.874 ± 0.04	2.22GlnVal: 2.22 ± 0.051	0.482GlnTrp: 0.482 ± 0.021	1.363GlnTyr: 1.363 ± 0.038	0.012GlnXaa: 0.012 ± 0.004
Arg	2.283ArgAla: 2.283 ± 0.042	0.217ArgCys: 0.217 ± 0.014	1.963ArgAsp: 1.963 ± 0.042	2.637ArgGlu: 2.637 ± 0.051	2.087ArgPhe: 2.087 ± 0.05	2.227ArgGly: 2.227 ± 0.048	0.683ArgHis: 0.683 ± 0.024	3.033ArgIle: 3.033 ± 0.054	2.931ArgLys: 2.931 ± 0.059	3.592ArgLeu: 3.592 ± 0.06	0.992ArgMet: 0.992 ± 0.029	2.214ArgAsn: 2.214 ± 0.046	1.366ArgPro: 1.366 ± 0.037	1.257ArgGln: 1.257 ± 0.039	1.552ArgArg: 1.552 ± 0.036	2.166ArgSer: 2.166 ± 0.05	2.093ArgThr: 2.093 ± 0.035	2.285ArgVal: 2.285 ± 0.054	0.418ArgTrp: 0.418 ± 0.021	1.722ArgTyr: 1.722 ± 0.041	0.01ArgXaa: 0.01 ± 0.004
Ser	3.725SerAla: 3.725 ± 0.059	0.602SerCys: 0.602 ± 0.025	3.483SerAsp: 3.483 ± 0.064	3.984SerGlu: 3.984 ± 0.072	3.469SerPhe: 3.469 ± 0.054	4.749SerGly: 4.749 ± 0.081	1.218SerHis: 1.218 ± 0.033	4.815SerIle: 4.815 ± 0.07	4.493SerLys: 4.493 ± 0.069	6.058SerLeu: 6.058 ± 0.093	1.46SerMet: 1.46 ± 0.039	3.358SerAsn: 3.358 ± 0.063	2.244SerPro: 2.244 ± 0.051	2.174SerGln: 2.174 ± 0.04	2.264SerArg: 2.264 ± 0.047	3.923SerSer: 3.923 ± 0.066	3.403SerThr: 3.403 ± 0.056	3.984SerVal: 3.984 ± 0.069	0.699SerTrp: 0.699 ± 0.023	2.604SerTyr: 2.604 ± 0.05	0.012SerXaa: 0.012 ± 0.004
Thr	3.744ThrAla: 3.744 ± 0.071	0.345ThrCys: 0.345 ± 0.024	3.325ThrAsp: 3.325 ± 0.079	3.399ThrGlu: 3.399 ± 0.055	2.886ThrPhe: 2.886 ± 0.062	4.175ThrGly: 4.175 ± 0.083	1.114ThrHis: 1.114 ± 0.035	4.41ThrIle: 4.41 ± 0.074	3.302ThrLys: 3.302 ± 0.062	5.522ThrLeu: 5.522 ± 0.072	1.136ThrMet: 1.136 ± 0.031	2.731ThrAsn: 2.731 ± 0.061	2.451ThrPro: 2.451 ± 0.055	2.015ThrGln: 2.015 ± 0.044	1.693ThrArg: 1.693 ± 0.04	3.689ThrSer: 3.689 ± 0.066	3.252ThrThr: 3.252 ± 0.063	3.985ThrVal: 3.985 ± 0.089	0.609ThrTrp: 0.609 ± 0.03	2.353ThrTyr: 2.353 ± 0.051	0.005ThrXaa: 0.005 ± 0.003
Val	4.625ValAla: 4.625 ± 0.076	0.519ValCys: 0.519 ± 0.022	4.216ValAsp: 4.216 ± 0.066	4.441ValGlu: 4.441 ± 0.063	3.469ValPhe: 3.469 ± 0.061	4.353ValGly: 4.353 ± 0.077	1.239ValHis: 1.239 ± 0.032	4.244ValIle: 4.244 ± 0.064	4.042ValLys: 4.042 ± 0.066	6.551ValLeu: 6.551 ± 0.085	1.495ValMet: 1.495 ± 0.041	3.245ValAsn: 3.245 ± 0.064	2.628ValPro: 2.628 ± 0.047	2.148ValGln: 2.148 ± 0.042	2.355ValArg: 2.355 ± 0.049	4.505ValSer: 4.505 ± 0.069	3.742ValThr: 3.742 ± 0.082	4.803ValVal: 4.803 ± 0.075	0.697ValTrp: 0.697 ± 0.028	2.278ValTyr: 2.278 ± 0.051	0.005ValXaa: 0.005 ± 0.002
Trp	0.695TrpAla: 0.695 ± 0.027	0.097TrpCys: 0.097 ± 0.009	0.686TrpAsp: 0.686 ± 0.028	0.8TrpGlu: 0.8 ± 0.03	0.569TrpPhe: 0.569 ± 0.026	0.761TrpGly: 0.761 ± 0.028	0.265TrpHis: 0.265 ± 0.016	0.738TrpIle: 0.738 ± 0.026	0.809TrpLys: 0.809 ± 0.028	1.068TrpLeu: 1.068 ± 0.032	0.355TrpMet: 0.355 ± 0.019	0.696TrpAsn: 0.696 ± 0.027	0.329TrpPro: 0.329 ± 0.017	0.423TrpGln: 0.423 ± 0.018	0.44TrpArg: 0.44 ± 0.022	0.665TrpSer: 0.665 ± 0.026	0.567TrpThr: 0.567 ± 0.024	0.773TrpVal: 0.773 ± 0.032	0.18TrpTrp: 0.18 ± 0.015	0.441TrpTyr: 0.441 ± 0.02	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.529TyrAla: 2.529 ± 0.045	0.323TyrCys: 0.323 ± 0.014	2.267TyrAsp: 2.267 ± 0.046	2.345TyrGlu: 2.345 ± 0.052	2.268TyrPhe: 2.268 ± 0.046	2.85TyrGly: 2.85 ± 0.05	0.835TyrHis: 0.835 ± 0.027	2.334TyrIle: 2.334 ± 0.05	2.452TyrLys: 2.452 ± 0.048	3.726TyrLeu: 3.726 ± 0.058	0.722TyrMet: 0.722 ± 0.025	2.121TyrAsn: 2.121 ± 0.051	1.459TyrPro: 1.459 ± 0.037	1.565TyrGln: 1.565 ± 0.036	1.813TyrArg: 1.813 ± 0.042	2.33TyrSer: 2.33 ± 0.051	2.302TyrThr: 2.302 ± 0.053	2.34TyrVal: 2.34 ± 0.048	0.511TyrTrp: 0.511 ± 0.018	1.595TyrTyr: 1.595 ± 0.045	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.007XaaAla: 0.007 ± 0.003	0.002XaaCys: 0.002 ± 0.001	0.004XaaAsp: 0.004 ± 0.002	0.005XaaGlu: 0.005 ± 0.002	0.008XaaPhe: 0.008 ± 0.004	0.005XaaGly: 0.005 ± 0.003	0.005XaaHis: 0.005 ± 0.002	0.016XaaIle: 0.016 ± 0.004	0.01XaaLys: 0.01 ± 0.003	0.014XaaLeu: 0.014 ± 0.004	0.004XaaMet: 0.004 ± 0.002	0.006XaaAsn: 0.006 ± 0.002	0.008XaaPro: 0.008 ± 0.003	0.004XaaGln: 0.004 ± 0.002	0.008XaaArg: 0.008 ± 0.003	0.012XaaSer: 0.012 ± 0.003	0.009XaaThr: 0.009 ± 0.003	0.009XaaVal: 0.009 ± 0.003	0.004XaaTrp: 0.004 ± 0.002	0.01XaaTyr: 0.01 ± 0.004	0.008XaaXaa: 0.008 ± 0.003

Statistics based on 3339 proteins (1128126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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