Amino acid dipepetide frequency for Candidatus Nitromaritima sp. SCGC AAA799-C22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.076AlaAla: 6.076 ± 0.16
1.021AlaCys: 1.021 ± 0.057
3.959AlaAsp: 3.959 ± 0.111
5.13AlaGlu: 5.13 ± 0.127
3.249AlaPhe: 3.249 ± 0.107
6.363AlaGly: 6.363 ± 0.143
1.441AlaHis: 1.441 ± 0.065
4.585AlaIle: 4.585 ± 0.128
4.067AlaLys: 4.067 ± 0.123
7.929AlaLeu: 7.929 ± 0.182
1.898AlaMet: 1.898 ± 0.077
2.549AlaAsn: 2.549 ± 0.094
2.659AlaPro: 2.659 ± 0.088
2.489AlaGln: 2.489 ± 0.09
4.53AlaArg: 4.53 ± 0.107
4.06AlaSer: 4.06 ± 0.112
3.287AlaThr: 3.287 ± 0.109
5.57AlaVal: 5.57 ± 0.138
0.898AlaTrp: 0.898 ± 0.052
2.101AlaTyr: 2.101 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.8CysAla: 0.8 ± 0.049
0.173CysCys: 0.173 ± 0.022
0.63CysAsp: 0.63 ± 0.046
0.543CysGlu: 0.543 ± 0.042
0.563CysPhe: 0.563 ± 0.042
0.985CysGly: 0.985 ± 0.054
0.348CysHis: 0.348 ± 0.041
0.59CysIle: 0.59 ± 0.036
0.543CysLys: 0.543 ± 0.037
1.076CysLeu: 1.076 ± 0.054
0.233CysMet: 0.233 ± 0.025
0.385CysAsn: 0.385 ± 0.031
0.635CysPro: 0.635 ± 0.044
0.32CysGln: 0.32 ± 0.029
0.745CysArg: 0.745 ± 0.045
0.705CysSer: 0.705 ± 0.041
0.438CysThr: 0.438 ± 0.035
0.675CysVal: 0.675 ± 0.048
0.16CysTrp: 0.16 ± 0.022
0.303CysTyr: 0.303 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.814AspAla: 3.814 ± 0.104
0.673AspCys: 0.673 ± 0.041
2.761AspAsp: 2.761 ± 0.097
3.932AspGlu: 3.932 ± 0.114
2.866AspPhe: 2.866 ± 0.092
3.699AspGly: 3.699 ± 0.115
1.296AspHis: 1.296 ± 0.053
3.859AspIle: 3.859 ± 0.107
3.137AspLys: 3.137 ± 0.085
6.138AspLeu: 6.138 ± 0.128
1.298AspMet: 1.298 ± 0.065
1.878AspAsn: 1.878 ± 0.08
2.994AspPro: 2.994 ± 0.076
1.853AspGln: 1.853 ± 0.073
3.669AspArg: 3.669 ± 0.098
3.089AspSer: 3.089 ± 0.107
2.606AspThr: 2.606 ± 0.09
3.229AspVal: 3.229 ± 0.09
0.745AspTrp: 0.745 ± 0.047
1.871AspTyr: 1.871 ± 0.089
0.0AspXaa: 0.0 ± 0.0
Glu
5.303GluAla: 5.303 ± 0.153
0.565GluCys: 0.565 ± 0.045
3.639GluAsp: 3.639 ± 0.109
5.938GluGlu: 5.938 ± 0.2
2.751GluPhe: 2.751 ± 0.088
4.367GluGly: 4.367 ± 0.112
1.318GluHis: 1.318 ± 0.07
5.34GluIle: 5.34 ± 0.129
5.828GluLys: 5.828 ± 0.143
6.053GluLeu: 6.053 ± 0.154
1.968GluMet: 1.968 ± 0.068
3.592GluAsn: 3.592 ± 0.112
2.531GluPro: 2.531 ± 0.093
2.256GluGln: 2.256 ± 0.082
3.729GluArg: 3.729 ± 0.108
4.105GluSer: 4.105 ± 0.123
3.954GluThr: 3.954 ± 0.103
4.58GluVal: 4.58 ± 0.127
0.82GluTrp: 0.82 ± 0.049
1.878GluTyr: 1.878 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.107PheAla: 3.107 ± 0.085
0.6PheCys: 0.6 ± 0.042
2.876PheAsp: 2.876 ± 0.086
2.784PheGlu: 2.784 ± 0.086
2.474PhePhe: 2.474 ± 0.1
3.342PheGly: 3.342 ± 0.104
1.068PheHis: 1.068 ± 0.056
2.997PheIle: 2.997 ± 0.099
2.861PheLys: 2.861 ± 0.09
5.248PheLeu: 5.248 ± 0.155
1.111PheMet: 1.111 ± 0.054
2.094PheAsn: 2.094 ± 0.08
2.179PhePro: 2.179 ± 0.091
1.528PheGln: 1.528 ± 0.064
2.391PheArg: 2.391 ± 0.066
3.302PheSer: 3.302 ± 0.088
2.349PheThr: 2.349 ± 0.085
2.646PheVal: 2.646 ± 0.095
0.528PheTrp: 0.528 ± 0.04
1.646PheTyr: 1.646 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
5.03GlyAla: 5.03 ± 0.137
0.883GlyCys: 0.883 ± 0.048
3.917GlyAsp: 3.917 ± 0.126
4.815GlyGlu: 4.815 ± 0.112
3.677GlyPhe: 3.677 ± 0.098
5.235GlyGly: 5.235 ± 0.15
1.513GlyHis: 1.513 ± 0.064
5.29GlyIle: 5.29 ± 0.139
5.358GlyLys: 5.358 ± 0.146
7.306GlyLeu: 7.306 ± 0.159
2.101GlyMet: 2.101 ± 0.073
3.062GlyAsn: 3.062 ± 0.103
2.316GlyPro: 2.316 ± 0.083
2.384GlyGln: 2.384 ± 0.078
3.779GlyArg: 3.779 ± 0.111
4.405GlySer: 4.405 ± 0.127
3.964GlyThr: 3.964 ± 0.125
4.797GlyVal: 4.797 ± 0.146
0.95GlyTrp: 0.95 ± 0.053
2.269GlyTyr: 2.269 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.411HisAla: 1.411 ± 0.065
0.303HisCys: 0.303 ± 0.026
1.006HisAsp: 1.006 ± 0.048
1.321HisGlu: 1.321 ± 0.064
1.086HisPhe: 1.086 ± 0.06
1.536HisGly: 1.536 ± 0.069
0.58HisHis: 0.58 ± 0.04
1.278HisIle: 1.278 ± 0.059
1.038HisLys: 1.038 ± 0.049
2.371HisLeu: 2.371 ± 0.081
0.438HisMet: 0.438 ± 0.034
0.693HisAsn: 0.693 ± 0.038
1.416HisPro: 1.416 ± 0.065
0.74HisGln: 0.74 ± 0.043
1.168HisArg: 1.168 ± 0.055
1.326HisSer: 1.326 ± 0.053
0.873HisThr: 0.873 ± 0.046
1.126HisVal: 1.126 ± 0.052
0.318HisTrp: 0.318 ± 0.03
0.715HisTyr: 0.715 ± 0.048
0.0HisXaa: 0.0 ± 0.0
Ile
4.855IleAla: 4.855 ± 0.113
0.68IleCys: 0.68 ± 0.039
4.22IleAsp: 4.22 ± 0.114
4.665IleGlu: 4.665 ± 0.118
3.034IlePhe: 3.034 ± 0.098
4.687IleGly: 4.687 ± 0.131
1.451IleHis: 1.451 ± 0.058
4.01IleIle: 4.01 ± 0.14
3.952IleLys: 3.952 ± 0.106
6.926IleLeu: 6.926 ± 0.145
1.456IleMet: 1.456 ± 0.074
2.819IleAsn: 2.819 ± 0.086
3.379IlePro: 3.379 ± 0.096
2.364IleGln: 2.364 ± 0.077
3.874IleArg: 3.874 ± 0.113
4.005IleSer: 4.005 ± 0.093
3.357IleThr: 3.357 ± 0.112
4.327IleVal: 4.327 ± 0.116
0.633IleTrp: 0.633 ± 0.043
1.871IleTyr: 1.871 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
4.417LysAla: 4.417 ± 0.144
0.478LysCys: 0.478 ± 0.038
3.399LysAsp: 3.399 ± 0.105
5.07LysGlu: 5.07 ± 0.13
2.651LysPhe: 2.651 ± 0.077
4.047LysGly: 4.047 ± 0.109
1.083LysHis: 1.083 ± 0.061
5.013LysIle: 5.013 ± 0.129
6.028LysLys: 6.028 ± 0.162
5.745LysLeu: 5.745 ± 0.129
1.758LysMet: 1.758 ± 0.068
3.467LysAsn: 3.467 ± 0.1
2.706LysPro: 2.706 ± 0.084
2.056LysGln: 2.056 ± 0.076
3.219LysArg: 3.219 ± 0.089
3.967LysSer: 3.967 ± 0.101
3.719LysThr: 3.719 ± 0.088
3.922LysVal: 3.922 ± 0.1
0.55LysTrp: 0.55 ± 0.034
1.783LysTyr: 1.783 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
8.317LeuAla: 8.317 ± 0.168
1.108LeuCys: 1.108 ± 0.056
5.82LeuAsp: 5.82 ± 0.12
7.104LeuGlu: 7.104 ± 0.167
4.662LeuPhe: 4.662 ± 0.137
7.209LeuGly: 7.209 ± 0.164
1.903LeuHis: 1.903 ± 0.069
6.241LeuIle: 6.241 ± 0.14
7.591LeuLys: 7.591 ± 0.172
9.077LeuLeu: 9.077 ± 0.2
2.489LeuMet: 2.489 ± 0.092
4.337LeuAsn: 4.337 ± 0.11
4.655LeuPro: 4.655 ± 0.121
3.202LeuGln: 3.202 ± 0.1
4.89LeuArg: 4.89 ± 0.121
6.761LeuSer: 6.761 ± 0.145
5.068LeuThr: 5.068 ± 0.115
6.366LeuVal: 6.366 ± 0.137
1.041LeuTrp: 1.041 ± 0.057
2.614LeuTyr: 2.614 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
2.244MetAla: 2.244 ± 0.088
0.175MetCys: 0.175 ± 0.022
1.508MetAsp: 1.508 ± 0.064
1.981MetGlu: 1.981 ± 0.077
0.996MetPhe: 0.996 ± 0.059
2.129MetGly: 2.129 ± 0.072
0.438MetHis: 0.438 ± 0.033
1.648MetIle: 1.648 ± 0.062
1.988MetLys: 1.988 ± 0.073
1.871MetLeu: 1.871 ± 0.074
0.665MetMet: 0.665 ± 0.04
1.133MetAsn: 1.133 ± 0.062
0.988MetPro: 0.988 ± 0.047
0.7MetGln: 0.7 ± 0.04
1.283MetArg: 1.283 ± 0.054
1.371MetSer: 1.371 ± 0.059
1.458MetThr: 1.458 ± 0.06
1.798MetVal: 1.798 ± 0.073
0.175MetTrp: 0.175 ± 0.021
0.515MetTyr: 0.515 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.554AsnAla: 2.554 ± 0.076
0.38AsnCys: 0.38 ± 0.033
1.816AsnAsp: 1.816 ± 0.074
2.444AsnGlu: 2.444 ± 0.082
2.019AsnPhe: 2.019 ± 0.078
2.914AsnGly: 2.914 ± 0.103
0.996AsnHis: 0.996 ± 0.058
2.919AsnIle: 2.919 ± 0.09
2.396AsnLys: 2.396 ± 0.079
4.757AsnLeu: 4.757 ± 0.143
0.938AsnMet: 0.938 ± 0.054
1.608AsnAsn: 1.608 ± 0.068
2.484AsnPro: 2.484 ± 0.086
1.643AsnGln: 1.643 ± 0.073
2.499AsnArg: 2.499 ± 0.081
2.194AsnSer: 2.194 ± 0.068
1.806AsnThr: 1.806 ± 0.059
2.356AsnVal: 2.356 ± 0.078
0.498AsnTrp: 0.498 ± 0.04
1.263AsnTyr: 1.263 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
3.547ProAla: 3.547 ± 0.104
0.425ProCys: 0.425 ± 0.035
3.092ProAsp: 3.092 ± 0.093
4.172ProGlu: 4.172 ± 0.117
2.074ProPhe: 2.074 ± 0.093
3.672ProGly: 3.672 ± 0.102
0.938ProHis: 0.938 ± 0.051
2.254ProIle: 2.254 ± 0.083
2.251ProLys: 2.251 ± 0.075
4.172ProLeu: 4.172 ± 0.112
1.013ProMet: 1.013 ± 0.055
1.443ProAsn: 1.443 ± 0.071
2.086ProPro: 2.086 ± 0.096
1.576ProGln: 1.576 ± 0.061
1.978ProArg: 1.978 ± 0.076
2.629ProSer: 2.629 ± 0.085
1.956ProThr: 1.956 ± 0.069
3.724ProVal: 3.724 ± 0.107
0.598ProTrp: 0.598 ± 0.04
1.221ProTyr: 1.221 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
2.831GlnAla: 2.831 ± 0.09
0.33GlnCys: 0.33 ± 0.032
1.763GlnAsp: 1.763 ± 0.059
2.389GlnGlu: 2.389 ± 0.084
1.418GlnPhe: 1.418 ± 0.054
2.329GlnGly: 2.329 ± 0.086
0.475GlnHis: 0.475 ± 0.032
2.371GlnIle: 2.371 ± 0.08
2.366GlnLys: 2.366 ± 0.074
2.987GlnLeu: 2.987 ± 0.097
0.898GlnMet: 0.898 ± 0.05
1.466GlnAsn: 1.466 ± 0.063
1.426GlnPro: 1.426 ± 0.058
1.048GlnGln: 1.048 ± 0.059
1.638GlnArg: 1.638 ± 0.065
2.109GlnSer: 2.109 ± 0.087
1.921GlnThr: 1.921 ± 0.076
2.501GlnVal: 2.501 ± 0.077
0.41GlnTrp: 0.41 ± 0.037
0.908GlnTyr: 0.908 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.712ArgAla: 3.712 ± 0.109
0.538ArgCys: 0.538 ± 0.039
2.941ArgAsp: 2.941 ± 0.073
4.67ArgGlu: 4.67 ± 0.132
2.831ArgPhe: 2.831 ± 0.09
3.379ArgGly: 3.379 ± 0.106
1.128ArgHis: 1.128 ± 0.055
3.934ArgIle: 3.934 ± 0.103
3.859ArgLys: 3.859 ± 0.102
5.63ArgLeu: 5.63 ± 0.12
1.528ArgMet: 1.528 ± 0.07
2.229ArgAsn: 2.229 ± 0.071
1.991ArgPro: 1.991 ± 0.08
2.074ArgGln: 2.074 ± 0.073
2.966ArgArg: 2.966 ± 0.099
3.132ArgSer: 3.132 ± 0.097
2.469ArgThr: 2.469 ± 0.088
3.802ArgVal: 3.802 ± 0.09
0.648ArgTrp: 0.648 ± 0.045
1.621ArgTyr: 1.621 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.527SerAla: 4.527 ± 0.118
0.623SerCys: 0.623 ± 0.043
3.182SerAsp: 3.182 ± 0.094
3.462SerGlu: 3.462 ± 0.102
3.017SerPhe: 3.017 ± 0.094
5.253SerGly: 5.253 ± 0.135
1.176SerHis: 1.176 ± 0.053
4.197SerIle: 4.197 ± 0.104
3.194SerLys: 3.194 ± 0.083
6.346SerLeu: 6.346 ± 0.146
1.591SerMet: 1.591 ± 0.063
2.056SerAsn: 2.056 ± 0.082
3.054SerPro: 3.054 ± 0.081
2.061SerGln: 2.061 ± 0.088
3.574SerArg: 3.574 ± 0.091
3.819SerSer: 3.819 ± 0.116
2.919SerThr: 2.919 ± 0.099
4.012SerVal: 4.012 ± 0.083
0.7SerTrp: 0.7 ± 0.047
1.646SerTyr: 1.646 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.967ThrAla: 3.967 ± 0.111
0.493ThrCys: 0.493 ± 0.041
2.729ThrAsp: 2.729 ± 0.087
2.839ThrGlu: 2.839 ± 0.081
2.284ThrPhe: 2.284 ± 0.09
4.645ThrGly: 4.645 ± 0.115
1.208ThrHis: 1.208 ± 0.066
3.264ThrIle: 3.264 ± 0.098
2.116ThrLys: 2.116 ± 0.077
5.991ThrLeu: 5.991 ± 0.141
1.006ThrMet: 1.006 ± 0.051
1.641ThrAsn: 1.641 ± 0.073
2.529ThrPro: 2.529 ± 0.085
1.728ThrGln: 1.728 ± 0.072
2.766ThrArg: 2.766 ± 0.088
2.689ThrSer: 2.689 ± 0.094
2.609ThrThr: 2.609 ± 0.11
3.837ThrVal: 3.837 ± 0.116
0.503ThrTrp: 0.503 ± 0.038
1.328ThrTyr: 1.328 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
4.682ValAla: 4.682 ± 0.126
0.858ValCys: 0.858 ± 0.049
3.822ValAsp: 3.822 ± 0.106
4.68ValGlu: 4.68 ± 0.134
3.297ValPhe: 3.297 ± 0.098
4.515ValGly: 4.515 ± 0.131
1.356ValHis: 1.356 ± 0.059
4.297ValIle: 4.297 ± 0.106
3.962ValLys: 3.962 ± 0.123
6.781ValLeu: 6.781 ± 0.146
1.621ValMet: 1.621 ± 0.061
2.444ValAsn: 2.444 ± 0.079
2.954ValPro: 2.954 ± 0.097
2.041ValGln: 2.041 ± 0.081
3.787ValArg: 3.787 ± 0.107
4.272ValSer: 4.272 ± 0.12
3.594ValThr: 3.594 ± 0.109
4.71ValVal: 4.71 ± 0.137
0.728ValTrp: 0.728 ± 0.038
1.953ValTyr: 1.953 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.765TrpAla: 0.765 ± 0.05
0.115TrpCys: 0.115 ± 0.018
0.595TrpAsp: 0.595 ± 0.036
0.788TrpGlu: 0.788 ± 0.049
0.578TrpPhe: 0.578 ± 0.044
0.788TrpGly: 0.788 ± 0.044
0.278TrpHis: 0.278 ± 0.028
0.823TrpIle: 0.823 ± 0.046
0.883TrpLys: 0.883 ± 0.052
1.033TrpLeu: 1.033 ± 0.056
0.383TrpMet: 0.383 ± 0.03
0.543TrpAsn: 0.543 ± 0.04
0.395TrpPro: 0.395 ± 0.033
0.345TrpGln: 0.345 ± 0.031
0.63TrpArg: 0.63 ± 0.042
0.61TrpSer: 0.61 ± 0.05
0.593TrpThr: 0.593 ± 0.044
0.878TrpVal: 0.878 ± 0.049
0.173TrpTrp: 0.173 ± 0.025
0.288TrpTyr: 0.288 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.901TyrAla: 1.901 ± 0.081
0.43TyrCys: 0.43 ± 0.029
1.736TyrAsp: 1.736 ± 0.07
1.793TyrGlu: 1.793 ± 0.077
1.603TyrPhe: 1.603 ± 0.071
1.958TyrGly: 1.958 ± 0.069
0.748TyrHis: 0.748 ± 0.045
1.653TyrIle: 1.653 ± 0.059
1.661TyrLys: 1.661 ± 0.065
3.017TyrLeu: 3.017 ± 0.1
0.67TyrMet: 0.67 ± 0.047
1.046TyrAsn: 1.046 ± 0.051
1.443TyrPro: 1.443 ± 0.064
1.176TyrGln: 1.176 ± 0.059
1.963TyrArg: 1.963 ± 0.066
1.861TyrSer: 1.861 ± 0.077
1.231TyrThr: 1.231 ± 0.06
1.496TyrVal: 1.496 ± 0.054
0.408TyrTrp: 0.408 ± 0.036
1.101TyrTyr: 1.101 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1350 proteins (399800 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski