Amino acid dipepetide frequency for Sulfitobacter guttiformis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.568AlaAla: 15.568 ± 0.194	1.138AlaCys: 1.138 ± 0.033	6.741AlaAsp: 6.741 ± 0.069	7.003AlaGlu: 7.003 ± 0.096	4.33AlaPhe: 4.33 ± 0.056	10.194AlaGly: 10.194 ± 0.11	2.427AlaHis: 2.427 ± 0.047	5.998AlaIle: 5.998 ± 0.082	4.162AlaLys: 4.162 ± 0.067	13.197AlaLeu: 13.197 ± 0.152	3.832AlaMet: 3.832 ± 0.067	2.942AlaAsn: 2.942 ± 0.06	5.432AlaPro: 5.432 ± 0.083	5.197AlaGln: 5.197 ± 0.083	7.645AlaArg: 7.645 ± 0.106	5.749AlaSer: 5.749 ± 0.081	6.131AlaThr: 6.131 ± 0.098	8.466AlaVal: 8.466 ± 0.107	1.367AlaTrp: 1.367 ± 0.037	2.52AlaTyr: 2.52 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.145CysAla: 1.145 ± 0.033	0.106CysCys: 0.106 ± 0.009	0.625CysAsp: 0.625 ± 0.026	0.459CysGlu: 0.459 ± 0.021	0.36CysPhe: 0.36 ± 0.019	0.959CysGly: 0.959 ± 0.029	0.266CysHis: 0.266 ± 0.018	0.51CysIle: 0.51 ± 0.021	0.252CysLys: 0.252 ± 0.016	0.789CysLeu: 0.789 ± 0.027	0.179CysMet: 0.179 ± 0.014	0.255CysAsn: 0.255 ± 0.016	0.515CysPro: 0.515 ± 0.024	0.233CysGln: 0.233 ± 0.014	0.501CysArg: 0.501 ± 0.022	0.494CysSer: 0.494 ± 0.023	0.501CysThr: 0.501 ± 0.027	0.66CysVal: 0.66 ± 0.027	0.113CysTrp: 0.113 ± 0.009	0.23CysTyr: 0.23 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.474AspAla: 7.474 ± 0.087	0.537AspCys: 0.537 ± 0.024	3.333AspAsp: 3.333 ± 0.08	3.413AspGlu: 3.413 ± 0.061	2.205AspPhe: 2.205 ± 0.047	5.302AspGly: 5.302 ± 0.101	1.342AspHis: 1.342 ± 0.037	3.394AspIle: 3.394 ± 0.063	1.832AspLys: 1.832 ± 0.042	6.135AspLeu: 6.135 ± 0.086	1.826AspMet: 1.826 ± 0.037	1.438AspAsn: 1.438 ± 0.042	3.343AspPro: 3.343 ± 0.066	1.834AspGln: 1.834 ± 0.042	3.625AspArg: 3.625 ± 0.05	2.205AspSer: 2.205 ± 0.054	3.407AspThr: 3.407 ± 0.075	4.646AspVal: 4.646 ± 0.065	1.047AspTrp: 1.047 ± 0.032	1.488AspTyr: 1.488 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.343GluAla: 7.343 ± 0.094	0.37GluCys: 0.37 ± 0.02	3.063GluAsp: 3.063 ± 0.056	3.153GluGlu: 3.153 ± 0.06	1.844GluPhe: 1.844 ± 0.038	4.828GluGly: 4.828 ± 0.075	1.11GluHis: 1.11 ± 0.029	3.605GluIle: 3.605 ± 0.059	2.272GluLys: 2.272 ± 0.055	4.848GluLeu: 4.848 ± 0.07	1.856GluMet: 1.856 ± 0.039	1.88GluAsn: 1.88 ± 0.04	2.116GluPro: 2.116 ± 0.049	2.126GluGln: 2.126 ± 0.045	3.69GluArg: 3.69 ± 0.059	2.041GluSer: 2.041 ± 0.049	3.517GluThr: 3.517 ± 0.052	4.229GluVal: 4.229 ± 0.058	0.717GluTrp: 0.717 ± 0.024	1.168GluTyr: 1.168 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.474PheAla: 4.474 ± 0.07	0.44PheCys: 0.44 ± 0.019	2.919PheAsp: 2.919 ± 0.053	2.276PheGlu: 2.276 ± 0.051	1.455PhePhe: 1.455 ± 0.039	3.851PheGly: 3.851 ± 0.061	0.748PheHis: 0.748 ± 0.027	1.901PheIle: 1.901 ± 0.041	1.124PheLys: 1.124 ± 0.03	3.234PheLeu: 3.234 ± 0.067	0.981PheMet: 0.981 ± 0.032	1.191PheAsn: 1.191 ± 0.033	1.442PhePro: 1.442 ± 0.035	1.045PheGln: 1.045 ± 0.029	1.896PheArg: 1.896 ± 0.041	2.274PheSer: 2.274 ± 0.044	2.234PheThr: 2.234 ± 0.05	2.806PheVal: 2.806 ± 0.046	0.559PheTrp: 0.559 ± 0.021	0.977PheTyr: 0.977 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.728GlyAla: 9.728 ± 0.101	0.798GlyCys: 0.798 ± 0.028	4.767GlyAsp: 4.767 ± 0.103	4.372GlyGlu: 4.372 ± 0.067	3.678GlyPhe: 3.678 ± 0.061	7.528GlyGly: 7.528 ± 0.112	1.826GlyHis: 1.826 ± 0.046	4.915GlyIle: 4.915 ± 0.073	3.316GlyLys: 3.316 ± 0.059	8.68GlyLeu: 8.68 ± 0.106	2.737GlyMet: 2.737 ± 0.066	2.419GlyAsn: 2.419 ± 0.078	3.4GlyPro: 3.4 ± 0.066	3.081GlyGln: 3.081 ± 0.06	5.148GlyArg: 5.148 ± 0.08	4.354GlySer: 4.354 ± 0.068	4.963GlyThr: 4.963 ± 0.087	6.411GlyVal: 6.411 ± 0.083	1.354GlyTrp: 1.354 ± 0.039	2.244GlyTyr: 2.244 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.348HisAla: 2.348 ± 0.051	0.239HisCys: 0.239 ± 0.016	1.256HisAsp: 1.256 ± 0.037	0.999HisGlu: 0.999 ± 0.029	0.825HisPhe: 0.825 ± 0.025	1.862HisGly: 1.862 ± 0.045	0.56HisHis: 0.56 ± 0.028	1.172HisIle: 1.172 ± 0.038	0.633HisLys: 0.633 ± 0.021	2.053HisLeu: 2.053 ± 0.047	0.584HisMet: 0.584 ± 0.023	0.581HisAsn: 0.581 ± 0.021	1.254HisPro: 1.254 ± 0.034	0.555HisGln: 0.555 ± 0.023	1.168HisArg: 1.168 ± 0.034	1.039HisSer: 1.039 ± 0.033	0.985HisThr: 0.985 ± 0.028	1.429HisVal: 1.429 ± 0.036	0.305HisTrp: 0.305 ± 0.017	0.543HisTyr: 0.543 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.447IleAla: 7.447 ± 0.084	0.69IleCys: 0.69 ± 0.025	3.635IleAsp: 3.635 ± 0.065	3.698IleGlu: 3.698 ± 0.057	1.981IlePhe: 1.981 ± 0.044	5.007IleGly: 5.007 ± 0.069	0.935IleHis: 0.935 ± 0.031	2.895IleIle: 2.895 ± 0.06	1.862IleLys: 1.862 ± 0.04	4.951IleLeu: 4.951 ± 0.072	1.34IleMet: 1.34 ± 0.038	1.729IleAsn: 1.729 ± 0.046	2.477IlePro: 2.477 ± 0.044	1.255IleGln: 1.255 ± 0.033	2.938IleArg: 2.938 ± 0.048	3.456IleSer: 3.456 ± 0.064	3.512IleThr: 3.512 ± 0.072	4.034IleVal: 4.034 ± 0.068	0.771IleTrp: 0.771 ± 0.027	1.231IleTyr: 1.231 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.952LysAla: 3.952 ± 0.066	0.211LysCys: 0.211 ± 0.014	1.872LysAsp: 1.872 ± 0.043	1.653LysGlu: 1.653 ± 0.042	1.083LysPhe: 1.083 ± 0.032	2.842LysGly: 2.842 ± 0.062	0.72LysHis: 0.72 ± 0.026	1.948LysIle: 1.948 ± 0.041	1.423LysLys: 1.423 ± 0.044	3.373LysLeu: 3.373 ± 0.054	1.102LysMet: 1.102 ± 0.031	1.019LysAsn: 1.019 ± 0.029	1.875LysPro: 1.875 ± 0.048	1.06LysGln: 1.06 ± 0.032	2.419LysArg: 2.419 ± 0.055	2.208LysSer: 2.208 ± 0.05	2.287LysThr: 2.287 ± 0.051	2.412LysVal: 2.412 ± 0.055	0.431LysTrp: 0.431 ± 0.021	0.753LysTyr: 0.753 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	11.715LeuAla: 11.715 ± 0.121	0.95LeuCys: 0.95 ± 0.031	5.669LeuAsp: 5.669 ± 0.07	5.485LeuGlu: 5.485 ± 0.071	3.447LeuPhe: 3.447 ± 0.072	8.259LeuGly: 8.259 ± 0.115	1.894LeuHis: 1.894 ± 0.047	5.477LeuIle: 5.477 ± 0.085	3.428LeuLys: 3.428 ± 0.056	8.779LeuLeu: 8.779 ± 0.134	2.854LeuMet: 2.854 ± 0.053	2.815LeuAsn: 2.815 ± 0.048	5.271LeuPro: 5.271 ± 0.075	2.697LeuGln: 2.697 ± 0.05	6.725LeuArg: 6.725 ± 0.094	6.651LeuSer: 6.651 ± 0.086	6.162LeuThr: 6.162 ± 0.074	6.821LeuVal: 6.821 ± 0.088	1.216LeuTrp: 1.216 ± 0.036	1.854LeuTyr: 1.854 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.501MetAla: 3.501 ± 0.07	0.236MetCys: 0.236 ± 0.015	1.478MetAsp: 1.478 ± 0.035	1.354MetGlu: 1.354 ± 0.034	0.959MetPhe: 0.959 ± 0.03	2.532MetGly: 2.532 ± 0.057	0.544MetHis: 0.544 ± 0.024	1.894MetIle: 1.894 ± 0.047	1.211MetLys: 1.211 ± 0.03	2.787MetLeu: 2.787 ± 0.055	0.949MetMet: 0.949 ± 0.034	0.99MetAsn: 0.99 ± 0.031	1.615MetPro: 1.615 ± 0.038	1.12MetGln: 1.12 ± 0.028	2.037MetArg: 2.037 ± 0.044	1.931MetSer: 1.931 ± 0.039	2.166MetThr: 2.166 ± 0.047	1.899MetVal: 1.899 ± 0.039	0.267MetTrp: 0.267 ± 0.017	0.419MetTyr: 0.419 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.483AsnAla: 3.483 ± 0.053	0.269AsnCys: 0.269 ± 0.014	1.749AsnAsp: 1.749 ± 0.071	1.389AsnGlu: 1.389 ± 0.034	1.119AsnPhe: 1.119 ± 0.033	2.645AsnGly: 2.645 ± 0.061	0.558AsnHis: 0.558 ± 0.023	1.682AsnIle: 1.682 ± 0.043	0.862AsnLys: 0.862 ± 0.029	2.696AsnLeu: 2.696 ± 0.051	0.761AsnMet: 0.761 ± 0.025	0.882AsnAsn: 0.882 ± 0.037	1.855AsnPro: 1.855 ± 0.045	0.787AsnGln: 0.787 ± 0.03	1.696AsnArg: 1.696 ± 0.038	1.459AsnSer: 1.459 ± 0.037	1.615AsnThr: 1.615 ± 0.057	2.073AsnVal: 2.073 ± 0.062	0.445AsnTrp: 0.445 ± 0.02	0.714AsnTyr: 0.714 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.622ProAla: 5.622 ± 0.097	0.348ProCys: 0.348 ± 0.018	3.754ProAsp: 3.754 ± 0.052	3.554ProGlu: 3.554 ± 0.058	1.973ProPhe: 1.973 ± 0.044	3.226ProGly: 3.226 ± 0.055	1.081ProHis: 1.081 ± 0.029	2.185ProIle: 2.185 ± 0.044	1.736ProLys: 1.736 ± 0.041	4.56ProLeu: 4.56 ± 0.07	1.33ProMet: 1.33 ± 0.034	1.372ProAsn: 1.372 ± 0.036	2.011ProPro: 2.011 ± 0.046	1.864ProGln: 1.864 ± 0.038	2.457ProArg: 2.457 ± 0.049	2.661ProSer: 2.661 ± 0.041	2.445ProThr: 2.445 ± 0.045	4.186ProVal: 4.186 ± 0.068	0.601ProTrp: 0.601 ± 0.021	1.151ProTyr: 1.151 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.09GlnAla: 4.09 ± 0.073	0.237GlnCys: 0.237 ± 0.013	1.71GlnAsp: 1.71 ± 0.043	1.576GlnGlu: 1.576 ± 0.04	1.154GlnPhe: 1.154 ± 0.035	2.638GlnGly: 2.638 ± 0.046	0.616GlnHis: 0.616 ± 0.026	2.267GlnIle: 2.267 ± 0.048	1.157GlnLys: 1.157 ± 0.034	3.023GlnLeu: 3.023 ± 0.053	1.222GlnMet: 1.222 ± 0.034	1.079GlnAsn: 1.079 ± 0.031	1.531GlnPro: 1.531 ± 0.037	1.192GlnGln: 1.192 ± 0.041	2.16GlnArg: 2.16 ± 0.043	2.016GlnSer: 2.016 ± 0.045	2.125GlnThr: 2.125 ± 0.043	2.358GlnVal: 2.358 ± 0.046	0.429GlnTrp: 0.429 ± 0.02	0.667GlnTyr: 0.667 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.204ArgAla: 7.204 ± 0.097	0.45ArgCys: 0.45 ± 0.021	3.942ArgAsp: 3.942 ± 0.063	3.463ArgGlu: 3.463 ± 0.056	2.468ArgPhe: 2.468 ± 0.054	4.358ArgGly: 4.358 ± 0.067	1.338ArgHis: 1.338 ± 0.038	3.734ArgIle: 3.734 ± 0.064	2.322ArgLys: 2.322 ± 0.053	6.234ArgLeu: 6.234 ± 0.081	1.981ArgMet: 1.981 ± 0.04	1.849ArgAsn: 1.849 ± 0.04	2.697ArgPro: 2.697 ± 0.051	1.983ArgGln: 1.983 ± 0.045	4.125ArgArg: 4.125 ± 0.072	3.308ArgSer: 3.308 ± 0.045	3.15ArgThr: 3.15 ± 0.051	4.41ArgVal: 4.41 ± 0.064	0.836ArgTrp: 0.836 ± 0.029	1.418ArgTyr: 1.418 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.058SerAla: 6.058 ± 0.075	0.487SerCys: 0.487 ± 0.027	3.467SerAsp: 3.467 ± 0.061	2.945SerGlu: 2.945 ± 0.059	2.36SerPhe: 2.36 ± 0.042	5.598SerGly: 5.598 ± 0.079	1.141SerHis: 1.141 ± 0.035	2.848SerIle: 2.848 ± 0.059	1.808SerLys: 1.808 ± 0.043	5.182SerLeu: 5.182 ± 0.074	1.58SerMet: 1.58 ± 0.035	1.581SerAsn: 1.581 ± 0.039	2.465SerPro: 2.465 ± 0.053	1.726SerGln: 1.726 ± 0.043	3.127SerArg: 3.127 ± 0.059	2.838SerSer: 2.838 ± 0.052	2.835SerThr: 2.835 ± 0.046	4.109SerVal: 4.109 ± 0.051	0.629SerTrp: 0.629 ± 0.026	1.344SerTyr: 1.344 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.703ThrAla: 6.703 ± 0.101	0.539ThrCys: 0.539 ± 0.031	3.343ThrAsp: 3.343 ± 0.07	2.844ThrGlu: 2.844 ± 0.056	2.107ThrPhe: 2.107 ± 0.045	5.424ThrGly: 5.424 ± 0.083	1.162ThrHis: 1.162 ± 0.038	2.964ThrIle: 2.964 ± 0.06	1.789ThrLys: 1.789 ± 0.044	6.576ThrLeu: 6.576 ± 0.086	1.473ThrMet: 1.473 ± 0.039	1.527ThrAsn: 1.527 ± 0.057	3.559ThrPro: 3.559 ± 0.07	1.886ThrGln: 1.886 ± 0.05	3.302ThrArg: 3.302 ± 0.057	3.129ThrSer: 3.129 ± 0.05	3.076ThrThr: 3.076 ± 0.063	4.566ThrVal: 4.566 ± 0.099	0.638ThrTrp: 0.638 ± 0.024	1.41ThrTyr: 1.41 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	8.38ValAla: 8.38 ± 0.1	0.715ValCys: 0.715 ± 0.024	4.129ValAsp: 4.129 ± 0.065	4.309ValGlu: 4.309 ± 0.073	2.964ValPhe: 2.964 ± 0.044	5.582ValGly: 5.582 ± 0.076	1.299ValHis: 1.299 ± 0.028	4.593ValIle: 4.593 ± 0.067	2.32ValLys: 2.32 ± 0.052	7.322ValLeu: 7.322 ± 0.097	2.379ValMet: 2.379 ± 0.045	2.125ValAsn: 2.125 ± 0.049	3.614ValPro: 3.614 ± 0.059	2.38ValGln: 2.38 ± 0.044	4.188ValArg: 4.188 ± 0.066	4.293ValSer: 4.293 ± 0.066	4.833ValThr: 4.833 ± 0.115	5.645ValVal: 5.645 ± 0.089	0.963ValTrp: 0.963 ± 0.033	1.47ValTyr: 1.47 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.276TrpAla: 1.276 ± 0.037	0.136TrpCys: 0.136 ± 0.012	0.764TrpAsp: 0.764 ± 0.027	0.625TrpGlu: 0.625 ± 0.026	0.56TrpPhe: 0.56 ± 0.025	1.001TrpGly: 1.001 ± 0.031	0.326TrpHis: 0.326 ± 0.017	0.783TrpIle: 0.783 ± 0.032	0.445TrpLys: 0.445 ± 0.018	1.486TrpLeu: 1.486 ± 0.041	0.392TrpMet: 0.392 ± 0.017	0.403TrpAsn: 0.403 ± 0.022	0.623TrpPro: 0.623 ± 0.024	0.565TrpGln: 0.565 ± 0.024	1.017TrpArg: 1.017 ± 0.031	0.78TrpSer: 0.78 ± 0.024	0.762TrpThr: 0.762 ± 0.029	0.828TrpVal: 0.828 ± 0.024	0.206TrpTrp: 0.206 ± 0.013	0.26TrpTyr: 0.26 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.531TyrAla: 2.531 ± 0.05	0.253TyrCys: 0.253 ± 0.016	1.611TyrAsp: 1.611 ± 0.038	1.207TyrGlu: 1.207 ± 0.034	0.953TyrPhe: 0.953 ± 0.029	2.08TyrGly: 2.08 ± 0.048	0.501TyrHis: 0.501 ± 0.023	1.079TyrIle: 1.079 ± 0.032	0.689TyrLys: 0.689 ± 0.024	2.265TyrLeu: 2.265 ± 0.05	0.532TyrMet: 0.532 ± 0.022	0.662TyrAsn: 0.662 ± 0.022	1.025TyrPro: 1.025 ± 0.031	0.66TyrGln: 0.66 ± 0.021	1.404TyrArg: 1.404 ± 0.036	1.243TyrSer: 1.243 ± 0.033	1.306TyrThr: 1.306 ± 0.051	1.516TyrVal: 1.516 ± 0.035	0.344TyrTrp: 0.344 ± 0.017	0.606TyrTyr: 0.606 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3751 proteins (1167314 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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