Amino acid dipepetide frequency for Corynebacterium pyruviciproducens ATCC BAA-1742

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.758AlaAla: 12.758 ± 0.191	1.06AlaCys: 1.06 ± 0.043	6.384AlaAsp: 6.384 ± 0.096	6.941AlaGlu: 6.941 ± 0.11	3.468AlaPhe: 3.468 ± 0.074	9.371AlaGly: 9.371 ± 0.129	2.427AlaHis: 2.427 ± 0.067	5.406AlaIle: 5.406 ± 0.094	3.824AlaLys: 3.824 ± 0.09	10.782AlaLeu: 10.782 ± 0.148	2.587AlaMet: 2.587 ± 0.061	2.734AlaAsn: 2.734 ± 0.064	5.064AlaPro: 5.064 ± 0.138	3.652AlaGln: 3.652 ± 0.069	6.603AlaArg: 6.603 ± 0.114	5.95AlaSer: 5.95 ± 0.089	7.498AlaThr: 7.498 ± 0.122	8.854AlaVal: 8.854 ± 0.146	1.362AlaTrp: 1.362 ± 0.047	2.329AlaTyr: 2.329 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.004CysAla: 1.004 ± 0.039	0.104CysCys: 0.104 ± 0.012	0.57CysAsp: 0.57 ± 0.03	0.495CysGlu: 0.495 ± 0.026	0.288CysPhe: 0.288 ± 0.02	0.915CysGly: 0.915 ± 0.035	0.22CysHis: 0.22 ± 0.019	0.379CysIle: 0.379 ± 0.024	0.232CysLys: 0.232 ± 0.018	0.648CysLeu: 0.648 ± 0.03	0.152CysMet: 0.152 ± 0.012	0.214CysAsn: 0.214 ± 0.018	0.469CysPro: 0.469 ± 0.03	0.234CysGln: 0.234 ± 0.016	0.39CysArg: 0.39 ± 0.026	0.556CysSer: 0.556 ± 0.025	0.542CysThr: 0.542 ± 0.027	0.704CysVal: 0.704 ± 0.032	0.102CysTrp: 0.102 ± 0.012	0.22CysTyr: 0.22 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.155AspAla: 6.155 ± 0.103	0.424AspCys: 0.424 ± 0.025	3.436AspAsp: 3.436 ± 0.087	4.623AspGlu: 4.623 ± 0.092	2.093AspPhe: 2.093 ± 0.057	5.491AspGly: 5.491 ± 0.162	1.334AspHis: 1.334 ± 0.046	3.047AspIle: 3.047 ± 0.064	2.545AspLys: 2.545 ± 0.071	5.18AspLeu: 5.18 ± 0.094	1.184AspMet: 1.184 ± 0.043	1.749AspAsn: 1.749 ± 0.049	3.949AspPro: 3.949 ± 0.091	1.704AspGln: 1.704 ± 0.048	3.286AspArg: 3.286 ± 0.066	3.463AspSer: 3.463 ± 0.07	3.482AspThr: 3.482 ± 0.069	4.721AspVal: 4.721 ± 0.08	0.748AspTrp: 0.748 ± 0.03	1.63AspTyr: 1.63 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.61GluAla: 6.61 ± 0.109	0.444GluCys: 0.444 ± 0.026	3.633GluAsp: 3.633 ± 0.064	4.824GluGlu: 4.824 ± 0.096	2.102GluPhe: 2.102 ± 0.057	4.497GluGly: 4.497 ± 0.082	1.403GluHis: 1.403 ± 0.044	3.386GluIle: 3.386 ± 0.069	3.218GluLys: 3.218 ± 0.073	6.448GluLeu: 6.448 ± 0.096	1.311GluMet: 1.311 ± 0.042	2.029GluAsn: 2.029 ± 0.056	2.875GluPro: 2.875 ± 0.064	2.347GluGln: 2.347 ± 0.061	3.766GluArg: 3.766 ± 0.079	3.19GluSer: 3.19 ± 0.066	3.337GluThr: 3.337 ± 0.064	4.986GluVal: 4.986 ± 0.089	0.795GluTrp: 0.795 ± 0.034	1.476GluTyr: 1.476 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.636PheAla: 3.636 ± 0.065	0.285PheCys: 0.285 ± 0.018	2.336PheAsp: 2.336 ± 0.05	1.823PheGlu: 1.823 ± 0.054	1.393PhePhe: 1.393 ± 0.048	3.236PheGly: 3.236 ± 0.071	0.831PheHis: 0.831 ± 0.037	1.786PheIle: 1.786 ± 0.051	0.923PheLys: 0.923 ± 0.036	3.09PheLeu: 3.09 ± 0.068	0.703PheMet: 0.703 ± 0.033	1.092PheAsn: 1.092 ± 0.04	1.604PhePro: 1.604 ± 0.044	0.86PheGln: 0.86 ± 0.03	1.639PheArg: 1.639 ± 0.043	2.286PheSer: 2.286 ± 0.065	2.555PheThr: 2.555 ± 0.06	2.796PheVal: 2.796 ± 0.059	0.416PheTrp: 0.416 ± 0.023	0.85PheTyr: 0.85 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	8.303GlyAla: 8.303 ± 0.126	0.823GlyCys: 0.823 ± 0.037	4.835GlyAsp: 4.835 ± 0.11	5.295GlyGlu: 5.295 ± 0.078	3.211GlyPhe: 3.211 ± 0.061	6.74GlyGly: 6.74 ± 0.122	1.956GlyHis: 1.956 ± 0.049	4.941GlyIle: 4.941 ± 0.082	3.668GlyLys: 3.668 ± 0.077	8.065GlyLeu: 8.065 ± 0.109	2.029GlyMet: 2.029 ± 0.051	2.391GlyAsn: 2.391 ± 0.06	3.161GlyPro: 3.161 ± 0.059	2.504GlyGln: 2.504 ± 0.059	4.475GlyArg: 4.475 ± 0.094	5.02GlySer: 5.02 ± 0.087	5.678GlyThr: 5.678 ± 0.119	6.851GlyVal: 6.851 ± 0.101	1.352GlyTrp: 1.352 ± 0.045	2.373GlyTyr: 2.373 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.083HisAla: 2.083 ± 0.054	0.211HisCys: 0.211 ± 0.014	1.287HisAsp: 1.287 ± 0.043	1.304HisGlu: 1.304 ± 0.049	0.705HisPhe: 0.705 ± 0.033	2.039HisGly: 2.039 ± 0.05	0.575HisHis: 0.575 ± 0.034	1.093HisIle: 1.093 ± 0.043	0.644HisLys: 0.644 ± 0.029	1.97HisLeu: 1.97 ± 0.049	0.502HisMet: 0.502 ± 0.027	0.712HisAsn: 0.712 ± 0.034	1.58HisPro: 1.58 ± 0.044	0.658HisGln: 0.658 ± 0.034	1.381HisArg: 1.381 ± 0.04	1.274HisSer: 1.274 ± 0.046	1.398HisThr: 1.398 ± 0.039	1.723HisVal: 1.723 ± 0.05	0.275HisTrp: 0.275 ± 0.019	0.604HisTyr: 0.604 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.412IleAla: 6.412 ± 0.102	0.456IleCys: 0.456 ± 0.024	3.545IleAsp: 3.545 ± 0.066	2.97IleGlu: 2.97 ± 0.067	1.637IlePhe: 1.637 ± 0.051	4.422IleGly: 4.422 ± 0.078	1.045IleHis: 1.045 ± 0.035	2.774IleIle: 2.774 ± 0.066	1.489IleLys: 1.489 ± 0.049	4.326IleLeu: 4.326 ± 0.08	1.005IleMet: 1.005 ± 0.039	1.545IleAsn: 1.545 ± 0.042	2.964IlePro: 2.964 ± 0.068	1.211IleGln: 1.211 ± 0.041	2.685IleArg: 2.685 ± 0.061	2.979IleSer: 2.979 ± 0.063	3.569IleThr: 3.569 ± 0.076	4.706IleVal: 4.706 ± 0.071	0.453IleTrp: 0.453 ± 0.026	1.121IleTyr: 1.121 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.876LysAla: 3.876 ± 0.086	0.191LysCys: 0.191 ± 0.017	2.614LysAsp: 2.614 ± 0.086	2.629LysGlu: 2.629 ± 0.066	1.025LysPhe: 1.025 ± 0.037	2.491LysGly: 2.491 ± 0.064	0.789LysHis: 0.789 ± 0.033	1.836LysIle: 1.836 ± 0.052	2.394LysLys: 2.394 ± 0.078	3.491LysLeu: 3.491 ± 0.083	0.988LysMet: 0.988 ± 0.031	1.441LysAsn: 1.441 ± 0.046	2.062LysPro: 2.062 ± 0.069	1.407LysGln: 1.407 ± 0.044	2.33LysArg: 2.33 ± 0.056	1.886LysSer: 1.886 ± 0.051	2.262LysThr: 2.262 ± 0.067	2.906LysVal: 2.906 ± 0.072	0.419LysTrp: 0.419 ± 0.024	0.901LysTyr: 0.901 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	11.226LeuAla: 11.226 ± 0.167	0.753LeuCys: 0.753 ± 0.031	5.574LeuAsp: 5.574 ± 0.082	4.87LeuGlu: 4.87 ± 0.089	2.969LeuPhe: 2.969 ± 0.072	7.961LeuGly: 7.961 ± 0.111	1.909LeuHis: 1.909 ± 0.058	4.847LeuIle: 4.847 ± 0.091	3.174LeuLys: 3.174 ± 0.072	8.07LeuLeu: 8.07 ± 0.134	1.951LeuMet: 1.951 ± 0.053	2.466LeuAsn: 2.466 ± 0.048	5.084LeuPro: 5.084 ± 0.081	2.455LeuGln: 2.455 ± 0.056	5.471LeuArg: 5.471 ± 0.097	5.606LeuSer: 5.606 ± 0.093	6.899LeuThr: 6.899 ± 0.104	8.11LeuVal: 8.11 ± 0.13	1.048LeuTrp: 1.048 ± 0.042	1.868LeuTyr: 1.868 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.364MetAla: 2.364 ± 0.056	0.223MetCys: 0.223 ± 0.018	1.138MetAsp: 1.138 ± 0.04	1.183MetGlu: 1.183 ± 0.041	0.753MetPhe: 0.753 ± 0.032	1.808MetGly: 1.808 ± 0.055	0.451MetHis: 0.451 ± 0.027	1.056MetIle: 1.056 ± 0.037	0.932MetLys: 0.932 ± 0.035	1.95MetLeu: 1.95 ± 0.059	0.47MetMet: 0.47 ± 0.028	0.771MetAsn: 0.771 ± 0.034	1.057MetPro: 1.057 ± 0.04	0.65MetGln: 0.65 ± 0.029	1.416MetArg: 1.416 ± 0.041	1.596MetSer: 1.596 ± 0.048	1.575MetThr: 1.575 ± 0.044	1.774MetVal: 1.774 ± 0.052	0.319MetTrp: 0.319 ± 0.02	0.502MetTyr: 0.502 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.97AsnAla: 2.97 ± 0.057	0.225AsnCys: 0.225 ± 0.018	1.531AsnAsp: 1.531 ± 0.05	1.719AsnGlu: 1.719 ± 0.047	1.032AsnPhe: 1.032 ± 0.044	2.38AsnGly: 2.38 ± 0.073	0.653AsnHis: 0.653 ± 0.033	1.438AsnIle: 1.438 ± 0.043	1.247AsnLys: 1.247 ± 0.049	2.635AsnLeu: 2.635 ± 0.06	0.589AsnMet: 0.589 ± 0.025	0.993AsnAsn: 0.993 ± 0.058	2.32AsnPro: 2.32 ± 0.065	0.932AsnGln: 0.932 ± 0.036	1.69AsnArg: 1.69 ± 0.051	1.685AsnSer: 1.685 ± 0.044	1.619AsnThr: 1.619 ± 0.04	2.252AsnVal: 2.252 ± 0.063	0.43AsnTrp: 0.43 ± 0.024	0.823AsnTyr: 0.823 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.809ProAla: 5.809 ± 0.121	0.332ProCys: 0.332 ± 0.022	3.295ProAsp: 3.295 ± 0.083	4.178ProGlu: 4.178 ± 0.078	1.672ProPhe: 1.672 ± 0.048	4.614ProGly: 4.614 ± 0.104	1.216ProHis: 1.216 ± 0.043	2.203ProIle: 2.203 ± 0.042	1.736ProLys: 1.736 ± 0.06	4.499ProLeu: 4.499 ± 0.085	0.997ProMet: 0.997 ± 0.033	1.418ProAsn: 1.418 ± 0.05	1.966ProPro: 1.966 ± 0.057	1.989ProGln: 1.989 ± 0.057	2.793ProArg: 2.793 ± 0.066	3.024ProSer: 3.024 ± 0.067	3.643ProThr: 3.643 ± 0.082	4.486ProVal: 4.486 ± 0.088	0.755ProTrp: 0.755 ± 0.033	1.196ProTyr: 1.196 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.609GlnAla: 3.609 ± 0.073	0.193GlnCys: 0.193 ± 0.016	1.449GlnAsp: 1.449 ± 0.038	1.913GlnGlu: 1.913 ± 0.053	0.993GlnPhe: 0.993 ± 0.041	2.204GlnGly: 2.204 ± 0.059	0.675GlnHis: 0.675 ± 0.029	1.581GlnIle: 1.581 ± 0.049	1.289GlnLys: 1.289 ± 0.039	3.381GlnLeu: 3.381 ± 0.064	0.827GlnMet: 0.827 ± 0.033	0.772GlnAsn: 0.772 ± 0.031	1.571GlnPro: 1.571 ± 0.051	1.325GlnGln: 1.325 ± 0.059	2.091GlnArg: 2.091 ± 0.06	1.663GlnSer: 1.663 ± 0.045	1.593GlnThr: 1.593 ± 0.051	2.485GlnVal: 2.485 ± 0.056	0.526GlnTrp: 0.526 ± 0.024	0.755GlnTyr: 0.755 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.864ArgAla: 5.864 ± 0.109	0.463ArgCys: 0.463 ± 0.025	3.477ArgAsp: 3.477 ± 0.064	3.892ArgGlu: 3.892 ± 0.076	2.143ArgPhe: 2.143 ± 0.052	4.409ArgGly: 4.409 ± 0.091	1.357ArgHis: 1.357 ± 0.042	3.051ArgIle: 3.051 ± 0.062	2.308ArgLys: 2.308 ± 0.064	5.263ArgLeu: 5.263 ± 0.098	1.466ArgMet: 1.466 ± 0.047	1.704ArgAsn: 1.704 ± 0.046	2.751ArgPro: 2.751 ± 0.071	1.834ArgGln: 1.834 ± 0.055	4.42ArgArg: 4.42 ± 0.094	3.289ArgSer: 3.289 ± 0.069	3.394ArgThr: 3.394 ± 0.071	4.538ArgVal: 4.538 ± 0.093	0.879ArgTrp: 0.879 ± 0.036	1.575ArgTyr: 1.575 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.19SerAla: 6.19 ± 0.099	0.474SerCys: 0.474 ± 0.028	3.339SerAsp: 3.339 ± 0.076	3.204SerGlu: 3.204 ± 0.063	2.17SerPhe: 2.17 ± 0.056	5.364SerGly: 5.364 ± 0.085	1.421SerHis: 1.421 ± 0.045	2.903SerIle: 2.903 ± 0.063	1.916SerLys: 1.916 ± 0.048	5.373SerLeu: 5.373 ± 0.097	1.465SerMet: 1.465 ± 0.042	1.617SerAsn: 1.617 ± 0.046	3.002SerPro: 3.002 ± 0.064	1.828SerGln: 1.828 ± 0.055	3.353SerArg: 3.353 ± 0.075	4.012SerSer: 4.012 ± 0.082	4.219SerThr: 4.219 ± 0.08	4.591SerVal: 4.591 ± 0.086	0.95SerTrp: 0.95 ± 0.039	1.505SerTyr: 1.505 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	7.134ThrAla: 7.134 ± 0.118	0.591ThrCys: 0.591 ± 0.028	4.112ThrAsp: 4.112 ± 0.096	3.392ThrGlu: 3.392 ± 0.068	2.257ThrPhe: 2.257 ± 0.059	5.748ThrGly: 5.748 ± 0.088	1.366ThrHis: 1.366 ± 0.042	3.504ThrIle: 3.504 ± 0.073	2.198ThrLys: 2.198 ± 0.058	5.992ThrLeu: 5.992 ± 0.087	1.331ThrMet: 1.331 ± 0.047	1.799ThrAsn: 1.799 ± 0.05	4.216ThrPro: 4.216 ± 0.09	1.886ThrGln: 1.886 ± 0.049	3.477ThrArg: 3.477 ± 0.065	3.903ThrSer: 3.903 ± 0.082	4.582ThrThr: 4.582 ± 0.111	6.511ThrVal: 6.511 ± 0.135	0.926ThrTrp: 0.926 ± 0.038	1.657ThrTyr: 1.657 ± 0.064	0.0ThrXaa: 0.0 ± 0.0
Val	9.3ValAla: 9.3 ± 0.152	0.808ValCys: 0.808 ± 0.033	5.541ValAsp: 5.541 ± 0.085	5.165ValGlu: 5.165 ± 0.09	2.732ValPhe: 2.732 ± 0.075	6.892ValGly: 6.892 ± 0.115	1.628ValHis: 1.628 ± 0.05	4.333ValIle: 4.333 ± 0.079	2.905ValLys: 2.905 ± 0.079	7.415ValLeu: 7.415 ± 0.115	1.577ValMet: 1.577 ± 0.05	2.445ValAsn: 2.445 ± 0.067	4.266ValPro: 4.266 ± 0.079	2.065ValGln: 2.065 ± 0.05	4.533ValArg: 4.533 ± 0.092	5.151ValSer: 5.151 ± 0.105	6.464ValThr: 6.464 ± 0.131	7.288ValVal: 7.288 ± 0.109	1.045ValTrp: 1.045 ± 0.041	1.721ValTyr: 1.721 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.354TrpAla: 1.354 ± 0.049	0.155TrpCys: 0.155 ± 0.015	0.737TrpAsp: 0.737 ± 0.029	0.744TrpGlu: 0.744 ± 0.034	0.538TrpPhe: 0.538 ± 0.036	0.967TrpGly: 0.967 ± 0.035	0.274TrpHis: 0.274 ± 0.016	0.716TrpIle: 0.716 ± 0.03	0.503TrpLys: 0.503 ± 0.025	1.433TrpLeu: 1.433 ± 0.042	0.364TrpMet: 0.364 ± 0.02	0.494TrpAsn: 0.494 ± 0.026	0.552TrpPro: 0.552 ± 0.03	0.518TrpGln: 0.518 ± 0.023	0.805TrpArg: 0.805 ± 0.035	0.781TrpSer: 0.781 ± 0.033	0.758TrpThr: 0.758 ± 0.032	1.146TrpVal: 1.146 ± 0.045	0.298TrpTrp: 0.298 ± 0.022	0.32TrpTyr: 0.32 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.396TyrAla: 2.396 ± 0.061	0.223TyrCys: 0.223 ± 0.019	1.409TyrAsp: 1.409 ± 0.05	1.513TyrGlu: 1.513 ± 0.05	0.96TyrPhe: 0.96 ± 0.039	2.123TyrGly: 2.123 ± 0.053	0.49TyrHis: 0.49 ± 0.024	1.034TyrIle: 1.034 ± 0.037	0.795TyrLys: 0.795 ± 0.041	2.3TyrLeu: 2.3 ± 0.059	0.488TyrMet: 0.488 ± 0.026	0.776TyrAsn: 0.776 ± 0.033	1.311TyrPro: 1.311 ± 0.057	0.833TyrGln: 0.833 ± 0.034	1.472TyrArg: 1.472 ± 0.051	1.582TyrSer: 1.582 ± 0.045	1.516TyrThr: 1.516 ± 0.048	1.846TyrVal: 1.846 ± 0.052	0.357TyrTrp: 0.357 ± 0.019	0.618TyrTyr: 0.618 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2443 proteins (781148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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