Amino acid dipepetide frequency for Flavihumibacter solisilvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.375AlaAla: 7.375 ± 0.091
0.749AlaCys: 0.749 ± 0.024
4.354AlaAsp: 4.354 ± 0.056
4.429AlaGlu: 4.429 ± 0.055
3.739AlaPhe: 3.739 ± 0.05
6.669AlaGly: 6.669 ± 0.076
1.315AlaHis: 1.315 ± 0.032
5.42AlaIle: 5.42 ± 0.07
3.919AlaLys: 3.919 ± 0.056
6.93AlaLeu: 6.93 ± 0.082
1.965AlaMet: 1.965 ± 0.035
3.501AlaAsn: 3.501 ± 0.056
2.578AlaPro: 2.578 ± 0.051
2.61AlaGln: 2.61 ± 0.041
3.39AlaArg: 3.39 ± 0.048
4.886AlaSer: 4.886 ± 0.065
4.354AlaThr: 4.354 ± 0.068
5.237AlaVal: 5.237 ± 0.067
1.005AlaTrp: 1.005 ± 0.028
2.75AlaTyr: 2.75 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.547CysAla: 0.547 ± 0.023
0.156CysCys: 0.156 ± 0.012
0.398CysAsp: 0.398 ± 0.016
0.432CysGlu: 0.432 ± 0.017
0.451CysPhe: 0.451 ± 0.019
0.68CysGly: 0.68 ± 0.024
0.21CysHis: 0.21 ± 0.012
0.651CysIle: 0.651 ± 0.021
0.381CysLys: 0.381 ± 0.015
0.795CysLeu: 0.795 ± 0.025
0.245CysMet: 0.245 ± 0.013
0.401CysAsn: 0.401 ± 0.019
0.359CysPro: 0.359 ± 0.017
0.249CysGln: 0.249 ± 0.014
0.42CysArg: 0.42 ± 0.017
0.594CysSer: 0.594 ± 0.021
0.473CysThr: 0.473 ± 0.016
0.426CysVal: 0.426 ± 0.017
0.132CysTrp: 0.132 ± 0.01
0.335CysTyr: 0.335 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.041AspAla: 4.041 ± 0.054
0.394AspCys: 0.394 ± 0.017
2.542AspAsp: 2.542 ± 0.05
3.322AspGlu: 3.322 ± 0.049
2.798AspPhe: 2.798 ± 0.05
3.895AspGly: 3.895 ± 0.071
1.109AspHis: 1.109 ± 0.029
3.563AspIle: 3.563 ± 0.047
3.312AspLys: 3.312 ± 0.049
5.007AspLeu: 5.007 ± 0.065
1.156AspMet: 1.156 ± 0.025
2.548AspAsn: 2.548 ± 0.045
2.46AspPro: 2.46 ± 0.046
1.799AspGln: 1.799 ± 0.031
2.595AspArg: 2.595 ± 0.04
3.2AspSer: 3.2 ± 0.051
2.432AspThr: 2.432 ± 0.041
3.225AspVal: 3.225 ± 0.05
0.892AspTrp: 0.892 ± 0.024
2.315AspTyr: 2.315 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
4.379GluAla: 4.379 ± 0.06
0.377GluCys: 0.377 ± 0.016
2.589GluAsp: 2.589 ± 0.048
3.798GluGlu: 3.798 ± 0.065
2.436GluPhe: 2.436 ± 0.044
3.678GluGly: 3.678 ± 0.057
1.123GluHis: 1.123 ± 0.031
4.033GluIle: 4.033 ± 0.053
4.906GluLys: 4.906 ± 0.073
5.745GluLeu: 5.745 ± 0.072
1.681GluMet: 1.681 ± 0.035
3.069GluAsn: 3.069 ± 0.042
1.948GluPro: 1.948 ± 0.038
2.514GluGln: 2.514 ± 0.046
2.707GluArg: 2.707 ± 0.046
3.135GluSer: 3.135 ± 0.045
2.987GluThr: 2.987 ± 0.044
3.907GluVal: 3.907 ± 0.058
0.875GluTrp: 0.875 ± 0.024
2.051GluTyr: 2.051 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.476PheAla: 3.476 ± 0.048
0.427PheCys: 0.427 ± 0.019
2.866PheAsp: 2.866 ± 0.049
2.631PheGlu: 2.631 ± 0.045
2.413PhePhe: 2.413 ± 0.054
3.549PheGly: 3.549 ± 0.054
0.934PheHis: 0.934 ± 0.025
3.265PheIle: 3.265 ± 0.055
2.249PheLys: 2.249 ± 0.044
4.392PheLeu: 4.392 ± 0.068
1.074PheMet: 1.074 ± 0.026
2.713PheAsn: 2.713 ± 0.048
1.918PhePro: 1.918 ± 0.039
1.482PheGln: 1.482 ± 0.033
2.796PheArg: 2.796 ± 0.044
3.662PheSer: 3.662 ± 0.053
3.152PheThr: 3.152 ± 0.05
2.941PheVal: 2.941 ± 0.051
0.628PheTrp: 0.628 ± 0.021
1.902PheTyr: 1.902 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
4.773GlyAla: 4.773 ± 0.063
0.758GlyCys: 0.758 ± 0.031
3.545GlyAsp: 3.545 ± 0.055
3.768GlyGlu: 3.768 ± 0.06
3.796GlyPhe: 3.796 ± 0.061
5.371GlyGly: 5.371 ± 0.082
1.344GlyHis: 1.344 ± 0.03
5.408GlyIle: 5.408 ± 0.061
5.412GlyLys: 5.412 ± 0.067
6.364GlyLeu: 6.364 ± 0.069
1.978GlyMet: 1.978 ± 0.045
4.004GlyAsn: 4.004 ± 0.062
1.87GlyPro: 1.87 ± 0.039
2.464GlyGln: 2.464 ± 0.042
3.367GlyArg: 3.367 ± 0.055
4.755GlySer: 4.755 ± 0.07
4.53GlyThr: 4.53 ± 0.082
4.536GlyVal: 4.536 ± 0.057
1.18GlyTrp: 1.18 ± 0.032
3.111GlyTyr: 3.111 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.378HisAla: 1.378 ± 0.033
0.193HisCys: 0.193 ± 0.011
0.946HisAsp: 0.946 ± 0.025
1.094HisGlu: 1.094 ± 0.026
1.186HisPhe: 1.186 ± 0.03
1.256HisGly: 1.256 ± 0.033
0.555HisHis: 0.555 ± 0.023
1.292HisIle: 1.292 ± 0.029
0.931HisLys: 0.931 ± 0.026
1.998HisLeu: 1.998 ± 0.041
0.423HisMet: 0.423 ± 0.018
0.94HisAsn: 0.94 ± 0.025
1.174HisPro: 1.174 ± 0.031
0.735HisGln: 0.735 ± 0.023
0.963HisArg: 0.963 ± 0.029
1.197HisSer: 1.197 ± 0.029
1.039HisThr: 1.039 ± 0.026
1.088HisVal: 1.088 ± 0.028
0.289HisTrp: 0.289 ± 0.016
0.932HisTyr: 0.932 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.548IleAla: 5.548 ± 0.067
0.698IleCys: 0.698 ± 0.023
3.861IleAsp: 3.861 ± 0.054
3.888IleGlu: 3.888 ± 0.055
2.934IlePhe: 2.934 ± 0.055
4.624IleGly: 4.624 ± 0.065
1.334IleHis: 1.334 ± 0.033
4.382IleIle: 4.382 ± 0.068
3.404IleLys: 3.404 ± 0.049
5.843IleLeu: 5.843 ± 0.076
1.362IleMet: 1.362 ± 0.033
3.494IleAsn: 3.494 ± 0.056
3.161IlePro: 3.161 ± 0.049
2.153IleGln: 2.153 ± 0.04
3.822IleArg: 3.822 ± 0.051
4.9IleSer: 4.9 ± 0.062
4.261IleThr: 4.261 ± 0.057
4.113IleVal: 4.113 ± 0.064
0.71IleTrp: 0.71 ± 0.025
2.239IleTyr: 2.239 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.681LysAla: 4.681 ± 0.059
0.327LysCys: 0.327 ± 0.015
3.447LysAsp: 3.447 ± 0.052
4.306LysGlu: 4.306 ± 0.068
2.26LysPhe: 2.26 ± 0.041
4.332LysGly: 4.332 ± 0.061
1.105LysHis: 1.105 ± 0.029
3.799LysIle: 3.799 ± 0.052
4.609LysLys: 4.609 ± 0.064
5.422LysLeu: 5.422 ± 0.065
1.767LysMet: 1.767 ± 0.034
3.047LysAsn: 3.047 ± 0.05
2.509LysPro: 2.509 ± 0.04
2.392LysGln: 2.392 ± 0.045
2.664LysArg: 2.664 ± 0.043
3.496LysSer: 3.496 ± 0.049
3.273LysThr: 3.273 ± 0.049
3.983LysVal: 3.983 ± 0.061
0.918LysTrp: 0.918 ± 0.027
2.327LysTyr: 2.327 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
7.443LeuAla: 7.443 ± 0.072
0.827LeuCys: 0.827 ± 0.027
4.667LeuAsp: 4.667 ± 0.052
5.198LeuGlu: 5.198 ± 0.063
4.627LeuPhe: 4.627 ± 0.074
5.867LeuGly: 5.867 ± 0.074
1.94LeuHis: 1.94 ± 0.042
5.493LeuIle: 5.493 ± 0.074
5.967LeuLys: 5.967 ± 0.068
9.757LeuLeu: 9.757 ± 0.121
2.203LeuMet: 2.203 ± 0.041
4.745LeuAsn: 4.745 ± 0.06
4.514LeuPro: 4.514 ± 0.061
4.193LeuGln: 4.193 ± 0.061
4.404LeuArg: 4.404 ± 0.053
6.518LeuSer: 6.518 ± 0.077
5.174LeuThr: 5.174 ± 0.052
6.741LeuVal: 6.741 ± 0.08
1.02LeuTrp: 1.02 ± 0.028
3.244LeuTyr: 3.244 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
1.948MetAla: 1.948 ± 0.038
0.146MetCys: 0.146 ± 0.011
1.283MetAsp: 1.283 ± 0.031
1.518MetGlu: 1.518 ± 0.036
0.891MetPhe: 0.891 ± 0.029
1.629MetGly: 1.629 ± 0.034
0.522MetHis: 0.522 ± 0.019
1.595MetIle: 1.595 ± 0.036
2.035MetLys: 2.035 ± 0.041
2.388MetLeu: 2.388 ± 0.045
0.627MetMet: 0.627 ± 0.023
1.303MetAsn: 1.303 ± 0.028
1.179MetPro: 1.179 ± 0.028
1.112MetGln: 1.112 ± 0.026
1.143MetArg: 1.143 ± 0.027
1.426MetSer: 1.426 ± 0.03
1.239MetThr: 1.239 ± 0.032
1.585MetVal: 1.585 ± 0.032
0.228MetTrp: 0.228 ± 0.012
0.718MetTyr: 0.718 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.83AsnAla: 3.83 ± 0.052
0.418AsnCys: 0.418 ± 0.018
2.691AsnAsp: 2.691 ± 0.047
2.917AsnGlu: 2.917 ± 0.046
2.339AsnPhe: 2.339 ± 0.043
4.176AsnGly: 4.176 ± 0.064
0.927AsnHis: 0.927 ± 0.03
3.514AsnIle: 3.514 ± 0.048
2.862AsnLys: 2.862 ± 0.047
4.453AsnLeu: 4.453 ± 0.066
1.172AsnMet: 1.172 ± 0.029
2.893AsnAsn: 2.893 ± 0.059
2.564AsnPro: 2.564 ± 0.048
1.699AsnGln: 1.699 ± 0.035
2.673AsnArg: 2.673 ± 0.045
3.076AsnSer: 3.076 ± 0.046
2.922AsnThr: 2.922 ± 0.052
2.979AsnVal: 2.979 ± 0.041
0.788AsnTrp: 0.788 ± 0.024
2.19AsnTyr: 2.19 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.05ProAla: 4.05 ± 0.059
0.234ProCys: 0.234 ± 0.014
2.768ProAsp: 2.768 ± 0.042
2.887ProGlu: 2.887 ± 0.041
2.088ProPhe: 2.088 ± 0.039
3.75ProGly: 3.75 ± 0.059
0.762ProHis: 0.762 ± 0.022
2.15ProIle: 2.15 ± 0.043
1.859ProLys: 1.859 ± 0.036
3.616ProLeu: 3.616 ± 0.049
0.899ProMet: 0.899 ± 0.027
1.665ProAsn: 1.665 ± 0.035
1.385ProPro: 1.385 ± 0.039
1.399ProGln: 1.399 ± 0.034
1.494ProArg: 1.494 ± 0.03
2.437ProSer: 2.437 ± 0.043
1.914ProThr: 1.914 ± 0.034
3.947ProVal: 3.947 ± 0.053
0.519ProTrp: 0.519 ± 0.021
1.585ProTyr: 1.585 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.732GlnAla: 2.732 ± 0.044
0.234GlnCys: 0.234 ± 0.014
1.609GlnAsp: 1.609 ± 0.033
2.148GlnGlu: 2.148 ± 0.042
1.797GlnPhe: 1.797 ± 0.035
2.089GlnGly: 2.089 ± 0.041
0.862GlnHis: 0.862 ± 0.027
1.919GlnIle: 1.919 ± 0.035
2.194GlnLys: 2.194 ± 0.037
4.373GlnLeu: 4.373 ± 0.06
0.974GlnMet: 0.974 ± 0.029
1.538GlnAsn: 1.538 ± 0.036
1.78GlnPro: 1.78 ± 0.032
2.28GlnGln: 2.28 ± 0.053
1.731GlnArg: 1.731 ± 0.033
2.264GlnSer: 2.264 ± 0.037
1.874GlnThr: 1.874 ± 0.038
2.92GlnVal: 2.92 ± 0.047
0.518GlnTrp: 0.518 ± 0.021
1.564GlnTyr: 1.564 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.759ArgAla: 2.759 ± 0.046
0.276ArgCys: 0.276 ± 0.013
2.453ArgAsp: 2.453 ± 0.042
3.007ArgGlu: 3.007 ± 0.048
2.576ArgPhe: 2.576 ± 0.038
2.441ArgGly: 2.441 ± 0.041
0.984ArgHis: 0.984 ± 0.026
3.696ArgIle: 3.696 ± 0.055
3.492ArgLys: 3.492 ± 0.049
4.698ArgLeu: 4.698 ± 0.054
1.381ArgMet: 1.381 ± 0.031
2.943ArgAsn: 2.943 ± 0.045
1.8ArgPro: 1.8 ± 0.035
2.139ArgGln: 2.139 ± 0.04
2.161ArgArg: 2.161 ± 0.038
2.926ArgSer: 2.926 ± 0.041
2.468ArgThr: 2.468 ± 0.035
2.81ArgVal: 2.81 ± 0.049
0.692ArgTrp: 0.692 ± 0.023
2.141ArgTyr: 2.141 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.978SerAla: 4.978 ± 0.062
0.605SerCys: 0.605 ± 0.021
3.102SerAsp: 3.102 ± 0.052
3.114SerGlu: 3.114 ± 0.054
3.627SerPhe: 3.627 ± 0.058
5.456SerGly: 5.456 ± 0.061
1.156SerHis: 1.156 ± 0.026
4.551SerIle: 4.551 ± 0.063
3.312SerLys: 3.312 ± 0.053
6.44SerLeu: 6.44 ± 0.072
1.546SerMet: 1.546 ± 0.034
2.999SerAsn: 2.999 ± 0.053
2.637SerPro: 2.637 ± 0.043
2.157SerGln: 2.157 ± 0.039
3.21SerArg: 3.21 ± 0.044
4.127SerSer: 4.127 ± 0.067
3.583SerThr: 3.583 ± 0.054
4.279SerVal: 4.279 ± 0.053
1.003SerTrp: 1.003 ± 0.026
2.517SerTyr: 2.517 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.729ThrAla: 4.729 ± 0.068
0.42ThrCys: 0.42 ± 0.016
3.192ThrAsp: 3.192 ± 0.045
2.992ThrGlu: 2.992 ± 0.05
2.437ThrPhe: 2.437 ± 0.041
5.384ThrGly: 5.384 ± 0.072
1.027ThrHis: 1.027 ± 0.027
4.099ThrIle: 4.099 ± 0.062
2.565ThrLys: 2.565 ± 0.044
5.063ThrLeu: 5.063 ± 0.06
1.13ThrMet: 1.13 ± 0.029
2.62ThrAsn: 2.62 ± 0.049
2.537ThrPro: 2.537 ± 0.049
1.592ThrGln: 1.592 ± 0.035
2.5ThrArg: 2.5 ± 0.043
3.543ThrSer: 3.543 ± 0.055
3.465ThrThr: 3.465 ± 0.074
3.968ThrVal: 3.968 ± 0.059
0.798ThrTrp: 0.798 ± 0.025
2.151ThrTyr: 2.151 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.015ValAla: 5.015 ± 0.065
0.614ValCys: 0.614 ± 0.019
3.348ValAsp: 3.348 ± 0.049
3.646ValGlu: 3.646 ± 0.049
3.194ValPhe: 3.194 ± 0.052
3.802ValGly: 3.802 ± 0.054
1.244ValHis: 1.244 ± 0.032
4.824ValIle: 4.824 ± 0.063
4.145ValLys: 4.145 ± 0.053
6.217ValLeu: 6.217 ± 0.072
1.671ValMet: 1.671 ± 0.036
3.682ValAsn: 3.682 ± 0.044
2.881ValPro: 2.881 ± 0.047
2.292ValGln: 2.292 ± 0.043
2.99ValArg: 2.99 ± 0.047
4.675ValSer: 4.675 ± 0.064
4.136ValThr: 4.136 ± 0.07
4.58ValVal: 4.58 ± 0.064
0.732ValTrp: 0.732 ± 0.024
2.441ValTyr: 2.441 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.817TrpAla: 0.817 ± 0.026
0.115TrpCys: 0.115 ± 0.01
0.714TrpAsp: 0.714 ± 0.022
0.751TrpGlu: 0.751 ± 0.022
0.676TrpPhe: 0.676 ± 0.023
0.905TrpGly: 0.905 ± 0.028
0.301TrpHis: 0.301 ± 0.015
0.898TrpIle: 0.898 ± 0.026
1.029TrpLys: 1.029 ± 0.029
1.426TrpLeu: 1.426 ± 0.038
0.47TrpMet: 0.47 ± 0.019
0.849TrpAsn: 0.849 ± 0.024
0.438TrpPro: 0.438 ± 0.02
0.614TrpGln: 0.614 ± 0.021
0.625TrpArg: 0.625 ± 0.023
0.816TrpSer: 0.816 ± 0.025
0.735TrpThr: 0.735 ± 0.026
0.778TrpVal: 0.778 ± 0.024
0.269TrpTrp: 0.269 ± 0.013
0.545TrpTyr: 0.545 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.675TyrAla: 2.675 ± 0.038
0.369TyrCys: 0.369 ± 0.018
2.23TyrAsp: 2.23 ± 0.047
2.092TyrGlu: 2.092 ± 0.038
2.207TyrPhe: 2.207 ± 0.043
2.779TyrGly: 2.779 ± 0.048
0.858TyrHis: 0.858 ± 0.025
2.176TyrIle: 2.176 ± 0.035
2.08TyrLys: 2.08 ± 0.036
3.615TyrLeu: 3.615 ± 0.062
0.792TyrMet: 0.792 ± 0.022
2.131TyrAsn: 2.131 ± 0.043
1.715TyrPro: 1.715 ± 0.035
1.527TyrGln: 1.527 ± 0.035
2.19TyrArg: 2.19 ± 0.037
2.764TyrSer: 2.764 ± 0.047
2.202TyrThr: 2.202 ± 0.044
2.083TyrVal: 2.083 ± 0.037
0.575TyrTrp: 0.575 ± 0.022
1.781TyrTyr: 1.781 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4215 proteins (1510737 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski