Amino acid dipepetide frequency for Janibacter limosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.62AlaAla: 18.62 ± 0.187	0.895AlaCys: 0.895 ± 0.028	8.293AlaAsp: 8.293 ± 0.112	7.166AlaGlu: 7.166 ± 0.09	3.126AlaPhe: 3.126 ± 0.053	11.876AlaGly: 11.876 ± 0.137	2.781AlaHis: 2.781 ± 0.052	4.92AlaIle: 4.92 ± 0.078	3.026AlaLys: 3.026 ± 0.062	13.583AlaLeu: 13.583 ± 0.152	3.085AlaMet: 3.085 ± 0.061	1.833AlaAsn: 1.833 ± 0.044	6.161AlaPro: 6.161 ± 0.102	3.991AlaGln: 3.991 ± 0.057	9.294AlaArg: 9.294 ± 0.105	6.395AlaSer: 6.395 ± 0.085	7.81AlaThr: 7.81 ± 0.106	10.927AlaVal: 10.927 ± 0.116	1.953AlaTrp: 1.953 ± 0.047	2.027AlaTyr: 2.027 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.818CysAla: 0.818 ± 0.029	0.08CysCys: 0.08 ± 0.009	0.452CysAsp: 0.452 ± 0.02	0.353CysGlu: 0.353 ± 0.018	0.194CysPhe: 0.194 ± 0.012	0.829CysGly: 0.829 ± 0.032	0.16CysHis: 0.16 ± 0.014	0.241CysIle: 0.241 ± 0.017	0.102CysLys: 0.102 ± 0.01	0.647CysLeu: 0.647 ± 0.027	0.102CysMet: 0.102 ± 0.01	0.098CysAsn: 0.098 ± 0.01	0.419CysPro: 0.419 ± 0.02	0.162CysGln: 0.162 ± 0.012	0.527CysArg: 0.527 ± 0.024	0.402CysSer: 0.402 ± 0.019	0.466CysThr: 0.466 ± 0.022	0.504CysVal: 0.504 ± 0.021	0.082CysTrp: 0.082 ± 0.009	0.103CysTyr: 0.103 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.762AspAla: 7.762 ± 0.091	0.369AspCys: 0.369 ± 0.019	4.539AspAsp: 4.539 ± 0.081	4.982AspGlu: 4.982 ± 0.064	1.641AspPhe: 1.641 ± 0.043	6.219AspGly: 6.219 ± 0.091	1.589AspHis: 1.589 ± 0.041	2.358AspIle: 2.358 ± 0.043	1.428AspLys: 1.428 ± 0.044	7.576AspLeu: 7.576 ± 0.084	0.95AspMet: 0.95 ± 0.03	1.137AspAsn: 1.137 ± 0.031	4.562AspPro: 4.562 ± 0.073	1.798AspGln: 1.798 ± 0.038	4.62AspArg: 4.62 ± 0.078	2.771AspSer: 2.771 ± 0.048	3.029AspThr: 3.029 ± 0.053	5.854AspVal: 5.854 ± 0.073	0.957AspTrp: 0.957 ± 0.034	1.149AspTyr: 1.149 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.06GluAla: 7.06 ± 0.093	0.353GluCys: 0.353 ± 0.017	3.394GluAsp: 3.394 ± 0.063	3.237GluGlu: 3.237 ± 0.066	1.239GluPhe: 1.239 ± 0.033	5.021GluGly: 5.021 ± 0.075	1.872GluHis: 1.872 ± 0.043	2.722GluIle: 2.722 ± 0.054	1.017GluLys: 1.017 ± 0.038	6.163GluLeu: 6.163 ± 0.085	1.116GluMet: 1.116 ± 0.036	0.631GluAsn: 0.631 ± 0.025	2.895GluPro: 2.895 ± 0.061	2.469GluGln: 2.469 ± 0.052	5.322GluArg: 5.322 ± 0.082	2.885GluSer: 2.885 ± 0.056	2.916GluThr: 2.916 ± 0.055	5.662GluVal: 5.662 ± 0.082	0.815GluTrp: 0.815 ± 0.026	1.027GluTyr: 1.027 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.714PheAla: 3.714 ± 0.054	0.219PheCys: 0.219 ± 0.014	1.996PheAsp: 1.996 ± 0.039	1.429PheGlu: 1.429 ± 0.038	0.907PhePhe: 0.907 ± 0.035	2.908PheGly: 2.908 ± 0.059	0.553PheHis: 0.553 ± 0.024	0.948PheIle: 0.948 ± 0.034	0.451PheLys: 0.451 ± 0.021	2.213PheLeu: 2.213 ± 0.05	0.443PheMet: 0.443 ± 0.021	0.52PheAsn: 0.52 ± 0.022	1.209PhePro: 1.209 ± 0.033	0.541PheGln: 0.541 ± 0.023	1.373PheArg: 1.373 ± 0.035	1.289PheSer: 1.289 ± 0.039	1.776PheThr: 1.776 ± 0.043	2.729PheVal: 2.729 ± 0.048	0.38PheTrp: 0.38 ± 0.024	0.541PheTyr: 0.541 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.58GlyAla: 10.58 ± 0.131	0.725GlyCys: 0.725 ± 0.027	5.539GlyAsp: 5.539 ± 0.079	5.413GlyGlu: 5.413 ± 0.069	2.755GlyPhe: 2.755 ± 0.058	8.474GlyGly: 8.474 ± 0.12	2.308GlyHis: 2.308 ± 0.053	3.978GlyIle: 3.978 ± 0.062	2.276GlyLys: 2.276 ± 0.057	9.577GlyLeu: 9.577 ± 0.108	2.185GlyMet: 2.185 ± 0.047	1.57GlyAsn: 1.57 ± 0.038	4.414GlyPro: 4.414 ± 0.071	2.877GlyGln: 2.877 ± 0.06	7.185GlyArg: 7.185 ± 0.103	5.727GlySer: 5.727 ± 0.083	5.598GlyThr: 5.598 ± 0.077	8.013GlyVal: 8.013 ± 0.102	1.775GlyTrp: 1.775 ± 0.048	2.119GlyTyr: 2.119 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.631HisAla: 2.631 ± 0.053	0.186HisCys: 0.186 ± 0.014	1.716HisAsp: 1.716 ± 0.039	1.495HisGlu: 1.495 ± 0.04	0.586HisPhe: 0.586 ± 0.023	2.285HisGly: 2.285 ± 0.052	0.727HisHis: 0.727 ± 0.025	0.705HisIle: 0.705 ± 0.027	0.378HisLys: 0.378 ± 0.019	2.604HisLeu: 2.604 ± 0.05	0.334HisMet: 0.334 ± 0.02	0.363HisAsn: 0.363 ± 0.019	1.686HisPro: 1.686 ± 0.042	0.598HisGln: 0.598 ± 0.023	1.929HisArg: 1.929 ± 0.04	0.989HisSer: 0.989 ± 0.029	1.201HisThr: 1.201 ± 0.032	2.153HisVal: 2.153 ± 0.048	0.334HisTrp: 0.334 ± 0.019	0.408HisTyr: 0.408 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.925IleAla: 5.925 ± 0.085	0.314IleCys: 0.314 ± 0.019	3.1IleAsp: 3.1 ± 0.052	2.555IleGlu: 2.555 ± 0.055	1.046IlePhe: 1.046 ± 0.029	4.269IleGly: 4.269 ± 0.071	0.794IleHis: 0.794 ± 0.028	1.542IleIle: 1.542 ± 0.039	0.86IleLys: 0.86 ± 0.031	2.845IleLeu: 2.845 ± 0.066	0.583IleMet: 0.583 ± 0.025	0.867IleAsn: 0.867 ± 0.031	1.953IlePro: 1.953 ± 0.046	0.781IleGln: 0.781 ± 0.029	2.227IleArg: 2.227 ± 0.048	2.173IleSer: 2.173 ± 0.051	2.781IleThr: 2.781 ± 0.055	3.73IleVal: 3.73 ± 0.061	0.439IleTrp: 0.439 ± 0.021	0.599IleTyr: 0.599 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.622LysAla: 2.622 ± 0.065	0.082LysCys: 0.082 ± 0.009	1.498LysAsp: 1.498 ± 0.044	1.159LysGlu: 1.159 ± 0.037	0.499LysPhe: 0.499 ± 0.021	2.187LysGly: 2.187 ± 0.05	0.459LysHis: 0.459 ± 0.022	0.937LysIle: 0.937 ± 0.032	0.895LysLys: 0.895 ± 0.049	1.596LysLeu: 1.596 ± 0.042	0.438LysMet: 0.438 ± 0.021	0.497LysAsn: 0.497 ± 0.024	1.028LysPro: 1.028 ± 0.033	0.69LysGln: 0.69 ± 0.028	1.336LysArg: 1.336 ± 0.039	1.168LysSer: 1.168 ± 0.035	1.22LysThr: 1.22 ± 0.039	2.015LysVal: 2.015 ± 0.048	0.214LysTrp: 0.214 ± 0.015	0.417LysTyr: 0.417 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.566LeuAla: 14.566 ± 0.143	0.634LeuCys: 0.634 ± 0.028	6.919LeuAsp: 6.919 ± 0.095	5.353LeuGlu: 5.353 ± 0.076	2.299LeuPhe: 2.299 ± 0.049	9.68LeuGly: 9.68 ± 0.104	2.071LeuHis: 2.071 ± 0.041	3.33LeuIle: 3.33 ± 0.062	1.812LeuLys: 1.812 ± 0.048	10.426LeuLeu: 10.426 ± 0.131	1.759LeuMet: 1.759 ± 0.039	1.392LeuAsn: 1.392 ± 0.042	5.853LeuPro: 5.853 ± 0.069	2.412LeuGln: 2.412 ± 0.054	7.747LeuArg: 7.747 ± 0.097	5.449LeuSer: 5.449 ± 0.061	6.86LeuThr: 6.86 ± 0.083	10.472LeuVal: 10.472 ± 0.114	1.168LeuTrp: 1.168 ± 0.035	1.328LeuTyr: 1.328 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.518MetAla: 2.518 ± 0.053	0.145MetCys: 0.145 ± 0.012	1.044MetAsp: 1.044 ± 0.031	0.747MetGlu: 0.747 ± 0.03	0.442MetPhe: 0.442 ± 0.023	1.679MetGly: 1.679 ± 0.041	0.374MetHis: 0.374 ± 0.018	0.817MetIle: 0.817 ± 0.029	0.49MetLys: 0.49 ± 0.023	1.953MetLeu: 1.953 ± 0.041	0.339MetMet: 0.339 ± 0.02	0.368MetAsn: 0.368 ± 0.021	1.148MetPro: 1.148 ± 0.032	0.536MetGln: 0.536 ± 0.021	1.577MetArg: 1.577 ± 0.037	1.724MetSer: 1.724 ± 0.042	1.933MetThr: 1.933 ± 0.04	1.532MetVal: 1.532 ± 0.04	0.251MetTrp: 0.251 ± 0.016	0.317MetTyr: 0.317 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	1.899AsnAla: 1.899 ± 0.045	0.125AsnCys: 0.125 ± 0.01	0.936AsnAsp: 0.936 ± 0.032	0.802AsnGlu: 0.802 ± 0.03	0.482AsnPhe: 0.482 ± 0.02	1.356AsnGly: 1.356 ± 0.043	0.378AsnHis: 0.378 ± 0.017	0.685AsnIle: 0.685 ± 0.028	0.379AsnLys: 0.379 ± 0.019	1.679AsnLeu: 1.679 ± 0.039	0.282AsnMet: 0.282 ± 0.017	0.4AsnAsn: 0.4 ± 0.022	1.324AsnPro: 1.324 ± 0.036	0.494AsnGln: 0.494 ± 0.025	1.097AsnArg: 1.097 ± 0.038	0.816AsnSer: 0.816 ± 0.028	0.885AsnThr: 0.885 ± 0.029	1.362AsnVal: 1.362 ± 0.037	0.22AsnTrp: 0.22 ± 0.014	0.344AsnTyr: 0.344 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.722ProAla: 6.722 ± 0.102	0.275ProCys: 0.275 ± 0.016	4.136ProAsp: 4.136 ± 0.061	3.843ProGlu: 3.843 ± 0.061	1.751ProPhe: 1.751 ± 0.035	5.406ProGly: 5.406 ± 0.072	1.285ProHis: 1.285 ± 0.035	1.845ProIle: 1.845 ± 0.045	1.154ProLys: 1.154 ± 0.04	4.79ProLeu: 4.79 ± 0.072	1.159ProMet: 1.159 ± 0.036	0.756ProAsn: 0.756 ± 0.029	2.757ProPro: 2.757 ± 0.061	1.899ProGln: 1.899 ± 0.048	3.686ProArg: 3.686 ± 0.064	3.185ProSer: 3.185 ± 0.056	3.711ProThr: 3.711 ± 0.063	5.006ProVal: 5.006 ± 0.074	0.923ProTrp: 0.923 ± 0.034	0.909ProTyr: 0.909 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.588GlnAla: 3.588 ± 0.066	0.161GlnCys: 0.161 ± 0.015	1.613GlnAsp: 1.613 ± 0.039	1.586GlnGlu: 1.586 ± 0.038	0.627GlnPhe: 0.627 ± 0.027	2.412GlnGly: 2.412 ± 0.051	0.735GlnHis: 0.735 ± 0.026	1.301GlnIle: 1.301 ± 0.038	0.532GlnLys: 0.532 ± 0.025	3.164GlnLeu: 3.164 ± 0.059	0.66GlnMet: 0.66 ± 0.024	0.368GlnAsn: 0.368 ± 0.019	1.746GlnPro: 1.746 ± 0.044	1.293GlnGln: 1.293 ± 0.038	2.572GlnArg: 2.572 ± 0.05	1.396GlnSer: 1.396 ± 0.036	1.554GlnThr: 1.554 ± 0.036	2.924GlnVal: 2.924 ± 0.051	0.473GlnTrp: 0.473 ± 0.02	0.505GlnTyr: 0.505 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.845ArgAla: 8.845 ± 0.11	0.47ArgCys: 0.47 ± 0.022	4.408ArgAsp: 4.408 ± 0.073	4.738ArgGlu: 4.738 ± 0.066	1.915ArgPhe: 1.915 ± 0.041	5.726ArgGly: 5.726 ± 0.079	1.89ArgHis: 1.89 ± 0.037	3.149ArgIle: 3.149 ± 0.063	1.346ArgLys: 1.346 ± 0.042	7.845ArgLeu: 7.845 ± 0.109	1.691ArgMet: 1.691 ± 0.039	1.114ArgAsn: 1.114 ± 0.034	4.197ArgPro: 4.197 ± 0.065	2.218ArgGln: 2.218 ± 0.049	6.93ArgArg: 6.93 ± 0.123	4.269ArgSer: 4.269 ± 0.075	4.698ArgThr: 4.698 ± 0.069	6.314ArgVal: 6.314 ± 0.089	1.433ArgTrp: 1.433 ± 0.038	1.501ArgTyr: 1.501 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.606SerAla: 6.606 ± 0.085	0.357SerCys: 0.357 ± 0.021	3.297SerAsp: 3.297 ± 0.061	2.736SerGlu: 2.736 ± 0.048	1.582SerPhe: 1.582 ± 0.042	5.844SerGly: 5.844 ± 0.07	1.114SerHis: 1.114 ± 0.03	2.19SerIle: 2.19 ± 0.046	1.119SerLys: 1.119 ± 0.035	5.243SerLeu: 5.243 ± 0.065	1.423SerMet: 1.423 ± 0.035	0.869SerAsn: 0.869 ± 0.028	3.156SerPro: 3.156 ± 0.057	1.427SerGln: 1.427 ± 0.035	3.898SerArg: 3.898 ± 0.063	3.753SerSer: 3.753 ± 0.078	3.874SerThr: 3.874 ± 0.074	4.61SerVal: 4.61 ± 0.072	0.917SerTrp: 0.917 ± 0.028	1.045SerTyr: 1.045 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.631ThrAla: 7.631 ± 0.091	0.433ThrCys: 0.433 ± 0.022	4.001ThrAsp: 4.001 ± 0.06	3.075ThrGlu: 3.075 ± 0.052	1.813ThrPhe: 1.813 ± 0.042	6.118ThrGly: 6.118 ± 0.085	1.42ThrHis: 1.42 ± 0.036	2.653ThrIle: 2.653 ± 0.053	1.473ThrLys: 1.473 ± 0.041	5.717ThrLeu: 5.717 ± 0.073	1.204ThrMet: 1.204 ± 0.036	1.105ThrAsn: 1.105 ± 0.034	4.049ThrPro: 4.049 ± 0.063	1.779ThrGln: 1.779 ± 0.038	4.277ThrArg: 4.277 ± 0.064	4.061ThrSer: 4.061 ± 0.077	4.656ThrThr: 4.656 ± 0.077	5.422ThrVal: 5.422 ± 0.073	1.085ThrTrp: 1.085 ± 0.035	1.297ThrTyr: 1.297 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	11.818ValAla: 11.818 ± 0.135	0.632ValCys: 0.632 ± 0.027	6.32ValAsp: 6.32 ± 0.089	5.423ValGlu: 5.423 ± 0.074	2.2ValPhe: 2.2 ± 0.055	7.911ValGly: 7.911 ± 0.098	2.168ValHis: 2.168 ± 0.045	3.883ValIle: 3.883 ± 0.069	1.586ValLys: 1.586 ± 0.048	10.154ValLeu: 10.154 ± 0.116	1.627ValMet: 1.627 ± 0.038	1.456ValAsn: 1.456 ± 0.037	4.907ValPro: 4.907 ± 0.081	2.17ValGln: 2.17 ± 0.047	6.463ValArg: 6.463 ± 0.093	4.624ValSer: 4.624 ± 0.056	6.358ValThr: 6.358 ± 0.069	9.818ValVal: 9.818 ± 0.121	1.122ValTrp: 1.122 ± 0.033	1.255ValTyr: 1.255 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.735TrpAla: 1.735 ± 0.05	0.16TrpCys: 0.16 ± 0.012	0.801TrpAsp: 0.801 ± 0.033	0.681TrpGlu: 0.681 ± 0.026	0.488TrpPhe: 0.488 ± 0.019	1.111TrpGly: 1.111 ± 0.034	0.312TrpHis: 0.312 ± 0.016	0.641TrpIle: 0.641 ± 0.024	0.279TrpLys: 0.279 ± 0.014	1.838TrpLeu: 1.838 ± 0.046	0.328TrpMet: 0.328 ± 0.02	0.288TrpAsn: 0.288 ± 0.017	0.79TrpPro: 0.79 ± 0.028	0.611TrpGln: 0.611 ± 0.025	1.234TrpArg: 1.234 ± 0.039	1.046TrpSer: 1.046 ± 0.031	0.963TrpThr: 0.963 ± 0.03	1.268TrpVal: 1.268 ± 0.038	0.403TrpTrp: 0.403 ± 0.02	0.268TrpTyr: 0.268 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.105TyrAla: 2.105 ± 0.038	0.126TyrCys: 0.126 ± 0.01	1.289TyrAsp: 1.289 ± 0.04	1.045TyrGlu: 1.045 ± 0.035	0.547TyrPhe: 0.547 ± 0.026	1.776TyrGly: 1.776 ± 0.043	0.318TyrHis: 0.318 ± 0.016	0.54TyrIle: 0.54 ± 0.022	0.353TyrLys: 0.353 ± 0.02	1.919TyrLeu: 1.919 ± 0.046	0.224TyrMet: 0.224 ± 0.014	0.311TyrAsn: 0.311 ± 0.018	0.942TyrPro: 0.942 ± 0.034	0.466TyrGln: 0.466 ± 0.021	1.403TyrArg: 1.403 ± 0.043	0.938TyrSer: 0.938 ± 0.029	0.979TyrThr: 0.979 ± 0.033	1.582TyrVal: 1.582 ± 0.036	0.297TyrTrp: 0.297 ± 0.017	0.372TyrTyr: 0.372 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3282 proteins (1067424 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---