Amino acid dipepetide frequency for Mycobacterium virus Dlane

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.153AlaAla: 14.153 ± 1.53
0.965AlaCys: 0.965 ± 0.237
7.13AlaAsp: 7.13 ± 0.643
7.345AlaGlu: 7.345 ± 0.785
2.841AlaPhe: 2.841 ± 0.442
10.4AlaGly: 10.4 ± 1.235
2.359AlaHis: 2.359 ± 0.362
4.235AlaIle: 4.235 ± 0.516
3.86AlaLys: 3.86 ± 0.518
8.149AlaLeu: 8.149 ± 0.786
2.305AlaMet: 2.305 ± 0.337
2.52AlaAsn: 2.52 ± 0.36
5.093AlaPro: 5.093 ± 0.65
3.377AlaGln: 3.377 ± 0.404
7.559AlaArg: 7.559 ± 0.758
5.522AlaSer: 5.522 ± 0.64
5.576AlaThr: 5.576 ± 0.461
7.077AlaVal: 7.077 ± 0.582
2.734AlaTrp: 2.734 ± 0.41
2.412AlaTyr: 2.412 ± 0.292
0.0AlaXaa: 0.0 ± 0.0
Cys
0.965CysAla: 0.965 ± 0.247
0.054CysCys: 0.054 ± 0.056
1.608CysAsp: 1.608 ± 0.371
0.965CysGlu: 0.965 ± 0.24
0.107CysPhe: 0.107 ± 0.077
1.447CysGly: 1.447 ± 0.31
0.107CysHis: 0.107 ± 0.085
0.375CysIle: 0.375 ± 0.182
0.482CysLys: 0.482 ± 0.185
0.697CysLeu: 0.697 ± 0.212
0.214CysMet: 0.214 ± 0.106
0.268CysAsn: 0.268 ± 0.113
1.233CysPro: 1.233 ± 0.354
0.429CysGln: 0.429 ± 0.158
0.697CysArg: 0.697 ± 0.182
0.536CysSer: 0.536 ± 0.173
0.751CysThr: 0.751 ± 0.171
0.536CysVal: 0.536 ± 0.162
0.268CysTrp: 0.268 ± 0.114
0.107CysTyr: 0.107 ± 0.073
0.0CysXaa: 0.0 ± 0.0
Asp
7.345AspAla: 7.345 ± 0.686
1.072AspCys: 1.072 ± 0.248
4.611AspAsp: 4.611 ± 0.606
3.485AspGlu: 3.485 ± 0.456
2.144AspPhe: 2.144 ± 0.348
7.077AspGly: 7.077 ± 0.652
1.501AspHis: 1.501 ± 0.325
2.52AspIle: 2.52 ± 0.345
1.287AspLys: 1.287 ± 0.236
6.112AspLeu: 6.112 ± 0.632
1.019AspMet: 1.019 ± 0.248
1.823AspAsn: 1.823 ± 0.355
5.683AspPro: 5.683 ± 0.547
1.876AspGln: 1.876 ± 0.338
4.879AspArg: 4.879 ± 0.624
3.806AspSer: 3.806 ± 0.597
4.289AspThr: 4.289 ± 0.508
4.557AspVal: 4.557 ± 0.547
1.608AspTrp: 1.608 ± 0.291
2.198AspTyr: 2.198 ± 0.332
0.0AspXaa: 0.0 ± 0.0
Glu
6.701GluAla: 6.701 ± 0.744
0.643GluCys: 0.643 ± 0.239
3.431GluAsp: 3.431 ± 0.413
2.895GluGlu: 2.895 ± 0.526
2.037GluPhe: 2.037 ± 0.312
2.841GluGly: 2.841 ± 0.365
1.608GluHis: 1.608 ± 0.365
2.091GluIle: 2.091 ± 0.31
1.662GluLys: 1.662 ± 0.311
5.79GluLeu: 5.79 ± 0.759
1.662GluMet: 1.662 ± 0.317
1.984GluAsn: 1.984 ± 0.262
2.949GluPro: 2.949 ± 0.436
2.734GluGln: 2.734 ± 0.429
4.771GluArg: 4.771 ± 0.56
2.734GluSer: 2.734 ± 0.392
4.021GluThr: 4.021 ± 0.594
3.967GluVal: 3.967 ± 0.478
1.179GluTrp: 1.179 ± 0.255
1.984GluTyr: 1.984 ± 0.348
0.0GluXaa: 0.0 ± 0.0
Phe
3.163PheAla: 3.163 ± 0.47
0.214PheCys: 0.214 ± 0.096
2.573PheAsp: 2.573 ± 0.484
1.662PheGlu: 1.662 ± 0.33
0.858PhePhe: 0.858 ± 0.231
3.109PheGly: 3.109 ± 0.559
0.322PheHis: 0.322 ± 0.134
1.447PheIle: 1.447 ± 0.319
0.965PheLys: 0.965 ± 0.263
1.394PheLeu: 1.394 ± 0.247
0.804PheMet: 0.804 ± 0.235
1.287PheAsn: 1.287 ± 0.313
1.769PhePro: 1.769 ± 0.299
0.911PheGln: 0.911 ± 0.285
1.555PheArg: 1.555 ± 0.256
1.716PheSer: 1.716 ± 0.266
2.305PheThr: 2.305 ± 0.353
1.93PheVal: 1.93 ± 0.308
0.482PheTrp: 0.482 ± 0.129
0.965PheTyr: 0.965 ± 0.288
0.0PheXaa: 0.0 ± 0.0
Gly
8.899GlyAla: 8.899 ± 1.096
0.965GlyCys: 0.965 ± 0.224
6.755GlyAsp: 6.755 ± 0.665
3.753GlyGlu: 3.753 ± 0.539
2.841GlyPhe: 2.841 ± 0.431
10.347GlyGly: 10.347 ± 1.859
1.984GlyHis: 1.984 ± 0.318
4.289GlyIle: 4.289 ± 0.528
2.52GlyLys: 2.52 ± 0.353
5.629GlyLeu: 5.629 ± 0.588
2.252GlyMet: 2.252 ± 0.476
3.217GlyAsn: 3.217 ± 0.398
4.182GlyPro: 4.182 ± 0.601
2.359GlyGln: 2.359 ± 0.537
5.683GlyArg: 5.683 ± 0.726
6.004GlySer: 6.004 ± 0.84
6.701GlyThr: 6.701 ± 0.681
5.897GlyVal: 5.897 ± 0.587
2.198GlyTrp: 2.198 ± 0.34
2.412GlyTyr: 2.412 ± 0.409
0.0GlyXaa: 0.0 ± 0.0
His
1.716HisAla: 1.716 ± 0.348
0.322HisCys: 0.322 ± 0.132
1.019HisAsp: 1.019 ± 0.221
1.447HisGlu: 1.447 ± 0.273
0.482HisPhe: 0.482 ± 0.156
1.716HisGly: 1.716 ± 0.282
1.019HisHis: 1.019 ± 0.308
1.34HisIle: 1.34 ± 0.27
0.751HisLys: 0.751 ± 0.215
1.608HisLeu: 1.608 ± 0.279
0.536HisMet: 0.536 ± 0.155
0.59HisAsn: 0.59 ± 0.151
1.662HisPro: 1.662 ± 0.36
0.804HisGln: 0.804 ± 0.193
2.466HisArg: 2.466 ± 0.385
0.643HisSer: 0.643 ± 0.188
1.394HisThr: 1.394 ± 0.31
1.233HisVal: 1.233 ± 0.324
0.482HisTrp: 0.482 ± 0.172
0.804HisTyr: 0.804 ± 0.197
0.0HisXaa: 0.0 ± 0.0
Ile
5.2IleAla: 5.2 ± 0.516
0.59IleCys: 0.59 ± 0.194
4.021IleAsp: 4.021 ± 0.488
3.27IleGlu: 3.27 ± 0.398
0.697IlePhe: 0.697 ± 0.242
3.592IleGly: 3.592 ± 0.471
1.501IleHis: 1.501 ± 0.311
1.447IleIle: 1.447 ± 0.272
0.965IleLys: 0.965 ± 0.245
2.198IleLeu: 2.198 ± 0.353
0.322IleMet: 0.322 ± 0.128
1.93IleAsn: 1.93 ± 0.294
2.841IlePro: 2.841 ± 0.385
1.126IleGln: 1.126 ± 0.217
3.109IleArg: 3.109 ± 0.438
2.144IleSer: 2.144 ± 0.383
3.592IleThr: 3.592 ± 0.402
2.627IleVal: 2.627 ± 0.321
0.965IleTrp: 0.965 ± 0.27
0.697IleTyr: 0.697 ± 0.197
0.0IleXaa: 0.0 ± 0.0
Lys
3.538LysAla: 3.538 ± 0.424
0.536LysCys: 0.536 ± 0.193
1.394LysAsp: 1.394 ± 0.306
1.394LysGlu: 1.394 ± 0.277
1.072LysPhe: 1.072 ± 0.203
2.359LysGly: 2.359 ± 0.347
0.858LysHis: 0.858 ± 0.21
0.965LysIle: 0.965 ± 0.287
1.126LysLys: 1.126 ± 0.377
2.841LysLeu: 2.841 ± 0.445
0.482LysMet: 0.482 ± 0.148
0.911LysAsn: 0.911 ± 0.235
2.359LysPro: 2.359 ± 0.435
1.555LysGln: 1.555 ± 0.245
2.359LysArg: 2.359 ± 0.411
1.769LysSer: 1.769 ± 0.299
1.876LysThr: 1.876 ± 0.296
2.252LysVal: 2.252 ± 0.367
0.751LysTrp: 0.751 ± 0.229
1.072LysTyr: 1.072 ± 0.254
0.0LysXaa: 0.0 ± 0.0
Leu
7.72LeuAla: 7.72 ± 0.804
0.911LeuCys: 0.911 ± 0.241
5.361LeuAsp: 5.361 ± 0.659
3.431LeuGlu: 3.431 ± 0.507
2.412LeuPhe: 2.412 ± 0.33
5.951LeuGly: 5.951 ± 0.532
0.965LeuHis: 0.965 ± 0.232
3.163LeuIle: 3.163 ± 0.445
2.091LeuLys: 2.091 ± 0.315
5.2LeuLeu: 5.2 ± 0.509
1.233LeuMet: 1.233 ± 0.242
2.627LeuAsn: 2.627 ± 0.367
5.147LeuPro: 5.147 ± 0.673
2.681LeuGln: 2.681 ± 0.41
5.683LeuArg: 5.683 ± 0.562
5.522LeuSer: 5.522 ± 0.5
5.307LeuThr: 5.307 ± 0.518
5.307LeuVal: 5.307 ± 0.577
1.447LeuTrp: 1.447 ± 0.277
1.876LeuTyr: 1.876 ± 0.376
0.0LeuXaa: 0.0 ± 0.0
Met
2.091MetAla: 2.091 ± 0.353
0.054MetCys: 0.054 ± 0.049
1.233MetAsp: 1.233 ± 0.218
0.965MetGlu: 0.965 ± 0.217
0.751MetPhe: 0.751 ± 0.17
1.769MetGly: 1.769 ± 0.254
0.214MetHis: 0.214 ± 0.103
0.858MetIle: 0.858 ± 0.227
0.697MetLys: 0.697 ± 0.242
1.555MetLeu: 1.555 ± 0.282
0.536MetMet: 0.536 ± 0.199
1.179MetAsn: 1.179 ± 0.235
1.555MetPro: 1.555 ± 0.312
0.59MetGln: 0.59 ± 0.177
1.394MetArg: 1.394 ± 0.274
2.681MetSer: 2.681 ± 0.376
2.412MetThr: 2.412 ± 0.33
1.34MetVal: 1.34 ± 0.324
0.268MetTrp: 0.268 ± 0.114
0.375MetTyr: 0.375 ± 0.144
0.0MetXaa: 0.0 ± 0.0
Asn
3.538AsnAla: 3.538 ± 0.403
0.214AsnCys: 0.214 ± 0.098
2.091AsnAsp: 2.091 ± 0.306
1.662AsnGlu: 1.662 ± 0.291
0.858AsnPhe: 0.858 ± 0.264
4.289AsnGly: 4.289 ± 0.616
0.804AsnHis: 0.804 ± 0.185
1.447AsnIle: 1.447 ± 0.36
1.126AsnLys: 1.126 ± 0.239
2.252AsnLeu: 2.252 ± 0.355
0.59AsnMet: 0.59 ± 0.146
1.93AsnAsn: 1.93 ± 0.375
2.788AsnPro: 2.788 ± 0.372
1.126AsnGln: 1.126 ± 0.35
2.198AsnArg: 2.198 ± 0.306
1.555AsnSer: 1.555 ± 0.305
2.144AsnThr: 2.144 ± 0.329
2.037AsnVal: 2.037 ± 0.343
0.804AsnTrp: 0.804 ± 0.204
0.59AsnTyr: 0.59 ± 0.158
0.0AsnXaa: 0.0 ± 0.0
Pro
5.361ProAla: 5.361 ± 0.607
0.804ProCys: 0.804 ± 0.235
4.825ProAsp: 4.825 ± 0.589
4.289ProGlu: 4.289 ± 0.524
1.823ProPhe: 1.823 ± 0.353
6.38ProGly: 6.38 ± 0.641
1.608ProHis: 1.608 ± 0.3
2.359ProIle: 2.359 ± 0.303
2.037ProLys: 2.037 ± 0.317
3.967ProLeu: 3.967 ± 0.536
1.769ProMet: 1.769 ± 0.358
2.573ProAsn: 2.573 ± 0.336
3.86ProPro: 3.86 ± 0.57
2.037ProGln: 2.037 ± 0.322
3.431ProArg: 3.431 ± 0.502
3.002ProSer: 3.002 ± 0.47
3.592ProThr: 3.592 ± 0.427
5.307ProVal: 5.307 ± 0.516
1.126ProTrp: 1.126 ± 0.202
1.608ProTyr: 1.608 ± 0.276
0.0ProXaa: 0.0 ± 0.0
Gln
4.396GlnAla: 4.396 ± 0.557
0.322GlnCys: 0.322 ± 0.139
1.662GlnAsp: 1.662 ± 0.253
1.769GlnGlu: 1.769 ± 0.294
1.179GlnPhe: 1.179 ± 0.244
2.144GlnGly: 2.144 ± 0.436
0.697GlnHis: 0.697 ± 0.19
1.555GlnIle: 1.555 ± 0.247
1.072GlnLys: 1.072 ± 0.212
3.377GlnLeu: 3.377 ± 0.411
0.59GlnMet: 0.59 ± 0.182
0.59GlnAsn: 0.59 ± 0.163
2.359GlnPro: 2.359 ± 0.341
1.019GlnGln: 1.019 ± 0.235
2.573GlnArg: 2.573 ± 0.372
2.091GlnSer: 2.091 ± 0.327
1.662GlnThr: 1.662 ± 0.354
2.412GlnVal: 2.412 ± 0.354
0.697GlnTrp: 0.697 ± 0.141
1.019GlnTyr: 1.019 ± 0.277
0.0GlnXaa: 0.0 ± 0.0
Arg
6.809ArgAla: 6.809 ± 0.54
1.447ArgCys: 1.447 ± 0.327
4.182ArgAsp: 4.182 ± 0.552
4.45ArgGlu: 4.45 ± 0.569
2.037ArgPhe: 2.037 ± 0.378
4.074ArgGly: 4.074 ± 0.473
1.394ArgHis: 1.394 ± 0.294
3.485ArgIle: 3.485 ± 0.48
2.52ArgLys: 2.52 ± 0.392
5.039ArgLeu: 5.039 ± 0.73
2.734ArgMet: 2.734 ± 0.376
2.573ArgAsn: 2.573 ± 0.497
3.324ArgPro: 3.324 ± 0.443
2.573ArgGln: 2.573 ± 0.354
6.433ArgArg: 6.433 ± 0.942
3.485ArgSer: 3.485 ± 0.354
3.914ArgThr: 3.914 ± 0.519
5.468ArgVal: 5.468 ± 0.63
2.091ArgTrp: 2.091 ± 0.346
1.93ArgTyr: 1.93 ± 0.319
0.0ArgXaa: 0.0 ± 0.0
Ser
5.951SerAla: 5.951 ± 0.68
0.59SerCys: 0.59 ± 0.16
3.967SerAsp: 3.967 ± 0.449
3.002SerGlu: 3.002 ± 0.361
2.144SerPhe: 2.144 ± 0.42
6.648SerGly: 6.648 ± 0.904
0.965SerHis: 0.965 ± 0.24
2.949SerIle: 2.949 ± 0.448
2.681SerLys: 2.681 ± 0.429
3.86SerLeu: 3.86 ± 0.448
1.34SerMet: 1.34 ± 0.251
2.091SerAsn: 2.091 ± 0.536
3.109SerPro: 3.109 ± 0.409
1.662SerGln: 1.662 ± 0.281
3.377SerArg: 3.377 ± 0.391
3.377SerSer: 3.377 ± 0.57
3.27SerThr: 3.27 ± 0.452
4.128SerVal: 4.128 ± 0.451
1.287SerTrp: 1.287 ± 0.261
1.394SerTyr: 1.394 ± 0.214
0.0SerXaa: 0.0 ± 0.0
Thr
6.433ThrAla: 6.433 ± 0.627
0.751ThrCys: 0.751 ± 0.22
3.967ThrAsp: 3.967 ± 0.548
3.592ThrGlu: 3.592 ± 0.386
1.501ThrPhe: 1.501 ± 0.272
5.736ThrGly: 5.736 ± 0.577
1.555ThrHis: 1.555 ± 0.296
3.753ThrIle: 3.753 ± 0.38
2.091ThrLys: 2.091 ± 0.289
4.825ThrLeu: 4.825 ± 0.499
1.447ThrMet: 1.447 ± 0.281
2.359ThrAsn: 2.359 ± 0.377
5.307ThrPro: 5.307 ± 0.688
1.93ThrGln: 1.93 ± 0.333
3.753ThrArg: 3.753 ± 0.323
4.074ThrSer: 4.074 ± 0.539
4.932ThrThr: 4.932 ± 0.589
5.844ThrVal: 5.844 ± 0.593
0.965ThrTrp: 0.965 ± 0.237
1.876ThrTyr: 1.876 ± 0.27
0.0ThrXaa: 0.0 ± 0.0
Val
7.237ValAla: 7.237 ± 0.561
1.019ValCys: 1.019 ± 0.234
5.468ValAsp: 5.468 ± 0.525
4.932ValGlu: 4.932 ± 0.655
2.144ValPhe: 2.144 ± 0.287
5.629ValGly: 5.629 ± 0.608
1.233ValHis: 1.233 ± 0.288
2.627ValIle: 2.627 ± 0.406
2.144ValLys: 2.144 ± 0.324
5.522ValLeu: 5.522 ± 0.574
1.555ValMet: 1.555 ± 0.222
2.359ValAsn: 2.359 ± 0.346
3.86ValPro: 3.86 ± 0.391
2.52ValGln: 2.52 ± 0.349
4.289ValArg: 4.289 ± 0.572
4.664ValSer: 4.664 ± 0.551
5.307ValThr: 5.307 ± 0.514
6.004ValVal: 6.004 ± 0.761
2.091ValTrp: 2.091 ± 0.408
1.608ValTyr: 1.608 ± 0.309
0.0ValXaa: 0.0 ± 0.0
Trp
1.93TrpAla: 1.93 ± 0.298
0.107TrpCys: 0.107 ± 0.066
1.716TrpAsp: 1.716 ± 0.299
1.34TrpGlu: 1.34 ± 0.325
0.804TrpPhe: 0.804 ± 0.236
1.019TrpGly: 1.019 ± 0.213
0.804TrpHis: 0.804 ± 0.2
1.019TrpIle: 1.019 ± 0.201
0.751TrpLys: 0.751 ± 0.17
1.769TrpLeu: 1.769 ± 0.302
0.858TrpMet: 0.858 ± 0.258
0.482TrpAsn: 0.482 ± 0.204
1.179TrpPro: 1.179 ± 0.302
1.072TrpGln: 1.072 ± 0.235
1.93TrpArg: 1.93 ± 0.413
1.233TrpSer: 1.233 ± 0.291
1.555TrpThr: 1.555 ± 0.28
1.93TrpVal: 1.93 ± 0.389
0.751TrpTrp: 0.751 ± 0.173
0.536TrpTyr: 0.536 ± 0.138
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.466TyrAla: 2.466 ± 0.347
0.268TyrCys: 0.268 ± 0.122
1.876TyrAsp: 1.876 ± 0.407
2.091TyrGlu: 2.091 ± 0.319
0.697TyrPhe: 0.697 ± 0.206
2.359TyrGly: 2.359 ± 0.457
0.536TyrHis: 0.536 ± 0.165
0.911TyrIle: 0.911 ± 0.199
0.643TyrLys: 0.643 ± 0.178
2.252TyrLeu: 2.252 ± 0.345
0.214TyrMet: 0.214 ± 0.111
0.751TyrAsn: 0.751 ± 0.171
1.501TyrPro: 1.501 ± 0.278
0.804TyrGln: 0.804 ± 0.198
1.823TyrArg: 1.823 ± 0.335
1.233TyrSer: 1.233 ± 0.273
2.091TyrThr: 2.091 ± 0.425
2.359TyrVal: 2.359 ± 0.327
0.59TyrTrp: 0.59 ± 0.166
0.858TyrTyr: 0.858 ± 0.193
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 105 proteins (18654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski