Amino acid dipepetide frequency for Pseudoruegeria aquimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.908AlaAla: 18.908 ± 0.227	1.312AlaCys: 1.312 ± 0.038	6.724AlaAsp: 6.724 ± 0.089	9.636AlaGlu: 9.636 ± 0.122	4.757AlaPhe: 4.757 ± 0.069	11.612AlaGly: 11.612 ± 0.137	2.479AlaHis: 2.479 ± 0.056	5.835AlaIle: 5.835 ± 0.081	3.836AlaLys: 3.836 ± 0.066	14.847AlaLeu: 14.847 ± 0.167	3.848AlaMet: 3.848 ± 0.062	2.632AlaAsn: 2.632 ± 0.051	6.865AlaPro: 6.865 ± 0.108	4.613AlaGln: 4.613 ± 0.069	9.831AlaArg: 9.831 ± 0.119	5.504AlaSer: 5.504 ± 0.082	5.88AlaThr: 5.88 ± 0.078	8.303AlaVal: 8.303 ± 0.104	1.489AlaTrp: 1.489 ± 0.036	2.797AlaTyr: 2.797 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.251CysAla: 1.251 ± 0.036	0.124CysCys: 0.124 ± 0.012	0.59CysAsp: 0.59 ± 0.026	0.478CysGlu: 0.478 ± 0.021	0.359CysPhe: 0.359 ± 0.017	0.989CysGly: 0.989 ± 0.035	0.281CysHis: 0.281 ± 0.018	0.405CysIle: 0.405 ± 0.021	0.209CysLys: 0.209 ± 0.014	0.887CysLeu: 0.887 ± 0.03	0.175CysMet: 0.175 ± 0.013	0.229CysAsn: 0.229 ± 0.014	0.546CysPro: 0.546 ± 0.023	0.221CysGln: 0.221 ± 0.014	0.609CysArg: 0.609 ± 0.024	0.423CysSer: 0.423 ± 0.02	0.484CysThr: 0.484 ± 0.021	0.644CysVal: 0.644 ± 0.026	0.111CysTrp: 0.111 ± 0.01	0.228CysTyr: 0.228 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.895AspAla: 6.895 ± 0.082	0.526AspCys: 0.526 ± 0.02	2.842AspAsp: 2.842 ± 0.077	3.199AspGlu: 3.199 ± 0.056	2.329AspPhe: 2.329 ± 0.052	5.293AspGly: 5.293 ± 0.081	1.232AspHis: 1.232 ± 0.033	2.759AspIle: 2.759 ± 0.046	1.402AspLys: 1.402 ± 0.037	6.139AspLeu: 6.139 ± 0.092	1.452AspMet: 1.452 ± 0.039	1.098AspAsn: 1.098 ± 0.035	3.683AspPro: 3.683 ± 0.069	1.437AspGln: 1.437 ± 0.035	3.615AspArg: 3.615 ± 0.067	2.043AspSer: 2.043 ± 0.044	2.686AspThr: 2.686 ± 0.066	4.036AspVal: 4.036 ± 0.068	1.122AspTrp: 1.122 ± 0.038	1.43AspTyr: 1.43 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	10.191GluAla: 10.191 ± 0.134	0.391GluCys: 0.391 ± 0.019	3.517GluAsp: 3.517 ± 0.069	4.378GluGlu: 4.378 ± 0.088	1.848GluPhe: 1.848 ± 0.04	5.918GluGly: 5.918 ± 0.073	1.165GluHis: 1.165 ± 0.037	4.027GluIle: 4.027 ± 0.059	2.46GluLys: 2.46 ± 0.061	5.037GluLeu: 5.037 ± 0.076	1.862GluMet: 1.862 ± 0.035	1.803GluAsn: 1.803 ± 0.038	2.693GluPro: 2.693 ± 0.046	1.903GluGln: 1.903 ± 0.039	4.521GluArg: 4.521 ± 0.069	2.629GluSer: 2.629 ± 0.057	3.88GluThr: 3.88 ± 0.06	4.491GluVal: 4.491 ± 0.061	0.724GluTrp: 0.724 ± 0.03	1.068GluTyr: 1.068 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.664PheAla: 4.664 ± 0.076	0.444PheCys: 0.444 ± 0.02	2.712PheAsp: 2.712 ± 0.057	2.321PheGlu: 2.321 ± 0.046	1.471PhePhe: 1.471 ± 0.043	3.795PheGly: 3.795 ± 0.064	0.754PheHis: 0.754 ± 0.021	1.703PheIle: 1.703 ± 0.042	0.923PheLys: 0.923 ± 0.03	3.667PheLeu: 3.667 ± 0.069	0.87PheMet: 0.87 ± 0.033	1.05PheAsn: 1.05 ± 0.031	1.659PhePro: 1.659 ± 0.04	0.964PheGln: 0.964 ± 0.029	2.249PheArg: 2.249 ± 0.05	2.141PheSer: 2.141 ± 0.045	2.295PheThr: 2.295 ± 0.049	2.658PheVal: 2.658 ± 0.055	0.581PheTrp: 0.581 ± 0.025	0.982PheTyr: 0.982 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.696GlyAla: 10.696 ± 0.118	0.911GlyCys: 0.911 ± 0.029	4.417GlyAsp: 4.417 ± 0.07	5.368GlyGlu: 5.368 ± 0.068	3.872GlyPhe: 3.872 ± 0.052	7.81GlyGly: 7.81 ± 0.118	1.96GlyHis: 1.96 ± 0.046	4.419GlyIle: 4.419 ± 0.065	3.258GlyLys: 3.258 ± 0.067	9.418GlyLeu: 9.418 ± 0.114	2.59GlyMet: 2.59 ± 0.043	2.146GlyAsn: 2.146 ± 0.054	3.827GlyPro: 3.827 ± 0.056	2.951GlyGln: 2.951 ± 0.057	6.153GlyArg: 6.153 ± 0.079	4.092GlySer: 4.092 ± 0.057	4.597GlyThr: 4.597 ± 0.068	6.558GlyVal: 6.558 ± 0.08	1.57GlyTrp: 1.57 ± 0.039	2.365GlyTyr: 2.365 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.44HisAla: 2.44 ± 0.05	0.247HisCys: 0.247 ± 0.018	1.139HisAsp: 1.139 ± 0.036	1.118HisGlu: 1.118 ± 0.033	0.877HisPhe: 0.877 ± 0.029	1.979HisGly: 1.979 ± 0.044	0.578HisHis: 0.578 ± 0.029	0.888HisIle: 0.888 ± 0.028	0.482HisLys: 0.482 ± 0.021	2.042HisLeu: 2.042 ± 0.047	0.536HisMet: 0.536 ± 0.024	0.429HisAsn: 0.429 ± 0.019	1.468HisPro: 1.468 ± 0.041	0.514HisGln: 0.514 ± 0.021	1.37HisArg: 1.37 ± 0.036	0.851HisSer: 0.851 ± 0.029	0.799HisThr: 0.799 ± 0.028	1.575HisVal: 1.575 ± 0.039	0.365HisTrp: 0.365 ± 0.017	0.542HisTyr: 0.542 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.922IleAla: 6.922 ± 0.07	0.569IleCys: 0.569 ± 0.024	3.06IleAsp: 3.06 ± 0.057	3.512IleGlu: 3.512 ± 0.051	1.798IlePhe: 1.798 ± 0.041	4.703IleGly: 4.703 ± 0.073	0.95IleHis: 0.95 ± 0.032	1.924IleIle: 1.924 ± 0.047	1.314IleLys: 1.314 ± 0.036	4.89IleLeu: 4.89 ± 0.079	0.972IleMet: 0.972 ± 0.032	1.295IleAsn: 1.295 ± 0.041	2.288IlePro: 2.288 ± 0.043	1.096IleGln: 1.096 ± 0.03	3.251IleArg: 3.251 ± 0.055	2.638IleSer: 2.638 ± 0.052	2.894IleThr: 2.894 ± 0.055	3.584IleVal: 3.584 ± 0.062	0.7IleTrp: 0.7 ± 0.03	1.172IleTyr: 1.172 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.401LysAla: 4.401 ± 0.072	0.174LysCys: 0.174 ± 0.011	1.702LysAsp: 1.702 ± 0.042	1.735LysGlu: 1.735 ± 0.046	0.892LysPhe: 0.892 ± 0.028	2.912LysGly: 2.912 ± 0.057	0.621LysHis: 0.621 ± 0.023	1.628LysIle: 1.628 ± 0.043	1.224LysLys: 1.224 ± 0.037	2.854LysLeu: 2.854 ± 0.059	0.854LysMet: 0.854 ± 0.029	0.748LysAsn: 0.748 ± 0.026	1.91LysPro: 1.91 ± 0.052	0.873LysGln: 0.873 ± 0.031	2.26LysArg: 2.26 ± 0.046	1.685LysSer: 1.685 ± 0.043	1.724LysThr: 1.724 ± 0.043	2.294LysVal: 2.294 ± 0.051	0.374LysTrp: 0.374 ± 0.019	0.652LysTyr: 0.652 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.002LeuAla: 14.002 ± 0.126	0.992LeuCys: 0.992 ± 0.029	5.563LeuAsp: 5.563 ± 0.085	5.827LeuGlu: 5.827 ± 0.089	3.72LeuPhe: 3.72 ± 0.069	8.523LeuGly: 8.523 ± 0.111	1.875LeuHis: 1.875 ± 0.046	4.78LeuIle: 4.78 ± 0.071	3.496LeuLys: 3.496 ± 0.059	9.589LeuLeu: 9.589 ± 0.141	2.569LeuMet: 2.569 ± 0.045	2.519LeuAsn: 2.519 ± 0.051	5.755LeuPro: 5.755 ± 0.075	2.717LeuGln: 2.717 ± 0.052	7.272LeuArg: 7.272 ± 0.099	6.284LeuSer: 6.284 ± 0.082	5.623LeuThr: 5.623 ± 0.078	6.76LeuVal: 6.76 ± 0.086	1.342LeuTrp: 1.342 ± 0.036	2.049LeuTyr: 2.049 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.595MetAla: 3.595 ± 0.051	0.194MetCys: 0.194 ± 0.014	1.372MetAsp: 1.372 ± 0.037	1.462MetGlu: 1.462 ± 0.041	0.813MetPhe: 0.813 ± 0.03	2.267MetGly: 2.267 ± 0.046	0.475MetHis: 0.475 ± 0.019	1.501MetIle: 1.501 ± 0.039	1.103MetLys: 1.103 ± 0.03	2.495MetLeu: 2.495 ± 0.051	0.748MetMet: 0.748 ± 0.031	0.812MetAsn: 0.812 ± 0.028	1.464MetPro: 1.464 ± 0.032	0.913MetGln: 0.913 ± 0.028	1.808MetArg: 1.808 ± 0.039	1.584MetSer: 1.584 ± 0.035	1.685MetThr: 1.685 ± 0.036	1.791MetVal: 1.791 ± 0.042	0.239MetTrp: 0.239 ± 0.014	0.337MetTyr: 0.337 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.101AsnAla: 3.101 ± 0.051	0.238AsnCys: 0.238 ± 0.014	1.224AsnAsp: 1.224 ± 0.043	1.22AsnGlu: 1.22 ± 0.028	0.905AsnPhe: 0.905 ± 0.028	2.4AsnGly: 2.4 ± 0.052	0.473AsnHis: 0.473 ± 0.02	1.312AsnIle: 1.312 ± 0.032	0.63AsnLys: 0.63 ± 0.028	2.299AsnLeu: 2.299 ± 0.05	0.67AsnMet: 0.67 ± 0.028	0.592AsnAsn: 0.592 ± 0.027	1.829AsnPro: 1.829 ± 0.045	0.629AsnGln: 0.629 ± 0.022	1.68AsnArg: 1.68 ± 0.04	1.056AsnSer: 1.056 ± 0.028	1.297AsnThr: 1.297 ± 0.039	1.794AsnVal: 1.794 ± 0.042	0.43AsnTrp: 0.43 ± 0.021	0.601AsnTyr: 0.601 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.712ProAla: 6.712 ± 0.098	0.427ProCys: 0.427 ± 0.02	3.603ProAsp: 3.603 ± 0.06	5.131ProGlu: 5.131 ± 0.072	2.067ProPhe: 2.067 ± 0.046	4.76ProGly: 4.76 ± 0.079	1.039ProHis: 1.039 ± 0.03	2.245ProIle: 2.245 ± 0.047	1.633ProLys: 1.633 ± 0.042	4.957ProLeu: 4.957 ± 0.073	1.336ProMet: 1.336 ± 0.035	1.257ProAsn: 1.257 ± 0.035	2.474ProPro: 2.474 ± 0.053	1.675ProGln: 1.675 ± 0.038	3.106ProArg: 3.106 ± 0.057	2.328ProSer: 2.328 ± 0.046	2.295ProThr: 2.295 ± 0.041	4.207ProVal: 4.207 ± 0.065	0.67ProTrp: 0.67 ± 0.025	1.218ProTyr: 1.218 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.269GlnAla: 4.269 ± 0.072	0.197GlnCys: 0.197 ± 0.013	1.54GlnAsp: 1.54 ± 0.036	1.792GlnGlu: 1.792 ± 0.045	1.012GlnPhe: 1.012 ± 0.031	2.557GlnGly: 2.557 ± 0.046	0.499GlnHis: 0.499 ± 0.022	1.796GlnIle: 1.796 ± 0.043	1.038GlnLys: 1.038 ± 0.031	2.57GlnLeu: 2.57 ± 0.052	0.979GlnMet: 0.979 ± 0.028	0.765GlnAsn: 0.765 ± 0.027	1.638GlnPro: 1.638 ± 0.04	1.06GlnGln: 1.06 ± 0.037	2.055GlnArg: 2.055 ± 0.052	1.584GlnSer: 1.584 ± 0.038	1.553GlnThr: 1.553 ± 0.037	2.207GlnVal: 2.207 ± 0.042	0.411GlnTrp: 0.411 ± 0.02	0.537GlnTyr: 0.537 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.759ArgAla: 8.759 ± 0.118	0.506ArgCys: 0.506 ± 0.021	3.736ArgAsp: 3.736 ± 0.06	4.216ArgGlu: 4.216 ± 0.064	2.888ArgPhe: 2.888 ± 0.052	4.84ArgGly: 4.84 ± 0.065	1.584ArgHis: 1.584 ± 0.043	3.902ArgIle: 3.902 ± 0.053	2.413ArgLys: 2.413 ± 0.053	7.666ArgLeu: 7.666 ± 0.099	1.978ArgMet: 1.978 ± 0.036	1.731ArgAsn: 1.731 ± 0.036	3.55ArgPro: 3.55 ± 0.064	2.222ArgGln: 2.222 ± 0.047	5.406ArgArg: 5.406 ± 0.079	3.194ArgSer: 3.194 ± 0.056	2.931ArgThr: 2.931 ± 0.05	4.616ArgVal: 4.616 ± 0.069	0.989ArgTrp: 0.989 ± 0.036	1.62ArgTyr: 1.62 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.708SerAla: 5.708 ± 0.084	0.43SerCys: 0.43 ± 0.021	2.749SerAsp: 2.749 ± 0.059	3.032SerGlu: 3.032 ± 0.058	2.135SerPhe: 2.135 ± 0.044	5.146SerGly: 5.146 ± 0.076	1.042SerHis: 1.042 ± 0.035	2.172SerIle: 2.172 ± 0.049	1.373SerLys: 1.373 ± 0.036	4.859SerLeu: 4.859 ± 0.07	1.218SerMet: 1.218 ± 0.032	1.184SerAsn: 1.184 ± 0.035	2.594SerPro: 2.594 ± 0.047	1.439SerGln: 1.439 ± 0.033	3.307SerArg: 3.307 ± 0.054	2.205SerSer: 2.205 ± 0.05	2.284SerThr: 2.284 ± 0.041	3.556SerVal: 3.556 ± 0.054	0.711SerTrp: 0.711 ± 0.031	1.233SerTyr: 1.233 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.105ThrAla: 6.105 ± 0.076	0.501ThrCys: 0.501 ± 0.022	2.693ThrAsp: 2.693 ± 0.048	3.08ThrGlu: 3.08 ± 0.054	1.922ThrPhe: 1.922 ± 0.046	5.152ThrGly: 5.152 ± 0.072	1.024ThrHis: 1.024 ± 0.03	2.49ThrIle: 2.49 ± 0.043	1.33ThrLys: 1.33 ± 0.032	5.752ThrLeu: 5.752 ± 0.077	1.169ThrMet: 1.169 ± 0.033	1.144ThrAsn: 1.144 ± 0.034	3.493ThrPro: 3.493 ± 0.054	1.437ThrGln: 1.437 ± 0.039	3.349ThrArg: 3.349 ± 0.056	2.39ThrSer: 2.39 ± 0.048	2.489ThrThr: 2.489 ± 0.063	3.957ThrVal: 3.957 ± 0.064	0.651ThrTrp: 0.651 ± 0.023	1.267ThrTyr: 1.267 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	8.934ValAla: 8.934 ± 0.106	0.669ValCys: 0.669 ± 0.025	3.896ValAsp: 3.896 ± 0.065	4.741ValGlu: 4.741 ± 0.066	2.768ValPhe: 2.768 ± 0.054	5.175ValGly: 5.175 ± 0.067	1.329ValHis: 1.329 ± 0.034	4.109ValIle: 4.109 ± 0.057	2.305ValLys: 2.305 ± 0.054	7.331ValLeu: 7.331 ± 0.088	1.945ValMet: 1.945 ± 0.044	1.96ValAsn: 1.96 ± 0.047	3.603ValPro: 3.603 ± 0.056	2.102ValGln: 2.102 ± 0.042	4.193ValArg: 4.193 ± 0.067	3.991ValSer: 3.991 ± 0.061	4.154ValThr: 4.154 ± 0.064	5.284ValVal: 5.284 ± 0.083	0.868ValTrp: 0.868 ± 0.027	1.437ValTyr: 1.437 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.54TrpAla: 1.54 ± 0.045	0.141TrpCys: 0.141 ± 0.01	0.676TrpAsp: 0.676 ± 0.025	0.794TrpGlu: 0.794 ± 0.03	0.579TrpPhe: 0.579 ± 0.024	0.977TrpGly: 0.977 ± 0.031	0.326TrpHis: 0.326 ± 0.016	0.755TrpIle: 0.755 ± 0.03	0.457TrpLys: 0.457 ± 0.019	1.667TrpLeu: 1.667 ± 0.043	0.395TrpMet: 0.395 ± 0.019	0.427TrpAsn: 0.427 ± 0.021	0.706TrpPro: 0.706 ± 0.025	0.625TrpGln: 0.625 ± 0.025	1.115TrpArg: 1.115 ± 0.031	0.684TrpSer: 0.684 ± 0.026	0.651TrpThr: 0.651 ± 0.026	0.913TrpVal: 0.913 ± 0.03	0.259TrpTrp: 0.259 ± 0.014	0.283TrpTyr: 0.283 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.614TyrAla: 2.614 ± 0.053	0.251TyrCys: 0.251 ± 0.015	1.468TyrAsp: 1.468 ± 0.043	1.468TyrGlu: 1.468 ± 0.038	0.889TyrPhe: 0.889 ± 0.027	2.171TyrGly: 2.171 ± 0.041	0.553TyrHis: 0.553 ± 0.021	0.88TyrIle: 0.88 ± 0.03	0.63TyrLys: 0.63 ± 0.028	2.29TyrLeu: 2.29 ± 0.047	0.491TyrMet: 0.491 ± 0.021	0.558TyrAsn: 0.558 ± 0.027	1.094TyrPro: 1.094 ± 0.028	0.67TyrGln: 0.67 ± 0.027	1.599TyrArg: 1.599 ± 0.037	1.07TyrSer: 1.07 ± 0.033	1.192TyrThr: 1.192 ± 0.037	1.567TyrVal: 1.567 ± 0.043	0.364TyrTrp: 0.364 ± 0.019	0.565TyrTyr: 0.565 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3590 proteins (1108921 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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