Amino acid dipepetide frequency for Marinobacter profundi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.799AlaAla: 11.799 ± 0.153	1.061AlaCys: 1.061 ± 0.034	6.057AlaAsp: 6.057 ± 0.064	6.923AlaGlu: 6.923 ± 0.093	3.598AlaPhe: 3.598 ± 0.066	9.795AlaGly: 9.795 ± 0.11	1.841AlaHis: 1.841 ± 0.042	5.522AlaIle: 5.522 ± 0.066	2.711AlaLys: 2.711 ± 0.055	11.936AlaLeu: 11.936 ± 0.141	3.077AlaMet: 3.077 ± 0.058	2.88AlaAsn: 2.88 ± 0.053	4.256AlaPro: 4.256 ± 0.071	3.159AlaGln: 3.159 ± 0.051	7.374AlaArg: 7.374 ± 0.09	5.992AlaSer: 5.992 ± 0.076	5.309AlaThr: 5.309 ± 0.077	7.91AlaVal: 7.91 ± 0.107	1.396AlaTrp: 1.396 ± 0.039	2.292AlaTyr: 2.292 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.841CysAla: 0.841 ± 0.025	0.145CysCys: 0.145 ± 0.012	0.546CysAsp: 0.546 ± 0.021	0.599CysGlu: 0.599 ± 0.026	0.363CysPhe: 0.363 ± 0.018	0.945CysGly: 0.945 ± 0.034	0.303CysHis: 0.303 ± 0.015	0.413CysIle: 0.413 ± 0.02	0.276CysLys: 0.276 ± 0.015	0.958CysLeu: 0.958 ± 0.031	0.204CysMet: 0.204 ± 0.013	0.264CysAsn: 0.264 ± 0.016	0.519CysPro: 0.519 ± 0.023	0.394CysGln: 0.394 ± 0.018	0.681CysArg: 0.681 ± 0.022	0.56CysSer: 0.56 ± 0.021	0.436CysThr: 0.436 ± 0.019	0.605CysVal: 0.605 ± 0.022	0.14CysTrp: 0.14 ± 0.011	0.262CysTyr: 0.262 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.403AspAla: 5.403 ± 0.073	0.503AspCys: 0.503 ± 0.021	3.414AspAsp: 3.414 ± 0.076	3.874AspGlu: 3.874 ± 0.065	2.161AspPhe: 2.161 ± 0.048	4.664AspGly: 4.664 ± 0.076	1.351AspHis: 1.351 ± 0.033	3.128AspIle: 3.128 ± 0.052	1.879AspLys: 1.879 ± 0.046	5.9AspLeu: 5.9 ± 0.077	1.412AspMet: 1.412 ± 0.036	1.887AspAsn: 1.887 ± 0.047	2.944AspPro: 2.944 ± 0.056	2.352AspGln: 2.352 ± 0.043	4.007AspArg: 4.007 ± 0.066	3.01AspSer: 3.01 ± 0.054	2.813AspThr: 2.813 ± 0.049	3.914AspVal: 3.914 ± 0.063	0.979AspTrp: 0.979 ± 0.032	1.881AspTyr: 1.881 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.78GluAla: 6.78 ± 0.085	0.442GluCys: 0.442 ± 0.02	3.192GluAsp: 3.192 ± 0.058	3.769GluGlu: 3.769 ± 0.072	2.147GluPhe: 2.147 ± 0.046	4.325GluGly: 4.325 ± 0.065	1.524GluHis: 1.524 ± 0.039	3.23GluIle: 3.23 ± 0.054	2.391GluLys: 2.391 ± 0.059	7.172GluLeu: 7.172 ± 0.084	1.474GluMet: 1.474 ± 0.037	1.898GluAsn: 1.898 ± 0.04	2.806GluPro: 2.806 ± 0.058	3.392GluGln: 3.392 ± 0.06	4.629GluArg: 4.629 ± 0.079	3.171GluSer: 3.171 ± 0.059	3.224GluThr: 3.224 ± 0.055	4.519GluVal: 4.519 ± 0.061	0.752GluTrp: 0.752 ± 0.026	1.372GluTyr: 1.372 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.661PheAla: 3.661 ± 0.068	0.432PheCys: 0.432 ± 0.019	2.449PheAsp: 2.449 ± 0.049	2.178PheGlu: 2.178 ± 0.046	1.514PhePhe: 1.514 ± 0.045	3.379PheGly: 3.379 ± 0.057	0.848PheHis: 0.848 ± 0.027	1.925PheIle: 1.925 ± 0.043	0.934PheLys: 0.934 ± 0.031	3.545PheLeu: 3.545 ± 0.058	0.89PheMet: 0.89 ± 0.027	1.298PheAsn: 1.298 ± 0.033	1.588PhePro: 1.588 ± 0.04	1.108PheGln: 1.108 ± 0.028	2.579PheArg: 2.579 ± 0.053	2.56PheSer: 2.56 ± 0.05	2.0PheThr: 2.0 ± 0.041	2.663PheVal: 2.663 ± 0.048	0.518PheTrp: 0.518 ± 0.023	1.126PheTyr: 1.126 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.319GlyAla: 7.319 ± 0.094	0.961GlyCys: 0.961 ± 0.032	4.578GlyAsp: 4.578 ± 0.063	5.201GlyGlu: 5.201 ± 0.072	3.458GlyPhe: 3.458 ± 0.055	6.359GlyGly: 6.359 ± 0.089	1.942GlyHis: 1.942 ± 0.041	4.764GlyIle: 4.764 ± 0.062	3.218GlyLys: 3.218 ± 0.059	8.973GlyLeu: 8.973 ± 0.108	2.365GlyMet: 2.365 ± 0.049	2.475GlyAsn: 2.475 ± 0.049	2.72GlyPro: 2.72 ± 0.047	3.432GlyGln: 3.432 ± 0.055	5.139GlyArg: 5.139 ± 0.078	4.703GlySer: 4.703 ± 0.074	4.12GlyThr: 4.12 ± 0.06	6.125GlyVal: 6.125 ± 0.077	1.34GlyTrp: 1.34 ± 0.035	2.586GlyTyr: 2.586 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.831HisAla: 1.831 ± 0.045	0.299HisCys: 0.299 ± 0.015	1.228HisAsp: 1.228 ± 0.036	1.154HisGlu: 1.154 ± 0.032	0.92HisPhe: 0.92 ± 0.03	1.921HisGly: 1.921 ± 0.04	0.718HisHis: 0.718 ± 0.023	1.092HisIle: 1.092 ± 0.031	0.668HisLys: 0.668 ± 0.023	2.239HisLeu: 2.239 ± 0.046	0.495HisMet: 0.495 ± 0.019	0.665HisAsn: 0.665 ± 0.023	1.434HisPro: 1.434 ± 0.036	1.042HisGln: 1.042 ± 0.031	1.657HisArg: 1.657 ± 0.035	1.233HisSer: 1.233 ± 0.032	1.016HisThr: 1.016 ± 0.031	1.238HisVal: 1.238 ± 0.036	0.437HisTrp: 0.437 ± 0.021	0.782HisTyr: 0.782 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.714IleAla: 5.714 ± 0.081	0.519IleCys: 0.519 ± 0.023	3.115IleAsp: 3.115 ± 0.046	3.424IleGlu: 3.424 ± 0.06	1.636IlePhe: 1.636 ± 0.045	4.409IleGly: 4.409 ± 0.069	1.15IleHis: 1.15 ± 0.034	2.459IleIle: 2.459 ± 0.053	1.611IleLys: 1.611 ± 0.045	4.706IleLeu: 4.706 ± 0.062	1.025IleMet: 1.025 ± 0.031	1.885IleAsn: 1.885 ± 0.037	2.593IlePro: 2.593 ± 0.056	1.566IleGln: 1.566 ± 0.035	3.869IleArg: 3.869 ± 0.065	2.975IleSer: 2.975 ± 0.053	2.892IleThr: 2.892 ± 0.048	3.493IleVal: 3.493 ± 0.065	0.55IleTrp: 0.55 ± 0.021	1.24IleTyr: 1.24 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.577LysAla: 3.577 ± 0.063	0.193LysCys: 0.193 ± 0.013	1.72LysAsp: 1.72 ± 0.045	1.819LysGlu: 1.819 ± 0.049	0.881LysPhe: 0.881 ± 0.03	2.405LysGly: 2.405 ± 0.053	0.725LysHis: 0.725 ± 0.026	1.517LysIle: 1.517 ± 0.038	1.385LysLys: 1.385 ± 0.041	3.336LysLeu: 3.336 ± 0.058	0.736LysMet: 0.736 ± 0.029	0.961LysAsn: 0.961 ± 0.033	1.845LysPro: 1.845 ± 0.049	1.357LysGln: 1.357 ± 0.035	2.123LysArg: 2.123 ± 0.051	1.688LysSer: 1.688 ± 0.041	1.857LysThr: 1.857 ± 0.043	2.623LysVal: 2.623 ± 0.05	0.36LysTrp: 0.36 ± 0.019	0.773LysTyr: 0.773 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	13.485LeuAla: 13.485 ± 0.144	1.008LeuCys: 1.008 ± 0.033	6.275LeuAsp: 6.275 ± 0.074	6.652LeuGlu: 6.652 ± 0.095	3.946LeuPhe: 3.946 ± 0.064	8.456LeuGly: 8.456 ± 0.105	2.098LeuHis: 2.098 ± 0.042	5.234LeuIle: 5.234 ± 0.071	3.65LeuLys: 3.65 ± 0.062	11.543LeuLeu: 11.543 ± 0.158	2.769LeuMet: 2.769 ± 0.047	3.31LeuAsn: 3.31 ± 0.048	5.623LeuPro: 5.623 ± 0.078	3.936LeuGln: 3.936 ± 0.065	6.792LeuArg: 6.792 ± 0.081	6.413LeuSer: 6.413 ± 0.072	6.079LeuThr: 6.079 ± 0.073	8.22LeuVal: 8.22 ± 0.107	1.336LeuTrp: 1.336 ± 0.035	2.392LeuTyr: 2.392 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.083MetAla: 3.083 ± 0.052	0.168MetCys: 0.168 ± 0.011	1.311MetAsp: 1.311 ± 0.034	1.332MetGlu: 1.332 ± 0.036	0.775MetPhe: 0.775 ± 0.028	1.911MetGly: 1.911 ± 0.046	0.471MetHis: 0.471 ± 0.021	1.264MetIle: 1.264 ± 0.034	1.092MetLys: 1.092 ± 0.027	2.608MetLeu: 2.608 ± 0.044	0.704MetMet: 0.704 ± 0.028	0.942MetAsn: 0.942 ± 0.028	1.317MetPro: 1.317 ± 0.031	0.887MetGln: 0.887 ± 0.027	1.358MetArg: 1.358 ± 0.036	1.567MetSer: 1.567 ± 0.039	1.786MetThr: 1.786 ± 0.035	1.877MetVal: 1.877 ± 0.036	0.179MetTrp: 0.179 ± 0.013	0.441MetTyr: 0.441 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.793AsnAla: 2.793 ± 0.055	0.303AsnCys: 0.303 ± 0.017	1.627AsnAsp: 1.627 ± 0.039	1.682AsnGlu: 1.682 ± 0.041	1.07AsnPhe: 1.07 ± 0.029	2.607AsnGly: 2.607 ± 0.054	0.709AsnHis: 0.709 ± 0.025	1.542AsnIle: 1.542 ± 0.035	0.921AsnLys: 0.921 ± 0.028	3.361AsnLeu: 3.361 ± 0.049	0.67AsnMet: 0.67 ± 0.025	0.989AsnAsn: 0.989 ± 0.033	2.105AsnPro: 2.105 ± 0.048	1.273AsnGln: 1.273 ± 0.036	2.263AsnArg: 2.263 ± 0.05	1.518AsnSer: 1.518 ± 0.04	1.572AsnThr: 1.572 ± 0.039	2.005AsnVal: 2.005 ± 0.046	0.48AsnTrp: 0.48 ± 0.02	0.881AsnTyr: 0.881 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.592ProAla: 5.592 ± 0.097	0.332ProCys: 0.332 ± 0.018	3.602ProAsp: 3.602 ± 0.06	4.192ProGlu: 4.192 ± 0.069	1.798ProPhe: 1.798 ± 0.039	4.413ProGly: 4.413 ± 0.068	0.901ProHis: 0.901 ± 0.029	1.871ProIle: 1.871 ± 0.042	1.369ProLys: 1.369 ± 0.041	4.975ProLeu: 4.975 ± 0.063	1.143ProMet: 1.143 ± 0.029	1.157ProAsn: 1.157 ± 0.038	1.922ProPro: 1.922 ± 0.048	1.761ProGln: 1.761 ± 0.038	2.501ProArg: 2.501 ± 0.043	2.247ProSer: 2.247 ± 0.045	1.981ProThr: 1.981 ± 0.04	4.634ProVal: 4.634 ± 0.066	0.7ProTrp: 0.7 ± 0.026	1.128ProTyr: 1.128 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.432GlnAla: 4.432 ± 0.074	0.316GlnCys: 0.316 ± 0.018	1.868GlnAsp: 1.868 ± 0.041	2.023GlnGlu: 2.023 ± 0.045	1.347GlnPhe: 1.347 ± 0.031	2.99GlnGly: 2.99 ± 0.054	0.886GlnHis: 0.886 ± 0.029	1.741GlnIle: 1.741 ± 0.043	1.279GlnLys: 1.279 ± 0.039	4.466GlnLeu: 4.466 ± 0.066	0.919GlnMet: 0.919 ± 0.03	1.01GlnAsn: 1.01 ± 0.032	2.179GlnPro: 2.179 ± 0.053	2.249GlnGln: 2.249 ± 0.047	2.932GlnArg: 2.932 ± 0.053	2.002GlnSer: 2.002 ± 0.038	1.829GlnThr: 1.829 ± 0.046	3.059GlnVal: 3.059 ± 0.05	0.649GlnTrp: 0.649 ± 0.023	0.921GlnTyr: 0.921 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.967ArgAla: 5.967 ± 0.074	0.58ArgCys: 0.58 ± 0.023	3.951ArgAsp: 3.951 ± 0.061	4.653ArgGlu: 4.653 ± 0.068	2.926ArgPhe: 2.926 ± 0.046	4.199ArgGly: 4.199 ± 0.064	1.762ArgHis: 1.762 ± 0.039	3.762ArgIle: 3.762 ± 0.052	2.669ArgLys: 2.669 ± 0.052	7.893ArgLeu: 7.893 ± 0.1	1.759ArgMet: 1.759 ± 0.039	2.264ArgAsn: 2.264 ± 0.048	2.947ArgPro: 2.947 ± 0.059	3.456ArgGln: 3.456 ± 0.058	4.71ArgArg: 4.71 ± 0.074	3.544ArgSer: 3.544 ± 0.051	3.014ArgThr: 3.014 ± 0.05	4.779ArgVal: 4.779 ± 0.072	1.094ArgTrp: 1.094 ± 0.03	2.143ArgTyr: 2.143 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.613SerAla: 5.613 ± 0.072	0.514SerCys: 0.514 ± 0.022	3.176SerAsp: 3.176 ± 0.055	3.241SerGlu: 3.241 ± 0.054	2.202SerPhe: 2.202 ± 0.046	5.635SerGly: 5.635 ± 0.078	1.363SerHis: 1.363 ± 0.035	2.648SerIle: 2.648 ± 0.051	1.6SerLys: 1.6 ± 0.04	6.211SerLeu: 6.211 ± 0.074	1.388SerMet: 1.388 ± 0.03	1.584SerAsn: 1.584 ± 0.044	2.704SerPro: 2.704 ± 0.047	2.086SerGln: 2.086 ± 0.042	3.969SerArg: 3.969 ± 0.054	3.19SerSer: 3.19 ± 0.063	2.55SerThr: 2.55 ± 0.051	4.017SerVal: 4.017 ± 0.064	0.837SerTrp: 0.837 ± 0.026	1.527SerTyr: 1.527 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.494ThrAla: 5.494 ± 0.073	0.476ThrCys: 0.476 ± 0.024	2.887ThrAsp: 2.887 ± 0.052	3.005ThrGlu: 3.005 ± 0.051	1.862ThrPhe: 1.862 ± 0.038	5.198ThrGly: 5.198 ± 0.075	0.976ThrHis: 0.976 ± 0.029	2.444ThrIle: 2.444 ± 0.046	1.049ThrLys: 1.049 ± 0.034	6.494ThrLeu: 6.494 ± 0.084	1.086ThrMet: 1.086 ± 0.032	1.329ThrAsn: 1.329 ± 0.037	3.095ThrPro: 3.095 ± 0.059	1.34ThrGln: 1.34 ± 0.033	3.492ThrArg: 3.492 ± 0.048	2.749ThrSer: 2.749 ± 0.052	2.841ThrThr: 2.841 ± 0.06	4.101ThrVal: 4.101 ± 0.062	0.66ThrTrp: 0.66 ± 0.023	1.195ThrTyr: 1.195 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.288ValAla: 8.288 ± 0.105	0.762ValCys: 0.762 ± 0.025	4.274ValAsp: 4.274 ± 0.066	4.443ValGlu: 4.443 ± 0.071	2.91ValPhe: 2.91 ± 0.055	5.059ValGly: 5.059 ± 0.081	1.479ValHis: 1.479 ± 0.034	4.505ValIle: 4.505 ± 0.066	2.127ValLys: 2.127 ± 0.045	7.713ValLeu: 7.713 ± 0.086	2.08ValMet: 2.08 ± 0.043	2.333ValAsn: 2.333 ± 0.044	3.563ValPro: 3.563 ± 0.052	2.119ValGln: 2.119 ± 0.038	4.844ValArg: 4.844 ± 0.07	4.587ValSer: 4.587 ± 0.056	4.538ValThr: 4.538 ± 0.068	6.271ValVal: 6.271 ± 0.076	0.9ValTrp: 0.9 ± 0.03	1.773ValTyr: 1.773 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.053TrpAla: 1.053 ± 0.029	0.149TrpCys: 0.149 ± 0.013	0.624TrpAsp: 0.624 ± 0.025	0.613TrpGlu: 0.613 ± 0.023	0.611TrpPhe: 0.611 ± 0.022	0.922TrpGly: 0.922 ± 0.026	0.4TrpHis: 0.4 ± 0.018	0.667TrpIle: 0.667 ± 0.021	0.357TrpLys: 0.357 ± 0.018	2.124TrpLeu: 2.124 ± 0.051	0.386TrpMet: 0.386 ± 0.021	0.427TrpAsn: 0.427 ± 0.021	0.681TrpPro: 0.681 ± 0.022	0.969TrpGln: 0.969 ± 0.036	0.988TrpArg: 0.988 ± 0.029	0.844TrpSer: 0.844 ± 0.025	0.637TrpThr: 0.637 ± 0.026	0.91TrpVal: 0.91 ± 0.029	0.236TrpTrp: 0.236 ± 0.016	0.349TrpTyr: 0.349 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.164TyrAla: 2.164 ± 0.051	0.292TyrCys: 0.292 ± 0.016	1.584TyrAsp: 1.584 ± 0.036	1.43TyrGlu: 1.43 ± 0.029	1.072TyrPhe: 1.072 ± 0.03	2.182TyrGly: 2.182 ± 0.048	0.62TyrHis: 0.62 ± 0.023	1.107TyrIle: 1.107 ± 0.034	0.692TyrLys: 0.692 ± 0.024	3.066TyrLeu: 3.066 ± 0.049	0.491TyrMet: 0.491 ± 0.021	0.814TyrAsn: 0.814 ± 0.029	1.377TyrPro: 1.377 ± 0.037	1.217TyrGln: 1.217 ± 0.03	2.165TyrArg: 2.165 ± 0.038	1.503TyrSer: 1.503 ± 0.038	1.28TyrThr: 1.28 ± 0.036	1.604TyrVal: 1.604 ± 0.037	0.404TyrTrp: 0.404 ± 0.017	0.764TyrTyr: 0.764 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3568 proteins (1209230 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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