Amino acid dipepetide frequency for Streptococcus phage vB_SthS_VA460

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.771AlaAla: 2.771 ± 0.911
0.317AlaCys: 0.317 ± 0.19
4.592AlaAsp: 4.592 ± 0.527
3.642AlaGlu: 3.642 ± 0.532
1.821AlaPhe: 1.821 ± 0.403
3.405AlaGly: 3.405 ± 0.59
0.792AlaHis: 0.792 ± 0.27
4.909AlaIle: 4.909 ± 0.777
5.146AlaLys: 5.146 ± 0.744
4.83AlaLeu: 4.83 ± 0.557
1.584AlaMet: 1.584 ± 0.374
4.276AlaAsn: 4.276 ± 0.854
1.663AlaPro: 1.663 ± 0.36
2.454AlaGln: 2.454 ± 0.523
2.613AlaArg: 2.613 ± 0.355
4.909AlaSer: 4.909 ± 0.612
3.959AlaThr: 3.959 ± 0.573
3.88AlaVal: 3.88 ± 0.759
1.188AlaTrp: 1.188 ± 0.269
2.771AlaTyr: 2.771 ± 0.498
0.0AlaXaa: 0.0 ± 0.0
Cys
0.238CysAla: 0.238 ± 0.139
0.079CysCys: 0.079 ± 0.084
0.713CysAsp: 0.713 ± 0.246
0.633CysGlu: 0.633 ± 0.227
0.396CysPhe: 0.396 ± 0.205
0.792CysGly: 0.792 ± 0.325
0.158CysHis: 0.158 ± 0.111
0.238CysIle: 0.238 ± 0.136
0.713CysLys: 0.713 ± 0.34
0.475CysLeu: 0.475 ± 0.22
0.158CysMet: 0.158 ± 0.101
0.396CysAsn: 0.396 ± 0.216
0.238CysPro: 0.238 ± 0.124
0.396CysGln: 0.396 ± 0.177
0.713CysArg: 0.713 ± 0.336
0.396CysSer: 0.396 ± 0.285
0.238CysThr: 0.238 ± 0.13
0.317CysVal: 0.317 ± 0.147
0.158CysTrp: 0.158 ± 0.112
0.317CysTyr: 0.317 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
3.088AspAla: 3.088 ± 0.524
0.475AspCys: 0.475 ± 0.22
4.038AspAsp: 4.038 ± 0.621
5.226AspGlu: 5.226 ± 0.667
3.8AspPhe: 3.8 ± 0.585
6.097AspGly: 6.097 ± 1.155
0.554AspHis: 0.554 ± 0.191
4.434AspIle: 4.434 ± 0.665
4.988AspLys: 4.988 ± 0.532
3.721AspLeu: 3.721 ± 0.615
2.059AspMet: 2.059 ± 0.395
4.355AspAsn: 4.355 ± 0.68
1.742AspPro: 1.742 ± 0.423
1.663AspGln: 1.663 ± 0.316
2.85AspArg: 2.85 ± 0.483
4.276AspSer: 4.276 ± 0.42
4.434AspThr: 4.434 ± 0.618
3.8AspVal: 3.8 ± 0.625
1.188AspTrp: 1.188 ± 0.248
3.8AspTyr: 3.8 ± 0.569
0.0AspXaa: 0.0 ± 0.0
Glu
4.276GluAla: 4.276 ± 0.504
0.792GluCys: 0.792 ± 0.267
3.246GluAsp: 3.246 ± 0.565
4.751GluGlu: 4.751 ± 0.951
2.771GluPhe: 2.771 ± 0.439
3.088GluGly: 3.088 ± 0.363
1.346GluHis: 1.346 ± 0.387
7.126GluIle: 7.126 ± 0.731
4.276GluLys: 4.276 ± 0.679
6.017GluLeu: 6.017 ± 0.706
1.979GluMet: 1.979 ± 0.424
4.513GluAsn: 4.513 ± 0.674
1.663GluPro: 1.663 ± 0.527
2.771GluGln: 2.771 ± 0.512
3.563GluArg: 3.563 ± 0.545
2.692GluSer: 2.692 ± 0.543
3.959GluThr: 3.959 ± 0.48
4.117GluVal: 4.117 ± 0.502
0.713GluTrp: 0.713 ± 0.195
3.009GluTyr: 3.009 ± 0.493
0.0GluXaa: 0.0 ± 0.0
Phe
2.692PheAla: 2.692 ± 0.423
0.475PheCys: 0.475 ± 0.26
3.167PheAsp: 3.167 ± 0.52
2.85PheGlu: 2.85 ± 0.632
1.663PhePhe: 1.663 ± 0.33
2.93PheGly: 2.93 ± 0.508
0.317PheHis: 0.317 ± 0.146
1.742PheIle: 1.742 ± 0.397
4.196PheLys: 4.196 ± 0.684
2.692PheLeu: 2.692 ± 0.46
0.792PheMet: 0.792 ± 0.256
3.167PheAsn: 3.167 ± 0.633
0.475PhePro: 0.475 ± 0.174
1.584PheGln: 1.584 ± 0.319
2.059PheArg: 2.059 ± 0.31
3.325PheSer: 3.325 ± 0.548
2.454PheThr: 2.454 ± 0.448
2.534PheVal: 2.534 ± 0.483
0.871PheTrp: 0.871 ± 0.2
2.059PheTyr: 2.059 ± 0.432
0.0PheXaa: 0.0 ± 0.0
Gly
3.484GlyAla: 3.484 ± 0.522
0.396GlyCys: 0.396 ± 0.199
3.88GlyAsp: 3.88 ± 0.569
3.88GlyGlu: 3.88 ± 0.598
3.009GlyPhe: 3.009 ± 0.459
4.513GlyGly: 4.513 ± 0.889
1.267GlyHis: 1.267 ± 0.245
4.671GlyIle: 4.671 ± 0.651
7.047GlyLys: 7.047 ± 0.848
6.176GlyLeu: 6.176 ± 0.703
1.346GlyMet: 1.346 ± 0.321
5.067GlyAsn: 5.067 ± 0.738
1.108GlyPro: 1.108 ± 0.607
3.088GlyGln: 3.088 ± 0.424
3.088GlyArg: 3.088 ± 0.492
4.276GlySer: 4.276 ± 0.575
4.276GlyThr: 4.276 ± 0.55
3.563GlyVal: 3.563 ± 0.563
1.346GlyTrp: 1.346 ± 0.321
3.246GlyTyr: 3.246 ± 0.375
0.0GlyXaa: 0.0 ± 0.0
His
0.475HisAla: 0.475 ± 0.186
0.238HisCys: 0.238 ± 0.136
0.95HisAsp: 0.95 ± 0.273
0.713HisGlu: 0.713 ± 0.189
0.554HisPhe: 0.554 ± 0.194
0.633HisGly: 0.633 ± 0.189
0.396HisHis: 0.396 ± 0.158
1.584HisIle: 1.584 ± 0.382
0.713HisLys: 0.713 ± 0.278
1.267HisLeu: 1.267 ± 0.282
0.475HisMet: 0.475 ± 0.197
1.108HisAsn: 1.108 ± 0.407
0.396HisPro: 0.396 ± 0.147
0.792HisGln: 0.792 ± 0.273
0.792HisArg: 0.792 ± 0.243
0.792HisSer: 0.792 ± 0.227
0.633HisThr: 0.633 ± 0.227
1.188HisVal: 1.188 ± 0.264
0.238HisTrp: 0.238 ± 0.133
0.792HisTyr: 0.792 ± 0.278
0.0HisXaa: 0.0 ± 0.0
Ile
4.751IleAla: 4.751 ± 0.661
0.633IleCys: 0.633 ± 0.223
5.463IleAsp: 5.463 ± 0.64
4.355IleGlu: 4.355 ± 0.648
1.9IlePhe: 1.9 ± 0.472
4.592IleGly: 4.592 ± 0.597
0.792IleHis: 0.792 ± 0.23
3.642IleIle: 3.642 ± 0.533
6.017IleLys: 6.017 ± 0.569
3.484IleLeu: 3.484 ± 0.596
2.138IleMet: 2.138 ± 0.514
4.117IleAsn: 4.117 ± 0.456
3.8IlePro: 3.8 ± 0.497
2.613IleGln: 2.613 ± 0.331
3.009IleArg: 3.009 ± 0.402
4.671IleSer: 4.671 ± 0.626
3.721IleThr: 3.721 ± 0.404
3.167IleVal: 3.167 ± 0.505
1.029IleTrp: 1.029 ± 0.248
2.454IleTyr: 2.454 ± 0.562
0.0IleXaa: 0.0 ± 0.0
Lys
5.622LysAla: 5.622 ± 0.52
0.633LysCys: 0.633 ± 0.342
4.513LysAsp: 4.513 ± 0.575
7.205LysGlu: 7.205 ± 0.786
3.563LysPhe: 3.563 ± 0.827
6.097LysGly: 6.097 ± 0.681
1.267LysHis: 1.267 ± 0.474
5.622LysIle: 5.622 ± 0.578
6.809LysLys: 6.809 ± 1.217
6.255LysLeu: 6.255 ± 0.765
1.504LysMet: 1.504 ± 0.37
5.305LysAsn: 5.305 ± 0.693
2.534LysPro: 2.534 ± 0.415
3.009LysGln: 3.009 ± 0.519
4.038LysArg: 4.038 ± 0.549
4.513LysSer: 4.513 ± 0.643
5.067LysThr: 5.067 ± 0.799
4.355LysVal: 4.355 ± 0.646
1.425LysTrp: 1.425 ± 0.289
3.959LysTyr: 3.959 ± 0.951
0.0LysXaa: 0.0 ± 0.0
Leu
5.859LeuAla: 5.859 ± 0.665
0.475LeuCys: 0.475 ± 0.227
5.859LeuAsp: 5.859 ± 0.529
6.255LeuGlu: 6.255 ± 0.953
2.93LeuPhe: 2.93 ± 0.324
4.909LeuGly: 4.909 ± 0.8
0.95LeuHis: 0.95 ± 0.33
4.196LeuIle: 4.196 ± 0.552
6.888LeuLys: 6.888 ± 0.803
5.067LeuLeu: 5.067 ± 0.669
2.296LeuMet: 2.296 ± 0.477
4.83LeuAsn: 4.83 ± 0.608
2.771LeuPro: 2.771 ± 0.446
2.613LeuGln: 2.613 ± 0.55
2.692LeuArg: 2.692 ± 0.604
4.513LeuSer: 4.513 ± 0.557
4.988LeuThr: 4.988 ± 0.716
4.276LeuVal: 4.276 ± 0.611
0.792LeuTrp: 0.792 ± 0.261
2.454LeuTyr: 2.454 ± 0.561
0.0LeuXaa: 0.0 ± 0.0
Met
2.217MetAla: 2.217 ± 0.457
0.0MetCys: 0.0 ± 0.0
0.95MetAsp: 0.95 ± 0.249
1.425MetGlu: 1.425 ± 0.337
0.95MetPhe: 0.95 ± 0.214
1.029MetGly: 1.029 ± 0.262
0.317MetHis: 0.317 ± 0.153
1.663MetIle: 1.663 ± 0.355
2.534MetLys: 2.534 ± 0.594
1.584MetLeu: 1.584 ± 0.323
0.633MetMet: 0.633 ± 0.23
1.029MetAsn: 1.029 ± 0.275
0.713MetPro: 0.713 ± 0.188
0.792MetGln: 0.792 ± 0.19
1.108MetArg: 1.108 ± 0.262
2.059MetSer: 2.059 ± 0.409
1.742MetThr: 1.742 ± 0.349
2.138MetVal: 2.138 ± 0.39
0.079MetTrp: 0.079 ± 0.069
0.95MetTyr: 0.95 ± 0.238
0.0MetXaa: 0.0 ± 0.0
Asn
4.355AsnAla: 4.355 ± 0.764
0.475AsnCys: 0.475 ± 0.171
4.434AsnAsp: 4.434 ± 0.629
3.484AsnGlu: 3.484 ± 0.661
2.534AsnPhe: 2.534 ± 0.522
6.888AsnGly: 6.888 ± 0.999
1.267AsnHis: 1.267 ± 0.299
3.563AsnIle: 3.563 ± 0.566
3.959AsnLys: 3.959 ± 0.477
5.067AsnLeu: 5.067 ± 0.494
1.821AsnMet: 1.821 ± 0.386
4.434AsnAsn: 4.434 ± 0.611
3.325AsnPro: 3.325 ± 0.464
2.613AsnGln: 2.613 ± 0.545
2.613AsnArg: 2.613 ± 0.465
4.355AsnSer: 4.355 ± 0.585
3.642AsnThr: 3.642 ± 0.423
3.563AsnVal: 3.563 ± 0.371
1.108AsnTrp: 1.108 ± 0.28
1.821AsnTyr: 1.821 ± 0.326
0.0AsnXaa: 0.0 ± 0.0
Pro
1.584ProAla: 1.584 ± 0.291
0.158ProCys: 0.158 ± 0.169
2.296ProAsp: 2.296 ± 0.451
2.138ProGlu: 2.138 ± 0.399
1.108ProPhe: 1.108 ± 0.275
1.346ProGly: 1.346 ± 0.457
0.396ProHis: 0.396 ± 0.148
1.504ProIle: 1.504 ± 0.381
3.8ProLys: 3.8 ± 0.454
2.138ProLeu: 2.138 ± 0.357
0.158ProMet: 0.158 ± 0.119
2.296ProAsn: 2.296 ± 0.388
0.792ProPro: 0.792 ± 0.326
1.267ProGln: 1.267 ± 0.345
1.029ProArg: 1.029 ± 0.319
2.534ProSer: 2.534 ± 0.412
2.534ProThr: 2.534 ± 0.412
1.584ProVal: 1.584 ± 0.423
0.475ProTrp: 0.475 ± 0.187
1.267ProTyr: 1.267 ± 0.361
0.0ProXaa: 0.0 ± 0.0
Gln
3.642GlnAla: 3.642 ± 0.566
0.238GlnCys: 0.238 ± 0.122
1.821GlnAsp: 1.821 ± 0.386
2.534GlnGlu: 2.534 ± 0.496
1.346GlnPhe: 1.346 ± 0.278
3.088GlnGly: 3.088 ± 0.606
0.396GlnHis: 0.396 ± 0.154
1.821GlnIle: 1.821 ± 0.463
2.534GlnLys: 2.534 ± 0.416
3.721GlnLeu: 3.721 ± 0.574
0.95GlnMet: 0.95 ± 0.268
2.771GlnAsn: 2.771 ± 0.398
0.713GlnPro: 0.713 ± 0.235
2.375GlnGln: 2.375 ± 0.602
1.9GlnArg: 1.9 ± 0.359
2.217GlnSer: 2.217 ± 0.406
3.088GlnThr: 3.088 ± 0.418
2.059GlnVal: 2.059 ± 0.391
0.554GlnTrp: 0.554 ± 0.257
1.979GlnTyr: 1.979 ± 0.331
0.0GlnXaa: 0.0 ± 0.0
Arg
1.9ArgAla: 1.9 ± 0.422
0.475ArgCys: 0.475 ± 0.242
3.246ArgAsp: 3.246 ± 0.578
3.088ArgGlu: 3.088 ± 0.473
1.979ArgPhe: 1.979 ± 0.336
2.613ArgGly: 2.613 ± 0.529
0.713ArgHis: 0.713 ± 0.209
3.088ArgIle: 3.088 ± 0.535
3.325ArgLys: 3.325 ± 0.611
3.721ArgLeu: 3.721 ± 0.575
1.267ArgMet: 1.267 ± 0.327
3.088ArgAsn: 3.088 ± 0.453
1.346ArgPro: 1.346 ± 0.302
1.9ArgGln: 1.9 ± 0.447
1.584ArgArg: 1.584 ± 0.391
1.663ArgSer: 1.663 ± 0.291
2.296ArgThr: 2.296 ± 0.704
2.85ArgVal: 2.85 ± 0.36
1.029ArgTrp: 1.029 ± 0.276
2.692ArgTyr: 2.692 ± 0.56
0.0ArgXaa: 0.0 ± 0.0
Ser
2.692SerAla: 2.692 ± 0.415
0.396SerCys: 0.396 ± 0.166
4.038SerAsp: 4.038 ± 0.503
3.642SerGlu: 3.642 ± 0.421
2.93SerPhe: 2.93 ± 0.337
5.226SerGly: 5.226 ± 0.539
0.396SerHis: 0.396 ± 0.154
4.751SerIle: 4.751 ± 0.61
5.542SerLys: 5.542 ± 0.755
4.117SerLeu: 4.117 ± 0.429
2.217SerMet: 2.217 ± 0.384
4.909SerAsn: 4.909 ± 0.605
2.059SerPro: 2.059 ± 0.285
2.534SerGln: 2.534 ± 0.562
2.85SerArg: 2.85 ± 0.544
3.959SerSer: 3.959 ± 0.627
3.563SerThr: 3.563 ± 0.476
5.542SerVal: 5.542 ± 0.733
0.475SerTrp: 0.475 ± 0.245
1.821SerTyr: 1.821 ± 0.395
0.0SerXaa: 0.0 ± 0.0
Thr
3.563ThrAla: 3.563 ± 0.68
0.554ThrCys: 0.554 ± 0.236
4.355ThrAsp: 4.355 ± 0.818
3.484ThrGlu: 3.484 ± 0.446
3.167ThrPhe: 3.167 ± 0.51
4.196ThrGly: 4.196 ± 0.601
1.029ThrHis: 1.029 ± 0.244
4.592ThrIle: 4.592 ± 0.703
5.226ThrLys: 5.226 ± 0.585
6.097ThrLeu: 6.097 ± 0.757
0.633ThrMet: 0.633 ± 0.174
3.405ThrAsn: 3.405 ± 0.614
1.663ThrPro: 1.663 ± 0.407
2.534ThrGln: 2.534 ± 0.5
1.584ThrArg: 1.584 ± 0.332
3.721ThrSer: 3.721 ± 0.561
3.484ThrThr: 3.484 ± 0.641
4.513ThrVal: 4.513 ± 0.745
0.871ThrTrp: 0.871 ± 0.286
3.009ThrTyr: 3.009 ± 0.51
0.0ThrXaa: 0.0 ± 0.0
Val
4.671ValAla: 4.671 ± 0.651
0.238ValCys: 0.238 ± 0.122
4.988ValAsp: 4.988 ± 0.676
3.721ValGlu: 3.721 ± 0.519
3.167ValPhe: 3.167 ± 0.571
4.276ValGly: 4.276 ± 0.491
1.029ValHis: 1.029 ± 0.26
4.038ValIle: 4.038 ± 0.565
5.463ValLys: 5.463 ± 0.741
3.484ValLeu: 3.484 ± 0.57
0.792ValMet: 0.792 ± 0.249
3.167ValAsn: 3.167 ± 0.453
1.821ValPro: 1.821 ± 0.34
1.821ValGln: 1.821 ± 0.402
2.138ValArg: 2.138 ± 0.508
4.434ValSer: 4.434 ± 0.662
4.909ValThr: 4.909 ± 0.698
3.325ValVal: 3.325 ± 0.49
0.95ValTrp: 0.95 ± 0.198
1.742ValTyr: 1.742 ± 0.341
0.0ValXaa: 0.0 ± 0.0
Trp
0.633TrpAla: 0.633 ± 0.194
0.079TrpCys: 0.079 ± 0.076
1.029TrpAsp: 1.029 ± 0.324
0.792TrpGlu: 0.792 ± 0.17
0.713TrpPhe: 0.713 ± 0.22
0.713TrpGly: 0.713 ± 0.206
0.475TrpHis: 0.475 ± 0.187
0.554TrpIle: 0.554 ± 0.161
1.029TrpLys: 1.029 ± 0.317
1.425TrpLeu: 1.425 ± 0.321
0.158TrpMet: 0.158 ± 0.099
1.346TrpAsn: 1.346 ± 0.433
0.158TrpPro: 0.158 ± 0.114
0.633TrpGln: 0.633 ± 0.207
1.029TrpArg: 1.029 ± 0.271
1.663TrpSer: 1.663 ± 0.523
0.871TrpThr: 0.871 ± 0.291
1.108TrpVal: 1.108 ± 0.212
0.238TrpTrp: 0.238 ± 0.154
0.475TrpTyr: 0.475 ± 0.193
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.009TyrAla: 3.009 ± 0.502
0.633TyrCys: 0.633 ± 0.26
3.009TyrAsp: 3.009 ± 0.474
2.85TyrGlu: 2.85 ± 0.638
1.742TyrPhe: 1.742 ± 0.308
2.375TyrGly: 2.375 ± 0.427
0.871TyrHis: 0.871 ± 0.25
2.613TyrIle: 2.613 ± 0.545
3.088TyrLys: 3.088 ± 0.491
4.276TyrLeu: 4.276 ± 0.562
0.871TyrMet: 0.871 ± 0.253
1.742TyrAsn: 1.742 ± 0.445
1.425TyrPro: 1.425 ± 0.3
2.296TyrGln: 2.296 ± 0.395
2.613TyrArg: 2.613 ± 0.501
2.692TyrSer: 2.692 ± 0.57
1.821TyrThr: 1.821 ± 0.491
2.296TyrVal: 2.296 ± 0.466
0.396TyrTrp: 0.396 ± 0.164
2.217TyrTyr: 2.217 ± 0.336
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (12631 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski