Amino acid dipepetide frequency for Devosia epidermidihirudinis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.877AlaAla: 15.877 ± 0.175	0.699AlaCys: 0.699 ± 0.028	7.093AlaAsp: 7.093 ± 0.088	7.293AlaGlu: 7.293 ± 0.099	4.448AlaPhe: 4.448 ± 0.06	10.078AlaGly: 10.078 ± 0.121	2.136AlaHis: 2.136 ± 0.045	7.265AlaIle: 7.265 ± 0.094	4.214AlaLys: 4.214 ± 0.06	13.648AlaLeu: 13.648 ± 0.143	3.636AlaMet: 3.636 ± 0.064	3.425AlaAsn: 3.425 ± 0.058	5.177AlaPro: 5.177 ± 0.087	4.158AlaGln: 4.158 ± 0.075	7.284AlaArg: 7.284 ± 0.088	6.415AlaSer: 6.415 ± 0.079	6.352AlaThr: 6.352 ± 0.088	8.767AlaVal: 8.767 ± 0.103	1.344AlaTrp: 1.344 ± 0.039	2.56AlaTyr: 2.56 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.779CysAla: 0.779 ± 0.027	0.073CysCys: 0.073 ± 0.008	0.423CysAsp: 0.423 ± 0.019	0.325CysGlu: 0.325 ± 0.019	0.256CysPhe: 0.256 ± 0.017	0.665CysGly: 0.665 ± 0.031	0.176CysHis: 0.176 ± 0.013	0.334CysIle: 0.334 ± 0.018	0.15CysLys: 0.15 ± 0.014	0.594CysLeu: 0.594 ± 0.021	0.119CysMet: 0.119 ± 0.01	0.165CysAsn: 0.165 ± 0.014	0.334CysPro: 0.334 ± 0.019	0.19CysGln: 0.19 ± 0.014	0.368CysArg: 0.368 ± 0.02	0.352CysSer: 0.352 ± 0.017	0.343CysThr: 0.343 ± 0.021	0.475CysVal: 0.475 ± 0.02	0.097CysTrp: 0.097 ± 0.01	0.177CysTyr: 0.177 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.07AspAla: 7.07 ± 0.084	0.363AspCys: 0.363 ± 0.019	3.07AspAsp: 3.07 ± 0.064	3.47AspGlu: 3.47 ± 0.067	2.302AspPhe: 2.302 ± 0.053	5.261AspGly: 5.261 ± 0.082	1.229AspHis: 1.229 ± 0.032	3.591AspIle: 3.591 ± 0.065	1.953AspLys: 1.953 ± 0.043	5.926AspLeu: 5.926 ± 0.081	1.389AspMet: 1.389 ± 0.033	1.621AspAsn: 1.621 ± 0.045	3.201AspPro: 3.201 ± 0.053	1.793AspGln: 1.793 ± 0.044	3.715AspArg: 3.715 ± 0.071	2.335AspSer: 2.335 ± 0.05	2.87AspThr: 2.87 ± 0.057	4.315AspVal: 4.315 ± 0.063	1.034AspTrp: 1.034 ± 0.03	1.534AspTyr: 1.534 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.073GluAla: 7.073 ± 0.093	0.271GluCys: 0.271 ± 0.018	2.706GluAsp: 2.706 ± 0.05	2.825GluGlu: 2.825 ± 0.071	1.894GluPhe: 1.894 ± 0.049	4.101GluGly: 4.101 ± 0.074	1.193GluHis: 1.193 ± 0.036	3.301GluIle: 3.301 ± 0.066	2.151GluLys: 2.151 ± 0.063	5.415GluLeu: 5.415 ± 0.079	1.475GluMet: 1.475 ± 0.035	1.544GluAsn: 1.544 ± 0.041	2.515GluPro: 2.515 ± 0.054	2.115GluGln: 2.115 ± 0.053	4.294GluArg: 4.294 ± 0.076	2.215GluSer: 2.215 ± 0.052	3.396GluThr: 3.396 ± 0.061	3.862GluVal: 3.862 ± 0.06	0.707GluTrp: 0.707 ± 0.027	1.008GluTyr: 1.008 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.93PheAla: 4.93 ± 0.078	0.345PheCys: 0.345 ± 0.017	2.752PheAsp: 2.752 ± 0.058	2.176PheGlu: 2.176 ± 0.049	1.521PhePhe: 1.521 ± 0.05	3.966PheGly: 3.966 ± 0.064	0.706PheHis: 0.706 ± 0.028	1.917PheIle: 1.917 ± 0.048	1.125PheLys: 1.125 ± 0.035	3.376PheLeu: 3.376 ± 0.054	0.834PheMet: 0.834 ± 0.028	1.243PheAsn: 1.243 ± 0.038	1.642PhePro: 1.642 ± 0.037	1.062PheGln: 1.062 ± 0.034	1.868PheArg: 1.868 ± 0.041	2.363PheSer: 2.363 ± 0.05	2.135PheThr: 2.135 ± 0.047	3.097PheVal: 3.097 ± 0.05	0.584PheTrp: 0.584 ± 0.025	0.944PheTyr: 0.944 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.074GlyAla: 9.074 ± 0.122	0.643GlyCys: 0.643 ± 0.026	4.487GlyAsp: 4.487 ± 0.065	4.69GlyGlu: 4.69 ± 0.085	3.695GlyPhe: 3.695 ± 0.061	7.181GlyGly: 7.181 ± 0.142	1.781GlyHis: 1.781 ± 0.044	4.944GlyIle: 4.944 ± 0.079	3.665GlyLys: 3.665 ± 0.074	9.032GlyLeu: 9.032 ± 0.11	2.243GlyMet: 2.243 ± 0.049	2.506GlyAsn: 2.506 ± 0.051	3.238GlyPro: 3.238 ± 0.057	3.152GlyGln: 3.152 ± 0.072	5.208GlyArg: 5.208 ± 0.08	4.644GlySer: 4.644 ± 0.062	4.867GlyThr: 4.867 ± 0.073	6.508GlyVal: 6.508 ± 0.082	1.355GlyTrp: 1.355 ± 0.039	2.456GlyTyr: 2.456 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.092HisAla: 2.092 ± 0.046	0.155HisCys: 0.155 ± 0.012	1.177HisAsp: 1.177 ± 0.037	0.997HisGlu: 0.997 ± 0.031	0.847HisPhe: 0.847 ± 0.027	1.794HisGly: 1.794 ± 0.04	0.552HisHis: 0.552 ± 0.024	1.076HisIle: 1.076 ± 0.031	0.554HisLys: 0.554 ± 0.023	1.994HisLeu: 1.994 ± 0.045	0.525HisMet: 0.525 ± 0.022	0.577HisAsn: 0.577 ± 0.027	1.166HisPro: 1.166 ± 0.034	0.642HisGln: 0.642 ± 0.026	1.275HisArg: 1.275 ± 0.036	0.92HisSer: 0.92 ± 0.032	0.932HisThr: 0.932 ± 0.032	1.434HisVal: 1.434 ± 0.041	0.321HisTrp: 0.321 ± 0.018	0.542HisTyr: 0.542 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	8.252IleAla: 8.252 ± 0.102	0.446IleCys: 0.446 ± 0.021	3.887IleAsp: 3.887 ± 0.06	3.638IleGlu: 3.638 ± 0.057	1.932IlePhe: 1.932 ± 0.044	5.502IleGly: 5.502 ± 0.088	0.921IleHis: 0.921 ± 0.028	2.884IleIle: 2.884 ± 0.061	1.672IleLys: 1.672 ± 0.048	4.964IleLeu: 4.964 ± 0.086	1.176IleMet: 1.176 ± 0.036	1.763IleAsn: 1.763 ± 0.037	2.356IlePro: 2.356 ± 0.048	1.246IleGln: 1.246 ± 0.039	2.944IleArg: 2.944 ± 0.053	3.33IleSer: 3.33 ± 0.059	3.173IleThr: 3.173 ± 0.055	4.834IleVal: 4.834 ± 0.084	0.727IleTrp: 0.727 ± 0.026	1.292IleTyr: 1.292 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.392LysAla: 4.392 ± 0.073	0.134LysCys: 0.134 ± 0.011	1.788LysAsp: 1.788 ± 0.05	1.444LysGlu: 1.444 ± 0.055	1.067LysPhe: 1.067 ± 0.035	2.774LysGly: 2.774 ± 0.06	0.666LysHis: 0.666 ± 0.027	1.805LysIle: 1.805 ± 0.044	1.27LysLys: 1.27 ± 0.049	3.45LysLeu: 3.45 ± 0.068	0.796LysMet: 0.796 ± 0.03	0.848LysAsn: 0.848 ± 0.028	2.049LysPro: 2.049 ± 0.053	1.036LysGln: 1.036 ± 0.035	2.239LysArg: 2.239 ± 0.053	2.057LysSer: 2.057 ± 0.051	1.982LysThr: 1.982 ± 0.047	2.685LysVal: 2.685 ± 0.052	0.406LysTrp: 0.406 ± 0.019	0.631LysTyr: 0.631 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.409LeuAla: 13.409 ± 0.138	0.719LeuCys: 0.719 ± 0.029	6.399LeuAsp: 6.399 ± 0.077	5.131LeuGlu: 5.131 ± 0.075	3.685LeuPhe: 3.685 ± 0.062	8.904LeuGly: 8.904 ± 0.116	1.727LeuHis: 1.727 ± 0.043	5.593LeuIle: 5.593 ± 0.087	3.551LeuLys: 3.551 ± 0.064	9.769LeuLeu: 9.769 ± 0.126	2.394LeuMet: 2.394 ± 0.057	2.924LeuAsn: 2.924 ± 0.054	5.524LeuPro: 5.524 ± 0.077	2.792LeuGln: 2.792 ± 0.049	6.133LeuArg: 6.133 ± 0.085	6.807LeuSer: 6.807 ± 0.094	6.103LeuThr: 6.103 ± 0.086	8.125LeuVal: 8.125 ± 0.089	1.149LeuTrp: 1.149 ± 0.039	2.168LeuTyr: 2.168 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.228MetAla: 3.228 ± 0.064	0.119MetCys: 0.119 ± 0.01	1.233MetAsp: 1.233 ± 0.032	1.046MetGlu: 1.046 ± 0.033	0.78MetPhe: 0.78 ± 0.028	1.948MetGly: 1.948 ± 0.04	0.411MetHis: 0.411 ± 0.019	1.357MetIle: 1.357 ± 0.038	0.812MetLys: 0.812 ± 0.031	2.645MetLeu: 2.645 ± 0.052	0.627MetMet: 0.627 ± 0.026	0.736MetAsn: 0.736 ± 0.025	1.42MetPro: 1.42 ± 0.037	0.801MetGln: 0.801 ± 0.027	1.677MetArg: 1.677 ± 0.042	1.817MetSer: 1.817 ± 0.041	1.969MetThr: 1.969 ± 0.041	1.963MetVal: 1.963 ± 0.042	0.213MetTrp: 0.213 ± 0.014	0.318MetTyr: 0.318 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.557AsnAla: 3.557 ± 0.057	0.189AsnCys: 0.189 ± 0.015	1.55AsnAsp: 1.55 ± 0.045	1.395AsnGlu: 1.395 ± 0.04	1.132AsnPhe: 1.132 ± 0.033	2.677AsnGly: 2.677 ± 0.054	0.609AsnHis: 0.609 ± 0.026	1.589AsnIle: 1.589 ± 0.04	0.884AsnLys: 0.884 ± 0.033	2.965AsnLeu: 2.965 ± 0.052	0.65AsnMet: 0.65 ± 0.027	0.87AsnAsn: 0.87 ± 0.03	1.954AsnPro: 1.954 ± 0.048	0.953AsnGln: 0.953 ± 0.03	1.786AsnArg: 1.786 ± 0.044	1.409AsnSer: 1.409 ± 0.038	1.541AsnThr: 1.541 ± 0.045	2.26AsnVal: 2.26 ± 0.047	0.487AsnTrp: 0.487 ± 0.021	0.793AsnTyr: 0.793 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.679ProAla: 5.679 ± 0.085	0.234ProCys: 0.234 ± 0.015	3.449ProAsp: 3.449 ± 0.059	3.443ProGlu: 3.443 ± 0.063	1.939ProPhe: 1.939 ± 0.05	4.03ProGly: 4.03 ± 0.064	0.997ProHis: 0.997 ± 0.035	2.62ProIle: 2.62 ± 0.048	1.665ProLys: 1.665 ± 0.047	4.689ProLeu: 4.689 ± 0.069	1.155ProMet: 1.155 ± 0.037	1.583ProAsn: 1.583 ± 0.04	1.978ProPro: 1.978 ± 0.056	1.531ProGln: 1.531 ± 0.036	2.476ProArg: 2.476 ± 0.046	2.793ProSer: 2.793 ± 0.051	2.833ProThr: 2.833 ± 0.059	3.98ProVal: 3.98 ± 0.066	0.586ProTrp: 0.586 ± 0.026	1.249ProTyr: 1.249 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.737GlnAla: 3.737 ± 0.069	0.163GlnCys: 0.163 ± 0.012	1.483GlnAsp: 1.483 ± 0.036	1.243GlnGlu: 1.243 ± 0.03	1.305GlnPhe: 1.305 ± 0.032	2.333GlnGly: 2.333 ± 0.042	0.684GlnHis: 0.684 ± 0.024	2.013GlnIle: 2.013 ± 0.047	0.986GlnLys: 0.986 ± 0.031	3.305GlnLeu: 3.305 ± 0.055	0.991GlnMet: 0.991 ± 0.031	0.938GlnAsn: 0.938 ± 0.031	1.739GlnPro: 1.739 ± 0.043	1.264GlnGln: 1.264 ± 0.038	2.484GlnArg: 2.484 ± 0.053	1.973GlnSer: 1.973 ± 0.042	1.878GlnThr: 1.878 ± 0.048	2.439GlnVal: 2.439 ± 0.048	0.412GlnTrp: 0.412 ± 0.022	0.722GlnTyr: 0.722 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.741ArgAla: 6.741 ± 0.091	0.352ArgCys: 0.352 ± 0.019	3.715ArgAsp: 3.715 ± 0.076	3.384ArgGlu: 3.384 ± 0.069	2.619ArgPhe: 2.619 ± 0.052	4.171ArgGly: 4.171 ± 0.071	1.435ArgHis: 1.435 ± 0.035	3.699ArgIle: 3.699 ± 0.065	2.094ArgLys: 2.094 ± 0.047	6.942ArgLeu: 6.942 ± 0.097	1.622ArgMet: 1.622 ± 0.048	1.88ArgAsn: 1.88 ± 0.047	2.924ArgPro: 2.924 ± 0.048	2.462ArgGln: 2.462 ± 0.053	4.282ArgArg: 4.282 ± 0.08	3.265ArgSer: 3.265 ± 0.061	3.101ArgThr: 3.101 ± 0.049	4.439ArgVal: 4.439 ± 0.07	0.789ArgTrp: 0.789 ± 0.031	1.59ArgTyr: 1.59 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.367SerAla: 6.367 ± 0.08	0.326SerCys: 0.326 ± 0.021	3.062SerAsp: 3.062 ± 0.054	2.7SerGlu: 2.7 ± 0.053	2.436SerPhe: 2.436 ± 0.051	5.529SerGly: 5.529 ± 0.087	1.154SerHis: 1.154 ± 0.031	3.246SerIle: 3.246 ± 0.058	1.664SerLys: 1.664 ± 0.046	5.728SerLeu: 5.728 ± 0.073	1.39SerMet: 1.39 ± 0.035	1.658SerAsn: 1.658 ± 0.038	2.685SerPro: 2.685 ± 0.054	1.775SerGln: 1.775 ± 0.048	3.299SerArg: 3.299 ± 0.058	3.058SerSer: 3.058 ± 0.066	2.96SerThr: 2.96 ± 0.058	4.46SerVal: 4.46 ± 0.062	0.803SerTrp: 0.803 ± 0.028	1.413SerTyr: 1.413 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.375ThrAla: 6.375 ± 0.085	0.346ThrCys: 0.346 ± 0.02	3.074ThrAsp: 3.074 ± 0.062	2.759ThrGlu: 2.759 ± 0.058	2.135ThrPhe: 2.135 ± 0.048	5.098ThrGly: 5.098 ± 0.082	1.083ThrHis: 1.083 ± 0.031	3.587ThrIle: 3.587 ± 0.056	1.813ThrLys: 1.813 ± 0.05	6.415ThrLeu: 6.415 ± 0.101	1.33ThrMet: 1.33 ± 0.035	1.633ThrAsn: 1.633 ± 0.044	3.298ThrPro: 3.298 ± 0.066	1.624ThrGln: 1.624 ± 0.036	3.17ThrArg: 3.17 ± 0.058	3.081ThrSer: 3.081 ± 0.057	3.23ThrThr: 3.23 ± 0.063	4.556ThrVal: 4.556 ± 0.064	0.612ThrTrp: 0.612 ± 0.026	1.298ThrTyr: 1.298 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.399ValAla: 9.399 ± 0.118	0.508ValCys: 0.508 ± 0.02	4.496ValAsp: 4.496 ± 0.064	4.285ValGlu: 4.285 ± 0.071	2.953ValPhe: 2.953 ± 0.054	6.236ValGly: 6.236 ± 0.089	1.335ValHis: 1.335 ± 0.037	4.523ValIle: 4.523 ± 0.079	2.235ValLys: 2.235 ± 0.05	8.28ValLeu: 8.28 ± 0.094	1.964ValMet: 1.964 ± 0.041	2.146ValAsn: 2.146 ± 0.044	3.868ValPro: 3.868 ± 0.065	2.153ValGln: 2.153 ± 0.043	4.457ValArg: 4.457 ± 0.067	4.691ValSer: 4.691 ± 0.066	4.957ValThr: 4.957 ± 0.071	6.324ValVal: 6.324 ± 0.083	0.899ValTrp: 0.899 ± 0.032	1.505ValTyr: 1.505 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.259TrpAla: 1.259 ± 0.038	0.115TrpCys: 0.115 ± 0.01	0.688TrpAsp: 0.688 ± 0.027	0.533TrpGlu: 0.533 ± 0.021	0.568TrpPhe: 0.568 ± 0.027	0.943TrpGly: 0.943 ± 0.031	0.3TrpHis: 0.3 ± 0.016	0.639TrpIle: 0.639 ± 0.027	0.412TrpLys: 0.412 ± 0.021	1.585TrpLeu: 1.585 ± 0.046	0.32TrpMet: 0.32 ± 0.016	0.477TrpAsn: 0.477 ± 0.022	0.688TrpPro: 0.688 ± 0.026	0.589TrpGln: 0.589 ± 0.026	0.977TrpArg: 0.977 ± 0.035	0.871TrpSer: 0.871 ± 0.035	0.763TrpThr: 0.763 ± 0.028	0.897TrpVal: 0.897 ± 0.03	0.265TrpTrp: 0.265 ± 0.017	0.297TrpTyr: 0.297 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.581TyrAla: 2.581 ± 0.046	0.196TyrCys: 0.196 ± 0.014	1.511TyrAsp: 1.511 ± 0.04	1.283TyrGlu: 1.283 ± 0.036	1.072TyrPhe: 1.072 ± 0.028	2.181TyrGly: 2.181 ± 0.045	0.477TyrHis: 0.477 ± 0.02	0.955TyrIle: 0.955 ± 0.028	0.648TyrLys: 0.648 ± 0.027	2.283TyrLeu: 2.283 ± 0.046	0.481TyrMet: 0.481 ± 0.02	0.713TyrAsn: 0.713 ± 0.026	1.157TyrPro: 1.157 ± 0.038	0.752TyrGln: 0.752 ± 0.027	1.57TyrArg: 1.57 ± 0.043	1.318TyrSer: 1.318 ± 0.039	1.131TyrThr: 1.131 ± 0.035	1.793TyrVal: 1.793 ± 0.045	0.394TyrTrp: 0.394 ± 0.021	0.64TyrTyr: 0.64 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3353 proteins (1031883 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---