Amino acid dipepetide frequency for Fonsecaea multimorphosa CBS 102226

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.282AlaAla: 9.282 ± 0.059	1.112AlaCys: 1.112 ± 0.014	4.319AlaAsp: 4.319 ± 0.03	5.276AlaGlu: 5.276 ± 0.04	3.233AlaPhe: 3.233 ± 0.025	6.003AlaGly: 6.003 ± 0.038	1.825AlaHis: 1.825 ± 0.018	4.293AlaIle: 4.293 ± 0.029	4.022AlaLys: 4.022 ± 0.033	7.913AlaLeu: 7.913 ± 0.041	1.993AlaMet: 1.993 ± 0.017	2.976AlaAsn: 2.976 ± 0.024	4.545AlaPro: 4.545 ± 0.038	3.63AlaGln: 3.63 ± 0.025	5.135AlaArg: 5.135 ± 0.034	7.2AlaSer: 7.2 ± 0.042	5.416AlaThr: 5.416 ± 0.03	5.537AlaVal: 5.537 ± 0.032	1.189AlaTrp: 1.189 ± 0.014	2.211AlaTyr: 2.211 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.989CysAla: 0.989 ± 0.015	0.238CysCys: 0.238 ± 0.005	0.652CysAsp: 0.652 ± 0.013	0.579CysGlu: 0.579 ± 0.01	0.559CysPhe: 0.559 ± 0.011	0.901CysGly: 0.901 ± 0.013	0.344CysHis: 0.344 ± 0.009	0.705CysIle: 0.705 ± 0.013	0.483CysLys: 0.483 ± 0.009	1.322CysLeu: 1.322 ± 0.013	0.269CysMet: 0.269 ± 0.007	0.403CysAsn: 0.403 ± 0.008	0.647CysPro: 0.647 ± 0.01	0.466CysGln: 0.466 ± 0.009	0.762CysArg: 0.762 ± 0.011	0.892CysSer: 0.892 ± 0.014	0.667CysThr: 0.667 ± 0.012	0.832CysVal: 0.832 ± 0.013	0.209CysTrp: 0.209 ± 0.005	0.373CysTyr: 0.373 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.712AspAla: 4.712 ± 0.027	0.617AspCys: 0.617 ± 0.011	4.139AspAsp: 4.139 ± 0.047	4.436AspGlu: 4.436 ± 0.041	2.29AspPhe: 2.29 ± 0.021	3.989AspGly: 3.989 ± 0.027	1.322AspHis: 1.322 ± 0.015	2.942AspIle: 2.942 ± 0.023	2.37AspLys: 2.37 ± 0.022	5.2AspLeu: 5.2 ± 0.035	1.268AspMet: 1.268 ± 0.016	1.798AspAsn: 1.798 ± 0.019	3.487AspPro: 3.487 ± 0.025	2.038AspGln: 2.038 ± 0.022	3.095AspArg: 3.095 ± 0.032	3.911AspSer: 3.911 ± 0.027	2.92AspThr: 2.92 ± 0.022	3.711AspVal: 3.711 ± 0.03	0.909AspTrp: 0.909 ± 0.014	1.554AspTyr: 1.554 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.386GluAla: 5.386 ± 0.039	0.619GluCys: 0.619 ± 0.01	4.221GluAsp: 4.221 ± 0.037	5.322GluGlu: 5.322 ± 0.054	1.897GluPhe: 1.897 ± 0.019	3.709GluGly: 3.709 ± 0.034	1.449GluHis: 1.449 ± 0.017	3.103GluIle: 3.103 ± 0.026	3.619GluLys: 3.619 ± 0.033	5.166GluLeu: 5.166 ± 0.035	1.494GluMet: 1.494 ± 0.017	2.178GluAsn: 2.178 ± 0.02	2.739GluPro: 2.739 ± 0.025	2.576GluGln: 2.576 ± 0.022	3.92GluArg: 3.92 ± 0.029	4.186GluSer: 4.186 ± 0.028	3.454GluThr: 3.454 ± 0.025	3.647GluVal: 3.647 ± 0.028	0.884GluTrp: 0.884 ± 0.012	1.644GluTyr: 1.644 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.181PheAla: 3.181 ± 0.023	0.576PheCys: 0.576 ± 0.012	2.35PheAsp: 2.35 ± 0.021	2.2PheGlu: 2.2 ± 0.022	1.669PhePhe: 1.669 ± 0.02	2.925PheGly: 2.925 ± 0.029	0.922PheHis: 0.922 ± 0.011	1.768PheIle: 1.768 ± 0.019	1.421PheLys: 1.421 ± 0.018	3.549PheLeu: 3.549 ± 0.029	0.794PheMet: 0.794 ± 0.011	1.384PheAsn: 1.384 ± 0.017	1.975PhePro: 1.975 ± 0.02	1.459PheGln: 1.459 ± 0.017	1.987PheArg: 1.987 ± 0.018	2.923PheSer: 2.923 ± 0.023	2.079PheThr: 2.079 ± 0.021	2.491PheVal: 2.491 ± 0.023	0.671PheTrp: 0.671 ± 0.013	1.126PheTyr: 1.126 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.432GlyAla: 5.432 ± 0.035	0.854GlyCys: 0.854 ± 0.013	3.565GlyAsp: 3.565 ± 0.027	3.637GlyGlu: 3.637 ± 0.026	2.901GlyPhe: 2.901 ± 0.023	5.865GlyGly: 5.865 ± 0.052	1.722GlyHis: 1.722 ± 0.017	3.552GlyIle: 3.552 ± 0.032	3.407GlyLys: 3.407 ± 0.031	6.213GlyLeu: 6.213 ± 0.034	1.66GlyMet: 1.66 ± 0.02	2.421GlyAsn: 2.421 ± 0.02	3.424GlyPro: 3.424 ± 0.031	2.683GlyGln: 2.683 ± 0.026	4.178GlyArg: 4.178 ± 0.033	5.546GlySer: 5.546 ± 0.031	4.051GlyThr: 4.051 ± 0.029	4.448GlyVal: 4.448 ± 0.03	1.17GlyTrp: 1.17 ± 0.015	2.155GlyTyr: 2.155 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.97HisAla: 1.97 ± 0.018	0.335HisCys: 0.335 ± 0.008	1.378HisAsp: 1.378 ± 0.015	1.412HisGlu: 1.412 ± 0.017	0.954HisPhe: 0.954 ± 0.011	1.804HisGly: 1.804 ± 0.018	0.903HisHis: 0.903 ± 0.015	1.191HisIle: 1.191 ± 0.014	0.97HisLys: 0.97 ± 0.013	2.308HisLeu: 2.308 ± 0.022	0.497HisMet: 0.497 ± 0.009	0.833HisAsn: 0.833 ± 0.011	1.707HisPro: 1.707 ± 0.018	1.012HisGln: 1.012 ± 0.015	1.552HisArg: 1.552 ± 0.016	1.838HisSer: 1.838 ± 0.021	1.27HisThr: 1.27 ± 0.013	1.52HisVal: 1.52 ± 0.016	0.36HisTrp: 0.36 ± 0.008	0.7HisTyr: 0.7 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.24IleAla: 4.24 ± 0.03	0.779IleCys: 0.779 ± 0.012	2.784IleAsp: 2.784 ± 0.024	2.781IleGlu: 2.781 ± 0.022	1.996IlePhe: 1.996 ± 0.021	3.213IleGly: 3.213 ± 0.026	1.215IleHis: 1.215 ± 0.014	2.44IleIle: 2.44 ± 0.024	2.085IleLys: 2.085 ± 0.023	4.631IleLeu: 4.631 ± 0.036	0.977IleMet: 0.977 ± 0.016	1.757IleAsn: 1.757 ± 0.017	3.068IlePro: 3.068 ± 0.023	1.924IleGln: 1.924 ± 0.018	2.722IleArg: 2.722 ± 0.023	3.813IleSer: 3.813 ± 0.026	2.721IleThr: 2.721 ± 0.024	3.209IleVal: 3.209 ± 0.029	0.75IleTrp: 0.75 ± 0.011	1.417IleTyr: 1.417 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.172LysAla: 4.172 ± 0.033	0.502LysCys: 0.502 ± 0.009	2.8LysAsp: 2.8 ± 0.027	3.275LysGlu: 3.275 ± 0.029	1.442LysPhe: 1.442 ± 0.016	2.919LysGly: 2.919 ± 0.024	1.163LysHis: 1.163 ± 0.015	2.288LysIle: 2.288 ± 0.018	3.009LysLys: 3.009 ± 0.045	3.947LysLeu: 3.947 ± 0.026	1.026LysMet: 1.026 ± 0.013	1.584LysAsn: 1.584 ± 0.017	2.669LysPro: 2.669 ± 0.029	1.858LysGln: 1.858 ± 0.019	3.341LysArg: 3.341 ± 0.025	3.43LysSer: 3.43 ± 0.03	2.715LysThr: 2.715 ± 0.021	2.83LysVal: 2.83 ± 0.024	0.696LysTrp: 0.696 ± 0.013	1.404LysTyr: 1.404 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.961LeuAla: 7.961 ± 0.042	1.28LeuCys: 1.28 ± 0.017	5.25LeuAsp: 5.25 ± 0.033	5.592LeuGlu: 5.592 ± 0.042	3.358LeuPhe: 3.358 ± 0.027	6.031LeuGly: 6.031 ± 0.035	2.29LeuHis: 2.29 ± 0.02	3.932LeuIle: 3.932 ± 0.032	4.172LeuLys: 4.172 ± 0.029	8.512LeuLeu: 8.512 ± 0.055	1.822LeuMet: 1.822 ± 0.018	3.152LeuAsn: 3.152 ± 0.025	5.531LeuPro: 5.531 ± 0.036	3.961LeuGln: 3.961 ± 0.029	5.803LeuArg: 5.803 ± 0.04	7.223LeuSer: 7.223 ± 0.039	4.868LeuThr: 4.868 ± 0.03	5.521LeuVal: 5.521 ± 0.035	1.269LeuTrp: 1.269 ± 0.016	2.379LeuTyr: 2.379 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.308MetAla: 2.308 ± 0.02	0.257MetCys: 0.257 ± 0.006	1.239MetAsp: 1.239 ± 0.015	1.2MetGlu: 1.2 ± 0.014	0.77MetPhe: 0.77 ± 0.013	1.475MetGly: 1.475 ± 0.015	0.502MetHis: 0.502 ± 0.008	0.992MetIle: 0.992 ± 0.014	0.975MetLys: 0.975 ± 0.012	1.892MetLeu: 1.892 ± 0.021	0.552MetMet: 0.552 ± 0.009	0.779MetAsn: 0.779 ± 0.013	1.296MetPro: 1.296 ± 0.014	0.871MetGln: 0.871 ± 0.014	1.232MetArg: 1.232 ± 0.016	1.893MetSer: 1.893 ± 0.017	1.345MetThr: 1.345 ± 0.017	1.333MetVal: 1.333 ± 0.015	0.257MetTrp: 0.257 ± 0.006	0.534MetTyr: 0.534 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.149AsnAla: 3.149 ± 0.028	0.432AsnCys: 0.432 ± 0.01	1.904AsnAsp: 1.904 ± 0.018	1.917AsnGlu: 1.917 ± 0.021	1.358AsnPhe: 1.358 ± 0.013	2.963AsnGly: 2.963 ± 0.023	0.874AsnHis: 0.874 ± 0.013	1.969AsnIle: 1.969 ± 0.023	1.457AsnLys: 1.457 ± 0.016	3.232AsnLeu: 3.232 ± 0.026	0.783AsnMet: 0.783 ± 0.011	1.43AsnAsn: 1.43 ± 0.018	2.425AsnPro: 2.425 ± 0.023	1.313AsnGln: 1.313 ± 0.015	1.861AsnArg: 1.861 ± 0.018	2.542AsnSer: 2.542 ± 0.025	2.08AsnThr: 2.08 ± 0.02	2.351AsnVal: 2.351 ± 0.02	0.555AsnTrp: 0.555 ± 0.012	1.018AsnTyr: 1.018 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.181ProAla: 5.181 ± 0.038	0.508ProCys: 0.508 ± 0.01	3.265ProAsp: 3.265 ± 0.023	3.851ProGlu: 3.851 ± 0.028	2.098ProPhe: 2.098 ± 0.02	3.998ProGly: 3.998 ± 0.028	1.363ProHis: 1.363 ± 0.017	2.462ProIle: 2.462 ± 0.019	2.607ProLys: 2.607 ± 0.023	4.852ProLeu: 4.852 ± 0.034	1.075ProMet: 1.075 ± 0.014	2.19ProAsn: 2.19 ± 0.025	5.232ProPro: 5.232 ± 0.061	2.619ProGln: 2.619 ± 0.03	3.432ProArg: 3.432 ± 0.027	5.969ProSer: 5.969 ± 0.044	3.992ProThr: 3.992 ± 0.035	3.615ProVal: 3.615 ± 0.027	0.771ProTrp: 0.771 ± 0.012	1.555ProTyr: 1.555 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.614GlnAla: 3.614 ± 0.032	0.453GlnCys: 0.453 ± 0.009	2.213GlnAsp: 2.213 ± 0.02	2.528GlnGlu: 2.528 ± 0.025	1.31GlnPhe: 1.31 ± 0.015	2.582GlnGly: 2.582 ± 0.022	1.136GlnHis: 1.136 ± 0.015	1.969GlnIle: 1.969 ± 0.017	2.036GlnLys: 2.036 ± 0.022	3.479GlnLeu: 3.479 ± 0.028	0.908GlnMet: 0.908 ± 0.013	1.585GlnAsn: 1.585 ± 0.017	2.624GlnPro: 2.624 ± 0.032	2.519GlnGln: 2.519 ± 0.039	2.749GlnArg: 2.749 ± 0.024	3.26GlnSer: 3.26 ± 0.026	2.413GlnThr: 2.413 ± 0.022	2.246GlnVal: 2.246 ± 0.02	0.59GlnTrp: 0.59 ± 0.011	1.184GlnTyr: 1.184 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.799ArgAla: 4.799 ± 0.032	0.7ArgCys: 0.7 ± 0.013	3.43ArgAsp: 3.43 ± 0.031	3.878ArgGlu: 3.878 ± 0.029	2.085ArgPhe: 2.085 ± 0.018	3.712ArgGly: 3.712 ± 0.03	1.665ArgHis: 1.665 ± 0.016	2.84ArgIle: 2.84 ± 0.023	3.505ArgLys: 3.505 ± 0.028	5.557ArgLeu: 5.557 ± 0.033	1.306ArgMet: 1.306 ± 0.015	2.182ArgAsn: 2.182 ± 0.016	3.625ArgPro: 3.625 ± 0.033	2.734ArgGln: 2.734 ± 0.024	5.243ArgArg: 5.243 ± 0.044	4.715ArgSer: 4.715 ± 0.036	3.343ArgThr: 3.343 ± 0.025	3.29ArgVal: 3.29 ± 0.025	0.957ArgTrp: 0.957 ± 0.015	1.722ArgTyr: 1.722 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.666SerAla: 6.666 ± 0.044	0.839SerCys: 0.839 ± 0.012	4.058SerAsp: 4.058 ± 0.03	4.04SerGlu: 4.04 ± 0.03	2.943SerPhe: 2.943 ± 0.019	5.477SerGly: 5.477 ± 0.037	1.95SerHis: 1.95 ± 0.021	3.876SerIle: 3.876 ± 0.027	3.588SerLys: 3.588 ± 0.029	7.132SerLeu: 7.132 ± 0.039	1.731SerMet: 1.731 ± 0.019	2.871SerAsn: 2.871 ± 0.022	5.514SerPro: 5.514 ± 0.046	3.379SerGln: 3.379 ± 0.03	5.004SerArg: 5.004 ± 0.037	8.821SerSer: 8.821 ± 0.072	5.754SerThr: 5.754 ± 0.05	4.525SerVal: 4.525 ± 0.032	1.152SerTrp: 1.152 ± 0.017	2.014SerTyr: 2.014 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.361ThrAla: 5.361 ± 0.034	0.733ThrCys: 0.733 ± 0.013	2.83ThrAsp: 2.83 ± 0.023	3.054ThrGlu: 3.054 ± 0.029	2.302ThrPhe: 2.302 ± 0.023	4.167ThrGly: 4.167 ± 0.028	1.249ThrHis: 1.249 ± 0.015	3.09ThrIle: 3.09 ± 0.022	2.56ThrLys: 2.56 ± 0.023	5.196ThrLeu: 5.196 ± 0.032	1.217ThrMet: 1.217 ± 0.013	2.141ThrAsn: 2.141 ± 0.019	4.259ThrPro: 4.259 ± 0.036	2.155ThrGln: 2.155 ± 0.02	3.113ThrArg: 3.113 ± 0.024	5.525ThrSer: 5.525 ± 0.05	4.667ThrThr: 4.667 ± 0.056	3.761ThrVal: 3.761 ± 0.029	0.882ThrTrp: 0.882 ± 0.015	1.6ThrTyr: 1.6 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.357ValAla: 5.357 ± 0.033	0.829ValCys: 0.829 ± 0.013	3.798ValAsp: 3.798 ± 0.026	3.898ValGlu: 3.898 ± 0.03	2.494ValPhe: 2.494 ± 0.025	4.103ValGly: 4.103 ± 0.026	1.45ValHis: 1.45 ± 0.017	2.923ValIle: 2.923 ± 0.024	2.911ValLys: 2.911 ± 0.022	5.668ValLeu: 5.668 ± 0.034	1.337ValMet: 1.337 ± 0.018	2.253ValAsn: 2.253 ± 0.02	3.685ValPro: 3.685 ± 0.025	2.485ValGln: 2.485 ± 0.022	3.529ValArg: 3.529 ± 0.027	4.551ValSer: 4.551 ± 0.024	3.518ValThr: 3.518 ± 0.025	4.505ValVal: 4.505 ± 0.034	0.883ValTrp: 0.883 ± 0.013	1.722ValTyr: 1.722 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.147TrpAla: 1.147 ± 0.015	0.2TrpCys: 0.2 ± 0.006	0.867TrpAsp: 0.867 ± 0.013	0.831TrpGlu: 0.831 ± 0.013	0.555TrpPhe: 0.555 ± 0.01	0.919TrpGly: 0.919 ± 0.015	0.393TrpHis: 0.393 ± 0.008	0.82TrpIle: 0.82 ± 0.013	0.807TrpLys: 0.807 ± 0.011	1.413TrpLeu: 1.413 ± 0.017	0.378TrpMet: 0.378 ± 0.007	0.616TrpAsn: 0.616 ± 0.012	0.653TrpPro: 0.653 ± 0.011	0.598TrpGln: 0.598 ± 0.01	1.01TrpArg: 1.01 ± 0.014	1.087TrpSer: 1.087 ± 0.015	0.992TrpThr: 0.992 ± 0.014	0.864TrpVal: 0.864 ± 0.012	0.293TrpTrp: 0.293 ± 0.007	0.467TrpTyr: 0.467 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.205TyrAla: 2.205 ± 0.023	0.429TyrCys: 0.429 ± 0.008	1.641TyrAsp: 1.641 ± 0.018	1.505TyrGlu: 1.505 ± 0.019	1.238TyrPhe: 1.238 ± 0.017	2.131TyrGly: 2.131 ± 0.022	0.777TyrHis: 0.777 ± 0.012	1.365TyrIle: 1.365 ± 0.015	1.067TyrLys: 1.067 ± 0.013	2.726TyrLeu: 2.726 ± 0.025	0.615TyrMet: 0.615 ± 0.011	1.079TyrAsn: 1.079 ± 0.014	1.531TyrPro: 1.531 ± 0.019	1.118TyrGln: 1.118 ± 0.014	1.617TyrArg: 1.617 ± 0.017	2.012TyrSer: 2.012 ± 0.022	1.597TyrThr: 1.597 ± 0.016	1.663TyrVal: 1.663 ± 0.019	0.462TyrTrp: 0.462 ± 0.009	0.92TyrTyr: 0.92 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12368 proteins (6118718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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