Amino acid dipepetide frequency for Lichenibacterium ramalinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.854AlaAla: 24.854 ± 0.231
1.252AlaCys: 1.252 ± 0.031
7.85AlaAsp: 7.85 ± 0.066
8.495AlaGlu: 8.495 ± 0.082
4.691AlaPhe: 4.691 ± 0.065
13.62AlaGly: 13.62 ± 0.111
2.403AlaHis: 2.403 ± 0.043
5.535AlaIle: 5.535 ± 0.059
3.29AlaLys: 3.29 ± 0.054
16.589AlaLeu: 16.589 ± 0.14
3.703AlaMet: 3.703 ± 0.049
2.156AlaAsn: 2.156 ± 0.043
7.568AlaPro: 7.568 ± 0.086
3.447AlaGln: 3.447 ± 0.052
11.467AlaArg: 11.467 ± 0.098
6.818AlaSer: 6.818 ± 0.069
6.788AlaThr: 6.788 ± 0.066
12.019AlaVal: 12.019 ± 0.1
1.792AlaTrp: 1.792 ± 0.036
2.44AlaTyr: 2.44 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.1CysAla: 1.1 ± 0.027
0.12CysCys: 0.12 ± 0.009
0.523CysAsp: 0.523 ± 0.018
0.384CysGlu: 0.384 ± 0.015
0.331CysPhe: 0.331 ± 0.014
0.973CysGly: 0.973 ± 0.024
0.215CysHis: 0.215 ± 0.012
0.328CysIle: 0.328 ± 0.012
0.115CysLys: 0.115 ± 0.009
0.862CysLeu: 0.862 ± 0.023
0.143CysMet: 0.143 ± 0.01
0.17CysAsn: 0.17 ± 0.011
0.494CysPro: 0.494 ± 0.018
0.183CysGln: 0.183 ± 0.01
0.836CysArg: 0.836 ± 0.023
0.423CysSer: 0.423 ± 0.016
0.36CysThr: 0.36 ± 0.015
0.583CysVal: 0.583 ± 0.023
0.134CysTrp: 0.134 ± 0.009
0.176CysTyr: 0.176 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
8.829AspAla: 8.829 ± 0.087
0.45AspCys: 0.45 ± 0.018
3.299AspAsp: 3.299 ± 0.047
3.097AspGlu: 3.097 ± 0.049
1.943AspPhe: 1.943 ± 0.037
6.246AspGly: 6.246 ± 0.062
1.381AspHis: 1.381 ± 0.034
2.42AspIle: 2.42 ± 0.039
1.274AspLys: 1.274 ± 0.031
6.764AspLeu: 6.764 ± 0.068
1.187AspMet: 1.187 ± 0.027
0.944AspAsn: 0.944 ± 0.025
4.141AspPro: 4.141 ± 0.054
1.353AspGln: 1.353 ± 0.033
5.323AspArg: 5.323 ± 0.062
1.809AspSer: 1.809 ± 0.035
2.582AspThr: 2.582 ± 0.043
4.741AspVal: 4.741 ± 0.054
0.958AspTrp: 0.958 ± 0.022
1.326AspTyr: 1.326 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
8.392GluAla: 8.392 ± 0.077
0.284GluCys: 0.284 ± 0.015
2.493GluAsp: 2.493 ± 0.045
2.251GluGlu: 2.251 ± 0.041
1.297GluPhe: 1.297 ± 0.03
4.182GluGly: 4.182 ± 0.054
1.028GluHis: 1.028 ± 0.028
2.541GluIle: 2.541 ± 0.039
1.222GluLys: 1.222 ± 0.029
3.984GluLeu: 3.984 ± 0.055
1.134GluMet: 1.134 ± 0.029
0.971GluAsn: 0.971 ± 0.021
2.873GluPro: 2.873 ± 0.047
1.37GluGln: 1.37 ± 0.03
5.055GluArg: 5.055 ± 0.066
1.779GluSer: 1.779 ± 0.034
2.929GluThr: 2.929 ± 0.045
3.774GluVal: 3.774 ± 0.052
0.485GluTrp: 0.485 ± 0.018
0.607GluTyr: 0.607 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
5.003PheAla: 5.003 ± 0.058
0.376PheCys: 0.376 ± 0.015
2.665PheAsp: 2.665 ± 0.039
1.703PheGlu: 1.703 ± 0.032
1.236PhePhe: 1.236 ± 0.032
3.779PheGly: 3.779 ± 0.054
0.734PheHis: 0.734 ± 0.022
1.2PheIle: 1.2 ± 0.029
0.827PheLys: 0.827 ± 0.023
3.02PheLeu: 3.02 ± 0.049
0.704PheMet: 0.704 ± 0.023
0.826PheAsn: 0.826 ± 0.026
1.58PhePro: 1.58 ± 0.031
0.782PheGln: 0.782 ± 0.02
2.356PheArg: 2.356 ± 0.033
1.748PheSer: 1.748 ± 0.034
1.873PheThr: 1.873 ± 0.034
2.826PheVal: 2.826 ± 0.038
0.492PheTrp: 0.492 ± 0.018
0.78PheTyr: 0.78 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
11.643GlyAla: 11.643 ± 0.087
0.942GlyCys: 0.942 ± 0.026
4.96GlyAsp: 4.96 ± 0.062
4.55GlyGlu: 4.55 ± 0.058
3.924GlyPhe: 3.924 ± 0.052
8.44GlyGly: 8.44 ± 0.106
2.08GlyHis: 2.08 ± 0.036
4.271GlyIle: 4.271 ± 0.056
2.277GlyLys: 2.277 ± 0.042
10.588GlyLeu: 10.588 ± 0.102
2.072GlyMet: 2.072 ± 0.037
1.705GlyAsn: 1.705 ± 0.044
4.768GlyPro: 4.768 ± 0.065
2.764GlyGln: 2.764 ± 0.052
8.442GlyArg: 8.442 ± 0.077
4.743GlySer: 4.743 ± 0.06
5.539GlyThr: 5.539 ± 0.063
6.584GlyVal: 6.584 ± 0.075
1.429GlyTrp: 1.429 ± 0.035
2.14GlyTyr: 2.14 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.671HisAla: 2.671 ± 0.047
0.222HisCys: 0.222 ± 0.013
1.359HisAsp: 1.359 ± 0.032
0.964HisGlu: 0.964 ± 0.026
0.748HisPhe: 0.748 ± 0.023
2.197HisGly: 2.197 ± 0.041
0.655HisHis: 0.655 ± 0.024
0.7HisIle: 0.7 ± 0.02
0.38HisLys: 0.38 ± 0.016
2.145HisLeu: 2.145 ± 0.036
0.447HisMet: 0.447 ± 0.019
0.375HisAsn: 0.375 ± 0.013
1.54HisPro: 1.54 ± 0.032
0.485HisGln: 0.485 ± 0.019
1.861HisArg: 1.861 ± 0.031
0.73HisSer: 0.73 ± 0.02
0.756HisThr: 0.756 ± 0.023
1.597HisVal: 1.597 ± 0.032
0.328HisTrp: 0.328 ± 0.014
0.528HisTyr: 0.528 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.261IleAla: 6.261 ± 0.065
0.372IleCys: 0.372 ± 0.016
3.039IleAsp: 3.039 ± 0.042
2.304IleGlu: 2.304 ± 0.037
1.164IlePhe: 1.164 ± 0.037
4.387IleGly: 4.387 ± 0.052
0.799IleHis: 0.799 ± 0.022
1.327IleIle: 1.327 ± 0.039
0.929IleLys: 0.929 ± 0.024
3.591IleLeu: 3.591 ± 0.05
0.715IleMet: 0.715 ± 0.023
0.863IleAsn: 0.863 ± 0.026
1.944IlePro: 1.944 ± 0.037
0.922IleGln: 0.922 ± 0.029
2.799IleArg: 2.799 ± 0.042
1.815IleSer: 1.815 ± 0.038
2.024IleThr: 2.024 ± 0.034
3.839IleVal: 3.839 ± 0.054
0.41IleTrp: 0.41 ± 0.017
0.789IleTyr: 0.789 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
3.481LysAla: 3.481 ± 0.06
0.105LysCys: 0.105 ± 0.008
1.302LysAsp: 1.302 ± 0.035
0.864LysGlu: 0.864 ± 0.026
0.618LysPhe: 0.618 ± 0.021
2.116LysGly: 2.116 ± 0.04
0.426LysHis: 0.426 ± 0.02
1.013LysIle: 1.013 ± 0.03
0.704LysLys: 0.704 ± 0.024
2.501LysLeu: 2.501 ± 0.044
0.484LysMet: 0.484 ± 0.018
0.453LysAsn: 0.453 ± 0.019
1.724LysPro: 1.724 ± 0.034
0.64LysGln: 0.64 ± 0.022
1.892LysArg: 1.892 ± 0.035
1.235LysSer: 1.235 ± 0.03
1.352LysThr: 1.352 ± 0.033
1.901LysVal: 1.901 ± 0.042
0.21LysTrp: 0.21 ± 0.012
0.358LysTyr: 0.358 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
16.395LeuAla: 16.395 ± 0.135
1.003LeuCys: 1.003 ± 0.026
7.104LeuAsp: 7.104 ± 0.073
4.214LeuGlu: 4.214 ± 0.051
3.407LeuPhe: 3.407 ± 0.051
9.62LeuGly: 9.62 ± 0.092
2.028LeuHis: 2.028 ± 0.038
3.624LeuIle: 3.624 ± 0.044
2.753LeuLys: 2.753 ± 0.046
9.711LeuLeu: 9.711 ± 0.09
2.139LeuMet: 2.139 ± 0.038
1.948LeuAsn: 1.948 ± 0.041
6.133LeuPro: 6.133 ± 0.055
2.522LeuGln: 2.522 ± 0.046
8.054LeuArg: 8.054 ± 0.088
6.037LeuSer: 6.037 ± 0.068
5.052LeuThr: 5.052 ± 0.052
8.827LeuVal: 8.827 ± 0.093
1.202LeuTrp: 1.202 ± 0.027
1.888LeuTyr: 1.888 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
3.198MetAla: 3.198 ± 0.041
0.135MetCys: 0.135 ± 0.009
1.037MetAsp: 1.037 ± 0.026
0.847MetGlu: 0.847 ± 0.023
0.565MetPhe: 0.565 ± 0.021
1.677MetGly: 1.677 ± 0.035
0.362MetHis: 0.362 ± 0.014
0.965MetIle: 0.965 ± 0.027
0.675MetLys: 0.675 ± 0.023
2.264MetLeu: 2.264 ± 0.036
0.577MetMet: 0.577 ± 0.021
0.56MetAsn: 0.56 ± 0.019
1.536MetPro: 1.536 ± 0.03
0.6MetGln: 0.6 ± 0.018
1.85MetArg: 1.85 ± 0.04
1.463MetSer: 1.463 ± 0.028
1.703MetThr: 1.703 ± 0.036
1.709MetVal: 1.709 ± 0.033
0.17MetTrp: 0.17 ± 0.01
0.221MetTyr: 0.221 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.527AsnAla: 2.527 ± 0.041
0.18AsnCys: 0.18 ± 0.011
1.046AsnAsp: 1.046 ± 0.029
0.734AsnGlu: 0.734 ± 0.02
0.702AsnPhe: 0.702 ± 0.021
1.824AsnGly: 1.824 ± 0.039
0.395AsnHis: 0.395 ± 0.015
0.923AsnIle: 0.923 ± 0.026
0.433AsnLys: 0.433 ± 0.019
2.072AsnLeu: 2.072 ± 0.034
0.433AsnMet: 0.433 ± 0.017
0.477AsnAsn: 0.477 ± 0.019
1.37AsnPro: 1.37 ± 0.028
0.54AsnGln: 0.54 ± 0.017
1.453AsnArg: 1.453 ± 0.03
0.798AsnSer: 0.798 ± 0.022
0.919AsnThr: 0.919 ± 0.026
1.561AsnVal: 1.561 ± 0.03
0.282AsnTrp: 0.282 ± 0.013
0.472AsnTyr: 0.472 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
8.777ProAla: 8.777 ± 0.091
0.378ProCys: 0.378 ± 0.015
4.328ProAsp: 4.328 ± 0.053
3.543ProGlu: 3.543 ± 0.052
2.081ProPhe: 2.081 ± 0.033
5.976ProGly: 5.976 ± 0.072
1.21ProHis: 1.21 ± 0.027
1.956ProIle: 1.956 ± 0.036
1.418ProLys: 1.418 ± 0.037
5.197ProLeu: 5.197 ± 0.059
1.265ProMet: 1.265 ± 0.03
1.141ProAsn: 1.141 ± 0.028
3.456ProPro: 3.456 ± 0.065
1.376ProGln: 1.376 ± 0.028
4.04ProArg: 4.04 ± 0.063
2.894ProSer: 2.894 ± 0.048
2.75ProThr: 2.75 ± 0.048
4.934ProVal: 4.934 ± 0.053
0.783ProTrp: 0.783 ± 0.022
1.129ProTyr: 1.129 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
3.912GlnAla: 3.912 ± 0.054
0.177GlnCys: 0.177 ± 0.01
1.401GlnAsp: 1.401 ± 0.032
0.981GlnGlu: 0.981 ± 0.024
0.809GlnPhe: 0.809 ± 0.023
2.358GlnGly: 2.358 ± 0.035
0.577GlnHis: 0.577 ± 0.018
1.191GlnIle: 1.191 ± 0.027
0.689GlnLys: 0.689 ± 0.023
2.221GlnLeu: 2.221 ± 0.038
0.583GlnMet: 0.583 ± 0.021
0.626GlnAsn: 0.626 ± 0.022
1.553GlnPro: 1.553 ± 0.035
0.823GlnGln: 0.823 ± 0.029
2.064GlnArg: 2.064 ± 0.04
1.328GlnSer: 1.328 ± 0.034
1.266GlnThr: 1.266 ± 0.034
2.047GlnVal: 2.047 ± 0.035
0.287GlnTrp: 0.287 ± 0.013
0.467GlnTyr: 0.467 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
10.528ArgAla: 10.528 ± 0.09
0.687ArgCys: 0.687 ± 0.022
5.433ArgAsp: 5.433 ± 0.064
3.604ArgGlu: 3.604 ± 0.05
3.194ArgPhe: 3.194 ± 0.042
6.174ArgGly: 6.174 ± 0.064
2.257ArgHis: 2.257 ± 0.04
3.751ArgIle: 3.751 ± 0.058
1.597ArgLys: 1.597 ± 0.035
9.034ArgLeu: 9.034 ± 0.083
1.862ArgMet: 1.862 ± 0.033
1.5ArgAsn: 1.5 ± 0.031
4.98ArgPro: 4.98 ± 0.069
2.416ArgGln: 2.416 ± 0.045
8.183ArgArg: 8.183 ± 0.095
4.048ArgSer: 4.048 ± 0.058
3.687ArgThr: 3.687 ± 0.047
5.653ArgVal: 5.653 ± 0.064
1.167ArgTrp: 1.167 ± 0.028
1.663ArgTyr: 1.663 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.12SerAla: 6.12 ± 0.067
0.403SerCys: 0.403 ± 0.016
2.658SerAsp: 2.658 ± 0.046
2.056SerGlu: 2.056 ± 0.03
2.126SerPhe: 2.126 ± 0.036
5.253SerGly: 5.253 ± 0.064
0.98SerHis: 0.98 ± 0.022
2.125SerIle: 2.125 ± 0.041
1.126SerLys: 1.126 ± 0.029
5.095SerLeu: 5.095 ± 0.053
1.04SerMet: 1.04 ± 0.025
1.003SerAsn: 1.003 ± 0.024
3.009SerPro: 3.009 ± 0.048
1.251SerGln: 1.251 ± 0.028
3.805SerArg: 3.805 ± 0.053
2.43SerSer: 2.43 ± 0.046
2.593SerThr: 2.593 ± 0.043
3.775SerVal: 3.775 ± 0.051
0.707SerTrp: 0.707 ± 0.021
1.127SerTyr: 1.127 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.946ThrAla: 6.946 ± 0.066
0.389ThrCys: 0.389 ± 0.016
2.667ThrAsp: 2.667 ± 0.044
2.146ThrGlu: 2.146 ± 0.033
1.789ThrPhe: 1.789 ± 0.033
5.226ThrGly: 5.226 ± 0.061
0.974ThrHis: 0.974 ± 0.023
2.207ThrIle: 2.207 ± 0.04
1.075ThrLys: 1.075 ± 0.027
5.977ThrLeu: 5.977 ± 0.059
1.116ThrMet: 1.116 ± 0.028
0.932ThrAsn: 0.932 ± 0.027
3.372ThrPro: 3.372 ± 0.046
1.138ThrGln: 1.138 ± 0.027
3.545ThrArg: 3.545 ± 0.047
2.509ThrSer: 2.509 ± 0.041
2.74ThrThr: 2.74 ± 0.048
4.964ThrVal: 4.964 ± 0.056
0.602ThrTrp: 0.602 ± 0.02
1.084ThrTyr: 1.084 ± 0.026
0.0ThrXaa: 0.0 ± 0.0
Val
12.124ValAla: 12.124 ± 0.098
0.654ValCys: 0.654 ± 0.02
4.923ValAsp: 4.923 ± 0.052
4.526ValGlu: 4.526 ± 0.055
2.674ValPhe: 2.674 ± 0.046
6.759ValGly: 6.759 ± 0.067
1.425ValHis: 1.425 ± 0.03
3.042ValIle: 3.042 ± 0.05
1.925ValLys: 1.925 ± 0.038
8.568ValLeu: 8.568 ± 0.084
1.817ValMet: 1.817 ± 0.036
1.658ValAsn: 1.658 ± 0.033
4.871ValPro: 4.871 ± 0.06
1.848ValGln: 1.848 ± 0.039
5.333ValArg: 5.333 ± 0.059
4.355ValSer: 4.355 ± 0.046
4.765ValThr: 4.765 ± 0.056
7.233ValVal: 7.233 ± 0.078
0.872ValTrp: 0.872 ± 0.024
1.421ValTyr: 1.421 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.355TrpAla: 1.355 ± 0.032
0.135TrpCys: 0.135 ± 0.01
0.663TrpAsp: 0.663 ± 0.02
0.446TrpGlu: 0.446 ± 0.017
0.508TrpPhe: 0.508 ± 0.018
0.933TrpGly: 0.933 ± 0.029
0.349TrpHis: 0.349 ± 0.014
0.541TrpIle: 0.541 ± 0.017
0.27TrpLys: 0.27 ± 0.013
1.52TrpLeu: 1.52 ± 0.031
0.344TrpMet: 0.344 ± 0.013
0.378TrpAsn: 0.378 ± 0.017
0.721TrpPro: 0.721 ± 0.022
0.406TrpGln: 0.406 ± 0.017
1.324TrpArg: 1.324 ± 0.03
0.863TrpSer: 0.863 ± 0.026
0.81TrpThr: 0.81 ± 0.029
0.783TrpVal: 0.783 ± 0.023
0.227TrpTrp: 0.227 ± 0.012
0.252TrpTyr: 0.252 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.663TyrAla: 2.663 ± 0.04
0.189TyrCys: 0.189 ± 0.01
1.317TyrAsp: 1.317 ± 0.029
0.939TyrGlu: 0.939 ± 0.025
0.703TyrPhe: 0.703 ± 0.021
2.123TyrGly: 2.123 ± 0.047
0.411TyrHis: 0.411 ± 0.016
0.632TyrIle: 0.632 ± 0.021
0.401TyrLys: 0.401 ± 0.017
1.96TyrLeu: 1.96 ± 0.034
0.348TyrMet: 0.348 ± 0.013
0.456TyrAsn: 0.456 ± 0.016
0.998TyrPro: 0.998 ± 0.026
0.493TyrGln: 0.493 ± 0.019
1.735TyrArg: 1.735 ± 0.035
0.859TyrSer: 0.859 ± 0.025
0.909TyrThr: 0.909 ± 0.022
1.441TyrVal: 1.441 ± 0.029
0.29TyrTrp: 0.29 ± 0.015
0.421TyrTyr: 0.421 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5222 proteins (1654282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski