Amino acid dipepetide frequency for Arthrobacter crusticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.596AlaAla: 21.596 ± 0.24
0.72AlaCys: 0.72 ± 0.029
7.453AlaAsp: 7.453 ± 0.094
8.266AlaGlu: 8.266 ± 0.095
3.727AlaPhe: 3.727 ± 0.062
13.958AlaGly: 13.958 ± 0.159
2.226AlaHis: 2.226 ± 0.051
4.405AlaIle: 4.405 ± 0.074
2.704AlaLys: 2.704 ± 0.058
14.038AlaLeu: 14.038 ± 0.154
2.479AlaMet: 2.479 ± 0.05
2.349AlaAsn: 2.349 ± 0.053
6.698AlaPro: 6.698 ± 0.127
3.897AlaGln: 3.897 ± 0.065
8.992AlaArg: 8.992 ± 0.104
6.927AlaSer: 6.927 ± 0.078
5.965AlaThr: 5.965 ± 0.071
12.019AlaVal: 12.019 ± 0.118
1.663AlaTrp: 1.663 ± 0.045
2.275AlaTyr: 2.275 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.719CysAla: 0.719 ± 0.028
0.061CysCys: 0.061 ± 0.008
0.307CysAsp: 0.307 ± 0.017
0.297CysGlu: 0.297 ± 0.017
0.176CysPhe: 0.176 ± 0.014
0.679CysGly: 0.679 ± 0.029
0.112CysHis: 0.112 ± 0.012
0.243CysIle: 0.243 ± 0.014
0.063CysLys: 0.063 ± 0.007
0.575CysLeu: 0.575 ± 0.026
0.083CysMet: 0.083 ± 0.011
0.111CysAsn: 0.111 ± 0.01
0.334CysPro: 0.334 ± 0.02
0.14CysGln: 0.14 ± 0.011
0.43CysArg: 0.43 ± 0.02
0.382CysSer: 0.382 ± 0.019
0.391CysThr: 0.391 ± 0.021
0.432CysVal: 0.432 ± 0.02
0.082CysTrp: 0.082 ± 0.009
0.122CysTyr: 0.122 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.177AspAla: 7.177 ± 0.084
0.28AspCys: 0.28 ± 0.018
3.031AspAsp: 3.031 ± 0.053
3.403AspGlu: 3.403 ± 0.065
1.82AspPhe: 1.82 ± 0.044
5.764AspGly: 5.764 ± 0.093
1.082AspHis: 1.082 ± 0.033
2.302AspIle: 2.302 ± 0.052
1.112AspLys: 1.112 ± 0.036
6.144AspLeu: 6.144 ± 0.086
0.752AspMet: 0.752 ± 0.03
1.054AspAsn: 1.054 ± 0.04
4.132AspPro: 4.132 ± 0.067
1.481AspGln: 1.481 ± 0.038
3.953AspArg: 3.953 ± 0.057
2.909AspSer: 2.909 ± 0.048
2.942AspThr: 2.942 ± 0.055
4.461AspVal: 4.461 ± 0.063
0.836AspTrp: 0.836 ± 0.029
1.283AspTyr: 1.283 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.831GluAla: 7.831 ± 0.101
0.285GluCys: 0.285 ± 0.018
3.303GluAsp: 3.303 ± 0.063
3.814GluGlu: 3.814 ± 0.065
1.691GluPhe: 1.691 ± 0.042
4.638GluGly: 4.638 ± 0.068
1.447GluHis: 1.447 ± 0.037
2.501GluIle: 2.501 ± 0.051
1.631GluLys: 1.631 ± 0.043
6.535GluLeu: 6.535 ± 0.078
0.951GluMet: 0.951 ± 0.029
1.436GluAsn: 1.436 ± 0.042
3.184GluPro: 3.184 ± 0.063
2.237GluGln: 2.237 ± 0.046
4.519GluArg: 4.519 ± 0.075
2.959GluSer: 2.959 ± 0.058
2.98GluThr: 2.98 ± 0.052
4.881GluVal: 4.881 ± 0.076
0.763GluTrp: 0.763 ± 0.027
1.111GluTyr: 1.111 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.924PheAla: 3.924 ± 0.064
0.211PheCys: 0.211 ± 0.014
2.168PheAsp: 2.168 ± 0.044
1.808PheGlu: 1.808 ± 0.04
1.1PhePhe: 1.1 ± 0.039
3.223PheGly: 3.223 ± 0.056
0.562PheHis: 0.562 ± 0.025
1.279PheIle: 1.279 ± 0.038
0.555PheLys: 0.555 ± 0.025
3.181PheLeu: 3.181 ± 0.065
0.437PheMet: 0.437 ± 0.023
0.861PheAsn: 0.861 ± 0.028
1.512PhePro: 1.512 ± 0.041
0.792PheGln: 0.792 ± 0.029
1.923PheArg: 1.923 ± 0.045
2.02PheSer: 2.02 ± 0.044
2.199PheThr: 2.199 ± 0.05
2.424PheVal: 2.424 ± 0.047
0.451PheTrp: 0.451 ± 0.022
0.657PheTyr: 0.657 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
11.29GlyAla: 11.29 ± 0.134
0.622GlyCys: 0.622 ± 0.025
4.446GlyAsp: 4.446 ± 0.076
4.863GlyGlu: 4.863 ± 0.073
3.275GlyPhe: 3.275 ± 0.054
8.547GlyGly: 8.547 ± 0.147
1.929GlyHis: 1.929 ± 0.048
4.617GlyIle: 4.617 ± 0.076
2.384GlyLys: 2.384 ± 0.058
9.528GlyLeu: 9.528 ± 0.105
2.032GlyMet: 2.032 ± 0.053
2.165GlyAsn: 2.165 ± 0.107
4.851GlyPro: 4.851 ± 0.072
2.78GlyGln: 2.78 ± 0.058
6.849GlyArg: 6.849 ± 0.089
6.241GlySer: 6.241 ± 0.089
6.33GlyThr: 6.33 ± 0.091
7.44GlyVal: 7.44 ± 0.091
1.555GlyTrp: 1.555 ± 0.041
2.257GlyTyr: 2.257 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.19HisAla: 2.19 ± 0.052
0.154HisCys: 0.154 ± 0.014
1.061HisAsp: 1.061 ± 0.036
1.039HisGlu: 1.039 ± 0.032
0.664HisPhe: 0.664 ± 0.025
1.904HisGly: 1.904 ± 0.045
0.562HisHis: 0.562 ± 0.027
0.712HisIle: 0.712 ± 0.028
0.321HisLys: 0.321 ± 0.015
2.277HisLeu: 2.277 ± 0.047
0.29HisMet: 0.29 ± 0.018
0.389HisAsn: 0.389 ± 0.02
1.548HisPro: 1.548 ± 0.037
0.578HisGln: 0.578 ± 0.021
1.766HisArg: 1.766 ± 0.045
1.138HisSer: 1.138 ± 0.035
1.033HisThr: 1.033 ± 0.036
1.383HisVal: 1.383 ± 0.036
0.295HisTrp: 0.295 ± 0.014
0.442HisTyr: 0.442 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.478IleAla: 5.478 ± 0.092
0.291IleCys: 0.291 ± 0.016
2.959IleAsp: 2.959 ± 0.058
2.634IleGlu: 2.634 ± 0.062
1.278IlePhe: 1.278 ± 0.036
4.044IleGly: 4.044 ± 0.064
0.735IleHis: 0.735 ± 0.028
1.708IleIle: 1.708 ± 0.052
0.879IleLys: 0.879 ± 0.031
4.089IleLeu: 4.089 ± 0.069
0.588IleMet: 0.588 ± 0.028
1.016IleAsn: 1.016 ± 0.027
2.287IlePro: 2.287 ± 0.053
1.016IleGln: 1.016 ± 0.031
2.594IleArg: 2.594 ± 0.052
2.528IleSer: 2.528 ± 0.045
2.748IleThr: 2.748 ± 0.052
3.428IleVal: 3.428 ± 0.058
0.459IleTrp: 0.459 ± 0.021
0.8IleTyr: 0.8 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.898LysAla: 2.898 ± 0.063
0.086LysCys: 0.086 ± 0.008
1.387LysAsp: 1.387 ± 0.038
1.319LysGlu: 1.319 ± 0.036
0.553LysPhe: 0.553 ± 0.025
1.777LysGly: 1.777 ± 0.043
0.478LysHis: 0.478 ± 0.021
1.002LysIle: 1.002 ± 0.034
0.758LysLys: 0.758 ± 0.034
2.043LysLeu: 2.043 ± 0.059
0.447LysMet: 0.447 ± 0.018
0.588LysAsn: 0.588 ± 0.024
1.315LysPro: 1.315 ± 0.041
0.675LysGln: 0.675 ± 0.03
1.486LysArg: 1.486 ± 0.044
1.261LysSer: 1.261 ± 0.036
1.287LysThr: 1.287 ± 0.035
1.902LysVal: 1.902 ± 0.049
0.254LysTrp: 0.254 ± 0.016
0.555LysTyr: 0.555 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
14.689LeuAla: 14.689 ± 0.153
0.594LeuCys: 0.594 ± 0.024
6.02LeuAsp: 6.02 ± 0.084
6.085LeuGlu: 6.085 ± 0.08
2.874LeuPhe: 2.874 ± 0.057
9.476LeuGly: 9.476 ± 0.111
2.018LeuHis: 2.018 ± 0.046
4.566LeuIle: 4.566 ± 0.079
2.326LeuLys: 2.326 ± 0.055
11.193LeuLeu: 11.193 ± 0.145
1.865LeuMet: 1.865 ± 0.042
2.419LeuAsn: 2.419 ± 0.051
6.179LeuPro: 6.179 ± 0.088
2.866LeuGln: 2.866 ± 0.053
7.808LeuArg: 7.808 ± 0.105
6.223LeuSer: 6.223 ± 0.072
6.537LeuThr: 6.537 ± 0.08
8.474LeuVal: 8.474 ± 0.112
1.247LeuTrp: 1.247 ± 0.04
1.766LeuTyr: 1.766 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.336MetAla: 2.336 ± 0.045
0.105MetCys: 0.105 ± 0.009
0.888MetAsp: 0.888 ± 0.032
0.875MetGlu: 0.875 ± 0.028
0.522MetPhe: 0.522 ± 0.022
1.394MetGly: 1.394 ± 0.045
0.324MetHis: 0.324 ± 0.018
0.822MetIle: 0.822 ± 0.03
0.569MetLys: 0.569 ± 0.023
1.707MetLeu: 1.707 ± 0.042
0.31MetMet: 0.31 ± 0.019
0.526MetAsn: 0.526 ± 0.022
1.042MetPro: 1.042 ± 0.031
0.489MetGln: 0.489 ± 0.02
1.198MetArg: 1.198 ± 0.038
1.441MetSer: 1.441 ± 0.034
1.506MetThr: 1.506 ± 0.036
1.464MetVal: 1.464 ± 0.035
0.2MetTrp: 0.2 ± 0.014
0.272MetTyr: 0.272 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.704AsnAla: 2.704 ± 0.062
0.146AsnCys: 0.146 ± 0.011
1.183AsnAsp: 1.183 ± 0.034
1.165AsnGlu: 1.165 ± 0.04
0.766AsnPhe: 0.766 ± 0.031
2.206AsnGly: 2.206 ± 0.086
0.462AsnHis: 0.462 ± 0.019
0.969AsnIle: 0.969 ± 0.035
0.492AsnLys: 0.492 ± 0.025
2.296AsnLeu: 2.296 ± 0.047
0.352AsnMet: 0.352 ± 0.016
0.616AsnAsn: 0.616 ± 0.028
1.864AsnPro: 1.864 ± 0.05
0.638AsnGln: 0.638 ± 0.024
1.537AsnArg: 1.537 ± 0.039
1.242AsnSer: 1.242 ± 0.036
1.278AsnThr: 1.278 ± 0.033
1.636AsnVal: 1.636 ± 0.037
0.353AsnTrp: 0.353 ± 0.018
0.531AsnTyr: 0.531 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
8.68ProAla: 8.68 ± 0.141
0.211ProCys: 0.211 ± 0.016
3.671ProAsp: 3.671 ± 0.065
4.3ProGlu: 4.3 ± 0.065
1.688ProPhe: 1.688 ± 0.04
6.381ProGly: 6.381 ± 0.103
1.098ProHis: 1.098 ± 0.032
1.654ProIle: 1.654 ± 0.046
1.059ProLys: 1.059 ± 0.04
5.159ProLeu: 5.159 ± 0.081
0.956ProMet: 0.956 ± 0.027
1.059ProAsn: 1.059 ± 0.03
2.793ProPro: 2.793 ± 0.073
1.625ProGln: 1.625 ± 0.043
3.464ProArg: 3.464 ± 0.063
3.401ProSer: 3.401 ± 0.058
3.008ProThr: 3.008 ± 0.058
5.212ProVal: 5.212 ± 0.082
0.809ProTrp: 0.809 ± 0.03
1.05ProTyr: 1.05 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.657GlnAla: 3.657 ± 0.065
0.147GlnCys: 0.147 ± 0.012
1.468GlnAsp: 1.468 ± 0.033
1.683GlnGlu: 1.683 ± 0.039
0.905GlnPhe: 0.905 ± 0.03
2.356GlnGly: 2.356 ± 0.048
0.68GlnHis: 0.68 ± 0.024
1.25GlnIle: 1.25 ± 0.033
0.663GlnLys: 0.663 ± 0.028
3.406GlnLeu: 3.406 ± 0.059
0.556GlnMet: 0.556 ± 0.025
0.621GlnAsn: 0.621 ± 0.027
1.61GlnPro: 1.61 ± 0.038
1.26GlnGln: 1.26 ± 0.037
2.471GlnArg: 2.471 ± 0.047
1.481GlnSer: 1.481 ± 0.037
1.323GlnThr: 1.323 ± 0.034
2.42GlnVal: 2.42 ± 0.046
0.491GlnTrp: 0.491 ± 0.022
0.628GlnTyr: 0.628 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.225ArgAla: 8.225 ± 0.099
0.399ArgCys: 0.399 ± 0.022
3.549ArgAsp: 3.549 ± 0.065
4.047ArgGlu: 4.047 ± 0.065
2.411ArgPhe: 2.411 ± 0.047
5.485ArgGly: 5.485 ± 0.069
1.564ArgHis: 1.564 ± 0.042
3.487ArgIle: 3.487 ± 0.066
1.609ArgLys: 1.609 ± 0.043
7.578ArgLeu: 7.578 ± 0.103
1.644ArgMet: 1.644 ± 0.045
1.73ArgAsn: 1.73 ± 0.042
3.899ArgPro: 3.899 ± 0.066
2.241ArgGln: 2.241 ± 0.045
6.747ArgArg: 6.747 ± 0.095
4.531ArgSer: 4.531 ± 0.07
4.407ArgThr: 4.407 ± 0.059
5.285ArgVal: 5.285 ± 0.072
1.174ArgTrp: 1.174 ± 0.032
1.576ArgTyr: 1.576 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
7.436SerAla: 7.436 ± 0.089
0.335SerCys: 0.335 ± 0.017
2.81SerAsp: 2.81 ± 0.058
3.088SerGlu: 3.088 ± 0.056
2.061SerPhe: 2.061 ± 0.042
6.182SerGly: 6.182 ± 0.08
1.066SerHis: 1.066 ± 0.032
2.538SerIle: 2.538 ± 0.058
1.243SerLys: 1.243 ± 0.035
5.809SerLeu: 5.809 ± 0.084
1.294SerMet: 1.294 ± 0.034
1.352SerAsn: 1.352 ± 0.034
3.536SerPro: 3.536 ± 0.063
1.522SerGln: 1.522 ± 0.04
3.853SerArg: 3.853 ± 0.065
3.776SerSer: 3.776 ± 0.056
3.915SerThr: 3.915 ± 0.058
4.919SerVal: 4.919 ± 0.072
0.89SerTrp: 0.89 ± 0.029
1.366SerTyr: 1.366 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
8.109ThrAla: 8.109 ± 0.096
0.308ThrCys: 0.308 ± 0.019
3.239ThrAsp: 3.239 ± 0.058
3.162ThrGlu: 3.162 ± 0.05
1.745ThrPhe: 1.745 ± 0.045
6.236ThrGly: 6.236 ± 0.086
1.075ThrHis: 1.075 ± 0.029
2.319ThrIle: 2.319 ± 0.053
1.237ThrLys: 1.237 ± 0.034
5.775ThrLeu: 5.775 ± 0.073
0.947ThrMet: 0.947 ± 0.029
1.182ThrAsn: 1.182 ± 0.033
3.729ThrPro: 3.729 ± 0.073
1.444ThrGln: 1.444 ± 0.038
3.527ThrArg: 3.527 ± 0.055
3.405ThrSer: 3.405 ± 0.062
3.458ThrThr: 3.458 ± 0.066
5.504ThrVal: 5.504 ± 0.067
0.718ThrTrp: 0.718 ± 0.027
1.265ThrTyr: 1.265 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
9.559ValAla: 9.559 ± 0.116
0.52ValCys: 0.52 ± 0.024
4.975ValAsp: 4.975 ± 0.074
5.004ValGlu: 5.004 ± 0.072
2.722ValPhe: 2.722 ± 0.061
6.781ValGly: 6.781 ± 0.081
1.691ValHis: 1.691 ± 0.044
3.9ValIle: 3.9 ± 0.065
1.714ValLys: 1.714 ± 0.045
9.913ValLeu: 9.913 ± 0.108
1.454ValMet: 1.454 ± 0.038
2.015ValAsn: 2.015 ± 0.047
4.965ValPro: 4.965 ± 0.065
2.287ValGln: 2.287 ± 0.048
5.837ValArg: 5.837 ± 0.078
4.989ValSer: 4.989 ± 0.063
5.067ValThr: 5.067 ± 0.078
7.752ValVal: 7.752 ± 0.1
0.978ValTrp: 0.978 ± 0.029
1.473ValTyr: 1.473 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.459TrpAla: 1.459 ± 0.039
0.102TrpCys: 0.102 ± 0.011
0.774TrpAsp: 0.774 ± 0.03
0.701TrpGlu: 0.701 ± 0.026
0.543TrpPhe: 0.543 ± 0.025
0.967TrpGly: 0.967 ± 0.025
0.316TrpHis: 0.316 ± 0.016
0.636TrpIle: 0.636 ± 0.022
0.362TrpLys: 0.362 ± 0.02
1.69TrpLeu: 1.69 ± 0.041
0.3TrpMet: 0.3 ± 0.018
0.454TrpAsn: 0.454 ± 0.023
0.683TrpPro: 0.683 ± 0.025
0.524TrpGln: 0.524 ± 0.023
1.045TrpArg: 1.045 ± 0.032
0.823TrpSer: 0.823 ± 0.029
0.861TrpThr: 0.861 ± 0.029
1.03TrpVal: 1.03 ± 0.031
0.317TrpTrp: 0.317 ± 0.02
0.274TrpTyr: 0.274 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.399TyrAla: 2.399 ± 0.048
0.16TyrCys: 0.16 ± 0.012
1.223TyrAsp: 1.223 ± 0.037
1.144TyrGlu: 1.144 ± 0.035
0.768TyrPhe: 0.768 ± 0.026
2.003TyrGly: 2.003 ± 0.047
0.321TyrHis: 0.321 ± 0.018
0.65TyrIle: 0.65 ± 0.024
0.391TyrLys: 0.391 ± 0.021
2.293TyrLeu: 2.293 ± 0.05
0.251TyrMet: 0.251 ± 0.017
0.492TyrAsn: 0.492 ± 0.02
1.118TyrPro: 1.118 ± 0.033
0.584TyrGln: 0.584 ± 0.024
1.589TyrArg: 1.589 ± 0.043
1.312TyrSer: 1.312 ± 0.037
1.15TyrThr: 1.15 ± 0.036
1.529TyrVal: 1.529 ± 0.042
0.328TyrTrp: 0.328 ± 0.018
0.493TyrTyr: 0.493 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3325 proteins (1063883 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski