Amino acid dipepetide frequency for Treponema socranskii subsp. socranskii VPI DR56BR1116 = ATCC 35536

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.137AlaAla: 11.137 ± 0.144
1.316AlaCys: 1.316 ± 0.044
5.621AlaAsp: 5.621 ± 0.088
6.707AlaGlu: 6.707 ± 0.105
4.348AlaPhe: 4.348 ± 0.089
7.286AlaGly: 7.286 ± 0.106
1.499AlaHis: 1.499 ± 0.039
5.228AlaIle: 5.228 ± 0.073
5.937AlaLys: 5.937 ± 0.103
9.817AlaLeu: 9.817 ± 0.137
2.28AlaMet: 2.28 ± 0.058
3.028AlaAsn: 3.028 ± 0.061
2.77AlaPro: 2.77 ± 0.057
2.754AlaGln: 2.754 ± 0.067
4.076AlaArg: 4.076 ± 0.078
6.985AlaSer: 6.985 ± 0.084
3.395AlaThr: 3.395 ± 0.061
7.902AlaVal: 7.902 ± 0.104
0.829AlaTrp: 0.829 ± 0.032
3.189AlaTyr: 3.189 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
1.575CysAla: 1.575 ± 0.051
0.229CysCys: 0.229 ± 0.016
0.749CysAsp: 0.749 ± 0.031
0.719CysGlu: 0.719 ± 0.029
0.671CysPhe: 0.671 ± 0.028
1.394CysGly: 1.394 ± 0.039
0.196CysHis: 0.196 ± 0.016
1.123CysIle: 1.123 ± 0.041
0.871CysLys: 0.871 ± 0.033
0.921CysLeu: 0.921 ± 0.033
0.349CysMet: 0.349 ± 0.023
0.46CysAsn: 0.46 ± 0.024
0.557CysPro: 0.557 ± 0.028
0.178CysGln: 0.178 ± 0.015
0.774CysArg: 0.774 ± 0.034
0.912CysSer: 0.912 ± 0.032
0.999CysThr: 0.999 ± 0.042
0.989CysVal: 0.989 ± 0.035
0.111CysTrp: 0.111 ± 0.012
0.415CysTyr: 0.415 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
6.283AspAla: 6.283 ± 0.102
0.727AspCys: 0.727 ± 0.033
3.286AspAsp: 3.286 ± 0.076
4.378AspGlu: 4.378 ± 0.079
3.095AspPhe: 3.095 ± 0.071
4.692AspGly: 4.692 ± 0.099
0.542AspHis: 0.542 ± 0.024
4.585AspIle: 4.585 ± 0.082
3.376AspLys: 3.376 ± 0.066
3.835AspLeu: 3.835 ± 0.069
1.566AspMet: 1.566 ± 0.047
1.897AspAsn: 1.897 ± 0.054
1.893AspPro: 1.893 ± 0.042
0.758AspGln: 0.758 ± 0.034
2.245AspArg: 2.245 ± 0.054
3.014AspSer: 3.014 ± 0.065
3.442AspThr: 3.442 ± 0.073
3.973AspVal: 3.973 ± 0.078
0.663AspTrp: 0.663 ± 0.029
2.211AspTyr: 2.211 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
5.869GluAla: 5.869 ± 0.105
0.734GluCys: 0.734 ± 0.029
2.956GluAsp: 2.956 ± 0.058
3.662GluGlu: 3.662 ± 0.081
2.136GluPhe: 2.136 ± 0.047
3.455GluGly: 3.455 ± 0.077
1.085GluHis: 1.085 ± 0.039
4.483GluIle: 4.483 ± 0.084
6.09GluLys: 6.09 ± 0.096
5.256GluLeu: 5.256 ± 0.08
1.5GluMet: 1.5 ± 0.046
3.483GluAsn: 3.483 ± 0.067
1.537GluPro: 1.537 ± 0.044
1.919GluGln: 1.919 ± 0.048
3.96GluArg: 3.96 ± 0.083
3.803GluSer: 3.803 ± 0.078
3.762GluThr: 3.762 ± 0.061
3.022GluVal: 3.022 ± 0.069
0.585GluTrp: 0.585 ± 0.028
2.276GluTyr: 2.276 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
4.579PheAla: 4.579 ± 0.094
0.84PheCys: 0.84 ± 0.032
2.936PheAsp: 2.936 ± 0.063
2.406PheGlu: 2.406 ± 0.047
2.736PhePhe: 2.736 ± 0.069
3.52PheGly: 3.52 ± 0.064
0.691PheHis: 0.691 ± 0.028
3.55PheIle: 3.55 ± 0.069
2.225PheLys: 2.225 ± 0.051
3.866PheLeu: 3.866 ± 0.083
1.141PheMet: 1.141 ± 0.039
1.702PheAsn: 1.702 ± 0.05
1.947PhePro: 1.947 ± 0.052
0.998PheGln: 0.998 ± 0.032
2.036PheArg: 2.036 ± 0.046
3.952PheSer: 3.952 ± 0.083
3.01PheThr: 3.01 ± 0.065
3.129PheVal: 3.129 ± 0.076
0.442PheTrp: 0.442 ± 0.024
1.711PheTyr: 1.711 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
6.221GlyAla: 6.221 ± 0.087
1.18GlyCys: 1.18 ± 0.04
3.73GlyAsp: 3.73 ± 0.075
4.143GlyGlu: 4.143 ± 0.071
3.553GlyPhe: 3.553 ± 0.07
5.527GlyGly: 5.527 ± 0.112
1.003GlyHis: 1.003 ± 0.036
6.041GlyIle: 6.041 ± 0.095
5.834GlyLys: 5.834 ± 0.098
5.226GlyLeu: 5.226 ± 0.071
2.059GlyMet: 2.059 ± 0.054
2.905GlyAsn: 2.905 ± 0.063
1.33GlyPro: 1.33 ± 0.039
1.601GlyGln: 1.601 ± 0.046
3.223GlyArg: 3.223 ± 0.074
4.591GlySer: 4.591 ± 0.077
4.91GlyThr: 4.91 ± 0.116
4.752GlyVal: 4.752 ± 0.072
0.714GlyTrp: 0.714 ± 0.032
2.408GlyTyr: 2.408 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.34HisAla: 1.34 ± 0.044
0.259HisCys: 0.259 ± 0.017
0.82HisAsp: 0.82 ± 0.037
0.874HisGlu: 0.874 ± 0.03
0.785HisPhe: 0.785 ± 0.03
1.233HisGly: 1.233 ± 0.04
0.272HisHis: 0.272 ± 0.018
1.388HisIle: 1.388 ± 0.042
0.86HisLys: 0.86 ± 0.032
1.275HisLeu: 1.275 ± 0.04
0.279HisMet: 0.279 ± 0.019
0.625HisAsn: 0.625 ± 0.026
0.834HisPro: 0.834 ± 0.032
0.317HisGln: 0.317 ± 0.023
0.785HisArg: 0.785 ± 0.03
0.861HisSer: 0.861 ± 0.032
1.032HisThr: 1.032 ± 0.032
0.948HisVal: 0.948 ± 0.033
0.164HisTrp: 0.164 ± 0.014
0.593HisTyr: 0.593 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
7.753IleAla: 7.753 ± 0.103
1.011IleCys: 1.011 ± 0.034
4.683IleAsp: 4.683 ± 0.078
4.497IleGlu: 4.497 ± 0.085
3.123IlePhe: 3.123 ± 0.066
4.881IleGly: 4.881 ± 0.091
0.99IleHis: 0.99 ± 0.037
4.903IleIle: 4.903 ± 0.095
4.272IleLys: 4.272 ± 0.075
5.671IleLeu: 5.671 ± 0.104
1.535IleMet: 1.535 ± 0.041
2.557IleAsn: 2.557 ± 0.056
3.504IlePro: 3.504 ± 0.069
1.688IleGln: 1.688 ± 0.046
3.485IleArg: 3.485 ± 0.074
4.524IleSer: 4.524 ± 0.087
3.843IleThr: 3.843 ± 0.078
5.638IleVal: 5.638 ± 0.107
0.396IleTrp: 0.396 ± 0.019
2.015IleTyr: 2.015 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
6.13LysAla: 6.13 ± 0.095
0.554LysCys: 0.554 ± 0.025
3.644LysAsp: 3.644 ± 0.076
4.323LysGlu: 4.323 ± 0.092
1.873LysPhe: 1.873 ± 0.045
3.862LysGly: 3.862 ± 0.067
0.917LysHis: 0.917 ± 0.034
5.383LysIle: 5.383 ± 0.088
6.171LysLys: 6.171 ± 0.112
5.375LysLeu: 5.375 ± 0.083
1.718LysMet: 1.718 ± 0.042
3.983LysAsn: 3.983 ± 0.071
2.164LysPro: 2.164 ± 0.054
1.802LysGln: 1.802 ± 0.047
3.875LysArg: 3.875 ± 0.066
4.135LysSer: 4.135 ± 0.062
4.789LysThr: 4.789 ± 0.086
3.143LysVal: 3.143 ± 0.066
0.52LysTrp: 0.52 ± 0.027
2.106LysTyr: 2.106 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
8.005LeuAla: 8.005 ± 0.106
1.63LeuCys: 1.63 ± 0.053
4.619LeuAsp: 4.619 ± 0.08
4.731LeuGlu: 4.731 ± 0.081
4.544LeuPhe: 4.544 ± 0.095
5.511LeuGly: 5.511 ± 0.092
1.607LeuHis: 1.607 ± 0.049
5.757LeuIle: 5.757 ± 0.124
5.298LeuLys: 5.298 ± 0.08
8.207LeuLeu: 8.207 ± 0.134
2.051LeuMet: 2.051 ± 0.05
2.969LeuAsn: 2.969 ± 0.055
3.941LeuPro: 3.941 ± 0.067
2.557LeuGln: 2.557 ± 0.061
4.248LeuArg: 4.248 ± 0.076
7.308LeuSer: 7.308 ± 0.109
4.941LeuThr: 4.941 ± 0.084
5.373LeuVal: 5.373 ± 0.091
0.82LeuTrp: 0.82 ± 0.031
3.309LeuTyr: 3.309 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
1.868MetAla: 1.868 ± 0.049
0.31MetCys: 0.31 ± 0.018
1.138MetAsp: 1.138 ± 0.036
1.339MetGlu: 1.339 ± 0.038
1.01MetPhe: 1.01 ± 0.04
1.449MetGly: 1.449 ± 0.046
0.464MetHis: 0.464 ± 0.023
1.683MetIle: 1.683 ± 0.05
2.072MetLys: 2.072 ± 0.048
2.459MetLeu: 2.459 ± 0.066
0.637MetMet: 0.637 ± 0.032
1.163MetAsn: 1.163 ± 0.035
1.202MetPro: 1.202 ± 0.036
1.023MetGln: 1.023 ± 0.033
1.448MetArg: 1.448 ± 0.037
1.651MetSer: 1.651 ± 0.043
1.664MetThr: 1.664 ± 0.039
1.145MetVal: 1.145 ± 0.036
0.195MetTrp: 0.195 ± 0.018
0.853MetTyr: 0.853 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
4.114AsnAla: 4.114 ± 0.075
0.507AsnCys: 0.507 ± 0.028
2.222AsnAsp: 2.222 ± 0.054
2.396AsnGlu: 2.396 ± 0.06
1.698AsnPhe: 1.698 ± 0.045
3.411AsnGly: 3.411 ± 0.07
0.523AsnHis: 0.523 ± 0.029
3.118AsnIle: 3.118 ± 0.06
2.372AsnLys: 2.372 ± 0.054
3.103AsnLeu: 3.103 ± 0.063
1.095AsnMet: 1.095 ± 0.032
1.551AsnAsn: 1.551 ± 0.047
1.94AsnPro: 1.94 ± 0.053
0.83AsnGln: 0.83 ± 0.035
1.949AsnArg: 1.949 ± 0.054
2.051AsnSer: 2.051 ± 0.051
2.352AsnThr: 2.352 ± 0.06
2.525AsnVal: 2.525 ± 0.055
0.392AsnTrp: 0.392 ± 0.023
1.473AsnTyr: 1.473 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
3.361ProAla: 3.361 ± 0.066
0.469ProCys: 0.469 ± 0.023
2.505ProAsp: 2.505 ± 0.05
2.939ProGlu: 2.939 ± 0.067
2.035ProPhe: 2.035 ± 0.047
2.262ProGly: 2.262 ± 0.05
0.728ProHis: 0.728 ± 0.028
2.059ProIle: 2.059 ± 0.052
1.919ProLys: 1.919 ± 0.049
3.679ProLeu: 3.679 ± 0.069
0.739ProMet: 0.739 ± 0.032
1.218ProAsn: 1.218 ± 0.036
1.332ProPro: 1.332 ± 0.044
1.03ProGln: 1.03 ± 0.031
1.374ProArg: 1.374 ± 0.039
2.519ProSer: 2.519 ± 0.063
1.493ProThr: 1.493 ± 0.043
3.293ProVal: 3.293 ± 0.068
0.324ProTrp: 0.324 ± 0.022
1.548ProTyr: 1.548 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.265GlnAla: 2.265 ± 0.057
0.304GlnCys: 0.304 ± 0.019
1.091GlnAsp: 1.091 ± 0.034
1.373GlnGlu: 1.373 ± 0.04
1.07GlnPhe: 1.07 ± 0.039
1.607GlnGly: 1.607 ± 0.049
0.407GlnHis: 0.407 ± 0.023
1.822GlnIle: 1.822 ± 0.045
2.633GlnLys: 2.633 ± 0.055
2.076GlnLeu: 2.076 ± 0.053
0.708GlnMet: 0.708 ± 0.03
1.683GlnAsn: 1.683 ± 0.048
0.674GlnPro: 0.674 ± 0.03
0.85GlnGln: 0.85 ± 0.032
1.364GlnArg: 1.364 ± 0.049
1.842GlnSer: 1.842 ± 0.048
1.596GlnThr: 1.596 ± 0.04
1.35GlnVal: 1.35 ± 0.039
0.249GlnTrp: 0.249 ± 0.017
1.067GlnTyr: 1.067 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
4.124ArgAla: 4.124 ± 0.076
0.69ArgCys: 0.69 ± 0.031
2.656ArgAsp: 2.656 ± 0.06
3.202ArgGlu: 3.202 ± 0.07
2.681ArgPhe: 2.681 ± 0.062
2.932ArgGly: 2.932 ± 0.066
0.739ArgHis: 0.739 ± 0.033
4.046ArgIle: 4.046 ± 0.071
3.177ArgLys: 3.177 ± 0.066
4.221ArgLeu: 4.221 ± 0.073
1.554ArgMet: 1.554 ± 0.04
1.902ArgAsn: 1.902 ± 0.05
1.461ArgPro: 1.461 ± 0.04
1.35ArgGln: 1.35 ± 0.039
2.804ArgArg: 2.804 ± 0.066
3.16ArgSer: 3.16 ± 0.067
2.894ArgThr: 2.894 ± 0.062
2.999ArgVal: 2.999 ± 0.065
0.434ArgTrp: 0.434 ± 0.026
1.954ArgTyr: 1.954 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
6.649SerAla: 6.649 ± 0.1
1.028SerCys: 1.028 ± 0.033
4.214SerAsp: 4.214 ± 0.083
4.221SerGlu: 4.221 ± 0.068
3.606SerPhe: 3.606 ± 0.077
6.206SerGly: 6.206 ± 0.089
1.001SerHis: 1.001 ± 0.033
4.183SerIle: 4.183 ± 0.077
3.138SerLys: 3.138 ± 0.068
6.571SerLeu: 6.571 ± 0.11
1.417SerMet: 1.417 ± 0.037
1.935SerAsn: 1.935 ± 0.046
2.426SerPro: 2.426 ± 0.057
1.454SerGln: 1.454 ± 0.042
3.041SerArg: 3.041 ± 0.058
4.404SerSer: 4.404 ± 0.084
2.872SerThr: 2.872 ± 0.065
5.505SerVal: 5.505 ± 0.092
0.67SerTrp: 0.67 ± 0.031
2.54SerTyr: 2.54 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
5.709ThrAla: 5.709 ± 0.101
0.577ThrCys: 0.577 ± 0.025
3.285ThrAsp: 3.285 ± 0.067
3.559ThrGlu: 3.559 ± 0.064
2.343ThrPhe: 2.343 ± 0.06
4.842ThrGly: 4.842 ± 0.102
0.983ThrHis: 0.983 ± 0.036
3.929ThrIle: 3.929 ± 0.074
3.164ThrLys: 3.164 ± 0.054
5.565ThrLeu: 5.565 ± 0.091
1.396ThrMet: 1.396 ± 0.033
1.86ThrAsn: 1.86 ± 0.046
2.417ThrPro: 2.417 ± 0.062
1.51ThrGln: 1.51 ± 0.044
2.016ThrArg: 2.016 ± 0.05
3.233ThrSer: 3.233 ± 0.06
2.673ThrThr: 2.673 ± 0.071
5.093ThrVal: 5.093 ± 0.097
0.503ThrTrp: 0.503 ± 0.026
1.848ThrTyr: 1.848 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
5.073ValAla: 5.073 ± 0.088
1.184ValCys: 1.184 ± 0.04
3.421ValAsp: 3.421 ± 0.061
3.393ValGlu: 3.393 ± 0.075
3.94ValPhe: 3.94 ± 0.081
3.739ValGly: 3.739 ± 0.076
1.193ValHis: 1.193 ± 0.038
4.646ValIle: 4.646 ± 0.083
4.263ValLys: 4.263 ± 0.077
6.686ValLeu: 6.686 ± 0.101
1.623ValMet: 1.623 ± 0.048
2.605ValAsn: 2.605 ± 0.062
3.203ValPro: 3.203 ± 0.075
2.226ValGln: 2.226 ± 0.053
3.782ValArg: 3.782 ± 0.064
5.534ValSer: 5.534 ± 0.094
3.92ValThr: 3.92 ± 0.093
4.605ValVal: 4.605 ± 0.077
0.629ValTrp: 0.629 ± 0.028
2.459ValTyr: 2.459 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.602TrpAla: 0.602 ± 0.027
0.144TrpCys: 0.144 ± 0.013
0.546TrpAsp: 0.546 ± 0.031
0.541TrpGlu: 0.541 ± 0.027
0.422TrpPhe: 0.422 ± 0.021
0.58TrpGly: 0.58 ± 0.026
0.189TrpHis: 0.189 ± 0.016
0.609TrpIle: 0.609 ± 0.028
0.774TrpLys: 0.774 ± 0.033
0.835TrpLeu: 0.835 ± 0.029
0.237TrpMet: 0.237 ± 0.017
0.569TrpAsn: 0.569 ± 0.029
0.283TrpPro: 0.283 ± 0.018
0.398TrpGln: 0.398 ± 0.019
0.451TrpArg: 0.451 ± 0.026
0.484TrpSer: 0.484 ± 0.024
0.556TrpThr: 0.556 ± 0.028
0.414TrpVal: 0.414 ± 0.025
0.102TrpTrp: 0.102 ± 0.01
0.387TrpTyr: 0.387 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.444TyrAla: 3.444 ± 0.061
0.502TyrCys: 0.502 ± 0.026
2.337TyrAsp: 2.337 ± 0.063
2.173TyrGlu: 2.173 ± 0.052
1.75TyrPhe: 1.75 ± 0.041
2.561TyrGly: 2.561 ± 0.05
0.515TyrHis: 0.515 ± 0.026
2.432TyrIle: 2.432 ± 0.052
2.017TyrLys: 2.017 ± 0.05
2.785TyrLeu: 2.785 ± 0.062
0.888TyrMet: 0.888 ± 0.033
1.529TyrAsn: 1.529 ± 0.048
1.411TyrPro: 1.411 ± 0.043
0.789TyrGln: 0.789 ± 0.033
2.043TyrArg: 2.043 ± 0.048
2.116TyrSer: 2.116 ± 0.051
2.359TyrThr: 2.359 ± 0.063
2.328TyrVal: 2.328 ± 0.052
0.382TyrTrp: 0.382 ± 0.019
1.482TyrTyr: 1.482 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2624 proteins (852725 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski