Amino acid dipepetide frequency for Sarcoptes scabiei (Itch mite) (Acarus scabiei)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.167AlaAla: 3.167 ± 0.056	0.811AlaCys: 0.811 ± 0.019	2.273AlaAsp: 2.273 ± 0.023	2.627AlaGlu: 2.627 ± 0.032	2.125AlaPhe: 2.125 ± 0.026	2.085AlaGly: 2.085 ± 0.037	0.965AlaHis: 0.965 ± 0.018	3.89AlaIle: 3.89 ± 0.038	3.287AlaLys: 3.287 ± 0.037	4.396AlaLeu: 4.396 ± 0.04	1.149AlaMet: 1.149 ± 0.016	2.983AlaAsn: 2.983 ± 0.029	1.671AlaPro: 1.671 ± 0.03	1.809AlaGln: 1.809 ± 0.025	2.082AlaArg: 2.082 ± 0.026	4.108AlaSer: 4.108 ± 0.037	2.634AlaThr: 2.634 ± 0.031	2.364AlaVal: 2.364 ± 0.033	0.397AlaTrp: 0.397 ± 0.011	1.375AlaTyr: 1.375 ± 0.019	0.001AlaXaa: 0.001 ± 0.001
Cys	0.76CysAla: 0.76 ± 0.018	0.443CysCys: 0.443 ± 0.012	1.316CysAsp: 1.316 ± 0.032	1.044CysGlu: 1.044 ± 0.025	0.978CysPhe: 0.978 ± 0.016	1.075CysGly: 1.075 ± 0.028	0.509CysHis: 0.509 ± 0.015	1.103CysIle: 1.103 ± 0.027	1.033CysLys: 1.033 ± 0.023	1.951CysLeu: 1.951 ± 0.027	0.323CysMet: 0.323 ± 0.01	0.973CysAsn: 0.973 ± 0.022	0.873CysPro: 0.873 ± 0.026	0.82CysGln: 0.82 ± 0.025	1.008CysArg: 1.008 ± 0.025	1.669CysSer: 1.669 ± 0.03	0.716CysThr: 0.716 ± 0.016	0.918CysVal: 0.918 ± 0.025	0.206CysTrp: 0.206 ± 0.008	0.616CysTyr: 0.616 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	2.398AspAla: 2.398 ± 0.027	1.337AspCys: 1.337 ± 0.032	5.328AspAsp: 5.328 ± 0.063	4.824AspGlu: 4.824 ± 0.046	2.884AspPhe: 2.884 ± 0.031	3.047AspGly: 3.047 ± 0.037	1.618AspHis: 1.618 ± 0.022	3.385AspIle: 3.385 ± 0.032	2.872AspLys: 2.872 ± 0.03	5.779AspLeu: 5.779 ± 0.042	0.94AspMet: 0.94 ± 0.018	3.162AspAsn: 3.162 ± 0.034	2.522AspPro: 2.522 ± 0.026	2.845AspGln: 2.845 ± 0.033	3.254AspArg: 3.254 ± 0.036	5.478AspSer: 5.478 ± 0.041	1.905AspThr: 1.905 ± 0.023	2.888AspVal: 2.888 ± 0.029	0.671AspTrp: 0.671 ± 0.013	2.177AspTyr: 2.177 ± 0.025	0.002AspXaa: 0.002 ± 0.001
Glu	2.664GluAla: 2.664 ± 0.032	1.13GluCys: 1.13 ± 0.031	3.515GluAsp: 3.515 ± 0.034	4.87GluGlu: 4.87 ± 0.06	2.842GluPhe: 2.842 ± 0.027	1.818GluGly: 1.818 ± 0.032	1.274GluHis: 1.274 ± 0.018	5.54GluIle: 5.54 ± 0.046	5.356GluLys: 5.356 ± 0.057	5.283GluLeu: 5.283 ± 0.046	1.67GluMet: 1.67 ± 0.022	5.007GluAsn: 5.007 ± 0.046	1.932GluPro: 1.932 ± 0.033	2.718GluGln: 2.718 ± 0.033	3.115GluArg: 3.115 ± 0.033	5.287GluSer: 5.287 ± 0.044	3.56GluThr: 3.56 ± 0.03	2.299GluVal: 2.299 ± 0.034	0.619GluTrp: 0.619 ± 0.013	1.829GluTyr: 1.829 ± 0.023	0.002GluXaa: 0.002 ± 0.001
Phe	2.243PheAla: 2.243 ± 0.029	0.948PheCys: 0.948 ± 0.017	3.681PheAsp: 3.681 ± 0.038	3.126PheGlu: 3.126 ± 0.03	2.388PhePhe: 2.388 ± 0.032	2.703PheGly: 2.703 ± 0.03	1.231PheHis: 1.231 ± 0.018	3.233PheIle: 3.233 ± 0.033	2.794PheLys: 2.794 ± 0.029	4.436PheLeu: 4.436 ± 0.036	0.945PheMet: 0.945 ± 0.018	2.995PheAsn: 2.995 ± 0.03	1.653PhePro: 1.653 ± 0.019	1.937PheGln: 1.937 ± 0.024	2.453PheArg: 2.453 ± 0.028	3.759PheSer: 3.759 ± 0.034	2.187PheThr: 2.187 ± 0.025	2.799PheVal: 2.799 ± 0.029	0.512PheTrp: 0.512 ± 0.012	1.781PheTyr: 1.781 ± 0.027	0.001PheXaa: 0.001 ± 0.001
Gly	2.004GlyAla: 2.004 ± 0.033	0.869GlyCys: 0.869 ± 0.026	2.473GlyAsp: 2.473 ± 0.038	2.286GlyGlu: 2.286 ± 0.037	2.325GlyPhe: 2.325 ± 0.033	3.17GlyGly: 3.17 ± 0.073	1.242GlyHis: 1.242 ± 0.021	2.958GlyIle: 2.958 ± 0.034	2.744GlyLys: 2.744 ± 0.037	3.977GlyLeu: 3.977 ± 0.05	0.87GlyMet: 0.87 ± 0.017	2.424GlyAsn: 2.424 ± 0.03	1.84GlyPro: 1.84 ± 0.037	1.875GlyGln: 1.875 ± 0.029	2.225GlyArg: 2.225 ± 0.029	4.029GlySer: 4.029 ± 0.043	2.319GlyThr: 2.319 ± 0.03	2.177GlyVal: 2.177 ± 0.025	0.5GlyTrp: 0.5 ± 0.012	1.719GlyTyr: 1.719 ± 0.03	0.001GlyXaa: 0.001 ± 0.001
His	0.762HisAla: 0.762 ± 0.014	0.609HisCys: 0.609 ± 0.013	0.997HisAsp: 0.997 ± 0.016	1.135HisGlu: 1.135 ± 0.015	1.239HisPhe: 1.239 ± 0.02	0.988HisGly: 0.988 ± 0.019	1.701HisHis: 1.701 ± 0.037	1.4HisIle: 1.4 ± 0.018	1.266HisLys: 1.266 ± 0.021	2.721HisLeu: 2.721 ± 0.027	0.407HisMet: 0.407 ± 0.011	1.434HisAsn: 1.434 ± 0.02	1.244HisPro: 1.244 ± 0.018	1.801HisGln: 1.801 ± 0.024	1.687HisArg: 1.687 ± 0.022	2.396HisSer: 2.396 ± 0.027	0.93HisThr: 0.93 ± 0.017	0.899HisVal: 0.899 ± 0.018	0.289HisTrp: 0.289 ± 0.007	1.014HisTyr: 1.014 ± 0.017	0.003HisXaa: 0.003 ± 0.001
Ile	3.956IleAla: 3.956 ± 0.036	1.387IleCys: 1.387 ± 0.03	5.968IleAsp: 5.968 ± 0.05	5.916IleGlu: 5.916 ± 0.055	3.355IlePhe: 3.355 ± 0.035	3.668IleGly: 3.668 ± 0.036	1.718IleHis: 1.718 ± 0.023	5.318IleIle: 5.318 ± 0.046	5.158IleLys: 5.158 ± 0.041	6.639IleLeu: 6.639 ± 0.051	1.379IleMet: 1.379 ± 0.019	5.06IleAsn: 5.06 ± 0.04	2.969IlePro: 2.969 ± 0.031	3.127IleGln: 3.127 ± 0.03	3.768IleArg: 3.768 ± 0.031	6.085IleSer: 6.085 ± 0.044	3.503IleThr: 3.503 ± 0.035	4.324IleVal: 4.324 ± 0.037	0.695IleTrp: 0.695 ± 0.014	2.503IleTyr: 2.503 ± 0.026	0.001IleXaa: 0.001 ± 0.0
Lys	2.812LysAla: 2.812 ± 0.035	1.205LysCys: 1.205 ± 0.025	3.249LysAsp: 3.249 ± 0.038	4.274LysGlu: 4.274 ± 0.044	3.276LysPhe: 3.276 ± 0.033	2.085LysGly: 2.085 ± 0.042	1.589LysHis: 1.589 ± 0.021	6.027LysIle: 6.027 ± 0.05	5.609LysLys: 5.609 ± 0.063	6.29LysLeu: 6.29 ± 0.054	1.624LysMet: 1.624 ± 0.023	5.176LysAsn: 5.176 ± 0.042	2.656LysPro: 2.656 ± 0.041	3.119LysGln: 3.119 ± 0.038	3.658LysArg: 3.658 ± 0.037	6.223LysSer: 6.223 ± 0.053	3.73LysThr: 3.73 ± 0.035	2.641LysVal: 2.641 ± 0.031	0.646LysTrp: 0.646 ± 0.014	2.059LysTyr: 2.059 ± 0.022	0.001LysXaa: 0.001 ± 0.001
Leu	4.779LeuAla: 4.779 ± 0.048	1.586LeuCys: 1.586 ± 0.022	5.285LeuAsp: 5.285 ± 0.053	5.658LeuGlu: 5.658 ± 0.052	4.425LeuPhe: 4.425 ± 0.041	3.721LeuGly: 3.721 ± 0.037	2.072LeuHis: 2.072 ± 0.023	7.771LeuIle: 7.771 ± 0.058	6.857LeuLys: 6.857 ± 0.06	8.491LeuLeu: 8.491 ± 0.077	2.434LeuMet: 2.434 ± 0.028	6.611LeuAsn: 6.611 ± 0.047	3.905LeuPro: 3.905 ± 0.04	3.925LeuGln: 3.925 ± 0.035	4.685LeuArg: 4.685 ± 0.043	7.849LeuSer: 7.849 ± 0.052	4.456LeuThr: 4.456 ± 0.034	4.371LeuVal: 4.371 ± 0.041	0.84LeuTrp: 0.84 ± 0.018	2.684LeuTyr: 2.684 ± 0.029	0.003LeuXaa: 0.003 ± 0.001
Met	1.391MetAla: 1.391 ± 0.02	0.288MetCys: 0.288 ± 0.009	1.217MetAsp: 1.217 ± 0.017	1.322MetGlu: 1.322 ± 0.019	1.048MetPhe: 1.048 ± 0.017	0.793MetGly: 0.793 ± 0.017	0.433MetHis: 0.433 ± 0.011	2.153MetIle: 2.153 ± 0.025	1.718MetLys: 1.718 ± 0.02	1.918MetLeu: 1.918 ± 0.024	0.813MetMet: 0.813 ± 0.021	1.74MetAsn: 1.74 ± 0.021	0.997MetPro: 0.997 ± 0.017	0.826MetGln: 0.826 ± 0.015	1.023MetArg: 1.023 ± 0.018	1.679MetSer: 1.679 ± 0.024	1.194MetThr: 1.194 ± 0.016	1.098MetVal: 1.098 ± 0.019	0.152MetTrp: 0.152 ± 0.006	0.468MetTyr: 0.468 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	2.813AsnAla: 2.813 ± 0.032	1.232AsnCys: 1.232 ± 0.019	4.917AsnAsp: 4.917 ± 0.046	4.988AsnGlu: 4.988 ± 0.045	3.222AsnPhe: 3.222 ± 0.028	3.561AsnGly: 3.561 ± 0.038	2.218AsnHis: 2.218 ± 0.027	4.067AsnIle: 4.067 ± 0.031	3.644AsnLys: 3.644 ± 0.034	6.75AsnLeu: 6.75 ± 0.053	1.044AsnMet: 1.044 ± 0.017	5.32AsnAsn: 5.32 ± 0.08	2.81AsnPro: 2.81 ± 0.035	3.985AsnGln: 3.985 ± 0.039	3.893AsnArg: 3.893 ± 0.039	6.253AsnSer: 6.253 ± 0.057	2.589AsnThr: 2.589 ± 0.03	3.325AsnVal: 3.325 ± 0.032	0.527AsnTrp: 0.527 ± 0.014	2.296AsnTyr: 2.296 ± 0.026	0.002AsnXaa: 0.002 ± 0.001
Pro	1.598ProAla: 1.598 ± 0.028	0.558ProCys: 0.558 ± 0.019	2.026ProAsp: 2.026 ± 0.026	2.427ProGlu: 2.427 ± 0.031	1.94ProPhe: 1.94 ± 0.023	1.738ProGly: 1.738 ± 0.054	0.862ProHis: 0.862 ± 0.017	3.61ProIle: 3.61 ± 0.034	2.948ProLys: 2.948 ± 0.033	3.502ProLeu: 3.502 ± 0.034	0.982ProMet: 0.982 ± 0.017	3.113ProAsn: 3.113 ± 0.033	2.546ProPro: 2.546 ± 0.051	1.719ProGln: 1.719 ± 0.028	1.623ProArg: 1.623 ± 0.02	4.227ProSer: 4.227 ± 0.045	2.333ProThr: 2.333 ± 0.029	1.869ProVal: 1.869 ± 0.032	0.334ProTrp: 0.334 ± 0.01	1.368ProTyr: 1.368 ± 0.024	0.001ProXaa: 0.001 ± 0.0
Gln	1.891GlnAla: 1.891 ± 0.024	0.845GlnCys: 0.845 ± 0.025	1.745GlnAsp: 1.745 ± 0.023	2.392GlnGlu: 2.392 ± 0.031	1.955GlnPhe: 1.955 ± 0.024	1.23GlnGly: 1.23 ± 0.026	1.201GlnHis: 1.201 ± 0.02	3.602GlnIle: 3.602 ± 0.036	3.098GlnLys: 3.098 ± 0.034	3.941GlnLeu: 3.941 ± 0.036	1.184GlnMet: 1.184 ± 0.02	3.604GlnAsn: 3.604 ± 0.037	1.821GlnPro: 1.821 ± 0.028	3.689GlnGln: 3.689 ± 0.079	2.141GlnArg: 2.141 ± 0.027	4.914GlnSer: 4.914 ± 0.051	2.754GlnThr: 2.754 ± 0.026	1.548GlnVal: 1.548 ± 0.023	0.455GlnTrp: 0.455 ± 0.012	1.379GlnTyr: 1.379 ± 0.021	0.002GlnXaa: 0.002 ± 0.001
Arg	2.022ArgAla: 2.022 ± 0.027	1.067ArgCys: 1.067 ± 0.025	2.373ArgAsp: 2.373 ± 0.028	2.705ArgGlu: 2.705 ± 0.036	2.817ArgPhe: 2.817 ± 0.033	1.801ArgGly: 1.801 ± 0.03	1.184ArgHis: 1.184 ± 0.019	4.032ArgIle: 4.032 ± 0.03	4.18ArgLys: 4.18 ± 0.04	4.946ArgLeu: 4.946 ± 0.043	1.219ArgMet: 1.219 ± 0.017	3.547ArgAsn: 3.547 ± 0.032	1.903ArgPro: 1.903 ± 0.024	2.084ArgGln: 2.084 ± 0.026	2.903ArgArg: 2.903 ± 0.033	4.6ArgSer: 4.6 ± 0.043	2.445ArgThr: 2.445 ± 0.03	1.962ArgVal: 1.962 ± 0.026	0.518ArgTrp: 0.518 ± 0.012	1.789ArgTyr: 1.789 ± 0.021	0.002ArgXaa: 0.002 ± 0.001
Ser	3.857SerAla: 3.857 ± 0.04	1.244SerCys: 1.244 ± 0.025	4.989SerAsp: 4.989 ± 0.046	4.543SerGlu: 4.543 ± 0.035	4.212SerPhe: 4.212 ± 0.038	3.8SerGly: 3.8 ± 0.041	1.849SerHis: 1.849 ± 0.023	7.696SerIle: 7.696 ± 0.05	6.611SerLys: 6.611 ± 0.055	8.325SerLeu: 8.325 ± 0.06	2.188SerMet: 2.188 ± 0.027	7.565SerAsn: 7.565 ± 0.074	3.819SerPro: 3.819 ± 0.049	3.589SerGln: 3.589 ± 0.042	3.766SerArg: 3.766 ± 0.033	12.343SerSer: 12.343 ± 0.139	5.439SerThr: 5.439 ± 0.055	4.063SerVal: 4.063 ± 0.034	0.68SerTrp: 0.68 ± 0.013	2.525SerTyr: 2.525 ± 0.027	0.002SerXaa: 0.002 ± 0.001
Thr	2.519ThrAla: 2.519 ± 0.033	0.77ThrCys: 0.77 ± 0.019	2.584ThrAsp: 2.584 ± 0.025	2.839ThrGlu: 2.839 ± 0.027	2.241ThrPhe: 2.241 ± 0.029	2.286ThrGly: 2.286 ± 0.032	0.909ThrHis: 0.909 ± 0.015	4.571ThrIle: 4.571 ± 0.036	3.602ThrLys: 3.602 ± 0.032	4.524ThrLeu: 4.524 ± 0.038	1.145ThrMet: 1.145 ± 0.019	3.679ThrAsn: 3.679 ± 0.035	2.197ThrPro: 2.197 ± 0.031	1.704ThrGln: 1.704 ± 0.022	1.972ThrArg: 1.972 ± 0.025	4.846ThrSer: 4.846 ± 0.054	3.388ThrThr: 3.388 ± 0.053	2.625ThrVal: 2.625 ± 0.027	0.39ThrTrp: 0.39 ± 0.009	1.336ThrTyr: 1.336 ± 0.02	0.001ThrXaa: 0.001 ± 0.0
Val	2.67ValAla: 2.67 ± 0.029	1.05ValCys: 1.05 ± 0.027	2.833ValAsp: 2.833 ± 0.026	2.912ValGlu: 2.912 ± 0.033	2.224ValPhe: 2.224 ± 0.03	2.211ValGly: 2.211 ± 0.033	1.118ValHis: 1.118 ± 0.018	3.428ValIle: 3.428 ± 0.037	2.847ValLys: 2.847 ± 0.033	4.228ValLeu: 4.228 ± 0.038	1.09ValMet: 1.09 ± 0.016	2.652ValAsn: 2.652 ± 0.031	2.245ValPro: 2.245 ± 0.034	1.896ValGln: 1.896 ± 0.023	2.317ValArg: 2.317 ± 0.025	3.873ValSer: 3.873 ± 0.035	2.342ValThr: 2.342 ± 0.032	2.723ValVal: 2.723 ± 0.033	0.572ValTrp: 0.572 ± 0.012	1.524ValTyr: 1.524 ± 0.022	0.002ValXaa: 0.002 ± 0.001
Trp	0.408TrpAla: 0.408 ± 0.011	0.193TrpCys: 0.193 ± 0.008	0.485TrpAsp: 0.485 ± 0.013	0.43TrpGlu: 0.43 ± 0.01	0.552TrpPhe: 0.552 ± 0.013	0.346TrpGly: 0.346 ± 0.008	0.224TrpHis: 0.224 ± 0.008	0.903TrpIle: 0.903 ± 0.018	0.679TrpLys: 0.679 ± 0.013	0.941TrpLeu: 0.941 ± 0.017	0.248TrpMet: 0.248 ± 0.007	0.731TrpAsn: 0.731 ± 0.015	0.387TrpPro: 0.387 ± 0.011	0.361TrpGln: 0.361 ± 0.01	0.545TrpArg: 0.545 ± 0.012	0.833TrpSer: 0.833 ± 0.017	0.491TrpThr: 0.491 ± 0.012	0.335TrpVal: 0.335 ± 0.01	0.138TrpTrp: 0.138 ± 0.007	0.304TrpTyr: 0.304 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.489TyrAla: 1.489 ± 0.021	0.757TyrCys: 0.757 ± 0.015	2.06TyrAsp: 2.06 ± 0.026	2.011TyrGlu: 2.011 ± 0.025	1.756TyrPhe: 1.756 ± 0.023	1.901TyrGly: 1.901 ± 0.029	1.001TyrHis: 1.001 ± 0.016	1.809TyrIle: 1.809 ± 0.026	1.644TyrLys: 1.644 ± 0.023	3.367TyrLeu: 3.367 ± 0.03	0.613TyrMet: 0.613 ± 0.014	1.678TyrAsn: 1.678 ± 0.024	1.335TyrPro: 1.335 ± 0.019	1.56TyrGln: 1.56 ± 0.019	1.977TyrArg: 1.977 ± 0.023	2.652TyrSer: 2.652 ± 0.029	1.212TyrThr: 1.212 ± 0.02	1.528TyrVal: 1.528 ± 0.02	0.394TyrTrp: 0.394 ± 0.013	1.352TyrTyr: 1.352 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.003XaaLeu: 0.003 ± 0.001	0.003XaaMet: 0.003 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.002XaaGln: 0.002 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.015XaaXaa: 0.015 ± 0.004

Statistics based on 10528 proteins (4005944 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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