Amino acid dipepetide frequency for Mesorhizobium hungaricum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.372AlaAla: 17.372 ± 0.127	0.96AlaCys: 0.96 ± 0.029	6.944AlaAsp: 6.944 ± 0.071	7.646AlaGlu: 7.646 ± 0.08	4.912AlaPhe: 4.912 ± 0.063	11.37AlaGly: 11.37 ± 0.107	2.103AlaHis: 2.103 ± 0.031	6.794AlaIle: 6.794 ± 0.059	4.647AlaLys: 4.647 ± 0.055	13.134AlaLeu: 13.134 ± 0.111	3.606AlaMet: 3.606 ± 0.041	3.212AlaAsn: 3.212 ± 0.043	5.19AlaPro: 5.19 ± 0.065	3.562AlaGln: 3.562 ± 0.048	8.327AlaArg: 8.327 ± 0.091	6.654AlaSer: 6.654 ± 0.071	6.237AlaThr: 6.237 ± 0.062	9.181AlaVal: 9.181 ± 0.081	1.526AlaTrp: 1.526 ± 0.033	2.734AlaTyr: 2.734 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.91CysAla: 0.91 ± 0.028	0.096CysCys: 0.096 ± 0.008	0.473CysAsp: 0.473 ± 0.016	0.386CysGlu: 0.386 ± 0.015	0.319CysPhe: 0.319 ± 0.014	0.849CysGly: 0.849 ± 0.024	0.2CysHis: 0.2 ± 0.01	0.347CysIle: 0.347 ± 0.014	0.179CysLys: 0.179 ± 0.011	0.714CysLeu: 0.714 ± 0.022	0.158CysMet: 0.158 ± 0.008	0.186CysAsn: 0.186 ± 0.01	0.393CysPro: 0.393 ± 0.018	0.214CysGln: 0.214 ± 0.011	0.579CysArg: 0.579 ± 0.019	0.443CysSer: 0.443 ± 0.018	0.389CysThr: 0.389 ± 0.017	0.573CysVal: 0.573 ± 0.019	0.124CysTrp: 0.124 ± 0.009	0.211CysTyr: 0.211 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.624AspAla: 6.624 ± 0.066	0.481AspCys: 0.481 ± 0.018	3.049AspAsp: 3.049 ± 0.044	3.404AspGlu: 3.404 ± 0.053	2.273AspPhe: 2.273 ± 0.038	5.202AspGly: 5.202 ± 0.072	1.238AspHis: 1.238 ± 0.028	3.2AspIle: 3.2 ± 0.043	2.026AspLys: 2.026 ± 0.044	5.593AspLeu: 5.593 ± 0.06	1.357AspMet: 1.357 ± 0.03	1.428AspAsn: 1.428 ± 0.03	3.274AspPro: 3.274 ± 0.049	1.682AspGln: 1.682 ± 0.035	4.276AspArg: 4.276 ± 0.051	2.05AspSer: 2.05 ± 0.034	2.565AspThr: 2.565 ± 0.038	3.94AspVal: 3.94 ± 0.05	0.97AspTrp: 0.97 ± 0.022	1.51AspTyr: 1.51 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.584GluAla: 7.584 ± 0.08	0.338GluCys: 0.338 ± 0.014	2.603GluAsp: 2.603 ± 0.048	2.937GluGlu: 2.937 ± 0.052	1.796GluPhe: 1.796 ± 0.031	3.902GluGly: 3.902 ± 0.052	1.14GluHis: 1.14 ± 0.029	3.387GluIle: 3.387 ± 0.04	2.577GluLys: 2.577 ± 0.046	5.179GluLeu: 5.179 ± 0.065	1.452GluMet: 1.452 ± 0.03	1.616GluAsn: 1.616 ± 0.032	2.801GluPro: 2.801 ± 0.045	2.068GluGln: 2.068 ± 0.035	4.871GluArg: 4.871 ± 0.062	2.054GluSer: 2.054 ± 0.037	3.582GluThr: 3.582 ± 0.05	3.664GluVal: 3.664 ± 0.046	0.704GluTrp: 0.704 ± 0.02	0.962GluTyr: 0.962 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.841PheAla: 4.841 ± 0.053	0.389PheCys: 0.389 ± 0.014	2.726PheAsp: 2.726 ± 0.041	2.236PheGlu: 2.236 ± 0.039	1.52PhePhe: 1.52 ± 0.038	3.925PheGly: 3.925 ± 0.047	0.766PheHis: 0.766 ± 0.02	1.785PheIle: 1.785 ± 0.033	1.083PheLys: 1.083 ± 0.025	3.561PheLeu: 3.561 ± 0.049	0.832PheMet: 0.832 ± 0.023	1.106PheAsn: 1.106 ± 0.028	1.622PhePro: 1.622 ± 0.032	1.121PheGln: 1.121 ± 0.024	2.318PheArg: 2.318 ± 0.036	2.385PheSer: 2.385 ± 0.04	1.941PheThr: 1.941 ± 0.035	3.107PheVal: 3.107 ± 0.042	0.585PheTrp: 0.585 ± 0.019	0.959PheTyr: 0.959 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.294GlyAla: 9.294 ± 0.083	0.771GlyCys: 0.771 ± 0.023	4.36GlyAsp: 4.36 ± 0.052	4.749GlyGlu: 4.749 ± 0.06	3.761GlyPhe: 3.761 ± 0.049	7.466GlyGly: 7.466 ± 0.136	1.844GlyHis: 1.844 ± 0.033	4.854GlyIle: 4.854 ± 0.054	3.856GlyLys: 3.856 ± 0.058	8.888GlyLeu: 8.888 ± 0.092	2.369GlyMet: 2.369 ± 0.039	2.372GlyAsn: 2.372 ± 0.046	3.345GlyPro: 3.345 ± 0.046	2.885GlyGln: 2.885 ± 0.038	5.924GlyArg: 5.924 ± 0.063	4.883GlySer: 4.883 ± 0.065	4.811GlyThr: 4.811 ± 0.095	6.184GlyVal: 6.184 ± 0.056	1.44GlyTrp: 1.44 ± 0.027	2.324GlyTyr: 2.324 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.245HisAla: 2.245 ± 0.035	0.234HisCys: 0.234 ± 0.012	1.214HisAsp: 1.214 ± 0.028	0.983HisGlu: 0.983 ± 0.025	0.893HisPhe: 0.893 ± 0.021	1.935HisGly: 1.935 ± 0.033	0.546HisHis: 0.546 ± 0.019	0.94HisIle: 0.94 ± 0.021	0.544HisLys: 0.544 ± 0.016	1.926HisLeu: 1.926 ± 0.037	0.513HisMet: 0.513 ± 0.017	0.442HisAsn: 0.442 ± 0.018	1.205HisPro: 1.205 ± 0.03	0.564HisGln: 0.564 ± 0.02	1.366HisArg: 1.366 ± 0.032	0.959HisSer: 0.959 ± 0.023	0.78HisThr: 0.78 ± 0.024	1.464HisVal: 1.464 ± 0.03	0.321HisTrp: 0.321 ± 0.013	0.537HisTyr: 0.537 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.737IleAla: 7.737 ± 0.067	0.486IleCys: 0.486 ± 0.017	3.657IleAsp: 3.657 ± 0.053	3.525IleGlu: 3.525 ± 0.05	1.79IlePhe: 1.79 ± 0.035	5.148IleGly: 5.148 ± 0.061	0.928IleHis: 0.928 ± 0.022	2.311IleIle: 2.311 ± 0.034	1.565IleLys: 1.565 ± 0.031	4.46IleLeu: 4.46 ± 0.049	1.027IleMet: 1.027 ± 0.024	1.444IleAsn: 1.444 ± 0.031	2.211IlePro: 2.211 ± 0.037	1.177IleGln: 1.177 ± 0.024	3.188IleArg: 3.188 ± 0.043	2.968IleSer: 2.968 ± 0.045	2.605IleThr: 2.605 ± 0.038	4.749IleVal: 4.749 ± 0.052	0.634IleTrp: 0.634 ± 0.02	1.166IleTyr: 1.166 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.975LysAla: 4.975 ± 0.065	0.158LysCys: 0.158 ± 0.01	1.926LysAsp: 1.926 ± 0.036	1.752LysGlu: 1.752 ± 0.034	0.986LysPhe: 0.986 ± 0.022	2.942LysGly: 2.942 ± 0.047	0.63LysHis: 0.63 ± 0.019	1.893LysIle: 1.893 ± 0.037	1.581LysLys: 1.581 ± 0.038	3.752LysLeu: 3.752 ± 0.051	0.869LysMet: 0.869 ± 0.025	1.036LysAsn: 1.036 ± 0.024	2.445LysPro: 2.445 ± 0.049	1.197LysGln: 1.197 ± 0.027	2.528LysArg: 2.528 ± 0.047	2.022LysSer: 2.022 ± 0.037	2.27LysThr: 2.27 ± 0.036	2.759LysVal: 2.759 ± 0.039	0.411LysTrp: 0.411 ± 0.015	0.648LysTyr: 0.648 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.726LeuAla: 13.726 ± 0.106	0.801LeuCys: 0.801 ± 0.022	5.876LeuAsp: 5.876 ± 0.076	5.015LeuGlu: 5.015 ± 0.07	3.756LeuPhe: 3.756 ± 0.053	8.338LeuGly: 8.338 ± 0.079	1.733LeuHis: 1.733 ± 0.037	5.095LeuIle: 5.095 ± 0.063	3.998LeuLys: 3.998 ± 0.048	9.323LeuLeu: 9.323 ± 0.106	2.214LeuMet: 2.214 ± 0.037	2.55LeuAsn: 2.55 ± 0.037	5.336LeuPro: 5.336 ± 0.06	2.641LeuGln: 2.641 ± 0.042	6.439LeuArg: 6.439 ± 0.064	6.443LeuSer: 6.443 ± 0.055	5.481LeuThr: 5.481 ± 0.071	7.747LeuVal: 7.747 ± 0.076	1.184LeuTrp: 1.184 ± 0.027	2.101LeuTyr: 2.101 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.206MetAla: 3.206 ± 0.043	0.143MetCys: 0.143 ± 0.01	1.077MetAsp: 1.077 ± 0.023	1.059MetGlu: 1.059 ± 0.021	0.729MetPhe: 0.729 ± 0.022	1.659MetGly: 1.659 ± 0.035	0.424MetHis: 0.424 ± 0.014	1.365MetIle: 1.365 ± 0.027	1.068MetLys: 1.068 ± 0.025	2.532MetLeu: 2.532 ± 0.04	0.684MetMet: 0.684 ± 0.022	0.804MetAsn: 0.804 ± 0.023	1.513MetPro: 1.513 ± 0.033	0.868MetGln: 0.868 ± 0.023	1.834MetArg: 1.834 ± 0.033	1.645MetSer: 1.645 ± 0.03	1.817MetThr: 1.817 ± 0.031	1.757MetVal: 1.757 ± 0.033	0.214MetTrp: 0.214 ± 0.011	0.301MetTyr: 0.301 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.308AsnAla: 3.308 ± 0.051	0.244AsnCys: 0.244 ± 0.012	1.431AsnAsp: 1.431 ± 0.028	1.303AsnGlu: 1.303 ± 0.026	1.02AsnPhe: 1.02 ± 0.026	2.66AsnGly: 2.66 ± 0.056	0.535AsnHis: 0.535 ± 0.017	1.423AsnIle: 1.423 ± 0.029	0.833AsnLys: 0.833 ± 0.023	2.577AsnLeu: 2.577 ± 0.038	0.636AsnMet: 0.636 ± 0.018	0.737AsnAsn: 0.737 ± 0.024	1.879AsnPro: 1.879 ± 0.033	0.832AsnGln: 0.832 ± 0.022	1.837AsnArg: 1.837 ± 0.034	1.363AsnSer: 1.363 ± 0.028	1.314AsnThr: 1.314 ± 0.03	1.967AsnVal: 1.967 ± 0.036	0.469AsnTrp: 0.469 ± 0.016	0.715AsnTyr: 0.715 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.317ProAla: 6.317 ± 0.072	0.287ProCys: 0.287 ± 0.012	3.305ProAsp: 3.305 ± 0.044	3.352ProGlu: 3.352 ± 0.045	1.999ProPhe: 1.999 ± 0.033	4.311ProGly: 4.311 ± 0.048	1.03ProHis: 1.03 ± 0.027	2.282ProIle: 2.282 ± 0.036	1.856ProLys: 1.856 ± 0.035	4.714ProLeu: 4.714 ± 0.059	1.142ProMet: 1.142 ± 0.024	1.418ProAsn: 1.418 ± 0.029	2.24ProPro: 2.24 ± 0.046	1.687ProGln: 1.687 ± 0.034	2.752ProArg: 2.752 ± 0.047	2.718ProSer: 2.718 ± 0.042	2.514ProThr: 2.514 ± 0.037	4.218ProVal: 4.218 ± 0.058	0.717ProTrp: 0.717 ± 0.022	1.239ProTyr: 1.239 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.01GlnAla: 4.01 ± 0.054	0.185GlnCys: 0.185 ± 0.011	1.404GlnAsp: 1.404 ± 0.03	1.415GlnGlu: 1.415 ± 0.034	1.07GlnPhe: 1.07 ± 0.024	2.23GlnGly: 2.23 ± 0.035	0.63GlnHis: 0.63 ± 0.019	1.755GlnIle: 1.755 ± 0.033	1.23GlnLys: 1.23 ± 0.029	2.852GlnLeu: 2.852 ± 0.042	0.879GlnMet: 0.879 ± 0.024	0.915GlnAsn: 0.915 ± 0.025	1.844GlnPro: 1.844 ± 0.035	1.188GlnGln: 1.188 ± 0.033	2.355GlnArg: 2.355 ± 0.044	1.773GlnSer: 1.773 ± 0.034	1.65GlnThr: 1.65 ± 0.03	2.141GlnVal: 2.141 ± 0.038	0.409GlnTrp: 0.409 ± 0.016	0.592GlnTyr: 0.592 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.524ArgAla: 7.524 ± 0.075	0.448ArgCys: 0.448 ± 0.018	3.981ArgAsp: 3.981 ± 0.05	3.792ArgGlu: 3.792 ± 0.051	3.058ArgPhe: 3.058 ± 0.044	4.501ArgGly: 4.501 ± 0.053	1.717ArgHis: 1.717 ± 0.03	3.882ArgIle: 3.882 ± 0.046	2.523ArgLys: 2.523 ± 0.041	7.774ArgLeu: 7.774 ± 0.074	1.767ArgMet: 1.767 ± 0.031	1.917ArgAsn: 1.917 ± 0.035	3.418ArgPro: 3.418 ± 0.047	2.621ArgGln: 2.621 ± 0.042	5.489ArgArg: 5.489 ± 0.073	3.666ArgSer: 3.666 ± 0.05	3.306ArgThr: 3.306 ± 0.045	4.474ArgVal: 4.474 ± 0.05	0.953ArgTrp: 0.953 ± 0.024	1.677ArgTyr: 1.677 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.333SerAla: 6.333 ± 0.069	0.386SerCys: 0.386 ± 0.018	2.933SerAsp: 2.933 ± 0.039	2.783SerGlu: 2.783 ± 0.042	2.329SerPhe: 2.329 ± 0.038	5.726SerGly: 5.726 ± 0.079	1.101SerHis: 1.101 ± 0.026	2.874SerIle: 2.874 ± 0.044	1.713SerLys: 1.713 ± 0.034	5.521SerLeu: 5.521 ± 0.063	1.328SerMet: 1.328 ± 0.027	1.452SerAsn: 1.452 ± 0.026	2.703SerPro: 2.703 ± 0.035	1.6SerGln: 1.6 ± 0.034	3.586SerArg: 3.586 ± 0.045	3.004SerSer: 3.004 ± 0.051	2.827SerThr: 2.827 ± 0.052	4.102SerVal: 4.102 ± 0.049	0.804SerTrp: 0.804 ± 0.021	1.324SerTyr: 1.324 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.45ThrAla: 6.45 ± 0.064	0.396ThrCys: 0.396 ± 0.015	2.776ThrAsp: 2.776 ± 0.043	2.578ThrGlu: 2.578 ± 0.041	2.101ThrPhe: 2.101 ± 0.035	5.213ThrGly: 5.213 ± 0.072	0.968ThrHis: 0.968 ± 0.024	3.12ThrIle: 3.12 ± 0.043	1.667ThrLys: 1.667 ± 0.038	5.729ThrLeu: 5.729 ± 0.065	1.245ThrMet: 1.245 ± 0.026	1.383ThrAsn: 1.383 ± 0.029	3.039ThrPro: 3.039 ± 0.047	1.399ThrGln: 1.399 ± 0.023	3.106ThrArg: 3.106 ± 0.045	2.818ThrSer: 2.818 ± 0.051	3.018ThrThr: 3.018 ± 0.071	4.675ThrVal: 4.675 ± 0.068	0.677ThrTrp: 0.677 ± 0.019	1.232ThrTyr: 1.232 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.816ValAla: 9.816 ± 0.079	0.597ValCys: 0.597 ± 0.019	4.301ValAsp: 4.301 ± 0.053	4.567ValGlu: 4.567 ± 0.056	2.968ValPhe: 2.968 ± 0.043	5.968ValGly: 5.968 ± 0.061	1.304ValHis: 1.304 ± 0.028	3.917ValIle: 3.917 ± 0.05	2.603ValLys: 2.603 ± 0.041	7.496ValLeu: 7.496 ± 0.071	1.819ValMet: 1.819 ± 0.033	1.919ValAsn: 1.919 ± 0.036	3.823ValPro: 3.823 ± 0.055	1.916ValGln: 1.916 ± 0.036	4.812ValArg: 4.812 ± 0.057	4.488ValSer: 4.488 ± 0.054	4.562ValThr: 4.562 ± 0.062	6.165ValVal: 6.165 ± 0.065	0.881ValTrp: 0.881 ± 0.025	1.53ValTyr: 1.53 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.296TrpAla: 1.296 ± 0.027	0.124TrpCys: 0.124 ± 0.009	0.618TrpAsp: 0.618 ± 0.018	0.533TrpGlu: 0.533 ± 0.018	0.576TrpPhe: 0.576 ± 0.022	0.879TrpGly: 0.879 ± 0.021	0.3TrpHis: 0.3 ± 0.013	0.656TrpIle: 0.656 ± 0.019	0.533TrpLys: 0.533 ± 0.02	1.754TrpLeu: 1.754 ± 0.04	0.353TrpMet: 0.353 ± 0.016	0.497TrpAsn: 0.497 ± 0.017	0.714TrpPro: 0.714 ± 0.018	0.558TrpGln: 0.558 ± 0.016	1.156TrpArg: 1.156 ± 0.027	0.849TrpSer: 0.849 ± 0.022	0.804TrpThr: 0.804 ± 0.023	0.869TrpVal: 0.869 ± 0.022	0.234TrpTrp: 0.234 ± 0.012	0.309TrpTyr: 0.309 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.539TyrAla: 2.539 ± 0.037	0.218TyrCys: 0.218 ± 0.011	1.489TyrAsp: 1.489 ± 0.035	1.204TyrGlu: 1.204 ± 0.027	0.953TyrPhe: 0.953 ± 0.023	2.158TyrGly: 2.158 ± 0.037	0.473TyrHis: 0.473 ± 0.016	0.894TyrIle: 0.894 ± 0.025	0.696TyrLys: 0.696 ± 0.02	2.318TyrLeu: 2.318 ± 0.04	0.447TyrMet: 0.447 ± 0.016	0.649TyrAsn: 0.649 ± 0.019	1.105TyrPro: 1.105 ± 0.03	0.748TyrGln: 0.748 ± 0.023	1.746TyrArg: 1.746 ± 0.034	1.247TyrSer: 1.247 ± 0.026	1.118TyrThr: 1.118 ± 0.027	1.717TyrVal: 1.717 ± 0.034	0.355TyrTrp: 0.355 ± 0.013	0.587TyrTyr: 0.587 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5848 proteins (1817757 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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