Amino acid dipepetide frequency for Human polyomavirus 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.579AlaAla: 10.579 ± 3.358
3.341AlaCys: 3.341 ± 1.412
2.227AlaAsp: 2.227 ± 0.997
3.898AlaGlu: 3.898 ± 1.385
2.227AlaPhe: 2.227 ± 1.096
8.352AlaGly: 8.352 ± 3.219
0.0AlaHis: 0.0 ± 0.0
3.898AlaIle: 3.898 ± 1.42
0.557AlaLys: 0.557 ± 0.41
11.136AlaLeu: 11.136 ± 5.16
0.557AlaMet: 0.557 ± 0.41
2.227AlaAsn: 2.227 ± 1.096
2.784AlaPro: 2.784 ± 0.903
2.784AlaGln: 2.784 ± 0.963
2.227AlaArg: 2.227 ± 1.157
5.011AlaSer: 5.011 ± 1.181
4.454AlaThr: 4.454 ± 1.171
5.568AlaVal: 5.568 ± 1.272
0.557AlaTrp: 0.557 ± 0.41
1.114AlaTyr: 1.114 ± 0.548
0.0AlaXaa: 0.0 ± 0.0
Cys
0.557CysAla: 0.557 ± 0.41
0.557CysCys: 0.557 ± 0.41
2.227CysAsp: 2.227 ± 1.157
0.0CysGlu: 0.0 ± 0.0
1.67CysPhe: 1.67 ± 0.892
1.114CysGly: 1.114 ± 0.548
0.557CysHis: 0.557 ± 0.534
1.67CysIle: 1.67 ± 0.687
2.227CysLys: 2.227 ± 1.532
5.011CysLeu: 5.011 ± 2.252
0.557CysMet: 0.557 ± 0.41
1.114CysAsn: 1.114 ± 0.82
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.557CysArg: 0.557 ± 0.534
0.0CysSer: 0.0 ± 0.0
2.227CysThr: 2.227 ± 1.64
2.227CysVal: 2.227 ± 1.157
1.67CysTrp: 1.67 ± 1.561
2.784CysTyr: 2.784 ± 1.378
0.0CysXaa: 0.0 ± 0.0
Asp
2.227AspAla: 2.227 ± 1.131
1.67AspCys: 1.67 ± 1.23
1.67AspAsp: 1.67 ± 0.711
4.454AspGlu: 4.454 ± 1.459
2.784AspPhe: 2.784 ± 1.49
0.557AspGly: 0.557 ± 0.41
0.0AspHis: 0.0 ± 0.0
1.114AspIle: 1.114 ± 0.841
3.898AspLys: 3.898 ± 1.172
3.341AspLeu: 3.341 ± 1.854
2.227AspMet: 2.227 ± 1.131
1.67AspAsn: 1.67 ± 1.23
5.011AspPro: 5.011 ± 0.541
2.227AspGln: 2.227 ± 0.975
1.67AspArg: 1.67 ± 0.892
1.67AspSer: 1.67 ± 0.892
2.227AspThr: 2.227 ± 1.509
1.67AspVal: 1.67 ± 0.807
2.784AspTrp: 2.784 ± 1.692
1.67AspTyr: 1.67 ± 1.23
0.0AspXaa: 0.0 ± 0.0
Glu
5.568GluAla: 5.568 ± 2.745
1.114GluCys: 1.114 ± 0.82
4.454GluAsp: 4.454 ± 1.459
4.454GluGlu: 4.454 ± 1.479
2.227GluPhe: 2.227 ± 1.532
7.795GluGly: 7.795 ± 2.297
1.114GluHis: 1.114 ± 0.766
7.238GluIle: 7.238 ± 2.511
3.898GluLys: 3.898 ± 2.113
7.238GluLeu: 7.238 ± 1.409
0.0GluMet: 0.0 ± 0.0
3.341GluAsn: 3.341 ± 1.644
1.114GluPro: 1.114 ± 0.548
2.784GluGln: 2.784 ± 0.517
2.784GluArg: 2.784 ± 0.517
2.227GluSer: 2.227 ± 1.64
4.454GluThr: 4.454 ± 1.13
5.011GluVal: 5.011 ± 1.006
0.0GluTrp: 0.0 ± 0.0
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.67PheAla: 1.67 ± 0.807
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
2.227PheGlu: 2.227 ± 0.757
0.557PhePhe: 0.557 ± 0.534
4.454PheGly: 4.454 ± 2.295
2.227PheHis: 2.227 ± 0.975
0.557PheIle: 0.557 ± 0.534
1.67PheLys: 1.67 ± 1.23
2.227PheLeu: 2.227 ± 0.748
2.784PheMet: 2.784 ± 0.838
1.114PheAsn: 1.114 ± 0.82
1.67PhePro: 1.67 ± 0.807
0.557PheGln: 0.557 ± 0.41
2.784PheArg: 2.784 ± 2.103
2.784PheSer: 2.784 ± 1.247
3.898PheThr: 3.898 ± 1.952
2.227PheVal: 2.227 ± 0.757
0.557PheTrp: 0.557 ± 0.534
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
8.352GlyAla: 8.352 ± 2.385
1.67GlyCys: 1.67 ± 1.23
1.67GlyAsp: 1.67 ± 0.892
3.898GlyGlu: 3.898 ± 1.454
1.114GlyPhe: 1.114 ± 0.841
10.022GlyGly: 10.022 ± 3.524
0.0GlyHis: 0.0 ± 0.0
6.125GlyIle: 6.125 ± 2.056
1.67GlyLys: 1.67 ± 1.561
7.795GlyLeu: 7.795 ± 3.32
1.67GlyMet: 1.67 ± 0.807
8.909GlyAsn: 8.909 ± 2.57
3.898GlyPro: 3.898 ± 1.396
1.114GlyGln: 1.114 ± 0.841
4.454GlyArg: 4.454 ± 2.408
5.011GlySer: 5.011 ± 3.004
2.227GlyThr: 2.227 ± 1.096
5.568GlyVal: 5.568 ± 1.272
1.114GlyTrp: 1.114 ± 0.82
3.898GlyTyr: 3.898 ± 1.17
0.0GlyXaa: 0.0 ± 0.0
His
0.557HisAla: 0.557 ± 0.41
0.557HisCys: 0.557 ± 0.846
1.67HisAsp: 1.67 ± 0.687
0.557HisGlu: 0.557 ± 0.41
1.114HisPhe: 1.114 ± 0.548
1.114HisGly: 1.114 ± 0.841
0.557HisHis: 0.557 ± 0.41
0.557HisIle: 0.557 ± 0.846
2.227HisLys: 2.227 ± 1.532
1.114HisLeu: 1.114 ± 0.82
0.0HisMet: 0.0 ± 0.0
0.557HisAsn: 0.557 ± 0.41
1.67HisPro: 1.67 ± 0.711
0.0HisGln: 0.0 ± 0.0
1.114HisArg: 1.114 ± 0.548
1.114HisSer: 1.114 ± 0.82
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.227IleAla: 2.227 ± 1.037
0.0IleCys: 0.0 ± 0.0
1.114IleAsp: 1.114 ± 0.82
1.67IleGlu: 1.67 ± 0.807
0.557IlePhe: 0.557 ± 0.534
2.784IleGly: 2.784 ± 0.946
1.114IleHis: 1.114 ± 0.841
2.784IleIle: 2.784 ± 1.247
2.784IleLys: 2.784 ± 0.859
7.238IleLeu: 7.238 ± 1.799
0.0IleMet: 0.0 ± 0.0
3.341IleAsn: 3.341 ± 0.487
3.341IlePro: 3.341 ± 0.487
2.227IleGln: 2.227 ± 0.565
1.67IleArg: 1.67 ± 0.711
1.114IleSer: 1.114 ± 0.766
2.227IleThr: 2.227 ± 1.157
2.227IleVal: 2.227 ± 1.18
3.341IleTrp: 3.341 ± 1.511
2.784IleTyr: 2.784 ± 1.577
0.0IleXaa: 0.0 ± 0.0
Lys
3.898LysAla: 3.898 ± 0.82
4.454LysCys: 4.454 ± 2.489
0.557LysAsp: 0.557 ± 0.41
6.682LysGlu: 6.682 ± 0.973
1.114LysPhe: 1.114 ± 0.548
5.011LysGly: 5.011 ± 1.75
1.67LysHis: 1.67 ± 0.807
1.67LysIle: 1.67 ± 0.892
7.795LysLys: 7.795 ± 3.413
3.341LysLeu: 3.341 ± 1.412
1.114LysMet: 1.114 ± 0.766
0.557LysAsn: 0.557 ± 0.41
2.227LysPro: 2.227 ± 0.748
2.784LysGln: 2.784 ± 0.946
3.898LysArg: 3.898 ± 1.385
1.114LysSer: 1.114 ± 0.82
0.557LysThr: 0.557 ± 0.41
2.227LysVal: 2.227 ± 0.748
1.67LysTrp: 1.67 ± 0.687
1.67LysTyr: 1.67 ± 0.892
0.0LysXaa: 0.0 ± 0.0
Leu
6.682LeuAla: 6.682 ± 1.967
2.227LeuCys: 2.227 ± 1.625
5.011LeuAsp: 5.011 ± 0.541
6.682LeuGlu: 6.682 ± 2.547
6.125LeuPhe: 6.125 ± 1.617
6.682LeuGly: 6.682 ± 1.964
2.227LeuHis: 2.227 ± 1.157
5.011LeuIle: 5.011 ± 1.006
3.341LeuLys: 3.341 ± 1.783
10.022LeuLeu: 10.022 ± 1.73
3.898LeuMet: 3.898 ± 1.593
3.898LeuAsn: 3.898 ± 2.025
7.795LeuPro: 7.795 ± 2.806
6.682LeuGln: 6.682 ± 1.945
2.784LeuArg: 2.784 ± 0.87
10.022LeuSer: 10.022 ± 2.728
2.784LeuThr: 2.784 ± 0.975
5.568LeuVal: 5.568 ± 1.234
2.784LeuTrp: 2.784 ± 1.914
2.227LeuTyr: 2.227 ± 1.113
0.0LeuXaa: 0.0 ± 0.0
Met
3.341MetAla: 3.341 ± 0.947
0.557MetCys: 0.557 ± 0.41
2.227MetAsp: 2.227 ± 1.532
2.227MetGlu: 2.227 ± 1.096
0.557MetPhe: 0.557 ± 0.534
0.557MetGly: 0.557 ± 0.537
0.557MetHis: 0.557 ± 0.41
0.0MetIle: 0.0 ± 0.0
1.114MetLys: 1.114 ± 0.82
2.784MetLeu: 2.784 ± 0.517
1.114MetMet: 1.114 ± 0.532
0.557MetAsn: 0.557 ± 0.534
0.557MetPro: 0.557 ± 0.534
3.898MetGln: 3.898 ± 1.279
0.0MetArg: 0.0 ± 0.0
1.67MetSer: 1.67 ± 0.892
0.557MetThr: 0.557 ± 0.41
0.557MetVal: 0.557 ± 0.534
0.557MetTrp: 0.557 ± 0.846
1.114MetTyr: 1.114 ± 0.548
0.0MetXaa: 0.0 ± 0.0
Asn
3.341AsnAla: 3.341 ± 1.295
1.114AsnCys: 1.114 ± 0.548
4.454AsnAsp: 4.454 ± 2.083
1.114AsnGlu: 1.114 ± 0.661
1.67AsnPhe: 1.67 ± 1.001
3.898AsnGly: 3.898 ± 1.921
0.0AsnHis: 0.0 ± 0.0
1.114AsnIle: 1.114 ± 0.82
2.227AsnLys: 2.227 ± 0.757
6.682AsnLeu: 6.682 ± 0.973
1.67AsnMet: 1.67 ± 0.687
1.114AsnAsn: 1.114 ± 0.841
2.227AsnPro: 2.227 ± 0.911
2.227AsnGln: 2.227 ± 1.096
1.67AsnArg: 1.67 ± 0.687
3.341AsnSer: 3.341 ± 1.373
3.341AsnThr: 3.341 ± 0.759
3.898AsnVal: 3.898 ± 1.656
0.557AsnTrp: 0.557 ± 0.41
3.898AsnTyr: 3.898 ± 2.871
0.0AsnXaa: 0.0 ± 0.0
Pro
1.67ProAla: 1.67 ± 0.807
1.67ProCys: 1.67 ± 0.807
4.454ProAsp: 4.454 ± 1.152
5.011ProGlu: 5.011 ± 1.97
0.557ProPhe: 0.557 ± 0.41
2.227ProGly: 2.227 ± 1.037
0.0ProHis: 0.0 ± 0.0
1.67ProIle: 1.67 ± 1.001
1.114ProLys: 1.114 ± 0.82
5.011ProLeu: 5.011 ± 2.352
0.557ProMet: 0.557 ± 0.41
2.227ProAsn: 2.227 ± 1.096
3.341ProPro: 3.341 ± 1.614
5.011ProGln: 5.011 ± 1.353
1.67ProArg: 1.67 ± 0.514
6.125ProSer: 6.125 ± 2.611
4.454ProThr: 4.454 ± 1.683
5.011ProVal: 5.011 ± 1.046
0.0ProTrp: 0.0 ± 0.0
1.114ProTyr: 1.114 ± 1.068
0.0ProXaa: 0.0 ± 0.0
Gln
1.67GlnAla: 1.67 ± 0.807
0.0GlnCys: 0.0 ± 0.0
1.114GlnAsp: 1.114 ± 0.82
3.341GlnGlu: 3.341 ± 1.929
1.114GlnPhe: 1.114 ± 0.548
5.011GlnGly: 5.011 ± 1.046
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
5.011GlnLys: 5.011 ± 0.541
3.341GlnLeu: 3.341 ± 1.126
2.227GlnMet: 2.227 ± 0.997
1.67GlnAsn: 1.67 ± 0.841
3.341GlnPro: 3.341 ± 2.003
2.784GlnGln: 2.784 ± 1.378
5.011GlnArg: 5.011 ± 1.046
3.898GlnSer: 3.898 ± 1.058
2.227GlnThr: 2.227 ± 0.654
3.898GlnVal: 3.898 ± 1.251
2.784GlnTrp: 2.784 ± 1.479
2.227GlnTyr: 2.227 ± 0.757
0.0GlnXaa: 0.0 ± 0.0
Arg
4.454ArgAla: 4.454 ± 2.144
0.0ArgCys: 0.0 ± 0.0
1.67ArgAsp: 1.67 ± 0.892
6.682ArgGlu: 6.682 ± 3.304
0.557ArgPhe: 0.557 ± 0.534
5.011ArgGly: 5.011 ± 1.934
0.557ArgHis: 0.557 ± 0.41
1.114ArgIle: 1.114 ± 0.548
3.341ArgLys: 3.341 ± 0.73
4.454ArgLeu: 4.454 ± 3.065
0.557ArgMet: 0.557 ± 0.534
1.114ArgAsn: 1.114 ± 0.548
1.67ArgPro: 1.67 ± 0.687
2.784ArgGln: 2.784 ± 0.859
2.784ArgArg: 2.784 ± 0.517
1.67ArgSer: 1.67 ± 0.841
1.114ArgThr: 1.114 ± 0.841
5.568ArgVal: 5.568 ± 1.52
0.557ArgTrp: 0.557 ± 0.41
0.557ArgTyr: 0.557 ± 0.534
0.0ArgXaa: 0.0 ± 0.0
Ser
6.682SerAla: 6.682 ± 1.227
2.227SerCys: 2.227 ± 1.157
2.784SerAsp: 2.784 ± 0.765
2.784SerGlu: 2.784 ± 0.553
5.011SerPhe: 5.011 ± 1.099
3.341SerGly: 3.341 ± 0.759
0.557SerHis: 0.557 ± 0.41
1.67SerIle: 1.67 ± 0.807
5.011SerLys: 5.011 ± 1.288
1.67SerLeu: 1.67 ± 0.514
2.227SerMet: 2.227 ± 1.157
2.784SerAsn: 2.784 ± 1.629
4.454SerPro: 4.454 ± 1.214
5.011SerGln: 5.011 ± 1.408
3.341SerArg: 3.341 ± 1.324
6.125SerSer: 6.125 ± 2.674
3.341SerThr: 3.341 ± 1.35
2.784SerVal: 2.784 ± 1.402
1.114SerTrp: 1.114 ± 0.841
2.227SerTyr: 2.227 ± 0.757
0.0SerXaa: 0.0 ± 0.0
Thr
2.784ThrAla: 2.784 ± 1.352
1.114ThrCys: 1.114 ± 0.82
1.67ThrAsp: 1.67 ± 0.807
2.784ThrGlu: 2.784 ± 0.765
2.227ThrPhe: 2.227 ± 0.565
2.227ThrGly: 2.227 ± 0.757
0.557ThrHis: 0.557 ± 0.846
2.227ThrIle: 2.227 ± 0.748
1.114ThrLys: 1.114 ± 0.548
7.795ThrLeu: 7.795 ± 1.982
1.114ThrMet: 1.114 ± 0.519
3.341ThrAsn: 3.341 ± 1.335
4.454ThrPro: 4.454 ± 2.192
2.227ThrGln: 2.227 ± 1.157
2.784ThrArg: 2.784 ± 0.859
2.227ThrSer: 2.227 ± 1.131
3.898ThrThr: 3.898 ± 1.367
5.011ThrVal: 5.011 ± 0.956
1.114ThrTrp: 1.114 ± 0.766
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
3.898ValAla: 3.898 ± 1.42
0.0ValCys: 0.0 ± 0.0
2.227ValAsp: 2.227 ± 1.096
5.011ValGlu: 5.011 ± 2.41
0.557ValPhe: 0.557 ± 0.41
5.011ValGly: 5.011 ± 1.995
1.67ValHis: 1.67 ± 0.807
4.454ValIle: 4.454 ± 0.805
2.227ValLys: 2.227 ± 1.157
6.125ValLeu: 6.125 ± 2.074
1.114ValMet: 1.114 ± 1.068
7.795ValAsn: 7.795 ± 3.396
2.784ValPro: 2.784 ± 0.903
3.898ValGln: 3.898 ± 1.251
3.898ValArg: 3.898 ± 1.46
6.125ValSer: 6.125 ± 1.103
1.114ValThr: 1.114 ± 1.068
3.341ValVal: 3.341 ± 1.314
2.227ValTrp: 2.227 ± 1.127
0.557ValTyr: 0.557 ± 0.534
0.0ValXaa: 0.0 ± 0.0
Trp
1.114TrpAla: 1.114 ± 0.548
1.67TrpCys: 1.67 ± 1.561
1.114TrpAsp: 1.114 ± 0.766
3.341TrpGlu: 3.341 ± 0.742
0.557TrpPhe: 0.557 ± 0.846
3.341TrpGly: 3.341 ± 2.491
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.557TrpLys: 0.557 ± 0.41
4.454TrpLeu: 4.454 ± 2.433
0.0TrpMet: 0.0 ± 0.67
0.557TrpAsn: 0.557 ± 0.41
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.67TrpSer: 1.67 ± 0.841
2.784TrpThr: 2.784 ± 1.914
1.67TrpVal: 1.67 ± 0.687
2.227TrpTrp: 2.227 ± 1.532
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.227TyrAla: 2.227 ± 0.565
2.784TyrCys: 2.784 ± 0.87
2.227TyrAsp: 2.227 ± 0.757
0.0TyrGlu: 0.0 ± 0.0
1.67TyrPhe: 1.67 ± 1.001
1.67TyrGly: 1.67 ± 0.687
1.114TyrHis: 1.114 ± 0.766
1.67TyrIle: 1.67 ± 0.807
2.227TyrLys: 2.227 ± 0.662
1.67TyrLeu: 1.67 ± 0.807
0.557TyrMet: 0.557 ± 0.41
1.67TyrAsn: 1.67 ± 1.236
0.557TyrPro: 0.557 ± 0.534
1.67TyrGln: 1.67 ± 0.711
1.114TyrArg: 1.114 ± 0.841
2.227TyrSer: 2.227 ± 0.911
2.784TyrThr: 2.784 ± 1.523
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
2.227TyrTyr: 2.227 ± 0.757
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1797 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski