Amino acid dipepetide frequency for Maribacter vaceletii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.114AlaAla: 4.114 ± 0.081	0.527AlaCys: 0.527 ± 0.023	3.177AlaAsp: 3.177 ± 0.068	3.632AlaGlu: 3.632 ± 0.059	3.072AlaPhe: 3.072 ± 0.054	4.033AlaGly: 4.033 ± 0.075	1.067AlaHis: 1.067 ± 0.036	5.517AlaIle: 5.517 ± 0.08	4.868AlaLys: 4.868 ± 0.075	6.005AlaLeu: 6.005 ± 0.085	1.547AlaMet: 1.547 ± 0.041	3.689AlaAsn: 3.689 ± 0.06	2.077AlaPro: 2.077 ± 0.051	2.136AlaGln: 2.136 ± 0.048	1.777AlaArg: 1.777 ± 0.044	4.282AlaSer: 4.282 ± 0.066	3.921AlaThr: 3.921 ± 0.085	3.911AlaVal: 3.911 ± 0.069	0.635AlaTrp: 0.635 ± 0.024	2.525AlaTyr: 2.525 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.431CysAla: 0.431 ± 0.021	0.091CysCys: 0.091 ± 0.009	0.388CysAsp: 0.388 ± 0.022	0.451CysGlu: 0.451 ± 0.023	0.39CysPhe: 0.39 ± 0.019	0.564CysGly: 0.564 ± 0.021	0.203CysHis: 0.203 ± 0.013	0.603CysIle: 0.603 ± 0.022	0.499CysLys: 0.499 ± 0.022	0.579CysLeu: 0.579 ± 0.021	0.131CysMet: 0.131 ± 0.012	0.488CysAsn: 0.488 ± 0.026	0.28CysPro: 0.28 ± 0.021	0.209CysGln: 0.209 ± 0.014	0.176CysArg: 0.176 ± 0.012	0.627CysSer: 0.627 ± 0.029	0.473CysThr: 0.473 ± 0.029	0.438CysVal: 0.438 ± 0.019	0.07CysTrp: 0.07 ± 0.008	0.315CysTyr: 0.315 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.826AspAla: 3.826 ± 0.078	0.388AspCys: 0.388 ± 0.022	2.506AspAsp: 2.506 ± 0.065	3.09AspGlu: 3.09 ± 0.059	3.592AspPhe: 3.592 ± 0.059	3.952AspGly: 3.952 ± 0.107	0.742AspHis: 0.742 ± 0.026	4.553AspIle: 4.553 ± 0.069	4.175AspLys: 4.175 ± 0.067	4.867AspLeu: 4.867 ± 0.061	1.068AspMet: 1.068 ± 0.03	3.252AspAsn: 3.252 ± 0.074	1.707AspPro: 1.707 ± 0.048	1.233AspGln: 1.233 ± 0.032	1.649AspArg: 1.649 ± 0.039	3.212AspSer: 3.212 ± 0.064	2.995AspThr: 2.995 ± 0.05	3.589AspVal: 3.589 ± 0.068	0.811AspTrp: 0.811 ± 0.027	2.73AspTyr: 2.73 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.092GluAla: 4.092 ± 0.058	0.336GluCys: 0.336 ± 0.015	3.822GluAsp: 3.822 ± 0.061	5.503GluGlu: 5.503 ± 0.086	2.832GluPhe: 2.832 ± 0.053	3.98GluGly: 3.98 ± 0.065	1.132GluHis: 1.132 ± 0.033	5.498GluIle: 5.498 ± 0.072	6.25GluLys: 6.25 ± 0.086	5.993GluLeu: 5.993 ± 0.085	1.497GluMet: 1.497 ± 0.042	4.956GluAsn: 4.956 ± 0.071	1.644GluPro: 1.644 ± 0.038	2.235GluGln: 2.235 ± 0.045	2.262GluArg: 2.262 ± 0.048	3.349GluSer: 3.349 ± 0.054	3.685GluThr: 3.685 ± 0.058	4.487GluVal: 4.487 ± 0.063	0.736GluTrp: 0.736 ± 0.027	2.531GluTyr: 2.531 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.764PheAla: 2.764 ± 0.054	0.426PheCys: 0.426 ± 0.017	2.874PheAsp: 2.874 ± 0.053	2.831PheGlu: 2.831 ± 0.049	2.812PhePhe: 2.812 ± 0.056	3.536PheGly: 3.536 ± 0.059	0.782PheHis: 0.782 ± 0.027	3.933PheIle: 3.933 ± 0.066	3.967PheLys: 3.967 ± 0.073	4.789PheLeu: 4.789 ± 0.078	1.15PheMet: 1.15 ± 0.03	3.599PheAsn: 3.599 ± 0.065	1.664PhePro: 1.664 ± 0.041	1.341PheGln: 1.341 ± 0.033	1.509PheArg: 1.509 ± 0.038	4.097PheSer: 4.097 ± 0.062	3.158PheThr: 3.158 ± 0.053	2.889PheVal: 2.889 ± 0.045	0.595PheTrp: 0.595 ± 0.024	2.104PheTyr: 2.104 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.32GlyAla: 4.32 ± 0.08	0.602GlyCys: 0.602 ± 0.041	3.554GlyAsp: 3.554 ± 0.061	3.962GlyGlu: 3.962 ± 0.061	3.646GlyPhe: 3.646 ± 0.065	4.63GlyGly: 4.63 ± 0.1	1.14GlyHis: 1.14 ± 0.034	5.617GlyIle: 5.617 ± 0.079	5.205GlyLys: 5.205 ± 0.084	5.748GlyLeu: 5.748 ± 0.095	1.579GlyMet: 1.579 ± 0.043	3.79GlyAsn: 3.79 ± 0.067	1.463GlyPro: 1.463 ± 0.044	1.713GlyGln: 1.713 ± 0.043	2.072GlyArg: 2.072 ± 0.045	4.114GlySer: 4.114 ± 0.081	4.065GlyThr: 4.065 ± 0.098	4.725GlyVal: 4.725 ± 0.067	0.824GlyTrp: 0.824 ± 0.03	2.902GlyTyr: 2.902 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	0.944HisAla: 0.944 ± 0.033	0.162HisCys: 0.162 ± 0.012	0.815HisAsp: 0.815 ± 0.031	0.907HisGlu: 0.907 ± 0.03	1.137HisPhe: 1.137 ± 0.031	1.051HisGly: 1.051 ± 0.033	0.425HisHis: 0.425 ± 0.022	1.383HisIle: 1.383 ± 0.037	1.335HisLys: 1.335 ± 0.038	1.682HisLeu: 1.682 ± 0.039	0.34HisMet: 0.34 ± 0.018	0.999HisAsn: 0.999 ± 0.032	0.826HisPro: 0.826 ± 0.03	0.572HisGln: 0.572 ± 0.023	0.623HisArg: 0.623 ± 0.023	1.04HisSer: 1.04 ± 0.033	0.996HisThr: 0.996 ± 0.025	0.937HisVal: 0.937 ± 0.028	0.242HisTrp: 0.242 ± 0.014	0.76HisTyr: 0.76 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.655IleAla: 5.655 ± 0.073	0.65IleCys: 0.65 ± 0.024	4.67IleAsp: 4.67 ± 0.068	5.392IleGlu: 5.392 ± 0.065	3.479IlePhe: 3.479 ± 0.064	5.25IleGly: 5.25 ± 0.076	1.338IleHis: 1.338 ± 0.032	6.069IleIle: 6.069 ± 0.101	6.345IleLys: 6.345 ± 0.091	7.27IleLeu: 7.27 ± 0.104	1.335IleMet: 1.335 ± 0.04	5.041IleAsn: 5.041 ± 0.079	3.296IlePro: 3.296 ± 0.056	2.37IleGln: 2.37 ± 0.047	2.462IleArg: 2.462 ± 0.053	5.792IleSer: 5.792 ± 0.077	5.405IleThr: 5.405 ± 0.095	4.82IleVal: 4.82 ± 0.075	0.764IleTrp: 0.764 ± 0.027	2.865IleTyr: 2.865 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.91LysAla: 4.91 ± 0.075	0.342LysCys: 0.342 ± 0.018	4.827LysAsp: 4.827 ± 0.078	7.914LysGlu: 7.914 ± 0.105	2.958LysPhe: 2.958 ± 0.059	5.136LysGly: 5.136 ± 0.079	1.448LysHis: 1.448 ± 0.039	6.62LysIle: 6.62 ± 0.089	8.308LysLys: 8.308 ± 0.104	6.791LysLeu: 6.791 ± 0.088	1.962LysMet: 1.962 ± 0.044	5.871LysAsn: 5.871 ± 0.098	2.513LysPro: 2.513 ± 0.049	2.548LysGln: 2.548 ± 0.049	2.783LysArg: 2.783 ± 0.044	4.494LysSer: 4.494 ± 0.078	4.901LysThr: 4.901 ± 0.069	4.89LysVal: 4.89 ± 0.073	0.89LysTrp: 0.89 ± 0.031	3.18LysTyr: 3.18 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	5.537LeuAla: 5.537 ± 0.071	0.674LeuCys: 0.674 ± 0.026	5.131LeuAsp: 5.131 ± 0.067	6.524LeuGlu: 6.524 ± 0.075	4.775LeuPhe: 4.775 ± 0.084	6.041LeuGly: 6.041 ± 0.091	1.578LeuHis: 1.578 ± 0.043	6.508LeuIle: 6.508 ± 0.1	8.054LeuLys: 8.054 ± 0.111	8.477LeuLeu: 8.477 ± 0.109	1.845LeuMet: 1.845 ± 0.038	5.716LeuAsn: 5.716 ± 0.082	3.449LeuPro: 3.449 ± 0.056	3.093LeuGln: 3.093 ± 0.058	2.878LeuArg: 2.878 ± 0.059	6.394LeuSer: 6.394 ± 0.076	4.938LeuThr: 4.938 ± 0.073	5.417LeuVal: 5.417 ± 0.077	0.871LeuTrp: 0.871 ± 0.031	3.208LeuTyr: 3.208 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.608MetAla: 1.608 ± 0.043	0.133MetCys: 0.133 ± 0.012	1.04MetAsp: 1.04 ± 0.03	1.323MetGlu: 1.323 ± 0.04	0.852MetPhe: 0.852 ± 0.042	1.455MetGly: 1.455 ± 0.037	0.43MetHis: 0.43 ± 0.022	1.314MetIle: 1.314 ± 0.035	1.998MetLys: 1.998 ± 0.043	1.972MetLeu: 1.972 ± 0.044	0.444MetMet: 0.444 ± 0.024	1.159MetAsn: 1.159 ± 0.029	0.886MetPro: 0.886 ± 0.024	0.857MetGln: 0.857 ± 0.028	0.817MetArg: 0.817 ± 0.027	1.333MetSer: 1.333 ± 0.036	1.033MetThr: 1.033 ± 0.034	1.39MetVal: 1.39 ± 0.036	0.193MetTrp: 0.193 ± 0.012	0.726MetTyr: 0.726 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.157AsnAla: 4.157 ± 0.069	0.495AsnCys: 0.495 ± 0.026	3.114AsnAsp: 3.114 ± 0.084	3.631AsnGlu: 3.631 ± 0.056	3.323AsnPhe: 3.323 ± 0.055	4.383AsnGly: 4.383 ± 0.086	1.065AsnHis: 1.065 ± 0.032	5.112AsnIle: 5.112 ± 0.071	5.216AsnLys: 5.216 ± 0.079	5.783AsnLeu: 5.783 ± 0.079	1.27AsnMet: 1.27 ± 0.034	4.331AsnAsn: 4.331 ± 0.095	2.772AsnPro: 2.772 ± 0.058	1.951AsnGln: 1.951 ± 0.052	2.007AsnArg: 2.007 ± 0.047	4.161AsnSer: 4.161 ± 0.068	4.414AsnThr: 4.414 ± 0.082	3.689AsnVal: 3.689 ± 0.061	0.815AsnTrp: 0.815 ± 0.032	2.951AsnTyr: 2.951 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	1.797ProAla: 1.797 ± 0.043	0.182ProCys: 0.182 ± 0.012	1.983ProAsp: 1.983 ± 0.048	2.977ProGlu: 2.977 ± 0.05	1.858ProPhe: 1.858 ± 0.039	1.994ProGly: 1.994 ± 0.047	0.638ProHis: 0.638 ± 0.025	2.758ProIle: 2.758 ± 0.052	2.74ProLys: 2.74 ± 0.055	2.962ProLeu: 2.962 ± 0.058	0.726ProMet: 0.726 ± 0.024	2.479ProAsn: 2.479 ± 0.062	0.813ProPro: 0.813 ± 0.032	0.965ProGln: 0.965 ± 0.03	0.893ProArg: 0.893 ± 0.029	2.261ProSer: 2.261 ± 0.043	2.048ProThr: 2.048 ± 0.054	2.256ProVal: 2.256 ± 0.046	0.426ProTrp: 0.426 ± 0.02	1.42ProTyr: 1.42 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.712GlnAla: 1.712 ± 0.042	0.18GlnCys: 0.18 ± 0.014	1.529GlnAsp: 1.529 ± 0.034	2.483GlnGlu: 2.483 ± 0.04	1.442GlnPhe: 1.442 ± 0.039	1.793GlnGly: 1.793 ± 0.047	0.535GlnHis: 0.535 ± 0.019	2.505GlnIle: 2.505 ± 0.049	2.687GlnLys: 2.687 ± 0.06	3.038GlnLeu: 3.038 ± 0.05	0.691GlnMet: 0.691 ± 0.026	1.97GlnAsn: 1.97 ± 0.047	0.921GlnPro: 0.921 ± 0.033	1.133GlnGln: 1.133 ± 0.037	1.031GlnArg: 1.031 ± 0.029	1.607GlnSer: 1.607 ± 0.038	1.677GlnThr: 1.677 ± 0.042	1.735GlnVal: 1.735 ± 0.044	0.399GlnTrp: 0.399 ± 0.02	1.209GlnTyr: 1.209 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	1.937ArgAla: 1.937 ± 0.042	0.195ArgCys: 0.195 ± 0.011	1.662ArgAsp: 1.662 ± 0.037	2.078ArgGlu: 2.078 ± 0.051	1.648ArgPhe: 1.648 ± 0.039	1.945ArgGly: 1.945 ± 0.044	0.531ArgHis: 0.531 ± 0.022	2.671ArgIle: 2.671 ± 0.048	2.718ArgLys: 2.718 ± 0.062	2.858ArgLeu: 2.858 ± 0.055	0.79ArgMet: 0.79 ± 0.03	1.989ArgAsn: 1.989 ± 0.044	1.078ArgPro: 1.078 ± 0.034	0.914ArgGln: 0.914 ± 0.028	1.139ArgArg: 1.139 ± 0.034	1.691ArgSer: 1.691 ± 0.042	1.778ArgThr: 1.778 ± 0.045	2.01ArgVal: 2.01 ± 0.043	0.404ArgTrp: 0.404 ± 0.018	1.409ArgTyr: 1.409 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.643SerAla: 3.643 ± 0.067	0.693SerCys: 0.693 ± 0.026	3.158SerAsp: 3.158 ± 0.05	3.879SerGlu: 3.879 ± 0.06	3.809SerPhe: 3.809 ± 0.053	4.631SerGly: 4.631 ± 0.088	1.067SerHis: 1.067 ± 0.033	5.676SerIle: 5.676 ± 0.077	5.526SerLys: 5.526 ± 0.08	6.082SerLeu: 6.082 ± 0.094	1.27SerMet: 1.27 ± 0.034	4.128SerAsn: 4.128 ± 0.073	2.116SerPro: 2.116 ± 0.046	1.822SerGln: 1.822 ± 0.042	2.052SerArg: 2.052 ± 0.046	4.577SerSer: 4.577 ± 0.083	3.63SerThr: 3.63 ± 0.079	3.915SerVal: 3.915 ± 0.056	0.757SerTrp: 0.757 ± 0.028	2.836SerTyr: 2.836 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.771ThrAla: 3.771 ± 0.075	0.385ThrCys: 0.385 ± 0.025	3.188ThrAsp: 3.188 ± 0.079	3.462ThrGlu: 3.462 ± 0.057	3.019ThrPhe: 3.019 ± 0.055	4.019ThrGly: 4.019 ± 0.083	0.996ThrHis: 0.996 ± 0.027	5.544ThrIle: 5.544 ± 0.09	4.442ThrLys: 4.442 ± 0.065	5.424ThrLeu: 5.424 ± 0.075	0.975ThrMet: 0.975 ± 0.031	3.969ThrAsn: 3.969 ± 0.083	2.644ThrPro: 2.644 ± 0.071	1.782ThrGln: 1.782 ± 0.04	1.553ThrArg: 1.553 ± 0.041	4.188ThrSer: 4.188 ± 0.071	3.885ThrThr: 3.885 ± 0.093	3.739ThrVal: 3.739 ± 0.085	0.611ThrTrp: 0.611 ± 0.026	2.501ThrTyr: 2.501 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.103ValAla: 4.103 ± 0.073	0.513ValCys: 0.513 ± 0.021	3.507ValAsp: 3.507 ± 0.064	3.724ValGlu: 3.724 ± 0.057	3.287ValPhe: 3.287 ± 0.049	3.847ValGly: 3.847 ± 0.063	1.055ValHis: 1.055 ± 0.032	4.782ValIle: 4.782 ± 0.066	4.555ValLys: 4.555 ± 0.079	6.105ValLeu: 6.105 ± 0.067	1.244ValMet: 1.244 ± 0.033	3.733ValAsn: 3.733 ± 0.066	2.239ValPro: 2.239 ± 0.04	1.629ValGln: 1.629 ± 0.038	1.833ValArg: 1.833 ± 0.043	4.635ValSer: 4.635 ± 0.071	3.9ValThr: 3.9 ± 0.096	4.245ValVal: 4.245 ± 0.064	0.632ValTrp: 0.632 ± 0.022	2.392ValTyr: 2.392 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.65TrpAla: 0.65 ± 0.03	0.09TrpCys: 0.09 ± 0.009	0.707TrpAsp: 0.707 ± 0.027	0.757TrpGlu: 0.757 ± 0.029	0.595TrpPhe: 0.595 ± 0.025	0.787TrpGly: 0.787 ± 0.028	0.263TrpHis: 0.263 ± 0.015	0.725TrpIle: 0.725 ± 0.028	0.916TrpLys: 0.916 ± 0.03	0.977TrpLeu: 0.977 ± 0.031	0.323TrpMet: 0.323 ± 0.02	0.758TrpAsn: 0.758 ± 0.036	0.34TrpPro: 0.34 ± 0.02	0.409TrpGln: 0.409 ± 0.021	0.428TrpArg: 0.428 ± 0.02	0.687TrpSer: 0.687 ± 0.026	0.578TrpThr: 0.578 ± 0.024	0.722TrpVal: 0.722 ± 0.025	0.165TrpTrp: 0.165 ± 0.015	0.466TrpTyr: 0.466 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.542TyrAla: 2.542 ± 0.044	0.342TyrCys: 0.342 ± 0.018	2.285TyrAsp: 2.285 ± 0.047	2.303TyrGlu: 2.303 ± 0.052	2.294TyrPhe: 2.294 ± 0.048	2.641TyrGly: 2.641 ± 0.048	0.743TyrHis: 0.743 ± 0.025	2.881TyrIle: 2.881 ± 0.053	3.482TyrLys: 3.482 ± 0.068	3.706TyrLeu: 3.706 ± 0.066	0.774TyrMet: 0.774 ± 0.024	2.721TyrAsn: 2.721 ± 0.055	1.448TyrPro: 1.448 ± 0.035	1.367TyrGln: 1.367 ± 0.038	1.497TyrArg: 1.497 ± 0.038	2.728TyrSer: 2.728 ± 0.044	2.617TyrThr: 2.617 ± 0.054	2.156TyrVal: 2.156 ± 0.048	0.503TyrTrp: 0.503 ± 0.024	1.8TyrTyr: 1.8 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3317 proteins (1184146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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