Amino acid dipepetide frequency for Meyerozyma sp. JA9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.807AlaAla: 5.807 ± 0.082	0.782AlaCys: 0.782 ± 0.02	3.338AlaAsp: 3.338 ± 0.038	4.02AlaGlu: 4.02 ± 0.055	2.599AlaPhe: 2.599 ± 0.033	3.921AlaGly: 3.921 ± 0.05	1.44AlaHis: 1.44 ± 0.022	4.023AlaIle: 4.023 ± 0.043	4.408AlaLys: 4.408 ± 0.048	5.982AlaLeu: 5.982 ± 0.059	1.465AlaMet: 1.465 ± 0.022	3.169AlaAsn: 3.169 ± 0.036	3.349AlaPro: 3.349 ± 0.054	2.547AlaGln: 2.547 ± 0.035	3.188AlaArg: 3.188 ± 0.033	6.277AlaSer: 6.277 ± 0.06	4.049AlaThr: 4.049 ± 0.046	4.372AlaVal: 4.372 ± 0.049	0.626AlaTrp: 0.626 ± 0.013	2.012AlaTyr: 2.012 ± 0.027	0.003AlaXaa: 0.003 ± 0.002
Cys	0.674CysAla: 0.674 ± 0.016	0.241CysCys: 0.241 ± 0.01	0.654CysAsp: 0.654 ± 0.018	0.572CysGlu: 0.572 ± 0.014	0.623CysPhe: 0.623 ± 0.015	0.88CysGly: 0.88 ± 0.022	0.308CysHis: 0.308 ± 0.011	0.768CysIle: 0.768 ± 0.017	0.609CysLys: 0.609 ± 0.014	1.167CysLeu: 1.167 ± 0.024	0.244CysMet: 0.244 ± 0.009	0.501CysAsn: 0.501 ± 0.013	0.487CysPro: 0.487 ± 0.016	0.375CysGln: 0.375 ± 0.012	0.54CysArg: 0.54 ± 0.014	0.955CysSer: 0.955 ± 0.02	0.567CysThr: 0.567 ± 0.017	0.767CysVal: 0.767 ± 0.018	0.156CysTrp: 0.156 ± 0.008	0.444CysTyr: 0.444 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.568AspAla: 3.568 ± 0.039	0.561AspCys: 0.561 ± 0.015	4.5AspAsp: 4.5 ± 0.051	4.954AspGlu: 4.954 ± 0.056	2.685AspPhe: 2.685 ± 0.035	3.118AspGly: 3.118 ± 0.041	1.323AspHis: 1.323 ± 0.026	3.726AspIle: 3.726 ± 0.039	3.341AspLys: 3.341 ± 0.032	5.481AspLeu: 5.481 ± 0.053	1.235AspMet: 1.235 ± 0.023	2.506AspAsn: 2.506 ± 0.031	2.832AspPro: 2.832 ± 0.037	1.925AspGln: 1.925 ± 0.031	2.331AspArg: 2.331 ± 0.034	5.047AspSer: 5.047 ± 0.052	3.035AspThr: 3.035 ± 0.039	3.746AspVal: 3.746 ± 0.037	0.635AspTrp: 0.635 ± 0.017	2.137AspTyr: 2.137 ± 0.03	0.001AspXaa: 0.001 ± 0.001
Glu	4.372GluAla: 4.372 ± 0.063	0.623GluCys: 0.623 ± 0.017	4.101GluAsp: 4.101 ± 0.051	5.519GluGlu: 5.519 ± 0.069	2.509GluPhe: 2.509 ± 0.03	2.8GluGly: 2.8 ± 0.034	1.332GluHis: 1.332 ± 0.024	3.747GluIle: 3.747 ± 0.042	4.898GluLys: 4.898 ± 0.05	6.053GluLeu: 6.053 ± 0.062	1.355GluMet: 1.355 ± 0.019	3.441GluAsn: 3.441 ± 0.046	2.603GluPro: 2.603 ± 0.038	2.522GluGln: 2.522 ± 0.038	3.032GluArg: 3.032 ± 0.038	5.311GluSer: 5.311 ± 0.058	3.665GluThr: 3.665 ± 0.038	3.941GluVal: 3.941 ± 0.042	0.67GluTrp: 0.67 ± 0.018	2.194GluTyr: 2.194 ± 0.029	0.003GluXaa: 0.003 ± 0.002
Phe	2.888PheAla: 2.888 ± 0.038	0.544PheCys: 0.544 ± 0.017	2.804PheAsp: 2.804 ± 0.039	2.706PheGlu: 2.706 ± 0.035	2.021PhePhe: 2.021 ± 0.036	2.917PheGly: 2.917 ± 0.058	1.044PheHis: 1.044 ± 0.021	2.386PheIle: 2.386 ± 0.036	2.536PheLys: 2.536 ± 0.03	3.981PheLeu: 3.981 ± 0.047	0.899PheMet: 0.899 ± 0.02	2.137PheAsn: 2.137 ± 0.028	1.815PhePro: 1.815 ± 0.029	1.657PheGln: 1.657 ± 0.026	1.874PheArg: 1.874 ± 0.031	3.661PheSer: 3.661 ± 0.041	2.351PheThr: 2.351 ± 0.029	3.033PheVal: 3.033 ± 0.041	0.56PheTrp: 0.56 ± 0.014	1.473PheTyr: 1.473 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	3.899GlyAla: 3.899 ± 0.065	0.728GlyCys: 0.728 ± 0.02	3.145GlyAsp: 3.145 ± 0.037	3.108GlyGlu: 3.108 ± 0.041	2.688GlyPhe: 2.688 ± 0.037	3.845GlyGly: 3.845 ± 0.067	1.346GlyHis: 1.346 ± 0.026	3.474GlyIle: 3.474 ± 0.041	3.339GlyLys: 3.339 ± 0.041	5.046GlyLeu: 5.046 ± 0.05	1.126GlyMet: 1.126 ± 0.023	2.531GlyAsn: 2.531 ± 0.031	2.303GlyPro: 2.303 ± 0.035	1.902GlyGln: 1.902 ± 0.037	2.55GlyArg: 2.55 ± 0.034	5.434GlySer: 5.434 ± 0.077	3.383GlyThr: 3.383 ± 0.055	3.616GlyVal: 3.616 ± 0.048	0.696GlyTrp: 0.696 ± 0.017	2.075GlyTyr: 2.075 ± 0.036	0.002GlyXaa: 0.002 ± 0.001
His	1.244HisAla: 1.244 ± 0.021	0.301HisCys: 0.301 ± 0.011	1.341HisAsp: 1.341 ± 0.022	1.513HisGlu: 1.513 ± 0.023	1.025HisPhe: 1.025 ± 0.019	1.388HisGly: 1.388 ± 0.028	0.822HisHis: 0.822 ± 0.024	1.394HisIle: 1.394 ± 0.024	1.337HisLys: 1.337 ± 0.025	2.223HisLeu: 2.223 ± 0.03	0.452HisMet: 0.452 ± 0.011	1.118HisAsn: 1.118 ± 0.018	1.262HisPro: 1.262 ± 0.022	1.077HisGln: 1.077 ± 0.023	1.221HisArg: 1.221 ± 0.025	1.961HisSer: 1.961 ± 0.028	1.19HisThr: 1.19 ± 0.025	1.269HisVal: 1.269 ± 0.023	0.25HisTrp: 0.25 ± 0.009	0.868HisTyr: 0.868 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	3.913IleAla: 3.913 ± 0.039	0.76IleCys: 0.76 ± 0.02	3.859IleAsp: 3.859 ± 0.045	3.613IleGlu: 3.613 ± 0.04	2.399IlePhe: 2.399 ± 0.04	3.207IleGly: 3.207 ± 0.048	1.343IleHis: 1.343 ± 0.026	3.278IleIle: 3.278 ± 0.043	3.546IleLys: 3.546 ± 0.041	5.31IleLeu: 5.31 ± 0.058	1.209IleMet: 1.209 ± 0.023	2.834IleAsn: 2.834 ± 0.033	2.932IlePro: 2.932 ± 0.034	2.013IleGln: 2.013 ± 0.028	2.697IleArg: 2.697 ± 0.035	4.976IleSer: 4.976 ± 0.045	3.271IleThr: 3.271 ± 0.049	3.793IleVal: 3.793 ± 0.052	0.627IleTrp: 0.627 ± 0.019	1.859IleTyr: 1.859 ± 0.027	0.002IleXaa: 0.002 ± 0.001
Lys	3.901LysAla: 3.901 ± 0.044	0.62LysCys: 0.62 ± 0.016	3.6LysAsp: 3.6 ± 0.042	4.311LysGlu: 4.311 ± 0.054	2.616LysPhe: 2.616 ± 0.033	2.718LysGly: 2.718 ± 0.041	1.474LysHis: 1.474 ± 0.024	3.592LysIle: 3.592 ± 0.036	5.227LysLys: 5.227 ± 0.069	6.288LysLeu: 6.288 ± 0.063	1.252LysMet: 1.252 ± 0.022	3.256LysAsn: 3.256 ± 0.039	3.008LysPro: 3.008 ± 0.04	2.548LysGln: 2.548 ± 0.032	3.587LysArg: 3.587 ± 0.044	5.385LysSer: 5.385 ± 0.056	3.445LysThr: 3.445 ± 0.038	4.032LysVal: 4.032 ± 0.043	0.714LysTrp: 0.714 ± 0.017	2.414LysTyr: 2.414 ± 0.03	0.002LysXaa: 0.002 ± 0.001
Leu	6.614LeuAla: 6.614 ± 0.056	1.181LeuCys: 1.181 ± 0.023	5.222LeuAsp: 5.222 ± 0.049	5.801LeuGlu: 5.801 ± 0.062	3.881LeuPhe: 3.881 ± 0.045	5.111LeuGly: 5.111 ± 0.047	2.149LeuHis: 2.149 ± 0.029	4.85LeuIle: 4.85 ± 0.053	5.94LeuLys: 5.94 ± 0.063	8.517LeuLeu: 8.517 ± 0.083	1.848LeuMet: 1.848 ± 0.025	4.437LeuAsn: 4.437 ± 0.047	4.401LeuPro: 4.401 ± 0.05	4.014LeuGln: 4.014 ± 0.047	4.784LeuArg: 4.784 ± 0.044	8.276LeuSer: 8.276 ± 0.071	5.072LeuThr: 5.072 ± 0.045	6.266LeuVal: 6.266 ± 0.062	0.94LeuTrp: 0.94 ± 0.021	2.954LeuTyr: 2.954 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	1.676MetAla: 1.676 ± 0.023	0.256MetCys: 0.256 ± 0.011	1.205MetAsp: 1.205 ± 0.022	1.219MetGlu: 1.219 ± 0.024	0.857MetPhe: 0.857 ± 0.019	1.245MetGly: 1.245 ± 0.021	0.367MetHis: 0.367 ± 0.014	1.119MetIle: 1.119 ± 0.019	1.302MetLys: 1.302 ± 0.021	1.742MetLeu: 1.742 ± 0.027	0.513MetMet: 0.513 ± 0.015	1.072MetAsn: 1.072 ± 0.023	0.878MetPro: 0.878 ± 0.02	0.631MetGln: 0.631 ± 0.016	0.904MetArg: 0.904 ± 0.018	2.125MetSer: 2.125 ± 0.032	1.07MetThr: 1.07 ± 0.021	1.415MetVal: 1.415 ± 0.022	0.206MetTrp: 0.206 ± 0.01	0.647MetTyr: 0.647 ± 0.017	0.001MetXaa: 0.001 ± 0.001
Asn	2.954AsnAla: 2.954 ± 0.036	0.565AsnCys: 0.565 ± 0.016	3.053AsnAsp: 3.053 ± 0.041	3.212AsnGlu: 3.212 ± 0.039	2.113AsnPhe: 2.113 ± 0.034	3.095AsnGly: 3.095 ± 0.033	1.193AsnHis: 1.193 ± 0.021	2.768AsnIle: 2.768 ± 0.036	2.747AsnLys: 2.747 ± 0.034	4.5AsnLeu: 4.5 ± 0.048	0.996AsnMet: 0.996 ± 0.02	2.405AsnAsn: 2.405 ± 0.035	2.402AsnPro: 2.402 ± 0.035	1.859AsnGln: 1.859 ± 0.032	2.049AsnArg: 2.049 ± 0.031	4.34AsnSer: 4.34 ± 0.05	2.487AsnThr: 2.487 ± 0.035	2.965AsnVal: 2.965 ± 0.039	0.591AsnTrp: 0.591 ± 0.016	1.886AsnTyr: 1.886 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	3.228ProAla: 3.228 ± 0.045	0.352ProCys: 0.352 ± 0.015	2.519ProAsp: 2.519 ± 0.032	3.488ProGlu: 3.488 ± 0.04	1.921ProPhe: 1.921 ± 0.03	2.575ProGly: 2.575 ± 0.051	1.171ProHis: 1.171 ± 0.025	2.594ProIle: 2.594 ± 0.034	2.945ProLys: 2.945 ± 0.042	3.849ProLeu: 3.849 ± 0.041	0.868ProMet: 0.868 ± 0.02	2.177ProAsn: 2.177 ± 0.033	3.113ProPro: 3.113 ± 0.069	2.393ProGln: 2.393 ± 0.039	2.163ProArg: 2.163 ± 0.032	4.749ProSer: 4.749 ± 0.061	3.062ProThr: 3.062 ± 0.063	3.207ProVal: 3.207 ± 0.038	0.452ProTrp: 0.452 ± 0.012	1.523ProTyr: 1.523 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.603GlnAla: 2.603 ± 0.039	0.403GlnCys: 0.403 ± 0.014	1.992GlnAsp: 1.992 ± 0.03	2.575GlnGlu: 2.575 ± 0.04	1.764GlnPhe: 1.764 ± 0.024	1.758GlnGly: 1.758 ± 0.028	0.919GlnHis: 0.919 ± 0.017	2.189GlnIle: 2.189 ± 0.032	2.564GlnLys: 2.564 ± 0.036	4.167GlnLeu: 4.167 ± 0.043	0.864GlnMet: 0.864 ± 0.019	1.909GlnAsn: 1.909 ± 0.034	1.951GlnPro: 1.951 ± 0.04	2.345GlnGln: 2.345 ± 0.068	1.947GlnArg: 1.947 ± 0.031	3.104GlnSer: 3.104 ± 0.045	2.008GlnThr: 2.008 ± 0.03	2.425GlnVal: 2.425 ± 0.034	0.463GlnTrp: 0.463 ± 0.012	1.325GlnTyr: 1.325 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.099ArgAla: 3.099 ± 0.039	0.548ArgCys: 0.548 ± 0.015	2.57ArgAsp: 2.57 ± 0.032	2.932ArgGlu: 2.932 ± 0.038	2.152ArgPhe: 2.152 ± 0.032	2.374ArgGly: 2.374 ± 0.038	1.194ArgHis: 1.194 ± 0.021	2.823ArgIle: 2.823 ± 0.031	3.48ArgLys: 3.48 ± 0.041	4.537ArgLeu: 4.537 ± 0.039	0.971ArgMet: 0.971 ± 0.019	2.37ArgAsn: 2.37 ± 0.032	2.084ArgPro: 2.084 ± 0.03	2.076ArgGln: 2.076 ± 0.03	3.15ArgArg: 3.15 ± 0.043	4.118ArgSer: 4.118 ± 0.05	2.467ArgThr: 2.467 ± 0.033	2.634ArgVal: 2.634 ± 0.032	0.517ArgTrp: 0.517 ± 0.013	1.686ArgTyr: 1.686 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	5.917SerAla: 5.917 ± 0.064	0.873SerCys: 0.873 ± 0.018	5.107SerAsp: 5.107 ± 0.05	5.228SerGlu: 5.228 ± 0.053	3.891SerPhe: 3.891 ± 0.042	5.379SerGly: 5.379 ± 0.075	2.093SerHis: 2.093 ± 0.029	5.132SerIle: 5.132 ± 0.052	5.578SerLys: 5.578 ± 0.055	8.13SerLeu: 8.13 ± 0.069	1.803SerMet: 1.803 ± 0.027	4.249SerAsn: 4.249 ± 0.046	4.49SerPro: 4.49 ± 0.066	3.556SerGln: 3.556 ± 0.048	4.277SerArg: 4.277 ± 0.049	10.236SerSer: 10.236 ± 0.115	5.67SerThr: 5.67 ± 0.075	5.699SerVal: 5.699 ± 0.052	0.944SerTrp: 0.944 ± 0.02	2.784SerTyr: 2.784 ± 0.032	0.003SerXaa: 0.003 ± 0.001
Thr	3.739ThrAla: 3.739 ± 0.043	0.625ThrCys: 0.625 ± 0.017	2.754ThrAsp: 2.754 ± 0.038	3.133ThrGlu: 3.133 ± 0.044	2.428ThrPhe: 2.428 ± 0.033	3.498ThrGly: 3.498 ± 0.072	1.196ThrHis: 1.196 ± 0.022	3.535ThrIle: 3.535 ± 0.049	3.615ThrLys: 3.615 ± 0.039	4.981ThrLeu: 4.981 ± 0.043	1.104ThrMet: 1.104 ± 0.018	2.769ThrAsn: 2.769 ± 0.033	3.157ThrPro: 3.157 ± 0.053	1.888ThrGln: 1.888 ± 0.033	2.487ThrArg: 2.487 ± 0.031	5.545ThrSer: 5.545 ± 0.075	3.95ThrThr: 3.95 ± 0.14	3.761ThrVal: 3.761 ± 0.067	0.649ThrTrp: 0.649 ± 0.036	1.833ThrTyr: 1.833 ± 0.03	0.001ThrXaa: 0.001 ± 0.0
Val	4.683ValAla: 4.683 ± 0.047	0.856ValCys: 0.856 ± 0.019	4.052ValAsp: 4.052 ± 0.038	4.162ValGlu: 4.162 ± 0.044	2.894ValPhe: 2.894 ± 0.042	3.645ValGly: 3.645 ± 0.044	1.418ValHis: 1.418 ± 0.024	3.444ValIle: 3.444 ± 0.044	3.808ValLys: 3.808 ± 0.037	5.918ValLeu: 5.918 ± 0.057	1.273ValMet: 1.273 ± 0.023	2.905ValAsn: 2.905 ± 0.033	3.519ValPro: 3.519 ± 0.048	2.244ValGln: 2.244 ± 0.03	2.825ValArg: 2.825 ± 0.044	5.82ValSer: 5.82 ± 0.045	3.497ValThr: 3.497 ± 0.046	4.769ValVal: 4.769 ± 0.057	0.688ValTrp: 0.688 ± 0.02	2.062ValTyr: 2.062 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	0.63TrpAla: 0.63 ± 0.019	0.224TrpCys: 0.224 ± 0.009	0.671TrpAsp: 0.671 ± 0.017	0.575TrpGlu: 0.575 ± 0.014	0.564TrpPhe: 0.564 ± 0.014	0.627TrpGly: 0.627 ± 0.018	0.253TrpHis: 0.253 ± 0.01	0.665TrpIle: 0.665 ± 0.017	0.766TrpLys: 0.766 ± 0.017	1.042TrpLeu: 1.042 ± 0.024	0.232TrpMet: 0.232 ± 0.009	0.612TrpAsn: 0.612 ± 0.015	0.343TrpPro: 0.343 ± 0.013	0.349TrpGln: 0.349 ± 0.012	0.577TrpArg: 0.577 ± 0.016	0.932TrpSer: 0.932 ± 0.021	0.674TrpThr: 0.674 ± 0.035	0.638TrpVal: 0.638 ± 0.017	0.182TrpTrp: 0.182 ± 0.008	0.423TrpTyr: 0.423 ± 0.012	0.001TrpXaa: 0.001 ± 0.001
Tyr	1.966TyrAla: 1.966 ± 0.03	0.487TyrCys: 0.487 ± 0.014	2.198TyrAsp: 2.198 ± 0.035	2.046TyrGlu: 2.046 ± 0.027	1.654TyrPhe: 1.654 ± 0.029	2.135TyrGly: 2.135 ± 0.034	0.871TyrHis: 0.871 ± 0.019	1.935TyrIle: 1.935 ± 0.028	2.001TyrLys: 2.001 ± 0.03	3.345TyrLeu: 3.345 ± 0.036	0.739TyrMet: 0.739 ± 0.016	1.78TyrAsn: 1.78 ± 0.027	1.417TyrPro: 1.417 ± 0.024	1.355TyrGln: 1.355 ± 0.024	1.595TyrArg: 1.595 ± 0.025	2.789TyrSer: 2.789 ± 0.033	1.738TyrThr: 1.738 ± 0.027	2.131TyrVal: 2.131 ± 0.029	0.416TyrTrp: 0.416 ± 0.014	1.414TyrTyr: 1.414 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.003XaaGlu: 0.003 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.025XaaXaa: 0.025 ± 0.025

Statistics based on 5012 proteins (2648595 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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