Amino acid dipepetide frequency for Beluga whale coronavirus SW1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.955AlaAla: 4.955 ± 0.481
1.628AlaCys: 1.628 ± 0.371
4.106AlaAsp: 4.106 ± 0.378
3.185AlaGlu: 3.185 ± 0.372
2.478AlaPhe: 2.478 ± 0.705
4.813AlaGly: 4.813 ± 0.508
0.849AlaHis: 0.849 ± 0.137
6.229AlaIle: 6.229 ± 0.8
4.318AlaLys: 4.318 ± 0.604
7.008AlaLeu: 7.008 ± 0.434
1.628AlaMet: 1.628 ± 0.263
4.53AlaAsn: 4.53 ± 0.828
2.265AlaPro: 2.265 ± 0.317
1.77AlaGln: 1.77 ± 0.417
2.69AlaArg: 2.69 ± 0.371
5.097AlaSer: 5.097 ± 0.582
4.247AlaThr: 4.247 ± 0.639
5.238AlaVal: 5.238 ± 0.729
0.637AlaTrp: 0.637 ± 0.218
3.327AlaTyr: 3.327 ± 0.473
0.0AlaXaa: 0.0 ± 0.0
Cys
2.265CysAla: 2.265 ± 0.424
0.849CysCys: 0.849 ± 0.237
2.407CysAsp: 2.407 ± 0.472
1.062CysGlu: 1.062 ± 0.179
1.274CysPhe: 1.274 ± 0.272
2.053CysGly: 2.053 ± 0.296
0.496CysHis: 0.496 ± 0.295
1.203CysIle: 1.203 ± 0.145
2.194CysLys: 2.194 ± 0.389
2.053CysLeu: 2.053 ± 0.376
0.142CysMet: 0.142 ± 0.057
2.194CysAsn: 2.194 ± 0.418
0.637CysPro: 0.637 ± 0.154
0.708CysGln: 0.708 ± 0.156
1.345CysArg: 1.345 ± 0.277
1.062CysSer: 1.062 ± 0.244
1.203CysThr: 1.203 ± 0.51
2.69CysVal: 2.69 ± 0.414
0.637CysTrp: 0.637 ± 0.177
1.557CysTyr: 1.557 ± 0.283
0.0CysXaa: 0.0 ± 0.0
Asp
5.026AspAla: 5.026 ± 0.64
1.557AspCys: 1.557 ± 0.352
2.619AspAsp: 2.619 ± 0.356
3.752AspGlu: 3.752 ± 0.6
3.893AspPhe: 3.893 ± 0.584
3.893AspGly: 3.893 ± 1.258
0.566AspHis: 0.566 ± 0.354
2.69AspIle: 2.69 ± 0.323
2.831AspLys: 2.831 ± 0.663
3.398AspLeu: 3.398 ± 0.544
1.557AspMet: 1.557 ± 0.261
2.407AspAsn: 2.407 ± 0.267
2.831AspPro: 2.831 ± 0.598
1.203AspGln: 1.203 ± 0.244
1.77AspArg: 1.77 ± 0.443
3.185AspSer: 3.185 ± 0.637
2.265AspThr: 2.265 ± 0.22
5.38AspVal: 5.38 ± 0.554
1.133AspTrp: 1.133 ± 0.18
3.185AspTyr: 3.185 ± 0.367
0.0AspXaa: 0.0 ± 0.0
Glu
3.115GluAla: 3.115 ± 0.355
1.203GluCys: 1.203 ± 0.241
3.681GluAsp: 3.681 ± 0.633
6.017GluGlu: 6.017 ± 0.995
2.053GluPhe: 2.053 ± 0.355
4.106GluGly: 4.106 ± 0.369
0.779GluHis: 0.779 ± 0.174
1.982GluIle: 1.982 ± 0.394
4.389GluLys: 4.389 ± 0.382
5.734GluLeu: 5.734 ± 1.348
0.566GluMet: 0.566 ± 0.173
2.69GluAsn: 2.69 ± 0.778
1.557GluPro: 1.557 ± 0.19
2.407GluGln: 2.407 ± 0.483
2.478GluArg: 2.478 ± 0.9
3.681GluSer: 3.681 ± 0.77
2.194GluThr: 2.194 ± 0.219
5.026GluVal: 5.026 ± 0.579
0.708GluTrp: 0.708 ± 0.368
1.911GluTyr: 1.911 ± 0.556
0.0GluXaa: 0.0 ± 0.0
Phe
2.69PheAla: 2.69 ± 0.499
1.345PheCys: 1.345 ± 0.246
2.973PheAsp: 2.973 ± 0.97
3.115PheGlu: 3.115 ± 0.513
1.84PhePhe: 1.84 ± 0.351
3.327PheGly: 3.327 ± 0.492
0.991PheHis: 0.991 ± 0.247
2.548PheIle: 2.548 ± 0.774
3.681PheLys: 3.681 ± 0.441
3.61PheLeu: 3.61 ± 0.489
0.991PheMet: 0.991 ± 0.179
3.185PheAsn: 3.185 ± 0.434
1.203PhePro: 1.203 ± 1.08
1.203PheGln: 1.203 ± 0.387
1.062PheArg: 1.062 ± 0.586
3.681PheSer: 3.681 ± 0.553
2.973PheThr: 2.973 ± 0.449
4.672PheVal: 4.672 ± 0.485
0.637PheTrp: 0.637 ± 0.167
3.185PheTyr: 3.185 ± 0.644
0.0PheXaa: 0.0 ± 0.0
Gly
4.247GlyAla: 4.247 ± 0.615
1.84GlyCys: 1.84 ± 0.358
4.601GlyAsp: 4.601 ± 0.544
3.822GlyGlu: 3.822 ± 0.829
3.539GlyPhe: 3.539 ± 0.659
4.106GlyGly: 4.106 ± 0.294
0.991GlyHis: 0.991 ± 0.531
4.318GlyIle: 4.318 ± 0.555
4.46GlyLys: 4.46 ± 0.676
4.743GlyLeu: 4.743 ± 0.456
2.265GlyMet: 2.265 ± 0.385
3.893GlyAsn: 3.893 ± 0.835
1.557GlyPro: 1.557 ± 0.375
1.416GlyGln: 1.416 ± 0.22
1.416GlyArg: 1.416 ± 0.988
5.521GlySer: 5.521 ± 0.667
2.265GlyThr: 2.265 ± 0.373
7.503GlyVal: 7.503 ± 0.887
0.849GlyTrp: 0.849 ± 0.218
3.539GlyTyr: 3.539 ± 0.392
0.0GlyXaa: 0.0 ± 0.0
His
1.77HisAla: 1.77 ± 0.353
0.354HisCys: 0.354 ± 0.081
0.92HisAsp: 0.92 ± 0.262
0.991HisGlu: 0.991 ± 0.244
1.274HisPhe: 1.274 ± 0.353
1.628HisGly: 1.628 ± 0.469
0.425HisHis: 0.425 ± 0.184
1.133HisIle: 1.133 ± 0.263
0.991HisLys: 0.991 ± 0.293
1.84HisLeu: 1.84 ± 0.272
0.283HisMet: 0.283 ± 0.113
0.991HisAsn: 0.991 ± 0.286
0.991HisPro: 0.991 ± 0.322
0.496HisGln: 0.496 ± 0.109
0.425HisArg: 0.425 ± 0.35
0.779HisSer: 0.779 ± 0.166
0.637HisThr: 0.637 ± 0.112
1.911HisVal: 1.911 ± 0.282
0.0HisTrp: 0.0 ± 0.0
1.416HisTyr: 1.416 ± 0.422
0.0HisXaa: 0.0 ± 0.0
Ile
2.831IleAla: 2.831 ± 0.456
0.92IleCys: 0.92 ± 0.39
3.327IleAsp: 3.327 ± 1.014
2.619IleGlu: 2.619 ± 0.378
1.628IlePhe: 1.628 ± 0.351
2.902IleGly: 2.902 ± 0.414
0.566IleHis: 0.566 ± 0.13
3.61IleIle: 3.61 ± 0.765
4.035IleLys: 4.035 ± 0.302
3.469IleLeu: 3.469 ± 0.669
1.982IleMet: 1.982 ± 0.351
3.61IleAsn: 3.61 ± 0.681
2.194IlePro: 2.194 ± 0.381
1.84IleGln: 1.84 ± 0.82
1.699IleArg: 1.699 ± 0.333
3.61IleSer: 3.61 ± 0.441
3.327IleThr: 3.327 ± 0.938
6.3IleVal: 6.3 ± 0.952
0.142IleTrp: 0.142 ± 0.057
1.487IleTyr: 1.487 ± 0.308
0.0IleXaa: 0.0 ± 0.0
Lys
5.167LysAla: 5.167 ± 0.595
2.124LysCys: 2.124 ± 0.389
1.699LysAsp: 1.699 ± 0.337
3.681LysGlu: 3.681 ± 0.325
3.61LysPhe: 3.61 ± 0.592
5.167LysGly: 5.167 ± 0.434
1.77LysHis: 1.77 ± 0.472
2.619LysIle: 2.619 ± 0.41
3.327LysLys: 3.327 ± 0.611
5.097LysLeu: 5.097 ± 0.431
1.557LysMet: 1.557 ± 0.341
3.681LysAsn: 3.681 ± 0.499
3.681LysPro: 3.681 ± 0.317
2.194LysGln: 2.194 ± 0.471
1.557LysArg: 1.557 ± 0.298
4.53LysSer: 4.53 ± 0.37
1.982LysThr: 1.982 ± 0.27
4.884LysVal: 4.884 ± 0.641
0.283LysTrp: 0.283 ± 0.362
4.035LysTyr: 4.035 ± 0.584
0.0LysXaa: 0.0 ± 0.0
Leu
6.088LeuAla: 6.088 ± 0.599
2.407LeuCys: 2.407 ± 0.285
4.247LeuAsp: 4.247 ± 0.561
3.327LeuGlu: 3.327 ± 0.327
4.247LeuPhe: 4.247 ± 0.482
4.53LeuGly: 4.53 ± 0.357
1.416LeuHis: 1.416 ± 0.304
3.752LeuIle: 3.752 ± 0.527
4.672LeuLys: 4.672 ± 1.043
6.158LeuLeu: 6.158 ± 0.814
2.548LeuMet: 2.548 ± 0.4
3.61LeuAsn: 3.61 ± 0.561
4.53LeuPro: 4.53 ± 0.383
3.681LeuGln: 3.681 ± 0.357
3.185LeuArg: 3.185 ± 0.43
6.158LeuSer: 6.158 ± 0.576
4.743LeuThr: 4.743 ± 0.657
6.583LeuVal: 6.583 ± 0.455
1.274LeuTrp: 1.274 ± 0.229
4.601LeuTyr: 4.601 ± 0.37
0.0LeuXaa: 0.0 ± 0.0
Met
1.628MetAla: 1.628 ± 0.184
0.779MetCys: 0.779 ± 0.238
1.203MetAsp: 1.203 ± 0.149
0.991MetGlu: 0.991 ± 0.169
0.708MetPhe: 0.708 ± 0.375
0.708MetGly: 0.708 ± 0.204
0.991MetHis: 0.991 ± 0.271
1.557MetIle: 1.557 ± 0.341
0.496MetLys: 0.496 ± 0.192
3.61MetLeu: 3.61 ± 0.452
0.708MetMet: 0.708 ± 0.156
0.708MetAsn: 0.708 ± 0.211
0.991MetPro: 0.991 ± 0.17
0.849MetGln: 0.849 ± 0.257
1.274MetArg: 1.274 ± 0.272
2.478MetSer: 2.478 ± 0.286
0.92MetThr: 0.92 ± 0.143
2.265MetVal: 2.265 ± 0.621
0.637MetTrp: 0.637 ± 0.184
1.416MetTyr: 1.416 ± 0.219
0.0MetXaa: 0.0 ± 0.0
Asn
3.752AsnAla: 3.752 ± 0.471
1.982AsnCys: 1.982 ± 0.226
2.548AsnAsp: 2.548 ± 0.317
3.752AsnGlu: 3.752 ± 0.736
2.902AsnPhe: 2.902 ± 0.435
4.176AsnGly: 4.176 ± 0.395
0.991AsnHis: 0.991 ± 0.322
2.478AsnIle: 2.478 ± 0.608
2.407AsnLys: 2.407 ± 0.239
3.185AsnLeu: 3.185 ± 0.336
1.84AsnMet: 1.84 ± 0.314
2.761AsnAsn: 2.761 ± 0.432
2.265AsnPro: 2.265 ± 0.556
1.699AsnGln: 1.699 ± 0.279
1.274AsnArg: 1.274 ± 0.486
3.327AsnSer: 3.327 ± 1.083
2.548AsnThr: 2.548 ± 0.207
4.601AsnVal: 4.601 ± 0.455
0.354AsnTrp: 0.354 ± 0.081
2.69AsnTyr: 2.69 ± 0.348
0.0AsnXaa: 0.0 ± 0.0
Pro
3.044ProAla: 3.044 ± 0.468
0.708ProCys: 0.708 ± 0.214
2.124ProAsp: 2.124 ± 0.475
2.478ProGlu: 2.478 ± 0.332
2.124ProPhe: 2.124 ± 0.549
2.831ProGly: 2.831 ± 0.496
0.637ProHis: 0.637 ± 0.22
2.124ProIle: 2.124 ± 0.368
2.265ProLys: 2.265 ± 0.593
3.964ProLeu: 3.964 ± 0.452
1.345ProMet: 1.345 ± 0.295
1.274ProAsn: 1.274 ± 0.712
1.77ProPro: 1.77 ± 0.179
1.274ProGln: 1.274 ± 0.324
1.84ProArg: 1.84 ± 0.446
2.194ProSer: 2.194 ± 0.224
2.407ProThr: 2.407 ± 0.453
2.619ProVal: 2.619 ± 0.394
0.142ProTrp: 0.142 ± 0.099
2.124ProTyr: 2.124 ± 0.257
0.0ProXaa: 0.0 ± 0.0
Gln
2.478GlnAla: 2.478 ± 0.658
0.92GlnCys: 0.92 ± 0.115
1.77GlnAsp: 1.77 ± 0.326
2.194GlnGlu: 2.194 ± 0.304
1.77GlnPhe: 1.77 ± 0.246
0.991GlnGly: 0.991 ± 0.179
1.487GlnHis: 1.487 ± 0.486
1.628GlnIle: 1.628 ± 0.292
2.336GlnLys: 2.336 ± 0.323
2.478GlnLeu: 2.478 ± 0.354
0.779GlnMet: 0.779 ± 0.323
1.133GlnAsn: 1.133 ± 0.728
1.345GlnPro: 1.345 ± 0.404
1.133GlnGln: 1.133 ± 0.308
1.133GlnArg: 1.133 ± 0.245
1.911GlnSer: 1.911 ± 0.299
1.699GlnThr: 1.699 ± 0.377
2.69GlnVal: 2.69 ± 0.327
0.354GlnTrp: 0.354 ± 0.134
1.345GlnTyr: 1.345 ± 0.284
0.0GlnXaa: 0.0 ± 0.0
Arg
2.124ArgAla: 2.124 ± 0.492
1.416ArgCys: 1.416 ± 0.246
1.911ArgAsp: 1.911 ± 0.461
1.487ArgGlu: 1.487 ± 0.508
2.265ArgPhe: 2.265 ± 0.484
1.84ArgGly: 1.84 ± 0.34
1.133ArgHis: 1.133 ± 0.192
1.557ArgIle: 1.557 ± 0.281
2.124ArgLys: 2.124 ± 0.707
4.318ArgLeu: 4.318 ± 0.347
0.496ArgMet: 0.496 ± 0.13
2.194ArgAsn: 2.194 ± 0.553
0.991ArgPro: 0.991 ± 0.153
1.557ArgGln: 1.557 ± 0.211
1.416ArgArg: 1.416 ± 0.467
2.265ArgSer: 2.265 ± 1.214
2.194ArgThr: 2.194 ± 0.429
2.407ArgVal: 2.407 ± 0.493
0.212ArgTrp: 0.212 ± 0.129
1.487ArgTyr: 1.487 ± 0.6
0.0ArgXaa: 0.0 ± 0.0
Ser
6.017SerAla: 6.017 ± 0.61
1.982SerCys: 1.982 ± 0.488
4.318SerAsp: 4.318 ± 0.592
4.106SerGlu: 4.106 ± 0.705
2.902SerPhe: 2.902 ± 0.514
5.451SerGly: 5.451 ± 0.583
1.416SerHis: 1.416 ± 0.269
2.973SerIle: 2.973 ± 0.472
3.61SerLys: 3.61 ± 0.695
5.097SerLeu: 5.097 ± 0.446
1.557SerMet: 1.557 ± 0.319
2.69SerAsn: 2.69 ± 0.288
1.911SerPro: 1.911 ± 0.454
2.407SerGln: 2.407 ± 0.409
2.69SerArg: 2.69 ± 1.262
5.663SerSer: 5.663 ± 0.36
5.097SerThr: 5.097 ± 0.49
7.574SerVal: 7.574 ± 0.897
1.062SerTrp: 1.062 ± 0.228
2.548SerTyr: 2.548 ± 0.655
0.0SerXaa: 0.0 ± 0.0
Thr
3.044ThrAla: 3.044 ± 0.386
0.637ThrCys: 0.637 ± 0.184
2.194ThrAsp: 2.194 ± 0.291
2.336ThrGlu: 2.336 ± 0.368
3.044ThrPhe: 3.044 ± 0.478
3.752ThrGly: 3.752 ± 0.753
0.779ThrHis: 0.779 ± 0.23
2.548ThrIle: 2.548 ± 0.508
2.831ThrLys: 2.831 ± 0.187
4.813ThrLeu: 4.813 ± 0.52
1.133ThrMet: 1.133 ± 0.161
2.336ThrAsn: 2.336 ± 0.385
3.115ThrPro: 3.115 ± 0.694
1.699ThrGln: 1.699 ± 0.292
3.327ThrArg: 3.327 ± 0.322
5.521ThrSer: 5.521 ± 0.423
3.964ThrThr: 3.964 ± 0.731
4.247ThrVal: 4.247 ± 0.369
0.283ThrTrp: 0.283 ± 0.099
1.699ThrTyr: 1.699 ± 0.214
0.0ThrXaa: 0.0 ± 0.0
Val
6.442ValAla: 6.442 ± 0.57
3.327ValCys: 3.327 ± 0.516
5.309ValAsp: 5.309 ± 0.677
4.389ValGlu: 4.389 ± 0.755
3.964ValPhe: 3.964 ± 0.387
5.804ValGly: 5.804 ± 0.764
1.982ValHis: 1.982 ± 0.349
3.893ValIle: 3.893 ± 0.678
8.494ValLys: 8.494 ± 1.504
6.371ValLeu: 6.371 ± 0.86
2.407ValMet: 2.407 ± 0.327
3.61ValAsn: 3.61 ± 1.126
3.61ValPro: 3.61 ± 0.419
2.69ValGln: 2.69 ± 0.329
3.044ValArg: 3.044 ± 0.381
6.654ValSer: 6.654 ± 0.353
4.955ValThr: 4.955 ± 0.376
9.485ValVal: 9.485 ± 2.366
0.425ValTrp: 0.425 ± 0.068
4.247ValTyr: 4.247 ± 1.306
0.0ValXaa: 0.0 ± 0.0
Trp
0.637TrpAla: 0.637 ± 0.279
0.142TrpCys: 0.142 ± 0.057
0.708TrpAsp: 0.708 ± 0.293
0.425TrpGlu: 0.425 ± 0.164
0.991TrpPhe: 0.991 ± 0.264
0.637TrpGly: 0.637 ± 0.117
0.0TrpHis: 0.0 ± 0.0
0.779TrpIle: 0.779 ± 0.337
0.496TrpLys: 0.496 ± 0.191
0.991TrpLeu: 0.991 ± 0.229
0.283TrpMet: 0.283 ± 0.127
0.92TrpAsn: 0.92 ± 0.148
0.354TrpPro: 0.354 ± 0.239
0.142TrpGln: 0.142 ± 0.184
0.425TrpArg: 0.425 ± 0.158
1.203TrpSer: 1.203 ± 0.221
0.425TrpThr: 0.425 ± 0.127
0.496TrpVal: 0.496 ± 0.212
0.496TrpTrp: 0.496 ± 0.388
0.425TrpTyr: 0.425 ± 0.068
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.752TyrAla: 3.752 ± 0.834
1.911TyrCys: 1.911 ± 0.387
2.478TyrAsp: 2.478 ± 0.614
2.548TyrGlu: 2.548 ± 0.969
2.407TyrPhe: 2.407 ± 0.234
4.176TyrGly: 4.176 ± 0.472
0.991TyrHis: 0.991 ± 0.322
2.478TyrIle: 2.478 ± 0.474
2.69TyrLys: 2.69 ± 0.21
3.822TyrLeu: 3.822 ± 0.376
0.779TyrMet: 0.779 ± 0.294
3.115TyrAsn: 3.115 ± 0.412
1.487TyrPro: 1.487 ± 0.251
1.203TyrGln: 1.203 ± 0.238
1.345TyrArg: 1.345 ± 0.306
2.548TyrSer: 2.548 ± 0.447
3.256TyrThr: 3.256 ± 0.3
4.53TyrVal: 4.53 ± 0.521
0.708TyrTrp: 0.708 ± 0.259
2.619TyrTyr: 2.619 ± 0.249
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (14128 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski