Amino acid dipepetide frequency for Micromonospora rhizosphaerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.868AlaAla: 22.868 ± 0.188	0.958AlaCys: 0.958 ± 0.023	8.661AlaAsp: 8.661 ± 0.075	8.629AlaGlu: 8.629 ± 0.084	3.381AlaPhe: 3.381 ± 0.04	14.288AlaGly: 14.288 ± 0.119	2.487AlaHis: 2.487 ± 0.041	4.225AlaIle: 4.225 ± 0.051	2.526AlaLys: 2.526 ± 0.048	14.506AlaLeu: 14.506 ± 0.105	2.548AlaMet: 2.548 ± 0.039	2.211AlaAsn: 2.211 ± 0.04	7.107AlaPro: 7.107 ± 0.086	3.559AlaGln: 3.559 ± 0.049	10.526AlaArg: 10.526 ± 0.09	5.603AlaSer: 5.603 ± 0.054	7.819AlaThr: 7.819 ± 0.069	12.62AlaVal: 12.62 ± 0.096	1.977AlaTrp: 1.977 ± 0.033	2.822AlaTyr: 2.822 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.927CysAla: 0.927 ± 0.019	0.119CysCys: 0.119 ± 0.009	0.473CysAsp: 0.473 ± 0.015	0.329CysGlu: 0.329 ± 0.012	0.218CysPhe: 0.218 ± 0.01	0.947CysGly: 0.947 ± 0.025	0.2CysHis: 0.2 ± 0.011	0.164CysIle: 0.164 ± 0.009	0.09CysLys: 0.09 ± 0.007	0.703CysLeu: 0.703 ± 0.019	0.105CysMet: 0.105 ± 0.008	0.127CysAsn: 0.127 ± 0.008	0.505CysPro: 0.505 ± 0.019	0.199CysGln: 0.199 ± 0.01	0.641CysArg: 0.641 ± 0.019	0.386CysSer: 0.386 ± 0.017	0.411CysThr: 0.411 ± 0.015	0.595CysVal: 0.595 ± 0.017	0.14CysTrp: 0.14 ± 0.008	0.169CysTyr: 0.169 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.452AspAla: 7.452 ± 0.077	0.376AspCys: 0.376 ± 0.014	3.521AspAsp: 3.521 ± 0.048	3.742AspGlu: 3.742 ± 0.05	1.529AspPhe: 1.529 ± 0.031	6.166AspGly: 6.166 ± 0.062	1.287AspHis: 1.287 ± 0.028	1.673AspIle: 1.673 ± 0.032	0.997AspLys: 0.997 ± 0.027	6.595AspLeu: 6.595 ± 0.059	0.723AspMet: 0.723 ± 0.018	0.958AspAsn: 0.958 ± 0.022	4.917AspPro: 4.917 ± 0.055	1.784AspGln: 1.784 ± 0.03	5.664AspArg: 5.664 ± 0.051	2.181AspSer: 2.181 ± 0.033	2.689AspThr: 2.689 ± 0.041	4.931AspVal: 4.931 ± 0.051	1.024AspTrp: 1.024 ± 0.024	1.094AspTyr: 1.094 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.743GluAla: 6.743 ± 0.073	0.324GluCys: 0.324 ± 0.013	2.196GluAsp: 2.196 ± 0.034	2.769GluGlu: 2.769 ± 0.041	1.455GluPhe: 1.455 ± 0.028	3.364GluGly: 3.364 ± 0.048	1.348GluHis: 1.348 ± 0.025	2.265GluIle: 2.265 ± 0.037	1.12GluLys: 1.12 ± 0.027	6.615GluLeu: 6.615 ± 0.071	0.859GluMet: 0.859 ± 0.021	0.844GluAsn: 0.844 ± 0.022	3.484GluPro: 3.484 ± 0.051	2.217GluGln: 2.217 ± 0.036	5.315GluArg: 5.315 ± 0.065	2.264GluSer: 2.264 ± 0.038	2.525GluThr: 2.525 ± 0.036	4.774GluVal: 4.774 ± 0.057	0.731GluTrp: 0.731 ± 0.02	1.093GluTyr: 1.093 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.836PheAla: 3.836 ± 0.042	0.26PheCys: 0.26 ± 0.011	1.972PheAsp: 1.972 ± 0.03	1.26PheGlu: 1.26 ± 0.028	0.864PhePhe: 0.864 ± 0.024	3.061PheGly: 3.061 ± 0.042	0.533PheHis: 0.533 ± 0.018	0.791PheIle: 0.791 ± 0.022	0.423PheLys: 0.423 ± 0.016	2.596PheLeu: 2.596 ± 0.039	0.331PheMet: 0.331 ± 0.014	0.573PheAsn: 0.573 ± 0.018	1.357PhePro: 1.357 ± 0.022	0.623PheGln: 0.623 ± 0.018	1.9PheArg: 1.9 ± 0.033	1.325PheSer: 1.325 ± 0.032	1.925PheThr: 1.925 ± 0.035	2.442PheVal: 2.442 ± 0.035	0.461PheTrp: 0.461 ± 0.018	0.595PheTyr: 0.595 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.673GlyAla: 10.673 ± 0.098	0.833GlyCys: 0.833 ± 0.021	5.11GlyAsp: 5.11 ± 0.067	4.861GlyGlu: 4.861 ± 0.056	2.827GlyPhe: 2.827 ± 0.037	8.605GlyGly: 8.605 ± 0.102	2.115GlyHis: 2.115 ± 0.035	3.326GlyIle: 3.326 ± 0.044	2.069GlyLys: 2.069 ± 0.035	9.72GlyLeu: 9.72 ± 0.064	1.956GlyMet: 1.956 ± 0.027	1.692GlyAsn: 1.692 ± 0.037	5.262GlyPro: 5.262 ± 0.062	2.836GlyGln: 2.836 ± 0.037	8.256GlyArg: 8.256 ± 0.061	4.72GlySer: 4.72 ± 0.052	5.525GlyThr: 5.525 ± 0.064	7.995GlyVal: 7.995 ± 0.071	1.977GlyTrp: 1.977 ± 0.031	2.386GlyTyr: 2.386 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.428HisAla: 2.428 ± 0.033	0.198HisCys: 0.198 ± 0.011	1.291HisAsp: 1.291 ± 0.028	1.069HisGlu: 1.069 ± 0.02	0.564HisPhe: 0.564 ± 0.017	2.109HisGly: 2.109 ± 0.034	0.608HisHis: 0.608 ± 0.018	0.579HisIle: 0.579 ± 0.015	0.274HisLys: 0.274 ± 0.011	2.449HisLeu: 2.449 ± 0.04	0.276HisMet: 0.276 ± 0.01	0.355HisAsn: 0.355 ± 0.013	1.771HisPro: 1.771 ± 0.029	0.616HisGln: 0.616 ± 0.015	2.106HisArg: 2.106 ± 0.034	0.848HisSer: 0.848 ± 0.024	1.073HisThr: 1.073 ± 0.026	1.716HisVal: 1.716 ± 0.033	0.384HisTrp: 0.384 ± 0.016	0.446HisTyr: 0.446 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.122IleAla: 5.122 ± 0.061	0.304IleCys: 0.304 ± 0.014	2.444IleAsp: 2.444 ± 0.043	2.067IleGlu: 2.067 ± 0.031	0.926IlePhe: 0.926 ± 0.024	3.647IleGly: 3.647 ± 0.047	0.577IleHis: 0.577 ± 0.017	1.064IleIle: 1.064 ± 0.03	0.692IleLys: 0.692 ± 0.02	2.594IleLeu: 2.594 ± 0.041	0.475IleMet: 0.475 ± 0.015	0.791IleAsn: 0.791 ± 0.02	1.73IlePro: 1.73 ± 0.03	0.727IleGln: 0.727 ± 0.021	2.558IleArg: 2.558 ± 0.038	1.827IleSer: 1.827 ± 0.026	2.142IleThr: 2.142 ± 0.037	2.946IleVal: 2.946 ± 0.041	0.435IleTrp: 0.435 ± 0.015	0.667IleTyr: 0.667 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.353LysAla: 2.353 ± 0.041	0.102LysCys: 0.102 ± 0.007	0.902LysAsp: 0.902 ± 0.029	0.864LysGlu: 0.864 ± 0.024	0.419LysPhe: 0.419 ± 0.016	1.367LysGly: 1.367 ± 0.029	0.347LysHis: 0.347 ± 0.014	0.832LysIle: 0.832 ± 0.023	0.546LysLys: 0.546 ± 0.026	1.907LysLeu: 1.907 ± 0.028	0.323LysMet: 0.323 ± 0.012	0.408LysAsn: 0.408 ± 0.017	1.211LysPro: 1.211 ± 0.025	0.66LysGln: 0.66 ± 0.019	1.346LysArg: 1.346 ± 0.028	0.904LysSer: 0.904 ± 0.022	1.075LysThr: 1.075 ± 0.028	1.696LysVal: 1.696 ± 0.034	0.217LysTrp: 0.217 ± 0.011	0.365LysTyr: 0.365 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.855LeuAla: 16.855 ± 0.12	0.75LeuCys: 0.75 ± 0.017	6.709LeuAsp: 6.709 ± 0.065	4.089LeuGlu: 4.089 ± 0.053	2.624LeuPhe: 2.624 ± 0.042	9.344LeuGly: 9.344 ± 0.078	2.255LeuHis: 2.255 ± 0.035	3.615LeuIle: 3.615 ± 0.051	1.537LeuLys: 1.537 ± 0.033	11.962LeuLeu: 11.962 ± 0.097	1.462LeuMet: 1.462 ± 0.031	1.701LeuAsn: 1.701 ± 0.025	6.667LeuPro: 6.667 ± 0.055	2.118LeuGln: 2.118 ± 0.034	9.293LeuArg: 9.293 ± 0.079	4.917LeuSer: 4.917 ± 0.047	6.787LeuThr: 6.787 ± 0.055	9.937LeuVal: 9.937 ± 0.097	1.34LeuTrp: 1.34 ± 0.028	1.75LeuTyr: 1.75 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.145MetAla: 2.145 ± 0.029	0.113MetCys: 0.113 ± 0.007	0.748MetAsp: 0.748 ± 0.019	0.628MetGlu: 0.628 ± 0.019	0.478MetPhe: 0.478 ± 0.017	1.143MetGly: 1.143 ± 0.028	0.322MetHis: 0.322 ± 0.014	0.713MetIle: 0.713 ± 0.02	0.359MetLys: 0.359 ± 0.013	1.777MetLeu: 1.777 ± 0.033	0.275MetMet: 0.275 ± 0.011	0.377MetAsn: 0.377 ± 0.013	1.093MetPro: 1.093 ± 0.025	0.426MetGln: 0.426 ± 0.016	1.445MetArg: 1.445 ± 0.028	1.222MetSer: 1.222 ± 0.026	1.624MetThr: 1.624 ± 0.03	1.363MetVal: 1.363 ± 0.023	0.212MetTrp: 0.212 ± 0.011	0.282MetTyr: 0.282 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.175AsnAla: 2.175 ± 0.034	0.151AsnCys: 0.151 ± 0.009	0.996AsnAsp: 0.996 ± 0.024	0.799AsnGlu: 0.799 ± 0.021	0.527AsnPhe: 0.527 ± 0.017	1.764AsnGly: 1.764 ± 0.038	0.388AsnHis: 0.388 ± 0.013	0.639AsnIle: 0.639 ± 0.02	0.339AsnLys: 0.339 ± 0.014	1.91AsnLeu: 1.91 ± 0.035	0.278AsnMet: 0.278 ± 0.013	0.45AsnAsn: 0.45 ± 0.018	1.503AsnPro: 1.503 ± 0.03	0.549AsnGln: 0.549 ± 0.018	1.425AsnArg: 1.425 ± 0.027	0.872AsnSer: 0.872 ± 0.022	0.97AsnThr: 0.97 ± 0.025	1.414AsnVal: 1.414 ± 0.026	0.305AsnTrp: 0.305 ± 0.012	0.414AsnTyr: 0.414 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.79ProAla: 9.79 ± 0.1	0.311ProCys: 0.311 ± 0.012	4.579ProAsp: 4.579 ± 0.051	4.066ProGlu: 4.066 ± 0.044	1.456ProPhe: 1.456 ± 0.025	6.595ProGly: 6.595 ± 0.064	1.243ProHis: 1.243 ± 0.025	1.758ProIle: 1.758 ± 0.033	1.034ProLys: 1.034 ± 0.025	5.262ProLeu: 5.262 ± 0.054	1.075ProMet: 1.075 ± 0.022	1.038ProAsn: 1.038 ± 0.025	4.296ProPro: 4.296 ± 0.085	1.63ProGln: 1.63 ± 0.031	4.13ProArg: 4.13 ± 0.049	3.051ProSer: 3.051 ± 0.043	3.846ProThr: 3.846 ± 0.05	5.908ProVal: 5.908 ± 0.055	0.956ProTrp: 0.956 ± 0.023	1.31ProTyr: 1.31 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.731GlnAla: 3.731 ± 0.042	0.151GlnCys: 0.151 ± 0.008	1.119GlnAsp: 1.119 ± 0.026	1.216GlnGlu: 1.216 ± 0.025	0.754GlnPhe: 0.754 ± 0.018	1.967GlnGly: 1.967 ± 0.035	0.652GlnHis: 0.652 ± 0.019	1.135GlnIle: 1.135 ± 0.025	0.483GlnLys: 0.483 ± 0.016	3.296GlnLeu: 3.296 ± 0.035	0.477GlnMet: 0.477 ± 0.015	0.458GlnAsn: 0.458 ± 0.014	1.979GlnPro: 1.979 ± 0.034	1.184GlnGln: 1.184 ± 0.031	2.805GlnArg: 2.805 ± 0.043	1.135GlnSer: 1.135 ± 0.027	1.352GlnThr: 1.352 ± 0.027	2.818GlnVal: 2.818 ± 0.037	0.488GlnTrp: 0.488 ± 0.016	0.549GlnTyr: 0.549 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.327ArgAla: 10.327 ± 0.096	0.63ArgCys: 0.63 ± 0.018	4.622ArgAsp: 4.622 ± 0.049	4.433ArgGlu: 4.433 ± 0.059	2.479ArgPhe: 2.479 ± 0.035	6.03ArgGly: 6.03 ± 0.057	2.152ArgHis: 2.152 ± 0.037	3.29ArgIle: 3.29 ± 0.036	1.43ArgLys: 1.43 ± 0.027	9.657ArgLeu: 9.657 ± 0.074	1.87ArgMet: 1.87 ± 0.032	1.478ArgAsn: 1.478 ± 0.027	5.648ArgPro: 5.648 ± 0.062	2.792ArgGln: 2.792 ± 0.035	9.136ArgArg: 9.136 ± 0.107	4.222ArgSer: 4.222 ± 0.049	4.721ArgThr: 4.721 ± 0.048	6.518ArgVal: 6.518 ± 0.056	1.766ArgTrp: 1.766 ± 0.029	2.109ArgTyr: 2.109 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.265SerAla: 6.265 ± 0.063	0.405SerCys: 0.405 ± 0.017	2.435SerAsp: 2.435 ± 0.036	2.044SerGlu: 2.044 ± 0.034	1.462SerPhe: 1.462 ± 0.031	5.274SerGly: 5.274 ± 0.056	0.884SerHis: 0.884 ± 0.022	1.56SerIle: 1.56 ± 0.028	0.815SerLys: 0.815 ± 0.023	4.281SerLeu: 4.281 ± 0.056	1.004SerMet: 1.004 ± 0.022	0.872SerAsn: 0.872 ± 0.02	3.1SerPro: 3.1 ± 0.048	1.174SerGln: 1.174 ± 0.026	3.854SerArg: 3.854 ± 0.042	2.41SerSer: 2.41 ± 0.038	2.97SerThr: 2.97 ± 0.045	4.048SerVal: 4.048 ± 0.049	0.91SerTrp: 0.91 ± 0.024	1.18SerTyr: 1.18 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	8.316ThrAla: 8.316 ± 0.085	0.407ThrCys: 0.407 ± 0.016	3.563ThrAsp: 3.563 ± 0.052	2.953ThrGlu: 2.953 ± 0.04	1.598ThrPhe: 1.598 ± 0.033	6.368ThrGly: 6.368 ± 0.046	1.038ThrHis: 1.038 ± 0.026	1.974ThrIle: 1.974 ± 0.028	0.982ThrLys: 0.982 ± 0.028	5.714ThrLeu: 5.714 ± 0.058	0.992ThrMet: 0.992 ± 0.023	1.032ThrAsn: 1.032 ± 0.023	4.043ThrPro: 4.043 ± 0.05	1.222ThrGln: 1.222 ± 0.026	3.986ThrArg: 3.986 ± 0.044	2.868ThrSer: 2.868 ± 0.042	3.572ThrThr: 3.572 ± 0.052	6.096ThrVal: 6.096 ± 0.055	0.896ThrTrp: 0.896 ± 0.021	1.247ThrTyr: 1.247 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	12.657ValAla: 12.657 ± 0.086	0.716ValCys: 0.716 ± 0.018	5.738ValAsp: 5.738 ± 0.058	4.798ValGlu: 4.798 ± 0.057	2.408ValPhe: 2.408 ± 0.031	7.566ValGly: 7.566 ± 0.064	1.838ValHis: 1.838 ± 0.03	3.113ValIle: 3.113 ± 0.038	1.523ValLys: 1.523 ± 0.031	9.791ValLeu: 9.791 ± 0.088	1.24ValMet: 1.24 ± 0.029	1.727ValAsn: 1.727 ± 0.032	5.474ValPro: 5.474 ± 0.062	2.073ValGln: 2.073 ± 0.03	7.286ValArg: 7.286 ± 0.067	4.285ValSer: 4.285 ± 0.051	5.805ValThr: 5.805 ± 0.068	8.84ValVal: 8.84 ± 0.083	1.125ValTrp: 1.125 ± 0.026	1.543ValTyr: 1.543 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.802TrpAla: 1.802 ± 0.035	0.16TrpCys: 0.16 ± 0.008	0.771TrpAsp: 0.771 ± 0.02	0.623TrpGlu: 0.623 ± 0.019	0.536TrpPhe: 0.536 ± 0.016	0.98TrpGly: 0.98 ± 0.02	0.418TrpHis: 0.418 ± 0.015	0.553TrpIle: 0.553 ± 0.016	0.29TrpLys: 0.29 ± 0.011	2.051TrpLeu: 2.051 ± 0.032	0.281TrpMet: 0.281 ± 0.012	0.382TrpAsn: 0.382 ± 0.014	0.927TrpPro: 0.927 ± 0.023	0.671TrpGln: 0.671 ± 0.018	1.705TrpArg: 1.705 ± 0.031	1.024TrpSer: 1.024 ± 0.025	0.982TrpThr: 0.982 ± 0.021	1.148TrpVal: 1.148 ± 0.024	0.39TrpTrp: 0.39 ± 0.016	0.394TrpTyr: 0.394 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.858TyrAla: 2.858 ± 0.033	0.177TyrCys: 0.177 ± 0.01	1.454TyrAsp: 1.454 ± 0.027	1.068TyrGlu: 1.068 ± 0.024	0.624TyrPhe: 0.624 ± 0.017	2.156TyrGly: 2.156 ± 0.035	0.467TyrHis: 0.467 ± 0.015	0.464TyrIle: 0.464 ± 0.015	0.315TyrLys: 0.315 ± 0.012	2.327TyrLeu: 2.327 ± 0.038	0.195TyrMet: 0.195 ± 0.01	0.39TyrAsn: 0.39 ± 0.016	1.261TyrPro: 1.261 ± 0.027	0.692TyrGln: 0.692 ± 0.018	1.935TyrArg: 1.935 ± 0.033	0.883TyrSer: 0.883 ± 0.024	1.055TyrThr: 1.055 ± 0.025	1.739TyrVal: 1.739 ± 0.031	0.353TyrTrp: 0.353 ± 0.014	0.439TyrTyr: 0.439 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6395 proteins (2039900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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