Amino acid dipepetide frequency for Penaeus monodon nudivirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.24AlaAla: 2.24 ± 0.25
0.843AlaCys: 0.843 ± 0.137
1.845AlaAsp: 1.845 ± 0.264
1.977AlaGlu: 1.977 ± 0.203
2.029AlaPhe: 2.029 ± 0.274
1.239AlaGly: 1.239 ± 0.158
0.791AlaHis: 0.791 ± 0.171
3.742AlaIle: 3.742 ± 0.333
3.321AlaLys: 3.321 ± 0.446
4.085AlaLeu: 4.085 ± 0.367
1.107AlaMet: 1.107 ± 0.181
3.716AlaAsn: 3.716 ± 0.32
1.397AlaPro: 1.397 ± 0.19
1.002AlaGln: 1.002 ± 0.151
1.239AlaArg: 1.239 ± 0.191
3.637AlaSer: 3.637 ± 0.312
2.846AlaThr: 2.846 ± 0.285
2.214AlaVal: 2.214 ± 0.248
0.343AlaTrp: 0.343 ± 0.09
2.029AlaTyr: 2.029 ± 0.283
0.0AlaXaa: 0.0 ± 0.0
Cys
0.685CysAla: 0.685 ± 0.145
0.316CysCys: 0.316 ± 0.088
1.133CysAsp: 1.133 ± 0.229
0.843CysGlu: 0.843 ± 0.128
0.738CysPhe: 0.738 ± 0.149
0.527CysGly: 0.527 ± 0.097
0.158CysHis: 0.158 ± 0.06
1.819CysIle: 1.819 ± 0.193
2.24CysLys: 2.24 ± 0.296
1.265CysLeu: 1.265 ± 0.168
0.316CysMet: 0.316 ± 0.09
1.792CysAsn: 1.792 ± 0.227
0.527CysPro: 0.527 ± 0.106
0.395CysGln: 0.395 ± 0.118
0.738CysArg: 0.738 ± 0.15
1.555CysSer: 1.555 ± 0.241
1.239CysThr: 1.239 ± 0.196
0.58CysVal: 0.58 ± 0.124
0.158CysTrp: 0.158 ± 0.06
0.922CysTyr: 0.922 ± 0.151
0.0CysXaa: 0.0 ± 0.0
Asp
2.609AspAla: 2.609 ± 0.275
1.054AspCys: 1.054 ± 0.164
5.666AspAsp: 5.666 ± 0.565
4.217AspGlu: 4.217 ± 0.372
2.636AspPhe: 2.636 ± 0.278
2.688AspGly: 2.688 ± 0.272
1.107AspHis: 1.107 ± 0.149
5.034AspIle: 5.034 ± 0.336
4.375AspLys: 4.375 ± 0.387
5.113AspLeu: 5.113 ± 0.413
1.871AspMet: 1.871 ± 0.259
4.533AspAsn: 4.533 ± 0.382
1.634AspPro: 1.634 ± 0.273
1.45AspGln: 1.45 ± 0.156
2.135AspArg: 2.135 ± 0.194
4.085AspSer: 4.085 ± 0.348
4.322AspThr: 4.322 ± 0.337
4.349AspVal: 4.349 ± 0.341
0.527AspTrp: 0.527 ± 0.104
3.057AspTyr: 3.057 ± 0.238
0.0AspXaa: 0.0 ± 0.0
Glu
2.451GluAla: 2.451 ± 0.245
1.002GluCys: 1.002 ± 0.142
4.48GluAsp: 4.48 ± 0.422
5.139GluGlu: 5.139 ± 0.621
3.479GluPhe: 3.479 ± 0.274
1.66GluGly: 1.66 ± 0.286
0.87GluHis: 0.87 ± 0.135
4.19GluIle: 4.19 ± 0.29
3.69GluLys: 3.69 ± 0.47
5.693GluLeu: 5.693 ± 0.323
1.871GluMet: 1.871 ± 0.245
3.953GluAsn: 3.953 ± 0.352
1.95GluPro: 1.95 ± 0.256
1.45GluGln: 1.45 ± 0.192
2.24GluArg: 2.24 ± 0.22
4.401GluSer: 4.401 ± 0.377
2.925GluThr: 2.925 ± 0.289
4.111GluVal: 4.111 ± 0.42
0.422GluTrp: 0.422 ± 0.106
3.373GluTyr: 3.373 ± 0.233
0.0GluXaa: 0.0 ± 0.0
Phe
2.029PheAla: 2.029 ± 0.246
0.87PheCys: 0.87 ± 0.142
3.347PheAsp: 3.347 ± 0.244
2.978PheGlu: 2.978 ± 0.246
1.739PhePhe: 1.739 ± 0.221
1.397PheGly: 1.397 ± 0.229
1.16PheHis: 1.16 ± 0.171
4.639PheIle: 4.639 ± 0.336
3.953PheLys: 3.953 ± 0.328
3.927PheLeu: 3.927 ± 0.389
1.291PheMet: 1.291 ± 0.186
4.612PheAsn: 4.612 ± 0.369
1.186PhePro: 1.186 ± 0.185
1.212PheGln: 1.212 ± 0.168
1.397PheArg: 1.397 ± 0.196
3.69PheSer: 3.69 ± 0.337
3.505PheThr: 3.505 ± 0.342
2.293PheVal: 2.293 ± 0.252
0.29PheTrp: 0.29 ± 0.079
2.609PheTyr: 2.609 ± 0.309
0.0PheXaa: 0.0 ± 0.0
Gly
1.16GlyAla: 1.16 ± 0.192
0.685GlyCys: 0.685 ± 0.15
2.214GlyAsp: 2.214 ± 0.202
1.397GlyGlu: 1.397 ± 0.208
1.739GlyPhe: 1.739 ± 0.198
1.66GlyGly: 1.66 ± 0.274
0.501GlyHis: 0.501 ± 0.116
3.294GlyIle: 3.294 ± 0.306
3.005GlyLys: 3.005 ± 0.303
2.425GlyLeu: 2.425 ± 0.261
0.817GlyMet: 0.817 ± 0.151
2.161GlyAsn: 2.161 ± 0.215
0.738GlyPro: 0.738 ± 0.13
1.054GlyGln: 1.054 ± 0.161
1.16GlyArg: 1.16 ± 0.173
2.925GlySer: 2.925 ± 0.285
2.161GlyThr: 2.161 ± 0.232
2.372GlyVal: 2.372 ± 0.251
0.158GlyTrp: 0.158 ± 0.06
1.555GlyTyr: 1.555 ± 0.274
0.0GlyXaa: 0.0 ± 0.0
His
0.843HisAla: 0.843 ± 0.117
0.474HisCys: 0.474 ± 0.092
1.212HisAsp: 1.212 ± 0.177
1.107HisGlu: 1.107 ± 0.181
1.291HisPhe: 1.291 ± 0.151
0.712HisGly: 0.712 ± 0.142
0.659HisHis: 0.659 ± 0.106
1.845HisIle: 1.845 ± 0.215
1.397HisLys: 1.397 ± 0.204
2.029HisLeu: 2.029 ± 0.202
0.553HisMet: 0.553 ± 0.111
1.423HisAsn: 1.423 ± 0.186
0.712HisPro: 0.712 ± 0.145
0.659HisGln: 0.659 ± 0.14
0.712HisArg: 0.712 ± 0.129
1.344HisSer: 1.344 ± 0.194
1.397HisThr: 1.397 ± 0.229
0.817HisVal: 0.817 ± 0.198
0.158HisTrp: 0.158 ± 0.064
0.791HisTyr: 0.791 ± 0.146
0.0HisXaa: 0.0 ± 0.0
Ile
3.822IleAla: 3.822 ± 0.289
1.265IleCys: 1.265 ± 0.224
6.167IleAsp: 6.167 ± 0.335
5.166IleGlu: 5.166 ± 0.534
3.822IlePhe: 3.822 ± 0.254
2.82IleGly: 2.82 ± 0.317
1.898IleHis: 1.898 ± 0.221
7.538IleIle: 7.538 ± 0.486
8.091IleLys: 8.091 ± 0.484
7.564IleLeu: 7.564 ± 0.438
2.161IleMet: 2.161 ± 0.219
7.274IleAsn: 7.274 ± 0.443
3.769IlePro: 3.769 ± 0.347
2.477IleGln: 2.477 ± 0.295
2.978IleArg: 2.978 ± 0.334
6.984IleSer: 6.984 ± 0.479
4.77IleThr: 4.77 ± 0.363
4.559IleVal: 4.559 ± 0.33
0.58IleTrp: 0.58 ± 0.124
5.245IleTyr: 5.245 ± 0.288
0.0IleXaa: 0.0 ± 0.0
Lys
2.794LysAla: 2.794 ± 0.274
1.423LysCys: 1.423 ± 0.247
4.085LysAsp: 4.085 ± 0.276
4.823LysGlu: 4.823 ± 0.438
4.243LysPhe: 4.243 ± 0.391
1.766LysGly: 1.766 ± 0.222
1.634LysHis: 1.634 ± 0.179
6.615LysIle: 6.615 ± 0.479
5.561LysLys: 5.561 ± 0.455
8.539LysLeu: 8.539 ± 0.438
2.161LysMet: 2.161 ± 0.243
6.352LysAsn: 6.352 ± 0.403
3.663LysPro: 3.663 ± 1.022
2.319LysGln: 2.319 ± 0.247
3.11LysArg: 3.11 ± 0.32
5.666LysSer: 5.666 ± 0.386
4.876LysThr: 4.876 ± 0.524
4.032LysVal: 4.032 ± 0.393
0.606LysTrp: 0.606 ± 0.104
4.928LysTyr: 4.928 ± 0.352
0.0LysXaa: 0.0 ± 0.0
Leu
4.164LeuAla: 4.164 ± 0.426
1.634LeuCys: 1.634 ± 0.197
5.561LeuAsp: 5.561 ± 0.359
4.718LeuGlu: 4.718 ± 0.437
4.375LeuPhe: 4.375 ± 0.283
2.583LeuGly: 2.583 ± 0.255
2.214LeuHis: 2.214 ± 0.221
6.905LeuIle: 6.905 ± 0.416
7.116LeuLys: 7.116 ± 0.473
8.381LeuLeu: 8.381 ± 0.653
2.504LeuMet: 2.504 ± 0.295
7.063LeuAsn: 7.063 ± 0.378
3.584LeuPro: 3.584 ± 0.375
2.609LeuGln: 2.609 ± 0.344
3.347LeuArg: 3.347 ± 0.286
6.299LeuSer: 6.299 ± 0.402
4.981LeuThr: 4.981 ± 0.341
4.797LeuVal: 4.797 ± 0.351
0.712LeuTrp: 0.712 ± 0.135
4.876LeuTyr: 4.876 ± 0.398
0.0LeuXaa: 0.0 ± 0.0
Met
1.239MetAla: 1.239 ± 0.185
0.448MetCys: 0.448 ± 0.102
1.766MetAsp: 1.766 ± 0.246
2.214MetGlu: 2.214 ± 0.24
1.239MetPhe: 1.239 ± 0.189
1.002MetGly: 1.002 ± 0.153
0.633MetHis: 0.633 ± 0.113
2.319MetIle: 2.319 ± 0.25
2.583MetLys: 2.583 ± 0.283
1.977MetLeu: 1.977 ± 0.199
1.186MetMet: 1.186 ± 0.178
2.161MetAsn: 2.161 ± 0.224
1.002MetPro: 1.002 ± 0.22
0.843MetGln: 0.843 ± 0.139
0.896MetArg: 0.896 ± 0.177
2.135MetSer: 2.135 ± 0.249
1.476MetThr: 1.476 ± 0.185
1.239MetVal: 1.239 ± 0.199
0.211MetTrp: 0.211 ± 0.078
1.16MetTyr: 1.16 ± 0.164
0.0MetXaa: 0.0 ± 0.0
Asn
3.294AsnAla: 3.294 ± 0.285
1.081AsnCys: 1.081 ± 0.128
4.322AsnAsp: 4.322 ± 0.355
4.454AsnGlu: 4.454 ± 0.356
3.505AsnPhe: 3.505 ± 0.33
2.767AsnGly: 2.767 ± 0.273
1.239AsnHis: 1.239 ± 0.191
7.59AsnIle: 7.59 ± 0.607
5.956AsnLys: 5.956 ± 0.436
6.721AsnLeu: 6.721 ± 0.458
2.24AsnMet: 2.24 ± 0.199
5.666AsnAsn: 5.666 ± 0.558
2.767AsnPro: 2.767 ± 0.335
2.504AsnGln: 2.504 ± 0.297
2.636AsnArg: 2.636 ± 0.28
6.246AsnSer: 6.246 ± 0.336
5.508AsnThr: 5.508 ± 0.407
4.586AsnVal: 4.586 ± 0.332
0.606AsnTrp: 0.606 ± 0.11
3.901AsnTyr: 3.901 ± 0.337
0.0AsnXaa: 0.0 ± 0.0
Pro
1.133ProAla: 1.133 ± 0.175
0.422ProCys: 0.422 ± 0.113
1.792ProAsp: 1.792 ± 0.244
1.977ProGlu: 1.977 ± 0.268
1.423ProPhe: 1.423 ± 0.174
1.054ProGly: 1.054 ± 0.153
0.606ProHis: 0.606 ± 0.144
3.874ProIle: 3.874 ± 0.496
2.636ProLys: 2.636 ± 0.255
3.347ProLeu: 3.347 ± 0.315
0.712ProMet: 0.712 ± 0.103
1.977ProAsn: 1.977 ± 0.241
1.529ProPro: 1.529 ± 0.278
1.212ProGln: 1.212 ± 0.18
1.16ProArg: 1.16 ± 0.157
3.136ProSer: 3.136 ± 0.274
3.373ProThr: 3.373 ± 0.777
1.766ProVal: 1.766 ± 0.236
0.211ProTrp: 0.211 ± 0.076
1.634ProTyr: 1.634 ± 0.266
0.0ProXaa: 0.0 ± 0.0
Gln
1.133GlnAla: 1.133 ± 0.161
0.685GlnCys: 0.685 ± 0.111
1.397GlnAsp: 1.397 ± 0.15
1.713GlnGlu: 1.713 ± 0.177
1.265GlnPhe: 1.265 ± 0.145
0.685GlnGly: 0.685 ± 0.111
0.659GlnHis: 0.659 ± 0.138
2.24GlnIle: 2.24 ± 0.255
2.056GlnLys: 2.056 ± 0.242
2.925GlnLeu: 2.925 ± 0.288
0.87GlnMet: 0.87 ± 0.154
2.161GlnAsn: 2.161 ± 0.239
1.186GlnPro: 1.186 ± 0.163
1.291GlnGln: 1.291 ± 0.188
0.87GlnArg: 0.87 ± 0.177
2.029GlnSer: 2.029 ± 0.208
1.555GlnThr: 1.555 ± 0.183
1.291GlnVal: 1.291 ± 0.195
0.264GlnTrp: 0.264 ± 0.068
2.187GlnTyr: 2.187 ± 0.269
0.0GlnXaa: 0.0 ± 0.0
Arg
1.423ArgAla: 1.423 ± 0.174
0.764ArgCys: 0.764 ± 0.164
1.845ArgAsp: 1.845 ± 0.218
2.161ArgGlu: 2.161 ± 0.243
1.713ArgPhe: 1.713 ± 0.212
1.265ArgGly: 1.265 ± 0.2
0.764ArgHis: 0.764 ± 0.131
2.662ArgIle: 2.662 ± 0.263
2.952ArgLys: 2.952 ± 0.26
3.031ArgLeu: 3.031 ± 0.282
1.107ArgMet: 1.107 ± 0.166
2.688ArgAsn: 2.688 ± 0.227
1.318ArgPro: 1.318 ± 0.198
1.028ArgGln: 1.028 ± 0.19
1.265ArgArg: 1.265 ± 0.189
2.767ArgSer: 2.767 ± 0.294
1.924ArgThr: 1.924 ± 0.19
1.977ArgVal: 1.977 ± 0.24
0.158ArgTrp: 0.158 ± 0.076
2.056ArgTyr: 2.056 ± 0.226
0.0ArgXaa: 0.0 ± 0.0
Ser
3.031SerAla: 3.031 ± 0.307
1.555SerCys: 1.555 ± 0.207
4.981SerAsp: 4.981 ± 0.409
4.217SerGlu: 4.217 ± 0.339
3.584SerPhe: 3.584 ± 0.264
2.794SerGly: 2.794 ± 0.312
1.318SerHis: 1.318 ± 0.204
8.117SerIle: 8.117 ± 0.421
6.299SerLys: 6.299 ± 0.385
6.062SerLeu: 6.062 ± 0.465
2.108SerMet: 2.108 ± 0.214
5.798SerAsn: 5.798 ± 0.432
1.739SerPro: 1.739 ± 0.198
2.003SerGln: 2.003 ± 0.193
2.767SerArg: 2.767 ± 0.295
6.747SerSer: 6.747 ± 0.476
5.482SerThr: 5.482 ± 0.359
4.718SerVal: 4.718 ± 0.422
0.29SerTrp: 0.29 ± 0.082
3.532SerTyr: 3.532 ± 0.348
0.0SerXaa: 0.0 ± 0.0
Thr
2.636ThrAla: 2.636 ± 0.386
0.922ThrCys: 0.922 ± 0.151
3.268ThrAsp: 3.268 ± 0.369
3.031ThrGlu: 3.031 ± 0.357
3.031ThrPhe: 3.031 ± 0.229
2.24ThrGly: 2.24 ± 0.252
1.397ThrHis: 1.397 ± 0.204
5.904ThrIle: 5.904 ± 0.377
4.849ThrLys: 4.849 ± 0.394
6.536ThrLeu: 6.536 ± 0.385
1.502ThrMet: 1.502 ± 0.219
4.718ThrAsn: 4.718 ± 0.33
2.504ThrPro: 2.504 ± 0.27
1.608ThrGln: 1.608 ± 0.176
2.319ThrArg: 2.319 ± 0.25
4.744ThrSer: 4.744 ± 0.323
5.35ThrThr: 5.35 ± 0.544
3.242ThrVal: 3.242 ± 0.287
0.448ThrTrp: 0.448 ± 0.111
3.321ThrTyr: 3.321 ± 0.266
0.0ThrXaa: 0.0 ± 0.0
Val
2.688ValAla: 2.688 ± 0.324
1.423ValCys: 1.423 ± 0.244
3.321ValAsp: 3.321 ± 0.269
3.716ValGlu: 3.716 ± 0.35
3.215ValPhe: 3.215 ± 0.351
2.161ValGly: 2.161 ± 0.296
1.133ValHis: 1.133 ± 0.153
4.559ValIle: 4.559 ± 0.379
3.848ValLys: 3.848 ± 0.353
4.612ValLeu: 4.612 ± 0.391
1.66ValMet: 1.66 ± 0.196
3.663ValAsn: 3.663 ± 0.291
2.003ValPro: 2.003 ± 0.218
1.529ValGln: 1.529 ± 0.17
1.608ValArg: 1.608 ± 0.209
4.797ValSer: 4.797 ± 0.32
2.767ValThr: 2.767 ± 0.319
3.927ValVal: 3.927 ± 0.397
0.422ValTrp: 0.422 ± 0.108
2.899ValTyr: 2.899 ± 0.252
0.0ValXaa: 0.0 ± 0.0
Trp
0.184TrpAla: 0.184 ± 0.066
0.079TrpCys: 0.079 ± 0.058
0.527TrpAsp: 0.527 ± 0.113
0.264TrpGlu: 0.264 ± 0.099
0.343TrpPhe: 0.343 ± 0.104
0.237TrpGly: 0.237 ± 0.085
0.132TrpHis: 0.132 ± 0.048
0.553TrpIle: 0.553 ± 0.123
0.58TrpLys: 0.58 ± 0.13
0.395TrpLeu: 0.395 ± 0.108
0.29TrpMet: 0.29 ± 0.073
0.738TrpAsn: 0.738 ± 0.141
0.264TrpPro: 0.264 ± 0.08
0.264TrpGln: 0.264 ± 0.082
0.29TrpArg: 0.29 ± 0.1
0.659TrpSer: 0.659 ± 0.118
0.527TrpThr: 0.527 ± 0.132
0.184TrpVal: 0.184 ± 0.072
0.026TrpTrp: 0.026 ± 0.026
0.422TrpTyr: 0.422 ± 0.096
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.082TyrAla: 2.082 ± 0.288
1.002TyrCys: 1.002 ± 0.138
3.532TyrAsp: 3.532 ± 0.337
3.242TyrGlu: 3.242 ± 0.304
2.715TyrPhe: 2.715 ± 0.294
1.924TyrGly: 1.924 ± 0.215
1.265TyrHis: 1.265 ± 0.139
5.508TyrIle: 5.508 ± 0.414
4.691TyrLys: 4.691 ± 0.385
3.795TyrLeu: 3.795 ± 0.406
1.37TyrMet: 1.37 ± 0.2
5.166TyrAsn: 5.166 ± 0.41
1.502TyrPro: 1.502 ± 0.228
1.555TyrGln: 1.555 ± 0.174
2.003TyrArg: 2.003 ± 0.208
3.294TyrSer: 3.294 ± 0.281
2.583TyrThr: 2.583 ± 0.259
2.899TyrVal: 2.899 ± 0.308
0.369TyrTrp: 0.369 ± 0.094
2.846TyrTyr: 2.846 ± 0.323
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 115 proteins (37944 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski