Amino acid dipepetide frequency for Ochrobactrum phage POA1180

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.328AlaAla: 15.328 ± 1.751
0.467AlaCys: 0.467 ± 0.166
6.614AlaAsp: 6.614 ± 1.018
8.559AlaGlu: 8.559 ± 1.199
3.968AlaPhe: 3.968 ± 0.42
8.715AlaGly: 8.715 ± 1.05
1.712AlaHis: 1.712 ± 0.394
7.703AlaIle: 7.703 ± 0.904
7.547AlaLys: 7.547 ± 1.202
9.415AlaLeu: 9.415 ± 1.083
3.346AlaMet: 3.346 ± 0.536
3.657AlaAsn: 3.657 ± 0.481
3.735AlaPro: 3.735 ± 0.462
4.98AlaGln: 4.98 ± 0.685
6.847AlaArg: 6.847 ± 0.784
5.602AlaSer: 5.602 ± 0.662
5.369AlaThr: 5.369 ± 0.871
7.236AlaVal: 7.236 ± 0.707
1.478AlaTrp: 1.478 ± 0.367
2.179AlaTyr: 2.179 ± 0.488
0.0AlaXaa: 0.0 ± 0.0
Cys
1.012CysAla: 1.012 ± 0.263
0.156CysCys: 0.156 ± 0.117
0.233CysAsp: 0.233 ± 0.121
0.622CysGlu: 0.622 ± 0.209
0.156CysPhe: 0.156 ± 0.114
0.622CysGly: 0.622 ± 0.215
0.0CysHis: 0.0 ± 0.0
0.467CysIle: 0.467 ± 0.182
0.233CysLys: 0.233 ± 0.125
0.467CysLeu: 0.467 ± 0.176
0.156CysMet: 0.156 ± 0.128
0.078CysAsn: 0.078 ± 0.074
0.311CysPro: 0.311 ± 0.125
0.233CysGln: 0.233 ± 0.122
0.156CysArg: 0.156 ± 0.102
0.467CysSer: 0.467 ± 0.173
0.467CysThr: 0.467 ± 0.205
0.311CysVal: 0.311 ± 0.168
0.0CysTrp: 0.0 ± 0.0
0.311CysTyr: 0.311 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
7.859AspAla: 7.859 ± 0.582
0.311AspCys: 0.311 ± 0.218
3.424AspAsp: 3.424 ± 0.572
3.112AspGlu: 3.112 ± 0.434
2.49AspPhe: 2.49 ± 0.462
6.069AspGly: 6.069 ± 0.817
1.167AspHis: 1.167 ± 0.28
3.89AspIle: 3.89 ± 0.55
2.256AspLys: 2.256 ± 0.418
5.291AspLeu: 5.291 ± 0.482
0.7AspMet: 0.7 ± 0.208
1.79AspAsn: 1.79 ± 0.4
3.657AspPro: 3.657 ± 0.493
2.179AspGln: 2.179 ± 0.386
4.746AspArg: 4.746 ± 0.66
1.556AspSer: 1.556 ± 0.35
2.646AspThr: 2.646 ± 0.393
3.89AspVal: 3.89 ± 0.469
0.7AspTrp: 0.7 ± 0.234
2.179AspTyr: 2.179 ± 0.397
0.0AspXaa: 0.0 ± 0.0
Glu
8.637GluAla: 8.637 ± 1.404
0.311GluCys: 0.311 ± 0.159
2.879GluAsp: 2.879 ± 0.361
3.813GluGlu: 3.813 ± 0.548
3.19GluPhe: 3.19 ± 0.435
3.579GluGly: 3.579 ± 0.528
1.556GluHis: 1.556 ± 0.463
4.98GluIle: 4.98 ± 0.56
3.501GluLys: 3.501 ± 0.374
6.458GluLeu: 6.458 ± 0.721
1.478GluMet: 1.478 ± 0.31
1.556GluAsn: 1.556 ± 0.433
3.501GluPro: 3.501 ± 0.578
2.723GluGln: 2.723 ± 0.546
4.902GluArg: 4.902 ± 0.752
1.79GluSer: 1.79 ± 0.367
4.98GluThr: 4.98 ± 0.585
4.202GluVal: 4.202 ± 0.584
1.401GluTrp: 1.401 ± 0.397
1.478GluTyr: 1.478 ± 0.313
0.0GluXaa: 0.0 ± 0.0
Phe
3.657PheAla: 3.657 ± 0.61
0.545PheCys: 0.545 ± 0.193
3.268PheAsp: 3.268 ± 0.437
2.49PheGlu: 2.49 ± 0.427
1.401PhePhe: 1.401 ± 0.284
4.046PheGly: 4.046 ± 0.736
0.545PheHis: 0.545 ± 0.178
1.712PheIle: 1.712 ± 0.405
1.945PheLys: 1.945 ± 0.297
2.334PheLeu: 2.334 ± 0.41
0.778PheMet: 0.778 ± 0.248
1.245PheAsn: 1.245 ± 0.364
1.478PhePro: 1.478 ± 0.355
1.401PheGln: 1.401 ± 0.383
2.023PheArg: 2.023 ± 0.391
3.19PheSer: 3.19 ± 0.513
2.023PheThr: 2.023 ± 0.706
3.035PheVal: 3.035 ± 0.5
0.622PheTrp: 0.622 ± 0.219
1.012PheTyr: 1.012 ± 0.274
0.0PheXaa: 0.0 ± 0.0
Gly
6.458GlyAla: 6.458 ± 0.953
0.622GlyCys: 0.622 ± 0.212
4.357GlyAsp: 4.357 ± 0.629
4.746GlyGlu: 4.746 ± 0.576
2.879GlyPhe: 2.879 ± 0.428
6.769GlyGly: 6.769 ± 1.017
1.089GlyHis: 1.089 ± 0.3
5.213GlyIle: 5.213 ± 0.751
5.836GlyLys: 5.836 ± 0.651
5.913GlyLeu: 5.913 ± 0.729
1.634GlyMet: 1.634 ± 0.375
2.179GlyAsn: 2.179 ± 0.466
2.256GlyPro: 2.256 ± 0.42
2.49GlyGln: 2.49 ± 0.483
5.991GlyArg: 5.991 ± 0.708
5.135GlySer: 5.135 ± 0.627
4.202GlyThr: 4.202 ± 0.634
6.069GlyVal: 6.069 ± 0.697
1.401GlyTrp: 1.401 ± 0.459
2.101GlyTyr: 2.101 ± 0.517
0.0GlyXaa: 0.0 ± 0.0
His
1.478HisAla: 1.478 ± 0.373
0.233HisCys: 0.233 ± 0.128
1.012HisAsp: 1.012 ± 0.245
1.556HisGlu: 1.556 ± 0.314
0.778HisPhe: 0.778 ± 0.183
1.245HisGly: 1.245 ± 0.282
0.156HisHis: 0.156 ± 0.107
0.778HisIle: 0.778 ± 0.229
0.7HisLys: 0.7 ± 0.225
1.401HisLeu: 1.401 ± 0.359
0.467HisMet: 0.467 ± 0.157
0.622HisAsn: 0.622 ± 0.168
0.856HisPro: 0.856 ± 0.279
0.311HisGln: 0.311 ± 0.194
1.478HisArg: 1.478 ± 0.305
0.622HisSer: 0.622 ± 0.252
1.012HisThr: 1.012 ± 0.255
1.089HisVal: 1.089 ± 0.262
0.311HisTrp: 0.311 ± 0.16
0.467HisTyr: 0.467 ± 0.191
0.0HisXaa: 0.0 ± 0.0
Ile
8.248IleAla: 8.248 ± 0.816
0.7IleCys: 0.7 ± 0.235
5.369IleAsp: 5.369 ± 0.53
4.824IleGlu: 4.824 ± 0.562
1.556IlePhe: 1.556 ± 0.341
4.98IleGly: 4.98 ± 0.626
0.7IleHis: 0.7 ± 0.208
4.279IleIle: 4.279 ± 0.606
2.723IleLys: 2.723 ± 0.473
3.968IleLeu: 3.968 ± 0.48
0.622IleMet: 0.622 ± 0.202
2.49IleAsn: 2.49 ± 0.46
2.256IlePro: 2.256 ± 0.382
1.945IleGln: 1.945 ± 0.429
4.435IleArg: 4.435 ± 0.659
3.968IleSer: 3.968 ± 0.542
3.735IleThr: 3.735 ± 0.61
4.202IleVal: 4.202 ± 0.521
0.389IleTrp: 0.389 ± 0.191
1.245IleTyr: 1.245 ± 0.355
0.0IleXaa: 0.0 ± 0.0
Lys
7.703LysAla: 7.703 ± 1.381
0.156LysCys: 0.156 ± 0.121
2.101LysAsp: 2.101 ± 0.49
2.879LysGlu: 2.879 ± 0.438
1.478LysPhe: 1.478 ± 0.404
4.357LysGly: 4.357 ± 0.589
0.778LysHis: 0.778 ± 0.247
2.879LysIle: 2.879 ± 0.416
2.334LysLys: 2.334 ± 0.429
5.447LysLeu: 5.447 ± 0.575
0.622LysMet: 0.622 ± 0.17
2.023LysAsn: 2.023 ± 0.406
2.957LysPro: 2.957 ± 0.476
1.556LysGln: 1.556 ± 0.375
4.202LysArg: 4.202 ± 0.722
2.179LysSer: 2.179 ± 0.381
2.49LysThr: 2.49 ± 0.483
2.568LysVal: 2.568 ± 0.386
0.467LysTrp: 0.467 ± 0.224
0.467LysTyr: 0.467 ± 0.17
0.0LysXaa: 0.0 ± 0.0
Leu
9.181LeuAla: 9.181 ± 0.985
0.622LeuCys: 0.622 ± 0.292
5.836LeuAsp: 5.836 ± 0.695
5.369LeuGlu: 5.369 ± 0.59
2.957LeuPhe: 2.957 ± 0.489
6.069LeuGly: 6.069 ± 0.753
1.401LeuHis: 1.401 ± 0.319
3.735LeuIle: 3.735 ± 0.588
4.046LeuLys: 4.046 ± 0.596
6.225LeuLeu: 6.225 ± 1.058
2.023LeuMet: 2.023 ± 0.431
3.579LeuAsn: 3.579 ± 0.641
4.824LeuPro: 4.824 ± 0.62
3.19LeuGln: 3.19 ± 0.461
5.913LeuArg: 5.913 ± 0.581
6.38LeuSer: 6.38 ± 0.757
4.124LeuThr: 4.124 ± 0.547
5.213LeuVal: 5.213 ± 0.699
1.556LeuTrp: 1.556 ± 0.378
1.323LeuTyr: 1.323 ± 0.329
0.0LeuXaa: 0.0 ± 0.0
Met
2.334MetAla: 2.334 ± 0.47
0.233MetCys: 0.233 ± 0.115
0.856MetAsp: 0.856 ± 0.234
1.245MetGlu: 1.245 ± 0.322
0.856MetPhe: 0.856 ± 0.233
1.478MetGly: 1.478 ± 0.435
0.389MetHis: 0.389 ± 0.181
1.245MetIle: 1.245 ± 0.345
1.089MetLys: 1.089 ± 0.296
1.478MetLeu: 1.478 ± 0.292
0.311MetMet: 0.311 ± 0.133
0.856MetAsn: 0.856 ± 0.275
1.478MetPro: 1.478 ± 0.389
0.856MetGln: 0.856 ± 0.267
1.089MetArg: 1.089 ± 0.281
2.179MetSer: 2.179 ± 0.425
1.79MetThr: 1.79 ± 0.428
1.089MetVal: 1.089 ± 0.29
0.233MetTrp: 0.233 ± 0.124
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.957AsnAla: 2.957 ± 0.396
0.389AsnCys: 0.389 ± 0.15
1.634AsnAsp: 1.634 ± 0.37
2.412AsnGlu: 2.412 ± 0.499
1.323AsnPhe: 1.323 ± 0.293
4.279AsnGly: 4.279 ± 0.583
0.7AsnHis: 0.7 ± 0.204
2.179AsnIle: 2.179 ± 0.435
1.245AsnLys: 1.245 ± 0.335
2.568AsnLeu: 2.568 ± 0.488
0.389AsnMet: 0.389 ± 0.161
1.012AsnAsn: 1.012 ± 0.238
2.256AsnPro: 2.256 ± 0.34
1.478AsnGln: 1.478 ± 0.278
2.023AsnArg: 2.023 ± 0.396
1.79AsnSer: 1.79 ± 0.482
1.245AsnThr: 1.245 ± 0.287
2.49AsnVal: 2.49 ± 0.567
0.7AsnTrp: 0.7 ± 0.319
0.934AsnTyr: 0.934 ± 0.269
0.0AsnXaa: 0.0 ± 0.0
Pro
5.913ProAla: 5.913 ± 0.645
0.156ProCys: 0.156 ± 0.096
3.268ProAsp: 3.268 ± 0.458
4.202ProGlu: 4.202 ± 0.43
2.49ProPhe: 2.49 ± 0.437
2.646ProGly: 2.646 ± 0.471
1.012ProHis: 1.012 ± 0.314
3.035ProIle: 3.035 ± 0.495
2.412ProLys: 2.412 ± 0.486
3.501ProLeu: 3.501 ± 0.481
1.167ProMet: 1.167 ± 0.279
1.712ProAsn: 1.712 ± 0.415
2.179ProPro: 2.179 ± 0.41
1.556ProGln: 1.556 ± 0.304
2.256ProArg: 2.256 ± 0.384
2.801ProSer: 2.801 ± 0.476
2.179ProThr: 2.179 ± 0.281
4.046ProVal: 4.046 ± 0.59
0.389ProTrp: 0.389 ± 0.144
1.089ProTyr: 1.089 ± 0.245
0.0ProXaa: 0.0 ± 0.0
Gln
4.513GlnAla: 4.513 ± 0.757
0.156GlnCys: 0.156 ± 0.096
1.79GlnAsp: 1.79 ± 0.327
2.957GlnGlu: 2.957 ± 0.451
1.323GlnPhe: 1.323 ± 0.299
2.334GlnGly: 2.334 ± 0.413
0.7GlnHis: 0.7 ± 0.193
2.646GlnIle: 2.646 ± 0.449
1.167GlnLys: 1.167 ± 0.231
3.424GlnLeu: 3.424 ± 0.538
0.778GlnMet: 0.778 ± 0.267
1.089GlnAsn: 1.089 ± 0.319
1.634GlnPro: 1.634 ± 0.394
1.634GlnGln: 1.634 ± 0.356
2.023GlnArg: 2.023 ± 0.424
1.79GlnSer: 1.79 ± 0.282
2.179GlnThr: 2.179 ± 0.417
2.334GlnVal: 2.334 ± 0.484
0.389GlnTrp: 0.389 ± 0.136
0.778GlnTyr: 0.778 ± 0.216
0.0GlnXaa: 0.0 ± 0.0
Arg
7.937ArgAla: 7.937 ± 1.003
0.622ArgCys: 0.622 ± 0.295
3.813ArgAsp: 3.813 ± 0.687
4.046ArgGlu: 4.046 ± 0.635
3.19ArgPhe: 3.19 ± 0.587
3.968ArgGly: 3.968 ± 0.442
1.245ArgHis: 1.245 ± 0.237
4.046ArgIle: 4.046 ± 0.429
2.723ArgLys: 2.723 ± 0.454
7.547ArgLeu: 7.547 ± 0.78
1.167ArgMet: 1.167 ± 0.327
2.334ArgAsn: 2.334 ± 0.488
3.657ArgPro: 3.657 ± 0.515
2.957ArgGln: 2.957 ± 0.381
5.758ArgArg: 5.758 ± 0.629
4.046ArgSer: 4.046 ± 0.558
4.279ArgThr: 4.279 ± 0.673
4.591ArgVal: 4.591 ± 0.816
0.856ArgTrp: 0.856 ± 0.23
1.945ArgTyr: 1.945 ± 0.377
0.0ArgXaa: 0.0 ± 0.0
Ser
5.913SerAla: 5.913 ± 0.738
0.233SerCys: 0.233 ± 0.138
3.501SerAsp: 3.501 ± 0.404
4.669SerGlu: 4.669 ± 0.599
2.334SerPhe: 2.334 ± 0.395
4.202SerGly: 4.202 ± 0.557
0.934SerHis: 0.934 ± 0.241
3.968SerIle: 3.968 ± 0.548
2.879SerLys: 2.879 ± 0.409
4.824SerLeu: 4.824 ± 0.599
2.101SerMet: 2.101 ± 0.369
1.634SerAsn: 1.634 ± 0.439
2.412SerPro: 2.412 ± 0.461
1.712SerGln: 1.712 ± 0.371
3.968SerArg: 3.968 ± 0.567
3.268SerSer: 3.268 ± 0.56
2.179SerThr: 2.179 ± 0.444
4.046SerVal: 4.046 ± 0.676
1.012SerTrp: 1.012 ± 0.271
0.7SerTyr: 0.7 ± 0.222
0.0SerXaa: 0.0 ± 0.0
Thr
5.369ThrAla: 5.369 ± 0.757
0.078ThrCys: 0.078 ± 0.075
3.19ThrAsp: 3.19 ± 0.58
2.957ThrGlu: 2.957 ± 0.46
2.101ThrPhe: 2.101 ± 0.373
5.213ThrGly: 5.213 ± 0.759
0.934ThrHis: 0.934 ± 0.33
3.19ThrIle: 3.19 ± 0.544
2.179ThrLys: 2.179 ± 0.415
4.824ThrLeu: 4.824 ± 0.57
1.401ThrMet: 1.401 ± 0.356
2.179ThrAsn: 2.179 ± 0.4
2.412ThrPro: 2.412 ± 0.444
1.401ThrGln: 1.401 ± 0.317
4.046ThrArg: 4.046 ± 0.583
2.879ThrSer: 2.879 ± 0.44
2.334ThrThr: 2.334 ± 0.437
5.058ThrVal: 5.058 ± 0.919
0.622ThrTrp: 0.622 ± 0.197
1.401ThrTyr: 1.401 ± 0.251
0.0ThrXaa: 0.0 ± 0.0
Val
6.692ValAla: 6.692 ± 0.699
0.156ValCys: 0.156 ± 0.101
4.046ValAsp: 4.046 ± 0.638
4.746ValGlu: 4.746 ± 0.607
2.723ValPhe: 2.723 ± 0.579
3.813ValGly: 3.813 ± 0.494
1.401ValHis: 1.401 ± 0.335
4.046ValIle: 4.046 ± 0.432
3.346ValLys: 3.346 ± 0.561
4.824ValLeu: 4.824 ± 0.574
1.167ValMet: 1.167 ± 0.301
2.723ValAsn: 2.723 ± 0.384
3.89ValPro: 3.89 ± 0.478
2.023ValGln: 2.023 ± 0.415
6.147ValArg: 6.147 ± 0.752
4.591ValSer: 4.591 ± 0.568
4.279ValThr: 4.279 ± 0.854
3.968ValVal: 3.968 ± 0.441
1.012ValTrp: 1.012 ± 0.295
1.712ValTyr: 1.712 ± 0.284
0.0ValXaa: 0.0 ± 0.0
Trp
1.79TrpAla: 1.79 ± 0.436
0.078TrpCys: 0.078 ± 0.07
1.245TrpAsp: 1.245 ± 0.268
0.7TrpGlu: 0.7 ± 0.203
0.7TrpPhe: 0.7 ± 0.229
1.167TrpGly: 1.167 ± 0.235
0.0TrpHis: 0.0 ± 0.0
1.012TrpIle: 1.012 ± 0.288
0.545TrpLys: 0.545 ± 0.199
1.167TrpLeu: 1.167 ± 0.27
0.389TrpMet: 0.389 ± 0.185
0.311TrpAsn: 0.311 ± 0.153
0.856TrpPro: 0.856 ± 0.249
0.389TrpGln: 0.389 ± 0.199
0.856TrpArg: 0.856 ± 0.319
1.245TrpSer: 1.245 ± 0.244
1.089TrpThr: 1.089 ± 0.277
0.467TrpVal: 0.467 ± 0.172
0.622TrpTrp: 0.622 ± 0.334
0.233TrpTyr: 0.233 ± 0.13
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.478TyrAla: 1.478 ± 0.311
0.233TyrCys: 0.233 ± 0.135
1.478TyrAsp: 1.478 ± 0.355
1.012TyrGlu: 1.012 ± 0.269
0.856TyrPhe: 0.856 ± 0.301
1.79TyrGly: 1.79 ± 0.308
0.156TyrHis: 0.156 ± 0.104
1.634TyrIle: 1.634 ± 0.409
0.934TyrLys: 0.934 ± 0.287
2.49TyrLeu: 2.49 ± 0.445
0.311TyrMet: 0.311 ± 0.196
0.934TyrAsn: 0.934 ± 0.263
1.401TyrPro: 1.401 ± 0.321
0.622TyrGln: 0.622 ± 0.172
1.867TyrArg: 1.867 ± 0.315
1.012TyrSer: 1.012 ± 0.292
1.167TyrThr: 1.167 ± 0.26
1.401TyrVal: 1.401 ± 0.303
0.7TyrTrp: 0.7 ± 0.229
0.389TyrTyr: 0.389 ± 0.182
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (12853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski