Amino acid dipepetide frequency for Sphingomonas oligophenolica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.759AlaAla: 21.759 ± 0.235	1.026AlaCys: 1.026 ± 0.033	8.708AlaAsp: 8.708 ± 0.102	6.779AlaGlu: 6.779 ± 0.102	4.373AlaPhe: 4.373 ± 0.067	11.767AlaGly: 11.767 ± 0.142	2.547AlaHis: 2.547 ± 0.054	7.9AlaIle: 7.9 ± 0.099	4.343AlaLys: 4.343 ± 0.084	14.499AlaLeu: 14.499 ± 0.169	4.273AlaMet: 4.273 ± 0.075	3.263AlaAsn: 3.263 ± 0.066	6.688AlaPro: 6.688 ± 0.113	4.263AlaGln: 4.263 ± 0.08	10.39AlaArg: 10.39 ± 0.137	6.49AlaSer: 6.49 ± 0.098	8.389AlaThr: 8.389 ± 0.105	9.45AlaVal: 9.45 ± 0.121	1.752AlaTrp: 1.752 ± 0.045	2.645AlaTyr: 2.645 ± 0.053	0.001AlaXaa: 0.001 ± 0.001
Cys	1.025CysAla: 1.025 ± 0.037	0.087CysCys: 0.087 ± 0.011	0.554CysAsp: 0.554 ± 0.029	0.341CysGlu: 0.341 ± 0.019	0.268CysPhe: 0.268 ± 0.018	0.798CysGly: 0.798 ± 0.034	0.187CysHis: 0.187 ± 0.014	0.315CysIle: 0.315 ± 0.02	0.144CysLys: 0.144 ± 0.013	0.578CysLeu: 0.578 ± 0.022	0.136CysMet: 0.136 ± 0.011	0.18CysAsn: 0.18 ± 0.013	0.434CysPro: 0.434 ± 0.027	0.169CysGln: 0.169 ± 0.014	0.505CysArg: 0.505 ± 0.028	0.382CysSer: 0.382 ± 0.026	0.383CysThr: 0.383 ± 0.021	0.541CysVal: 0.541 ± 0.026	0.103CysTrp: 0.103 ± 0.011	0.16CysTyr: 0.16 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	9.059AspAla: 9.059 ± 0.115	0.444AspCys: 0.444 ± 0.027	4.063AspAsp: 4.063 ± 0.081	3.319AspGlu: 3.319 ± 0.062	2.084AspPhe: 2.084 ± 0.046	5.907AspGly: 5.907 ± 0.089	1.46AspHis: 1.46 ± 0.039	3.06AspIle: 3.06 ± 0.061	1.692AspLys: 1.692 ± 0.052	5.977AspLeu: 5.977 ± 0.085	1.283AspMet: 1.283 ± 0.041	1.295AspAsn: 1.295 ± 0.043	3.996AspPro: 3.996 ± 0.067	2.087AspGln: 2.087 ± 0.052	5.477AspArg: 5.477 ± 0.077	2.454AspSer: 2.454 ± 0.055	3.298AspThr: 3.298 ± 0.063	4.306AspVal: 4.306 ± 0.074	1.106AspTrp: 1.106 ± 0.033	1.643AspTyr: 1.643 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.919GluAla: 6.919 ± 0.11	0.26GluCys: 0.26 ± 0.017	2.396GluAsp: 2.396 ± 0.054	2.239GluGlu: 2.239 ± 0.06	1.298GluPhe: 1.298 ± 0.041	3.798GluGly: 3.798 ± 0.075	1.108GluHis: 1.108 ± 0.031	2.672GluIle: 2.672 ± 0.054	1.461GluLys: 1.461 ± 0.053	4.409GluLeu: 4.409 ± 0.073	1.262GluMet: 1.262 ± 0.038	1.13GluAsn: 1.13 ± 0.038	2.475GluPro: 2.475 ± 0.057	1.705GluGln: 1.705 ± 0.047	4.509GluArg: 4.509 ± 0.077	1.976GluSer: 1.976 ± 0.049	2.979GluThr: 2.979 ± 0.06	3.246GluVal: 3.246 ± 0.073	0.633GluTrp: 0.633 ± 0.024	0.792GluTyr: 0.792 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	5.132PheAla: 5.132 ± 0.083	0.281PheCys: 0.281 ± 0.019	2.696PheAsp: 2.696 ± 0.052	1.753PheGlu: 1.753 ± 0.043	1.204PhePhe: 1.204 ± 0.043	3.492PheGly: 3.492 ± 0.074	0.671PheHis: 0.671 ± 0.029	1.269PheIle: 1.269 ± 0.04	0.822PheLys: 0.822 ± 0.032	2.889PheLeu: 2.889 ± 0.056	0.661PheMet: 0.661 ± 0.028	0.802PheAsn: 0.802 ± 0.033	1.429PhePro: 1.429 ± 0.039	0.827PheGln: 0.827 ± 0.034	2.104PheArg: 2.104 ± 0.054	1.717PheSer: 1.717 ± 0.041	1.948PheThr: 1.948 ± 0.049	2.8PheVal: 2.8 ± 0.058	0.474PheTrp: 0.474 ± 0.024	0.872PheTyr: 0.872 ± 0.03	0.001PheXaa: 0.001 ± 0.001
Gly	10.419GlyAla: 10.419 ± 0.133	0.869GlyCys: 0.869 ± 0.036	5.39GlyAsp: 5.39 ± 0.085	4.435GlyGlu: 4.435 ± 0.078	3.588GlyPhe: 3.588 ± 0.079	8.404GlyGly: 8.404 ± 0.154	1.927GlyHis: 1.927 ± 0.046	4.707GlyIle: 4.707 ± 0.081	3.072GlyLys: 3.072 ± 0.068	8.201GlyLeu: 8.201 ± 0.101	2.306GlyMet: 2.306 ± 0.06	2.236GlyAsn: 2.236 ± 0.063	3.421GlyPro: 3.421 ± 0.064	2.725GlyGln: 2.725 ± 0.062	6.195GlyArg: 6.195 ± 0.084	4.766GlySer: 4.766 ± 0.086	5.158GlyThr: 5.158 ± 0.087	6.74GlyVal: 6.74 ± 0.099	1.646GlyTrp: 1.646 ± 0.047	2.451GlyTyr: 2.451 ± 0.062	0.001GlyXaa: 0.001 ± 0.001
His	2.69HisAla: 2.69 ± 0.052	0.194HisCys: 0.194 ± 0.016	1.455HisAsp: 1.455 ± 0.045	0.931HisGlu: 0.931 ± 0.033	0.768HisPhe: 0.768 ± 0.031	2.022HisGly: 2.022 ± 0.054	0.64HisHis: 0.64 ± 0.032	0.87HisIle: 0.87 ± 0.03	0.373HisLys: 0.373 ± 0.019	1.817HisLeu: 1.817 ± 0.049	0.396HisMet: 0.396 ± 0.022	0.428HisAsn: 0.428 ± 0.022	1.313HisPro: 1.313 ± 0.044	0.588HisGln: 0.588 ± 0.027	1.672HisArg: 1.672 ± 0.049	0.768HisSer: 0.768 ± 0.03	0.764HisThr: 0.764 ± 0.031	1.489HisVal: 1.489 ± 0.036	0.362HisTrp: 0.362 ± 0.02	0.497HisTyr: 0.497 ± 0.024	0.001HisXaa: 0.001 ± 0.001
Ile	9.096IleAla: 9.096 ± 0.099	0.375IleCys: 0.375 ± 0.024	4.655IleAsp: 4.655 ± 0.078	3.486IleGlu: 3.486 ± 0.061	1.413IlePhe: 1.413 ± 0.037	5.458IleGly: 5.458 ± 0.093	0.912IleHis: 0.912 ± 0.031	1.813IleIle: 1.813 ± 0.054	1.254IleLys: 1.254 ± 0.037	3.992IleLeu: 3.992 ± 0.075	0.873IleMet: 0.873 ± 0.033	1.231IleAsn: 1.231 ± 0.044	2.34IlePro: 2.34 ± 0.05	1.148IleGln: 1.148 ± 0.039	3.212IleArg: 3.212 ± 0.062	2.129IleSer: 2.129 ± 0.052	2.602IleThr: 2.602 ± 0.052	4.735IleVal: 4.735 ± 0.078	0.519IleTrp: 0.519 ± 0.023	0.945IleTyr: 0.945 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.752LysAla: 3.752 ± 0.092	0.149LysCys: 0.149 ± 0.013	1.508LysAsp: 1.508 ± 0.05	1.045LysGlu: 1.045 ± 0.035	0.778LysPhe: 0.778 ± 0.034	2.413LysGly: 2.413 ± 0.062	0.5LysHis: 0.5 ± 0.025	1.388LysIle: 1.388 ± 0.047	1.008LysLys: 1.008 ± 0.05	3.013LysLeu: 3.013 ± 0.063	0.722LysMet: 0.722 ± 0.031	0.689LysAsn: 0.689 ± 0.03	2.064LysPro: 2.064 ± 0.051	0.868LysGln: 0.868 ± 0.035	2.286LysArg: 2.286 ± 0.057	1.492LysSer: 1.492 ± 0.044	1.862LysThr: 1.862 ± 0.053	2.032LysVal: 2.032 ± 0.053	0.304LysTrp: 0.304 ± 0.018	0.585LysTyr: 0.585 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.681LeuAla: 14.681 ± 0.181	0.677LeuCys: 0.677 ± 0.027	6.431LeuAsp: 6.431 ± 0.09	3.929LeuGlu: 3.929 ± 0.069	3.395LeuPhe: 3.395 ± 0.065	8.234LeuGly: 8.234 ± 0.114	1.697LeuHis: 1.697 ± 0.046	5.064LeuIle: 5.064 ± 0.074	2.906LeuLys: 2.906 ± 0.064	8.646LeuLeu: 8.646 ± 0.126	2.061LeuMet: 2.061 ± 0.054	2.119LeuAsn: 2.119 ± 0.048	5.33LeuPro: 5.33 ± 0.081	2.314LeuGln: 2.314 ± 0.052	6.395LeuArg: 6.395 ± 0.091	5.352LeuSer: 5.352 ± 0.088	5.938LeuThr: 5.938 ± 0.092	7.633LeuVal: 7.633 ± 0.103	1.149LeuTrp: 1.149 ± 0.036	1.837LeuTyr: 1.837 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.323MetAla: 3.323 ± 0.063	0.132MetCys: 0.132 ± 0.012	1.025MetAsp: 1.025 ± 0.034	0.838MetGlu: 0.838 ± 0.033	0.665MetPhe: 0.665 ± 0.03	1.857MetGly: 1.857 ± 0.05	0.397MetHis: 0.397 ± 0.021	1.502MetIle: 1.502 ± 0.043	0.902MetLys: 0.902 ± 0.033	2.647MetLeu: 2.647 ± 0.054	0.705MetMet: 0.705 ± 0.036	0.667MetAsn: 0.667 ± 0.028	1.523MetPro: 1.523 ± 0.044	0.604MetGln: 0.604 ± 0.025	1.735MetArg: 1.735 ± 0.046	1.247MetSer: 1.247 ± 0.039	2.111MetThr: 2.111 ± 0.052	1.652MetVal: 1.652 ± 0.043	0.209MetTrp: 0.209 ± 0.016	0.298MetTyr: 0.298 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.182AsnAla: 3.182 ± 0.071	0.208AsnCys: 0.208 ± 0.014	1.466AsnAsp: 1.466 ± 0.049	0.911AsnGlu: 0.911 ± 0.034	0.822AsnPhe: 0.822 ± 0.033	2.188AsnGly: 2.188 ± 0.068	0.469AsnHis: 0.469 ± 0.023	1.126AsnIle: 1.126 ± 0.039	0.556AsnLys: 0.556 ± 0.027	2.358AsnLeu: 2.358 ± 0.063	0.484AsnMet: 0.484 ± 0.022	0.637AsnAsn: 0.637 ± 0.033	1.697AsnPro: 1.697 ± 0.051	0.764AsnGln: 0.764 ± 0.033	1.792AsnArg: 1.792 ± 0.044	1.103AsnSer: 1.103 ± 0.038	1.11AsnThr: 1.11 ± 0.044	1.783AsnVal: 1.783 ± 0.052	0.334AsnTrp: 0.334 ± 0.019	0.634AsnTyr: 0.634 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.428ProAla: 7.428 ± 0.094	0.273ProCys: 0.273 ± 0.018	4.011ProAsp: 4.011 ± 0.065	2.709ProGlu: 2.709 ± 0.058	1.842ProPhe: 1.842 ± 0.051	4.749ProGly: 4.749 ± 0.079	1.087ProHis: 1.087 ± 0.034	2.779ProIle: 2.779 ± 0.049	1.455ProLys: 1.455 ± 0.042	4.803ProLeu: 4.803 ± 0.078	1.264ProMet: 1.264 ± 0.039	1.22ProAsn: 1.22 ± 0.04	2.965ProPro: 2.965 ± 0.089	1.515ProGln: 1.515 ± 0.037	3.281ProArg: 3.281 ± 0.068	2.644ProSer: 2.644 ± 0.052	3.198ProThr: 3.198 ± 0.075	4.387ProVal: 4.387 ± 0.077	0.653ProTrp: 0.653 ± 0.028	1.065ProTyr: 1.065 ± 0.035	0.001ProXaa: 0.001 ± 0.001
Gln	3.983GlnAla: 3.983 ± 0.075	0.225GlnCys: 0.225 ± 0.017	1.302GlnAsp: 1.302 ± 0.038	1.01GlnGlu: 1.01 ± 0.034	0.987GlnPhe: 0.987 ± 0.033	2.303GlnGly: 2.303 ± 0.054	0.597GlnHis: 0.597 ± 0.027	1.552GlnIle: 1.552 ± 0.043	0.796GlnLys: 0.796 ± 0.031	2.928GlnLeu: 2.928 ± 0.061	0.737GlnMet: 0.737 ± 0.029	0.736GlnAsn: 0.736 ± 0.036	1.754GlnPro: 1.754 ± 0.049	1.12GlnGln: 1.12 ± 0.042	2.596GlnArg: 2.596 ± 0.055	1.552GlnSer: 1.552 ± 0.041	1.574GlnThr: 1.574 ± 0.041	2.188GlnVal: 2.188 ± 0.06	0.351GlnTrp: 0.351 ± 0.019	0.574GlnTyr: 0.574 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.541ArgAla: 9.541 ± 0.12	0.512ArgCys: 0.512 ± 0.029	4.803ArgAsp: 4.803 ± 0.084	3.453ArgGlu: 3.453 ± 0.074	3.029ArgPhe: 3.029 ± 0.056	5.466ArgGly: 5.466 ± 0.084	1.761ArgHis: 1.761 ± 0.053	4.272ArgIle: 4.272 ± 0.065	1.831ArgLys: 1.831 ± 0.052	7.82ArgLeu: 7.82 ± 0.112	1.946ArgMet: 1.946 ± 0.048	1.686ArgAsn: 1.686 ± 0.045	3.439ArgPro: 3.439 ± 0.071	2.385ArgGln: 2.385 ± 0.054	6.115ArgArg: 6.115 ± 0.102	3.667ArgSer: 3.667 ± 0.067	3.779ArgThr: 3.779 ± 0.07	5.368ArgVal: 5.368 ± 0.079	1.296ArgTrp: 1.296 ± 0.044	1.898ArgTyr: 1.898 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.164SerAla: 6.164 ± 0.085	0.35SerCys: 0.35 ± 0.02	2.956SerAsp: 2.956 ± 0.063	2.014SerGlu: 2.014 ± 0.049	1.904SerPhe: 1.904 ± 0.047	5.001SerGly: 5.001 ± 0.071	0.884SerHis: 0.884 ± 0.033	2.798SerIle: 2.798 ± 0.066	1.313SerLys: 1.313 ± 0.041	4.689SerLeu: 4.689 ± 0.067	1.201SerMet: 1.201 ± 0.033	1.24SerAsn: 1.24 ± 0.04	2.853SerPro: 2.853 ± 0.057	1.324SerGln: 1.324 ± 0.037	3.221SerArg: 3.221 ± 0.07	2.631SerSer: 2.631 ± 0.079	2.786SerThr: 2.786 ± 0.058	3.578SerVal: 3.578 ± 0.069	0.649SerTrp: 0.649 ± 0.026	1.251SerTyr: 1.251 ± 0.041	0.001SerXaa: 0.001 ± 0.001
Thr	7.454ThrAla: 7.454 ± 0.102	0.387ThrCys: 0.387 ± 0.021	3.402ThrAsp: 3.402 ± 0.067	2.326ThrGlu: 2.326 ± 0.049	1.705ThrPhe: 1.705 ± 0.048	5.549ThrGly: 5.549 ± 0.086	1.009ThrHis: 1.009 ± 0.032	3.611ThrIle: 3.611 ± 0.063	1.537ThrLys: 1.537 ± 0.044	6.361ThrLeu: 6.361 ± 0.083	1.368ThrMet: 1.368 ± 0.042	1.348ThrAsn: 1.348 ± 0.048	3.858ThrPro: 3.858 ± 0.077	1.543ThrGln: 1.543 ± 0.045	4.188ThrArg: 4.188 ± 0.065	2.773ThrSer: 2.773 ± 0.067	3.424ThrThr: 3.424 ± 0.068	4.451ThrVal: 4.451 ± 0.07	0.675ThrTrp: 0.675 ± 0.029	1.21ThrTyr: 1.21 ± 0.04	0.002ThrXaa: 0.002 ± 0.002
Val	11.372ValAla: 11.372 ± 0.132	0.499ValCys: 0.499 ± 0.021	4.892ValAsp: 4.892 ± 0.092	4.271ValGlu: 4.271 ± 0.078	2.343ValPhe: 2.343 ± 0.055	6.221ValGly: 6.221 ± 0.086	1.349ValHis: 1.349 ± 0.041	3.981ValIle: 3.981 ± 0.064	2.077ValLys: 2.077 ± 0.056	6.399ValLeu: 6.399 ± 0.096	1.656ValMet: 1.656 ± 0.045	1.812ValAsn: 1.812 ± 0.047	4.01ValPro: 4.01 ± 0.073	1.731ValGln: 1.731 ± 0.049	5.124ValArg: 5.124 ± 0.077	3.837ValSer: 3.837 ± 0.061	4.99ValThr: 4.99 ± 0.082	6.118ValVal: 6.118 ± 0.099	0.84ValTrp: 0.84 ± 0.035	1.4ValTyr: 1.4 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.396TrpAla: 1.396 ± 0.043	0.129TrpCys: 0.129 ± 0.013	0.676TrpAsp: 0.676 ± 0.031	0.495TrpGlu: 0.495 ± 0.022	0.58TrpPhe: 0.58 ± 0.028	0.909TrpGly: 0.909 ± 0.036	0.373TrpHis: 0.373 ± 0.021	0.667TrpIle: 0.667 ± 0.025	0.367TrpLys: 0.367 ± 0.021	1.71TrpLeu: 1.71 ± 0.049	0.325TrpMet: 0.325 ± 0.02	0.362TrpAsn: 0.362 ± 0.023	0.691TrpPro: 0.691 ± 0.028	0.51TrpGln: 0.51 ± 0.026	1.391TrpArg: 1.391 ± 0.044	0.837TrpSer: 0.837 ± 0.035	0.867TrpThr: 0.867 ± 0.03	0.817TrpVal: 0.817 ± 0.033	0.277TrpTrp: 0.277 ± 0.019	0.276TrpTyr: 0.276 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.928TyrAla: 2.928 ± 0.064	0.212TyrCys: 0.212 ± 0.014	1.62TyrAsp: 1.62 ± 0.046	0.984TyrGlu: 0.984 ± 0.037	0.796TyrPhe: 0.796 ± 0.031	2.119TyrGly: 2.119 ± 0.059	0.463TyrHis: 0.463 ± 0.023	0.843TyrIle: 0.843 ± 0.03	0.549TyrLys: 0.549 ± 0.028	2.049TyrLeu: 2.049 ± 0.046	0.382TyrMet: 0.382 ± 0.02	0.543TyrAsn: 0.543 ± 0.026	1.052TyrPro: 1.052 ± 0.031	0.675TyrGln: 0.675 ± 0.027	1.875TyrArg: 1.875 ± 0.047	0.989TyrSer: 0.989 ± 0.038	1.025TyrThr: 1.025 ± 0.035	1.606TyrVal: 1.606 ± 0.039	0.323TyrTrp: 0.323 ± 0.017	0.626TyrTyr: 0.626 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2977 proteins (903567 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---