Amino acid dipepetide frequency for Corynebacterium phage P1201

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.355AlaAla: 6.355 ± 0.994
0.759AlaCys: 0.759 ± 0.214
4.695AlaAsp: 4.695 ± 0.424
7.351AlaGlu: 7.351 ± 0.66
2.893AlaPhe: 2.893 ± 0.48
7.208AlaGly: 7.208 ± 0.785
0.948AlaHis: 0.948 ± 0.217
5.359AlaIle: 5.359 ± 0.581
5.169AlaLys: 5.169 ± 0.539
7.92AlaLeu: 7.92 ± 0.665
2.656AlaMet: 2.656 ± 0.298
2.94AlaAsn: 2.94 ± 0.339
3.509AlaPro: 3.509 ± 0.695
2.276AlaGln: 2.276 ± 0.294
4.885AlaArg: 4.885 ± 0.468
6.26AlaSer: 6.26 ± 0.589
5.311AlaThr: 5.311 ± 0.673
4.6AlaVal: 4.6 ± 0.515
1.565AlaTrp: 1.565 ± 0.263
2.371AlaTyr: 2.371 ± 0.42
0.0AlaXaa: 0.0 ± 0.0
Cys
1.043CysAla: 1.043 ± 0.474
0.379CysCys: 0.379 ± 0.207
0.664CysAsp: 0.664 ± 0.203
0.522CysGlu: 0.522 ± 0.166
0.332CysPhe: 0.332 ± 0.125
0.854CysGly: 0.854 ± 0.212
0.047CysHis: 0.047 ± 0.053
0.19CysIle: 0.19 ± 0.08
0.427CysLys: 0.427 ± 0.171
0.901CysLeu: 0.901 ± 0.32
0.142CysMet: 0.142 ± 0.077
0.379CysAsn: 0.379 ± 0.15
0.569CysPro: 0.569 ± 0.205
0.237CysGln: 0.237 ± 0.109
0.285CysArg: 0.285 ± 0.129
0.616CysSer: 0.616 ± 0.163
0.569CysThr: 0.569 ± 0.163
0.379CysVal: 0.379 ± 0.145
0.095CysTrp: 0.095 ± 0.067
0.379CysTyr: 0.379 ± 0.14
0.0CysXaa: 0.0 ± 0.0
Asp
4.173AspAla: 4.173 ± 0.382
0.522AspCys: 0.522 ± 0.178
3.794AspAsp: 3.794 ± 0.465
4.41AspGlu: 4.41 ± 0.518
2.798AspPhe: 2.798 ± 0.284
4.363AspGly: 4.363 ± 0.41
1.043AspHis: 1.043 ± 0.229
4.268AspIle: 4.268 ± 0.521
3.177AspLys: 3.177 ± 0.486
5.691AspLeu: 5.691 ± 0.528
1.565AspMet: 1.565 ± 0.266
1.802AspAsn: 1.802 ± 0.262
3.13AspPro: 3.13 ± 0.409
1.992AspGln: 1.992 ± 0.278
3.889AspArg: 3.889 ± 0.521
4.505AspSer: 4.505 ± 0.382
3.272AspThr: 3.272 ± 0.37
3.983AspVal: 3.983 ± 0.584
1.707AspTrp: 1.707 ± 0.251
2.087AspTyr: 2.087 ± 0.367
0.0AspXaa: 0.0 ± 0.0
Glu
7.019GluAla: 7.019 ± 0.649
0.569GluCys: 0.569 ± 0.252
4.932GluAsp: 4.932 ± 0.563
7.588GluGlu: 7.588 ± 0.753
2.988GluPhe: 2.988 ± 0.395
5.501GluGly: 5.501 ± 0.514
1.138GluHis: 1.138 ± 0.205
5.406GluIle: 5.406 ± 0.588
4.315GluLys: 4.315 ± 0.465
5.833GluLeu: 5.833 ± 0.621
2.134GluMet: 2.134 ± 0.281
2.561GluAsn: 2.561 ± 0.447
2.656GluPro: 2.656 ± 0.398
2.656GluGln: 2.656 ± 0.435
4.553GluArg: 4.553 ± 0.421
5.501GluSer: 5.501 ± 0.408
3.699GluThr: 3.699 ± 0.39
6.449GluVal: 6.449 ± 0.638
1.518GluTrp: 1.518 ± 0.304
1.992GluTyr: 1.992 ± 0.324
0.0GluXaa: 0.0 ± 0.0
Phe
2.988PheAla: 2.988 ± 0.403
0.427PheCys: 0.427 ± 0.125
2.608PheAsp: 2.608 ± 0.373
2.798PheGlu: 2.798 ± 0.276
1.707PhePhe: 1.707 ± 0.293
2.798PheGly: 2.798 ± 0.671
1.091PheHis: 1.091 ± 0.239
1.849PheIle: 1.849 ± 0.358
1.375PheLys: 1.375 ± 0.246
3.794PheLeu: 3.794 ± 0.433
0.759PheMet: 0.759 ± 0.194
1.802PheAsn: 1.802 ± 0.291
1.138PhePro: 1.138 ± 0.178
1.375PheGln: 1.375 ± 0.232
2.371PheArg: 2.371 ± 0.3
3.557PheSer: 3.557 ± 0.416
2.324PheThr: 2.324 ± 0.391
2.087PheVal: 2.087 ± 0.335
0.522PheTrp: 0.522 ± 0.145
1.375PheTyr: 1.375 ± 0.287
0.0PheXaa: 0.0 ± 0.0
Gly
5.691GlyAla: 5.691 ± 0.96
0.664GlyCys: 0.664 ± 0.176
5.454GlyAsp: 5.454 ± 0.462
5.264GlyGlu: 5.264 ± 0.505
3.32GlyPhe: 3.32 ± 0.302
5.643GlyGly: 5.643 ± 1.205
1.802GlyHis: 1.802 ± 0.287
4.126GlyIle: 4.126 ± 0.58
4.885GlyLys: 4.885 ± 0.475
4.647GlyLeu: 4.647 ± 0.633
2.324GlyMet: 2.324 ± 0.455
2.466GlyAsn: 2.466 ± 0.351
2.845GlyPro: 2.845 ± 0.35
1.897GlyGln: 1.897 ± 0.245
3.652GlyArg: 3.652 ± 0.425
5.264GlySer: 5.264 ± 0.483
4.6GlyThr: 4.6 ± 0.467
5.454GlyVal: 5.454 ± 0.562
1.755GlyTrp: 1.755 ± 0.23
2.561GlyTyr: 2.561 ± 0.368
0.0GlyXaa: 0.0 ± 0.0
His
1.375HisAla: 1.375 ± 0.212
0.19HisCys: 0.19 ± 0.111
0.996HisAsp: 0.996 ± 0.25
1.138HisGlu: 1.138 ± 0.286
0.569HisPhe: 0.569 ± 0.149
1.233HisGly: 1.233 ± 0.242
0.759HisHis: 0.759 ± 0.204
0.664HisIle: 0.664 ± 0.171
0.948HisLys: 0.948 ± 0.279
1.518HisLeu: 1.518 ± 0.308
0.285HisMet: 0.285 ± 0.113
0.379HisAsn: 0.379 ± 0.125
1.28HisPro: 1.28 ± 0.27
0.332HisGln: 0.332 ± 0.121
1.186HisArg: 1.186 ± 0.235
0.901HisSer: 0.901 ± 0.238
0.854HisThr: 0.854 ± 0.239
1.138HisVal: 1.138 ± 0.229
0.142HisTrp: 0.142 ± 0.088
0.948HisTyr: 0.948 ± 0.183
0.0HisXaa: 0.0 ± 0.0
Ile
4.885IleAla: 4.885 ± 0.503
0.379IleCys: 0.379 ± 0.133
3.367IleAsp: 3.367 ± 0.312
4.553IleGlu: 4.553 ± 0.415
2.371IlePhe: 2.371 ± 0.417
4.363IleGly: 4.363 ± 0.726
1.375IleHis: 1.375 ± 0.258
3.414IleIle: 3.414 ± 0.419
2.988IleLys: 2.988 ± 0.458
3.652IleLeu: 3.652 ± 0.449
1.138IleMet: 1.138 ± 0.205
2.513IleAsn: 2.513 ± 0.384
3.177IlePro: 3.177 ± 0.318
2.039IleGln: 2.039 ± 0.347
3.367IleArg: 3.367 ± 0.327
4.41IleSer: 4.41 ± 0.45
2.798IleThr: 2.798 ± 0.431
3.414IleVal: 3.414 ± 0.395
0.379IleTrp: 0.379 ± 0.132
2.371IleTyr: 2.371 ± 0.518
0.0IleXaa: 0.0 ± 0.0
Lys
6.639LysAla: 6.639 ± 0.672
0.19LysCys: 0.19 ± 0.083
3.652LysAsp: 3.652 ± 0.371
5.169LysGlu: 5.169 ± 0.635
2.276LysPhe: 2.276 ± 0.337
3.652LysGly: 3.652 ± 0.377
0.522LysHis: 0.522 ± 0.168
3.32LysIle: 3.32 ± 0.336
3.509LysLys: 3.509 ± 0.442
3.082LysLeu: 3.082 ± 0.388
1.565LysMet: 1.565 ± 0.247
2.324LysAsn: 2.324 ± 0.332
2.134LysPro: 2.134 ± 0.326
1.897LysGln: 1.897 ± 0.277
3.889LysArg: 3.889 ± 0.507
4.078LysSer: 4.078 ± 0.435
3.983LysThr: 3.983 ± 0.572
3.936LysVal: 3.936 ± 0.494
0.948LysTrp: 0.948 ± 0.172
1.518LysTyr: 1.518 ± 0.286
0.0LysXaa: 0.0 ± 0.0
Leu
7.256LeuAla: 7.256 ± 0.595
0.711LeuCys: 0.711 ± 0.192
5.548LeuAsp: 5.548 ± 0.61
6.402LeuGlu: 6.402 ± 0.535
3.082LeuPhe: 3.082 ± 0.382
5.833LeuGly: 5.833 ± 0.529
1.043LeuHis: 1.043 ± 0.224
3.604LeuIle: 3.604 ± 0.4
5.169LeuLys: 5.169 ± 0.506
6.544LeuLeu: 6.544 ± 0.708
1.849LeuMet: 1.849 ± 0.307
3.414LeuAsn: 3.414 ± 0.382
3.272LeuPro: 3.272 ± 0.394
2.419LeuGln: 2.419 ± 0.282
4.458LeuArg: 4.458 ± 0.438
7.066LeuSer: 7.066 ± 0.643
4.315LeuThr: 4.315 ± 0.463
5.027LeuVal: 5.027 ± 0.468
1.28LeuTrp: 1.28 ± 0.19
1.233LeuTyr: 1.233 ± 0.29
0.0LeuXaa: 0.0 ± 0.0
Met
3.13MetAla: 3.13 ± 0.44
0.237MetCys: 0.237 ± 0.131
1.375MetAsp: 1.375 ± 0.21
1.707MetGlu: 1.707 ± 0.253
0.664MetPhe: 0.664 ± 0.191
1.328MetGly: 1.328 ± 0.232
0.237MetHis: 0.237 ± 0.086
0.854MetIle: 0.854 ± 0.177
1.707MetLys: 1.707 ± 0.235
1.518MetLeu: 1.518 ± 0.286
0.237MetMet: 0.237 ± 0.091
1.328MetAsn: 1.328 ± 0.293
1.138MetPro: 1.138 ± 0.231
0.854MetGln: 0.854 ± 0.23
1.47MetArg: 1.47 ± 0.327
2.419MetSer: 2.419 ± 0.342
1.849MetThr: 1.849 ± 0.319
1.186MetVal: 1.186 ± 0.263
0.285MetTrp: 0.285 ± 0.113
0.901MetTyr: 0.901 ± 0.308
0.0MetXaa: 0.0 ± 0.0
Asn
2.656AsnAla: 2.656 ± 0.411
0.427AsnCys: 0.427 ± 0.139
1.944AsnAsp: 1.944 ± 0.28
2.845AsnGlu: 2.845 ± 0.391
1.897AsnPhe: 1.897 ± 0.338
3.841AsnGly: 3.841 ± 0.369
0.711AsnHis: 0.711 ± 0.187
1.992AsnIle: 1.992 ± 0.256
2.371AsnLys: 2.371 ± 0.248
3.367AsnLeu: 3.367 ± 0.336
0.854AsnMet: 0.854 ± 0.185
1.328AsnAsn: 1.328 ± 0.24
2.134AsnPro: 2.134 ± 0.294
1.66AsnGln: 1.66 ± 0.28
2.181AsnArg: 2.181 ± 0.325
2.513AsnSer: 2.513 ± 0.336
1.992AsnThr: 1.992 ± 0.373
2.134AsnVal: 2.134 ± 0.244
0.379AsnTrp: 0.379 ± 0.137
1.423AsnTyr: 1.423 ± 0.357
0.0AsnXaa: 0.0 ± 0.0
Pro
3.082ProAla: 3.082 ± 0.43
0.142ProCys: 0.142 ± 0.073
2.798ProAsp: 2.798 ± 0.301
3.936ProGlu: 3.936 ± 0.48
1.707ProPhe: 1.707 ± 0.317
3.936ProGly: 3.936 ± 0.439
0.759ProHis: 0.759 ± 0.196
2.324ProIle: 2.324 ± 0.432
2.608ProLys: 2.608 ± 0.392
3.272ProLeu: 3.272 ± 0.453
0.901ProMet: 0.901 ± 0.22
1.849ProAsn: 1.849 ± 0.35
2.703ProPro: 2.703 ± 0.539
1.66ProGln: 1.66 ± 0.252
1.944ProArg: 1.944 ± 0.313
3.225ProSer: 3.225 ± 0.442
2.039ProThr: 2.039 ± 0.325
3.794ProVal: 3.794 ± 1.024
0.616ProTrp: 0.616 ± 0.207
1.423ProTyr: 1.423 ± 0.213
0.0ProXaa: 0.0 ± 0.0
Gln
3.035GlnAla: 3.035 ± 0.483
0.095GlnCys: 0.095 ± 0.063
1.992GlnAsp: 1.992 ± 0.361
2.845GlnGlu: 2.845 ± 0.468
1.233GlnPhe: 1.233 ± 0.288
2.608GlnGly: 2.608 ± 0.377
0.237GlnHis: 0.237 ± 0.105
2.751GlnIle: 2.751 ± 0.355
1.755GlnLys: 1.755 ± 0.288
3.13GlnLeu: 3.13 ± 0.42
0.616GlnMet: 0.616 ± 0.171
1.233GlnAsn: 1.233 ± 0.294
1.28GlnPro: 1.28 ± 0.221
1.186GlnGln: 1.186 ± 0.237
2.276GlnArg: 2.276 ± 0.311
1.612GlnSer: 1.612 ± 0.314
1.47GlnThr: 1.47 ± 0.227
1.992GlnVal: 1.992 ± 0.345
0.522GlnTrp: 0.522 ± 0.154
0.996GlnTyr: 0.996 ± 0.189
0.0GlnXaa: 0.0 ± 0.0
Arg
5.074ArgAla: 5.074 ± 0.503
0.332ArgCys: 0.332 ± 0.119
4.505ArgAsp: 4.505 ± 0.438
5.216ArgGlu: 5.216 ± 0.529
2.276ArgPhe: 2.276 ± 0.289
3.889ArgGly: 3.889 ± 0.358
0.948ArgHis: 0.948 ± 0.25
3.414ArgIle: 3.414 ± 0.375
4.268ArgLys: 4.268 ± 0.4
4.41ArgLeu: 4.41 ± 0.584
1.233ArgMet: 1.233 ± 0.3
2.419ArgAsn: 2.419 ± 0.317
2.513ArgPro: 2.513 ± 0.609
1.47ArgGln: 1.47 ± 0.242
3.889ArgArg: 3.889 ± 0.514
3.604ArgSer: 3.604 ± 0.525
2.419ArgThr: 2.419 ± 0.299
4.315ArgVal: 4.315 ± 0.537
0.569ArgTrp: 0.569 ± 0.144
1.802ArgTyr: 1.802 ± 0.253
0.0ArgXaa: 0.0 ± 0.0
Ser
6.355SerAla: 6.355 ± 0.713
0.948SerCys: 0.948 ± 0.298
4.078SerAsp: 4.078 ± 0.473
5.643SerGlu: 5.643 ± 0.557
2.466SerPhe: 2.466 ± 0.359
5.975SerGly: 5.975 ± 0.628
1.233SerHis: 1.233 ± 0.216
3.841SerIle: 3.841 ± 0.401
3.794SerLys: 3.794 ± 0.399
6.212SerLeu: 6.212 ± 0.554
1.565SerMet: 1.565 ± 0.229
2.513SerAsn: 2.513 ± 0.308
3.746SerPro: 3.746 ± 0.519
3.272SerGln: 3.272 ± 0.421
5.074SerArg: 5.074 ± 0.488
5.833SerSer: 5.833 ± 0.675
3.367SerThr: 3.367 ± 0.532
4.695SerVal: 4.695 ± 0.465
1.138SerTrp: 1.138 ± 0.19
1.66SerTyr: 1.66 ± 0.338
0.0SerXaa: 0.0 ± 0.0
Thr
5.691ThrAla: 5.691 ± 0.615
0.474ThrCys: 0.474 ± 0.201
3.035ThrAsp: 3.035 ± 0.383
3.177ThrGlu: 3.177 ± 0.336
2.229ThrPhe: 2.229 ± 0.345
3.794ThrGly: 3.794 ± 0.476
0.996ThrHis: 0.996 ± 0.202
2.988ThrIle: 2.988 ± 0.335
3.272ThrLys: 3.272 ± 0.38
4.553ThrLeu: 4.553 ± 0.453
1.707ThrMet: 1.707 ± 0.425
2.94ThrAsn: 2.94 ± 0.467
3.035ThrPro: 3.035 ± 0.395
1.707ThrGln: 1.707 ± 0.326
2.561ThrArg: 2.561 ± 0.255
3.841ThrSer: 3.841 ± 0.606
3.604ThrThr: 3.604 ± 0.434
3.13ThrVal: 3.13 ± 0.37
1.091ThrTrp: 1.091 ± 0.256
1.565ThrTyr: 1.565 ± 0.244
0.0ThrXaa: 0.0 ± 0.0
Val
5.501ValAla: 5.501 ± 0.53
0.901ValCys: 0.901 ± 0.495
3.746ValAsp: 3.746 ± 0.453
4.742ValGlu: 4.742 ± 0.499
2.703ValPhe: 2.703 ± 0.376
3.841ValGly: 3.841 ± 0.49
1.328ValHis: 1.328 ± 0.233
3.462ValIle: 3.462 ± 0.313
4.031ValLys: 4.031 ± 0.455
4.458ValLeu: 4.458 ± 0.475
1.612ValMet: 1.612 ± 0.242
2.466ValAsn: 2.466 ± 0.297
2.134ValPro: 2.134 ± 0.335
2.276ValGln: 2.276 ± 0.317
3.794ValArg: 3.794 ± 0.514
5.311ValSer: 5.311 ± 0.485
4.553ValThr: 4.553 ± 0.466
4.458ValVal: 4.458 ± 0.582
1.375ValTrp: 1.375 ± 0.237
2.276ValTyr: 2.276 ± 0.405
0.0ValXaa: 0.0 ± 0.0
Trp
0.996TrpAla: 0.996 ± 0.255
0.285TrpCys: 0.285 ± 0.109
1.423TrpAsp: 1.423 ± 0.247
1.612TrpGlu: 1.612 ± 0.269
0.474TrpPhe: 0.474 ± 0.154
1.186TrpGly: 1.186 ± 0.232
0.237TrpHis: 0.237 ± 0.111
0.948TrpIle: 0.948 ± 0.186
1.043TrpLys: 1.043 ± 0.227
1.565TrpLeu: 1.565 ± 0.301
0.332TrpMet: 0.332 ± 0.134
0.569TrpAsn: 0.569 ± 0.16
0.711TrpPro: 0.711 ± 0.186
0.711TrpGln: 0.711 ± 0.174
0.996TrpArg: 0.996 ± 0.227
1.091TrpSer: 1.091 ± 0.2
0.806TrpThr: 0.806 ± 0.192
1.186TrpVal: 1.186 ± 0.256
0.19TrpTrp: 0.19 ± 0.102
0.379TrpTyr: 0.379 ± 0.124
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.087TyrAla: 2.087 ± 0.4
0.379TyrCys: 0.379 ± 0.151
1.565TyrAsp: 1.565 ± 0.228
2.134TyrGlu: 2.134 ± 0.347
0.759TyrPhe: 0.759 ± 0.186
2.466TyrGly: 2.466 ± 0.257
0.379TyrHis: 0.379 ± 0.12
2.181TyrIle: 2.181 ± 0.49
1.47TyrLys: 1.47 ± 0.206
3.462TyrLeu: 3.462 ± 0.49
0.901TyrMet: 0.901 ± 0.247
1.423TyrAsn: 1.423 ± 0.273
1.612TyrPro: 1.612 ± 0.283
0.948TyrGln: 0.948 ± 0.204
1.849TyrArg: 1.849 ± 0.361
1.802TyrSer: 1.802 ± 0.312
1.565TyrThr: 1.565 ± 0.306
1.612TyrVal: 1.612 ± 0.259
0.664TyrTrp: 0.664 ± 0.185
1.138TyrTyr: 1.138 ± 0.301
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (21088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski