Amino acid dipepetide frequency for Mycobacterium virus Littlee

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.336AlaAla: 11.336 ± 1.087
1.052AlaCys: 1.052 ± 0.194
6.808AlaAsp: 6.808 ± 0.521
7.976AlaGlu: 7.976 ± 0.555
3.155AlaPhe: 3.155 ± 0.274
8.327AlaGly: 8.327 ± 0.737
1.841AlaHis: 1.841 ± 0.25
5.639AlaIle: 5.639 ± 0.331
4.324AlaLys: 4.324 ± 0.331
8.765AlaLeu: 8.765 ± 0.529
2.776AlaMet: 2.776 ± 0.351
3.185AlaAsn: 3.185 ± 0.376
4.675AlaPro: 4.675 ± 0.411
2.951AlaGln: 2.951 ± 0.274
6.369AlaArg: 6.369 ± 0.434
4.762AlaSer: 4.762 ± 0.408
5.172AlaThr: 5.172 ± 0.447
6.048AlaVal: 6.048 ± 0.387
1.928AlaTrp: 1.928 ± 0.238
2.513AlaTyr: 2.513 ± 0.288
0.0AlaXaa: 0.0 ± 0.0
Cys
1.023CysAla: 1.023 ± 0.166
0.117CysCys: 0.117 ± 0.057
0.964CysAsp: 0.964 ± 0.164
0.877CysGlu: 0.877 ± 0.169
0.467CysPhe: 0.467 ± 0.12
1.782CysGly: 1.782 ± 0.271
0.409CysHis: 0.409 ± 0.108
0.584CysIle: 0.584 ± 0.143
0.701CysLys: 0.701 ± 0.145
1.198CysLeu: 1.198 ± 0.235
0.234CysMet: 0.234 ± 0.079
0.555CysAsn: 0.555 ± 0.134
0.701CysPro: 0.701 ± 0.167
0.351CysGln: 0.351 ± 0.098
1.023CysArg: 1.023 ± 0.224
0.672CysSer: 0.672 ± 0.137
0.76CysThr: 0.76 ± 0.143
0.877CysVal: 0.877 ± 0.146
0.351CysTrp: 0.351 ± 0.11
0.409CysTyr: 0.409 ± 0.097
0.0CysXaa: 0.0 ± 0.0
Asp
5.873AspAla: 5.873 ± 0.468
1.052AspCys: 1.052 ± 0.17
4.675AspAsp: 4.675 ± 0.439
4.587AspGlu: 4.587 ± 0.447
2.104AspPhe: 2.104 ± 0.244
6.223AspGly: 6.223 ± 0.478
1.899AspHis: 1.899 ± 0.239
3.068AspIle: 3.068 ± 0.318
2.688AspLys: 2.688 ± 0.288
5.785AspLeu: 5.785 ± 0.423
1.461AspMet: 1.461 ± 0.18
2.162AspAsn: 2.162 ± 0.232
3.74AspPro: 3.74 ± 0.373
1.841AspGln: 1.841 ± 0.202
3.652AspArg: 3.652 ± 0.289
2.571AspSer: 2.571 ± 0.315
2.98AspThr: 2.98 ± 0.261
4.383AspVal: 4.383 ± 0.446
2.074AspTrp: 2.074 ± 0.268
2.133AspTyr: 2.133 ± 0.241
0.0AspXaa: 0.0 ± 0.0
Glu
6.837GluAla: 6.837 ± 0.585
1.432GluCys: 1.432 ± 0.254
4.237GluAsp: 4.237 ± 0.315
5.668GluGlu: 5.668 ± 0.607
3.009GluPhe: 3.009 ± 0.37
4.09GluGly: 4.09 ± 0.323
1.373GluHis: 1.373 ± 0.199
3.944GluIle: 3.944 ± 0.317
2.834GluLys: 2.834 ± 0.32
6.72GluLeu: 6.72 ± 0.51
2.542GluMet: 2.542 ± 0.308
1.665GluAsn: 1.665 ± 0.243
3.155GluPro: 3.155 ± 0.314
2.396GluGln: 2.396 ± 0.223
4.646GluArg: 4.646 ± 0.392
3.389GluSer: 3.389 ± 0.303
3.155GluThr: 3.155 ± 0.289
4.587GluVal: 4.587 ± 0.399
1.373GluTrp: 1.373 ± 0.231
2.98GluTyr: 2.98 ± 0.316
0.0GluXaa: 0.0 ± 0.0
Phe
2.337PheAla: 2.337 ± 0.312
0.38PheCys: 0.38 ± 0.1
2.513PheAsp: 2.513 ± 0.288
2.279PheGlu: 2.279 ± 0.26
1.023PhePhe: 1.023 ± 0.201
3.302PheGly: 3.302 ± 0.37
0.643PheHis: 0.643 ± 0.119
1.402PheIle: 1.402 ± 0.183
1.023PheLys: 1.023 ± 0.17
2.279PheLeu: 2.279 ± 0.255
0.906PheMet: 0.906 ± 0.167
1.227PheAsn: 1.227 ± 0.223
2.221PhePro: 2.221 ± 0.308
0.701PheGln: 0.701 ± 0.164
1.928PheArg: 1.928 ± 0.219
1.811PheSer: 1.811 ± 0.236
1.811PheThr: 1.811 ± 0.215
2.045PheVal: 2.045 ± 0.232
0.584PheTrp: 0.584 ± 0.117
0.906PheTyr: 0.906 ± 0.162
0.0PheXaa: 0.0 ± 0.0
Gly
7.86GlyAla: 7.86 ± 0.839
1.286GlyCys: 1.286 ± 0.188
5.873GlyAsp: 5.873 ± 0.403
5.405GlyGlu: 5.405 ± 0.358
2.98GlyPhe: 2.98 ± 0.351
9.116GlyGly: 9.116 ± 1.225
1.928GlyHis: 1.928 ± 0.217
3.944GlyIle: 3.944 ± 0.394
3.506GlyLys: 3.506 ± 0.355
7.304GlyLeu: 7.304 ± 0.6
2.337GlyMet: 2.337 ± 0.231
3.009GlyAsn: 3.009 ± 0.35
3.623GlyPro: 3.623 ± 0.298
2.6GlyGln: 2.6 ± 0.253
5.581GlyArg: 5.581 ± 0.388
4.762GlySer: 4.762 ± 0.389
5.113GlyThr: 5.113 ± 0.442
5.288GlyVal: 5.288 ± 0.396
2.221GlyTrp: 2.221 ± 0.347
3.097GlyTyr: 3.097 ± 0.281
0.0GlyXaa: 0.0 ± 0.0
His
1.782HisAla: 1.782 ± 0.253
0.351HisCys: 0.351 ± 0.102
1.344HisAsp: 1.344 ± 0.183
1.607HisGlu: 1.607 ± 0.203
0.526HisPhe: 0.526 ± 0.11
2.016HisGly: 2.016 ± 0.237
0.906HisHis: 0.906 ± 0.153
1.023HisIle: 1.023 ± 0.184
0.877HisLys: 0.877 ± 0.174
1.87HisLeu: 1.87 ± 0.246
0.555HisMet: 0.555 ± 0.115
0.672HisAsn: 0.672 ± 0.134
1.49HisPro: 1.49 ± 0.182
0.672HisGln: 0.672 ± 0.133
2.045HisArg: 2.045 ± 0.214
0.935HisSer: 0.935 ± 0.163
0.76HisThr: 0.76 ± 0.154
1.286HisVal: 1.286 ± 0.193
0.789HisTrp: 0.789 ± 0.17
0.701HisTyr: 0.701 ± 0.126
0.0HisXaa: 0.0 ± 0.0
Ile
5.318IleAla: 5.318 ± 0.456
0.497IleCys: 0.497 ± 0.117
3.798IleAsp: 3.798 ± 0.316
4.324IleGlu: 4.324 ± 0.353
1.344IlePhe: 1.344 ± 0.196
3.535IleGly: 3.535 ± 0.379
1.373IleHis: 1.373 ± 0.29
2.074IleIle: 2.074 ± 0.226
1.665IleLys: 1.665 ± 0.235
3.506IleLeu: 3.506 ± 0.312
0.701IleMet: 0.701 ± 0.157
2.191IleAsn: 2.191 ± 0.239
3.302IlePro: 3.302 ± 0.31
1.665IleGln: 1.665 ± 0.214
3.068IleArg: 3.068 ± 0.316
2.571IleSer: 2.571 ± 0.243
2.834IleThr: 2.834 ± 0.288
3.214IleVal: 3.214 ± 0.312
0.877IleTrp: 0.877 ± 0.135
1.198IleTyr: 1.198 ± 0.193
0.0IleXaa: 0.0 ± 0.0
Lys
4.178LysAla: 4.178 ± 0.403
0.73LysCys: 0.73 ± 0.149
1.782LysAsp: 1.782 ± 0.238
2.104LysGlu: 2.104 ± 0.236
1.432LysPhe: 1.432 ± 0.186
2.483LysGly: 2.483 ± 0.291
1.023LysHis: 1.023 ± 0.191
1.695LysIle: 1.695 ± 0.239
2.279LysLys: 2.279 ± 0.345
3.623LysLeu: 3.623 ± 0.382
1.432LysMet: 1.432 ± 0.165
0.993LysAsn: 0.993 ± 0.154
2.454LysPro: 2.454 ± 0.249
1.227LysGln: 1.227 ± 0.168
2.805LysArg: 2.805 ± 0.34
2.308LysSer: 2.308 ± 0.382
1.841LysThr: 1.841 ± 0.259
3.331LysVal: 3.331 ± 0.367
1.081LysTrp: 1.081 ± 0.163
1.169LysTyr: 1.169 ± 0.168
0.0LysXaa: 0.0 ± 0.0
Leu
8.97LeuAla: 8.97 ± 0.601
0.73LeuCys: 0.73 ± 0.156
5.434LeuAsp: 5.434 ± 0.306
5.434LeuGlu: 5.434 ± 0.465
2.133LeuPhe: 2.133 ± 0.238
6.954LeuGly: 6.954 ± 0.441
1.695LeuHis: 1.695 ± 0.223
3.331LeuIle: 3.331 ± 0.347
2.893LeuLys: 2.893 ± 0.287
5.902LeuLeu: 5.902 ± 0.458
2.074LeuMet: 2.074 ± 0.233
2.513LeuAsn: 2.513 ± 0.278
4.733LeuPro: 4.733 ± 0.412
2.571LeuGln: 2.571 ± 0.28
6.194LeuArg: 6.194 ± 0.429
5.522LeuSer: 5.522 ± 0.385
5.23LeuThr: 5.23 ± 0.358
4.996LeuVal: 4.996 ± 0.403
1.607LeuTrp: 1.607 ± 0.22
2.191LeuTyr: 2.191 ± 0.289
0.0LeuXaa: 0.0 ± 0.0
Met
2.308MetAla: 2.308 ± 0.274
0.146MetCys: 0.146 ± 0.068
1.198MetAsp: 1.198 ± 0.183
1.402MetGlu: 1.402 ± 0.203
0.643MetPhe: 0.643 ± 0.122
1.958MetGly: 1.958 ± 0.233
0.38MetHis: 0.38 ± 0.117
1.139MetIle: 1.139 ± 0.165
1.286MetLys: 1.286 ± 0.203
1.899MetLeu: 1.899 ± 0.211
0.497MetMet: 0.497 ± 0.114
1.519MetAsn: 1.519 ± 0.25
0.964MetPro: 0.964 ± 0.163
0.672MetGln: 0.672 ± 0.154
1.665MetArg: 1.665 ± 0.245
2.454MetSer: 2.454 ± 0.287
2.25MetThr: 2.25 ± 0.244
1.256MetVal: 1.256 ± 0.21
0.555MetTrp: 0.555 ± 0.118
0.526MetTyr: 0.526 ± 0.112
0.0MetXaa: 0.0 ± 0.0
Asn
3.302AsnAla: 3.302 ± 0.384
0.409AsnCys: 0.409 ± 0.104
2.133AsnAsp: 2.133 ± 0.231
1.841AsnGlu: 1.841 ± 0.22
1.139AsnPhe: 1.139 ± 0.185
3.886AsnGly: 3.886 ± 0.427
0.906AsnHis: 0.906 ± 0.15
1.402AsnIle: 1.402 ± 0.232
1.373AsnLys: 1.373 ± 0.21
2.25AsnLeu: 2.25 ± 0.313
0.526AsnMet: 0.526 ± 0.12
0.906AsnAsn: 0.906 ± 0.173
2.483AsnPro: 2.483 ± 0.258
0.877AsnGln: 0.877 ± 0.13
2.367AsnArg: 2.367 ± 0.224
1.841AsnSer: 1.841 ± 0.231
1.519AsnThr: 1.519 ± 0.214
2.016AsnVal: 2.016 ± 0.246
0.672AsnTrp: 0.672 ± 0.129
0.73AsnTyr: 0.73 ± 0.127
0.0AsnXaa: 0.0 ± 0.0
Pro
5.434ProAla: 5.434 ± 0.379
0.906ProCys: 0.906 ± 0.192
3.535ProAsp: 3.535 ± 0.316
4.207ProGlu: 4.207 ± 0.339
1.87ProPhe: 1.87 ± 0.242
6.019ProGly: 6.019 ± 0.486
0.906ProHis: 0.906 ± 0.149
2.659ProIle: 2.659 ± 0.283
1.753ProLys: 1.753 ± 0.228
3.915ProLeu: 3.915 ± 0.324
1.023ProMet: 1.023 ± 0.161
2.104ProAsn: 2.104 ± 0.239
3.185ProPro: 3.185 ± 0.364
1.023ProGln: 1.023 ± 0.161
3.565ProArg: 3.565 ± 0.36
3.009ProSer: 3.009 ± 0.349
3.126ProThr: 3.126 ± 0.279
3.974ProVal: 3.974 ± 0.315
1.344ProTrp: 1.344 ± 0.193
1.461ProTyr: 1.461 ± 0.233
0.0ProXaa: 0.0 ± 0.0
Gln
3.535GlnAla: 3.535 ± 0.345
0.38GlnCys: 0.38 ± 0.106
1.432GlnAsp: 1.432 ± 0.209
2.016GlnGlu: 2.016 ± 0.284
0.847GlnPhe: 0.847 ± 0.161
1.695GlnGly: 1.695 ± 0.2
0.643GlnHis: 0.643 ± 0.148
1.665GlnIle: 1.665 ± 0.204
1.753GlnLys: 1.753 ± 0.266
2.396GlnLeu: 2.396 ± 0.252
0.964GlnMet: 0.964 ± 0.169
0.584GlnAsn: 0.584 ± 0.117
1.724GlnPro: 1.724 ± 0.196
1.198GlnGln: 1.198 ± 0.206
2.367GlnArg: 2.367 ± 0.238
1.899GlnSer: 1.899 ± 0.24
1.402GlnThr: 1.402 ± 0.228
1.899GlnVal: 1.899 ± 0.238
0.467GlnTrp: 0.467 ± 0.149
0.701GlnTyr: 0.701 ± 0.132
0.0GlnXaa: 0.0 ± 0.0
Arg
6.486ArgAla: 6.486 ± 0.551
1.023ArgCys: 1.023 ± 0.173
3.74ArgAsp: 3.74 ± 0.294
4.616ArgGlu: 4.616 ± 0.394
2.074ArgPhe: 2.074 ± 0.252
5.142ArgGly: 5.142 ± 0.456
1.256ArgHis: 1.256 ± 0.191
3.681ArgIle: 3.681 ± 0.34
2.834ArgLys: 2.834 ± 0.297
5.259ArgLeu: 5.259 ± 0.394
2.454ArgMet: 2.454 ± 0.27
2.104ArgAsn: 2.104 ± 0.221
3.711ArgPro: 3.711 ± 0.373
2.454ArgGln: 2.454 ± 0.313
5.581ArgArg: 5.581 ± 0.445
3.331ArgSer: 3.331 ± 0.303
3.535ArgThr: 3.535 ± 0.358
5.084ArgVal: 5.084 ± 0.372
2.074ArgTrp: 2.074 ± 0.257
2.454ArgTyr: 2.454 ± 0.263
0.0ArgXaa: 0.0 ± 0.0
Ser
5.405SerAla: 5.405 ± 0.361
0.818SerCys: 0.818 ± 0.152
3.565SerAsp: 3.565 ± 0.338
3.36SerGlu: 3.36 ± 0.35
1.461SerPhe: 1.461 ± 0.251
6.077SerGly: 6.077 ± 0.513
1.344SerHis: 1.344 ± 0.191
2.951SerIle: 2.951 ± 0.321
2.045SerLys: 2.045 ± 0.269
4.383SerLeu: 4.383 ± 0.367
1.198SerMet: 1.198 ± 0.183
1.607SerAsn: 1.607 ± 0.251
3.126SerPro: 3.126 ± 0.259
1.578SerGln: 1.578 ± 0.186
3.331SerArg: 3.331 ± 0.305
3.272SerSer: 3.272 ± 0.34
2.688SerThr: 2.688 ± 0.282
3.448SerVal: 3.448 ± 0.336
1.344SerTrp: 1.344 ± 0.209
1.461SerTyr: 1.461 ± 0.19
0.0SerXaa: 0.0 ± 0.0
Thr
5.201ThrAla: 5.201 ± 0.378
0.76ThrCys: 0.76 ± 0.138
3.331ThrAsp: 3.331 ± 0.268
3.711ThrGlu: 3.711 ± 0.372
2.162ThrPhe: 2.162 ± 0.239
4.324ThrGly: 4.324 ± 0.428
1.11ThrHis: 1.11 ± 0.179
3.009ThrIle: 3.009 ± 0.291
1.841ThrLys: 1.841 ± 0.282
4.412ThrLeu: 4.412 ± 0.396
0.73ThrMet: 0.73 ± 0.137
1.811ThrAsn: 1.811 ± 0.25
3.681ThrPro: 3.681 ± 0.365
1.344ThrGln: 1.344 ± 0.183
3.302ThrArg: 3.302 ± 0.285
2.337ThrSer: 2.337 ± 0.29
2.98ThrThr: 2.98 ± 0.41
4.704ThrVal: 4.704 ± 0.343
1.49ThrTrp: 1.49 ± 0.203
2.016ThrTyr: 2.016 ± 0.264
0.0ThrXaa: 0.0 ± 0.0
Val
6.895ValAla: 6.895 ± 0.502
0.964ValCys: 0.964 ± 0.181
5.259ValAsp: 5.259 ± 0.404
5.201ValGlu: 5.201 ± 0.378
1.724ValPhe: 1.724 ± 0.239
5.376ValGly: 5.376 ± 0.418
1.344ValHis: 1.344 ± 0.226
3.565ValIle: 3.565 ± 0.339
2.6ValLys: 2.6 ± 0.318
4.762ValLeu: 4.762 ± 0.429
1.49ValMet: 1.49 ± 0.216
2.367ValAsn: 2.367 ± 0.28
3.711ValPro: 3.711 ± 0.284
1.928ValGln: 1.928 ± 0.238
4.5ValArg: 4.5 ± 0.441
3.857ValSer: 3.857 ± 0.308
4.295ValThr: 4.295 ± 0.42
5.376ValVal: 5.376 ± 0.52
1.081ValTrp: 1.081 ± 0.205
1.958ValTyr: 1.958 ± 0.256
0.0ValXaa: 0.0 ± 0.0
Trp
1.958TrpAla: 1.958 ± 0.272
0.614TrpCys: 0.614 ± 0.148
1.256TrpAsp: 1.256 ± 0.197
1.139TrpGlu: 1.139 ± 0.19
0.672TrpPhe: 0.672 ± 0.149
1.724TrpGly: 1.724 ± 0.243
0.76TrpHis: 0.76 ± 0.144
1.023TrpIle: 1.023 ± 0.207
0.584TrpLys: 0.584 ± 0.145
1.987TrpLeu: 1.987 ± 0.287
0.584TrpMet: 0.584 ± 0.145
0.672TrpAsn: 0.672 ± 0.153
1.139TrpPro: 1.139 ± 0.175
0.614TrpGln: 0.614 ± 0.13
2.074TrpArg: 2.074 ± 0.262
1.841TrpSer: 1.841 ± 0.251
1.256TrpThr: 1.256 ± 0.183
2.016TrpVal: 2.016 ± 0.289
0.555TrpTrp: 0.555 ± 0.149
0.614TrpTyr: 0.614 ± 0.147
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.565TyrAla: 3.565 ± 0.306
0.409TyrCys: 0.409 ± 0.122
2.074TyrAsp: 2.074 ± 0.236
2.279TyrGlu: 2.279 ± 0.286
0.555TyrPhe: 0.555 ± 0.12
2.805TyrGly: 2.805 ± 0.285
0.467TyrHis: 0.467 ± 0.124
1.256TyrIle: 1.256 ± 0.199
1.11TyrLys: 1.11 ± 0.179
2.893TyrLeu: 2.893 ± 0.291
0.205TyrMet: 0.205 ± 0.072
0.73TyrAsn: 0.73 ± 0.138
1.227TyrPro: 1.227 ± 0.168
0.906TyrGln: 0.906 ± 0.17
2.834TyrArg: 2.834 ± 0.303
1.315TyrSer: 1.315 ± 0.202
1.549TyrThr: 1.549 ± 0.256
2.425TyrVal: 2.425 ± 0.299
0.614TyrTrp: 0.614 ± 0.142
0.818TyrTyr: 0.818 ± 0.172
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 229 proteins (34227 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski