Amino acid dipepetide frequency for Tatlockia micdadei (Legionella micdadei)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.826AlaAla: 6.826 ± 0.117	1.076AlaCys: 1.076 ± 0.038	3.448AlaAsp: 3.448 ± 0.06	4.581AlaGlu: 4.581 ± 0.07	3.346AlaPhe: 3.346 ± 0.063	5.056AlaGly: 5.056 ± 0.098	1.771AlaHis: 1.771 ± 0.05	6.476AlaIle: 6.476 ± 0.089	5.155AlaLys: 5.155 ± 0.085	9.428AlaLeu: 9.428 ± 0.12	2.125AlaMet: 2.125 ± 0.06	3.793AlaAsn: 3.793 ± 0.075	2.523AlaPro: 2.523 ± 0.053	3.59AlaGln: 3.59 ± 0.068	3.567AlaArg: 3.567 ± 0.071	4.782AlaSer: 4.782 ± 0.081	3.991AlaThr: 3.991 ± 0.073	4.942AlaVal: 4.942 ± 0.084	0.815AlaTrp: 0.815 ± 0.034	2.597AlaTyr: 2.597 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.816CysAla: 0.816 ± 0.029	0.194CysCys: 0.194 ± 0.013	0.559CysAsp: 0.559 ± 0.025	0.677CysGlu: 0.677 ± 0.024	0.655CysPhe: 0.655 ± 0.027	0.879CysGly: 0.879 ± 0.029	0.369CysHis: 0.369 ± 0.017	0.791CysIle: 0.791 ± 0.025	0.591CysLys: 0.591 ± 0.024	1.417CysLeu: 1.417 ± 0.044	0.26CysMet: 0.26 ± 0.018	0.479CysAsn: 0.479 ± 0.025	0.51CysPro: 0.51 ± 0.022	0.535CysGln: 0.535 ± 0.022	0.534CysArg: 0.534 ± 0.022	0.748CysSer: 0.748 ± 0.033	0.543CysThr: 0.543 ± 0.027	0.673CysVal: 0.673 ± 0.024	0.161CysTrp: 0.161 ± 0.011	0.496CysTyr: 0.496 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.464AspAla: 3.464 ± 0.073	0.618AspCys: 0.618 ± 0.024	2.199AspAsp: 2.199 ± 0.047	3.559AspGlu: 3.559 ± 0.066	2.407AspPhe: 2.407 ± 0.051	2.654AspGly: 2.654 ± 0.061	0.918AspHis: 0.918 ± 0.031	3.361AspIle: 3.361 ± 0.06	3.305AspLys: 3.305 ± 0.062	5.054AspLeu: 5.054 ± 0.072	1.004AspMet: 1.004 ± 0.032	2.197AspAsn: 2.197 ± 0.049	2.033AspPro: 2.033 ± 0.048	1.64AspGln: 1.64 ± 0.042	1.958AspArg: 1.958 ± 0.048	2.903AspSer: 2.903 ± 0.06	2.101AspThr: 2.101 ± 0.054	2.692AspVal: 2.692 ± 0.056	0.713AspTrp: 0.713 ± 0.029	2.119AspTyr: 2.119 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.772GluAla: 4.772 ± 0.096	0.539GluCys: 0.539 ± 0.025	2.556GluAsp: 2.556 ± 0.055	4.562GluGlu: 4.562 ± 0.106	2.405GluPhe: 2.405 ± 0.055	3.13GluGly: 3.13 ± 0.076	1.487GluHis: 1.487 ± 0.047	4.78GluIle: 4.78 ± 0.073	4.742GluLys: 4.742 ± 0.093	6.905GluLeu: 6.905 ± 0.123	1.581GluMet: 1.581 ± 0.04	2.974GluAsn: 2.974 ± 0.065	1.886GluPro: 1.886 ± 0.051	3.395GluGln: 3.395 ± 0.116	3.082GluArg: 3.082 ± 0.068	3.33GluSer: 3.33 ± 0.064	3.136GluThr: 3.136 ± 0.064	3.515GluVal: 3.515 ± 0.066	0.63GluTrp: 0.63 ± 0.029	1.812GluTyr: 1.812 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.732PheAla: 3.732 ± 0.064	0.669PheCys: 0.669 ± 0.028	2.501PheAsp: 2.501 ± 0.046	2.246PheGlu: 2.246 ± 0.047	2.591PhePhe: 2.591 ± 0.059	2.73PheGly: 2.73 ± 0.066	1.041PheHis: 1.041 ± 0.031	3.582PheIle: 3.582 ± 0.073	2.363PheLys: 2.363 ± 0.051	4.868PheLeu: 4.868 ± 0.079	0.946PheMet: 0.946 ± 0.03	2.305PheAsn: 2.305 ± 0.055	1.877PhePro: 1.877 ± 0.05	1.472PheGln: 1.472 ± 0.04	1.668PheArg: 1.668 ± 0.043	3.629PheSer: 3.629 ± 0.069	2.552PheThr: 2.552 ± 0.048	2.592PheVal: 2.592 ± 0.052	0.556PheTrp: 0.556 ± 0.025	1.798PheTyr: 1.798 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.386GlyAla: 4.386 ± 0.087	0.824GlyCys: 0.824 ± 0.031	2.658GlyAsp: 2.658 ± 0.056	3.537GlyGlu: 3.537 ± 0.079	3.292GlyPhe: 3.292 ± 0.079	4.15GlyGly: 4.15 ± 0.087	1.501GlyHis: 1.501 ± 0.041	4.858GlyIle: 4.858 ± 0.101	3.846GlyLys: 3.846 ± 0.072	6.797GlyLeu: 6.797 ± 0.11	1.636GlyMet: 1.636 ± 0.044	2.571GlyAsn: 2.571 ± 0.052	1.622GlyPro: 1.622 ± 0.044	2.603GlyGln: 2.603 ± 0.055	2.727GlyArg: 2.727 ± 0.067	3.609GlySer: 3.609 ± 0.058	2.972GlyThr: 2.972 ± 0.061	4.019GlyVal: 4.019 ± 0.083	0.833GlyTrp: 0.833 ± 0.032	2.432GlyTyr: 2.432 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.868HisAla: 1.868 ± 0.045	0.416HisCys: 0.416 ± 0.025	1.093HisAsp: 1.093 ± 0.036	1.366HisGlu: 1.366 ± 0.044	1.438HisPhe: 1.438 ± 0.043	1.544HisGly: 1.544 ± 0.047	0.886HisHis: 0.886 ± 0.034	1.449HisIle: 1.449 ± 0.037	1.125HisLys: 1.125 ± 0.033	2.81HisLeu: 2.81 ± 0.058	0.476HisMet: 0.476 ± 0.022	0.891HisAsn: 0.891 ± 0.029	1.326HisPro: 1.326 ± 0.038	1.296HisGln: 1.296 ± 0.04	1.26HisArg: 1.26 ± 0.039	1.48HisSer: 1.48 ± 0.041	1.095HisThr: 1.095 ± 0.037	1.309HisVal: 1.309 ± 0.039	0.399HisTrp: 0.399 ± 0.018	1.186HisTyr: 1.186 ± 0.041	0.0HisXaa: 0.0 ± 0.0
Ile	6.662IleAla: 6.662 ± 0.105	0.864IleCys: 0.864 ± 0.034	4.146IleAsp: 4.146 ± 0.071	4.679IleGlu: 4.679 ± 0.072	2.826IlePhe: 2.826 ± 0.072	4.615IleGly: 4.615 ± 0.092	1.792IleHis: 1.792 ± 0.039	5.127IleIle: 5.127 ± 0.096	4.554IleLys: 4.554 ± 0.073	7.083IleLeu: 7.083 ± 0.118	1.402IleMet: 1.402 ± 0.035	3.985IleAsn: 3.985 ± 0.072	3.465IlePro: 3.465 ± 0.065	2.676IleGln: 2.676 ± 0.056	3.275IleArg: 3.275 ± 0.056	4.928IleSer: 4.928 ± 0.075	4.026IleThr: 4.026 ± 0.071	4.089IleVal: 4.089 ± 0.074	0.627IleTrp: 0.627 ± 0.027	2.215IleTyr: 2.215 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.894LysAla: 4.894 ± 0.09	0.391LysCys: 0.391 ± 0.02	2.667LysAsp: 2.667 ± 0.053	4.438LysGlu: 4.438 ± 0.112	1.824LysPhe: 1.824 ± 0.044	3.163LysGly: 3.163 ± 0.061	1.449LysHis: 1.449 ± 0.041	4.516LysIle: 4.516 ± 0.078	4.581LysLys: 4.581 ± 0.089	6.096LysLeu: 6.096 ± 0.084	1.438LysMet: 1.438 ± 0.037	3.192LysAsn: 3.192 ± 0.056	2.853LysPro: 2.853 ± 0.051	3.333LysGln: 3.333 ± 0.068	3.054LysArg: 3.054 ± 0.053	3.543LysSer: 3.543 ± 0.084	3.478LysThr: 3.478 ± 0.056	3.163LysVal: 3.163 ± 0.066	0.552LysTrp: 0.552 ± 0.023	1.623LysTyr: 1.623 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	9.872LeuAla: 9.872 ± 0.128	1.374LeuCys: 1.374 ± 0.044	5.095LeuAsp: 5.095 ± 0.086	6.095LeuGlu: 6.095 ± 0.125	5.326LeuPhe: 5.326 ± 0.087	6.828LeuGly: 6.828 ± 0.112	2.602LeuHis: 2.602 ± 0.051	8.309LeuIle: 8.309 ± 0.102	6.506LeuLys: 6.506 ± 0.119	12.307LeuLeu: 12.307 ± 0.156	2.49LeuMet: 2.49 ± 0.055	5.351LeuAsn: 5.351 ± 0.079	5.238LeuPro: 5.238 ± 0.078	4.602LeuGln: 4.602 ± 0.075	4.892LeuArg: 4.892 ± 0.084	8.174LeuSer: 8.174 ± 0.104	6.096LeuThr: 6.096 ± 0.082	6.446LeuVal: 6.446 ± 0.085	1.075LeuTrp: 1.075 ± 0.034	3.125LeuTyr: 3.125 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.012MetAla: 2.012 ± 0.047	0.18MetCys: 0.18 ± 0.014	1.095MetAsp: 1.095 ± 0.032	1.155MetGlu: 1.155 ± 0.037	0.717MetPhe: 0.717 ± 0.026	1.448MetGly: 1.448 ± 0.045	0.599MetHis: 0.599 ± 0.026	1.486MetIle: 1.486 ± 0.042	1.483MetLys: 1.483 ± 0.039	2.526MetLeu: 2.526 ± 0.055	0.686MetMet: 0.686 ± 0.03	1.081MetAsn: 1.081 ± 0.033	1.135MetPro: 1.135 ± 0.034	1.134MetGln: 1.134 ± 0.03	1.189MetArg: 1.189 ± 0.031	1.499MetSer: 1.499 ± 0.038	1.319MetThr: 1.319 ± 0.038	1.41MetVal: 1.41 ± 0.042	0.165MetTrp: 0.165 ± 0.012	0.505MetTyr: 0.505 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.432AsnAla: 3.432 ± 0.059	0.6AsnCys: 0.6 ± 0.024	2.174AsnAsp: 2.174 ± 0.051	2.889AsnGlu: 2.889 ± 0.058	2.061AsnPhe: 2.061 ± 0.055	2.546AsnGly: 2.546 ± 0.058	1.344AsnHis: 1.344 ± 0.041	2.901AsnIle: 2.901 ± 0.062	2.826AsnLys: 2.826 ± 0.054	5.185AsnLeu: 5.185 ± 0.081	0.824AsnMet: 0.824 ± 0.029	2.394AsnAsn: 2.394 ± 0.056	2.755AsnPro: 2.755 ± 0.062	2.669AsnGln: 2.669 ± 0.063	2.263AsnArg: 2.263 ± 0.048	2.909AsnSer: 2.909 ± 0.066	2.384AsnThr: 2.384 ± 0.048	2.232AsnVal: 2.232 ± 0.053	0.614AsnTrp: 0.614 ± 0.026	1.891AsnTyr: 1.891 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.043ProAla: 3.043 ± 0.064	0.456ProCys: 0.456 ± 0.023	2.159ProAsp: 2.159 ± 0.048	3.099ProGlu: 3.099 ± 0.058	2.043ProPhe: 2.043 ± 0.054	2.705ProGly: 2.705 ± 0.058	1.058ProHis: 1.058 ± 0.037	3.056ProIle: 3.056 ± 0.061	2.27ProLys: 2.27 ± 0.051	4.703ProLeu: 4.703 ± 0.076	0.897ProMet: 0.897 ± 0.027	1.979ProAsn: 1.979 ± 0.045	1.683ProPro: 1.683 ± 0.046	1.876ProGln: 1.876 ± 0.038	1.525ProArg: 1.525 ± 0.046	2.743ProSer: 2.743 ± 0.05	2.248ProThr: 2.248 ± 0.056	2.887ProVal: 2.887 ± 0.063	0.514ProTrp: 0.514 ± 0.022	1.434ProTyr: 1.434 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.155GlnAla: 4.155 ± 0.076	0.452GlnCys: 0.452 ± 0.022	1.851GlnAsp: 1.851 ± 0.045	2.793GlnGlu: 2.793 ± 0.055	2.181GlnPhe: 2.181 ± 0.046	2.726GlnGly: 2.726 ± 0.06	1.195GlnHis: 1.195 ± 0.039	3.222GlnIle: 3.222 ± 0.064	2.621GlnLys: 2.621 ± 0.053	5.353GlnLeu: 5.353 ± 0.101	0.989GlnMet: 0.989 ± 0.033	1.957GlnAsn: 1.957 ± 0.045	1.74GlnPro: 1.74 ± 0.048	2.881GlnGln: 2.881 ± 0.071	2.21GlnArg: 2.21 ± 0.056	2.599GlnSer: 2.599 ± 0.053	2.418GlnThr: 2.418 ± 0.054	2.679GlnVal: 2.679 ± 0.055	0.571GlnTrp: 0.571 ± 0.025	1.395GlnTyr: 1.395 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.239ArgAla: 3.239 ± 0.059	0.504ArgCys: 0.504 ± 0.023	2.179ArgAsp: 2.179 ± 0.052	3.161ArgGlu: 3.161 ± 0.069	2.323ArgPhe: 2.323 ± 0.047	2.444ArgGly: 2.444 ± 0.068	1.21ArgHis: 1.21 ± 0.033	3.434ArgIle: 3.434 ± 0.075	2.661ArgLys: 2.661 ± 0.06	5.412ArgLeu: 5.412 ± 0.071	1.057ArgMet: 1.057 ± 0.029	2.054ArgAsn: 2.054 ± 0.046	1.537ArgPro: 1.537 ± 0.039	2.218ArgGln: 2.218 ± 0.05	2.217ArgArg: 2.217 ± 0.057	2.401ArgSer: 2.401 ± 0.052	2.121ArgThr: 2.121 ± 0.047	2.804ArgVal: 2.804 ± 0.058	0.572ArgTrp: 0.572 ± 0.024	1.842ArgTyr: 1.842 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.571SerAla: 4.571 ± 0.077	0.795SerCys: 0.795 ± 0.033	2.794SerAsp: 2.794 ± 0.049	3.733SerGlu: 3.733 ± 0.063	3.098SerPhe: 3.098 ± 0.067	4.183SerGly: 4.183 ± 0.073	1.586SerHis: 1.586 ± 0.039	4.515SerIle: 4.515 ± 0.082	3.431SerLys: 3.431 ± 0.056	7.735SerLeu: 7.735 ± 0.104	1.584SerMet: 1.584 ± 0.037	2.729SerAsn: 2.729 ± 0.059	2.913SerPro: 2.913 ± 0.055	2.955SerGln: 2.955 ± 0.06	2.753SerArg: 2.753 ± 0.051	4.571SerSer: 4.571 ± 0.081	3.379SerThr: 3.379 ± 0.067	3.624SerVal: 3.624 ± 0.065	0.789SerTrp: 0.789 ± 0.026	2.234SerTyr: 2.234 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.184ThrAla: 4.184 ± 0.075	0.536ThrCys: 0.536 ± 0.022	2.353ThrAsp: 2.353 ± 0.044	2.866ThrGlu: 2.866 ± 0.055	2.015ThrPhe: 2.015 ± 0.05	3.616ThrGly: 3.616 ± 0.061	1.359ThrHis: 1.359 ± 0.037	3.799ThrIle: 3.799 ± 0.075	2.644ThrLys: 2.644 ± 0.059	6.086ThrLeu: 6.086 ± 0.098	1.079ThrMet: 1.079 ± 0.035	2.322ThrAsn: 2.322 ± 0.058	2.789ThrPro: 2.789 ± 0.059	2.332ThrGln: 2.332 ± 0.044	2.258ThrArg: 2.258 ± 0.05	3.195ThrSer: 3.195 ± 0.064	2.837ThrThr: 2.837 ± 0.063	3.421ThrVal: 3.421 ± 0.062	0.563ThrTrp: 0.563 ± 0.027	1.602ThrTyr: 1.602 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	4.836ValAla: 4.836 ± 0.086	0.74ValCys: 0.74 ± 0.028	3.214ValAsp: 3.214 ± 0.059	3.492ValGlu: 3.492 ± 0.061	2.762ValPhe: 2.762 ± 0.051	3.636ValGly: 3.636 ± 0.078	1.253ValHis: 1.253 ± 0.038	4.658ValIle: 4.658 ± 0.076	3.388ValLys: 3.388 ± 0.064	6.265ValLeu: 6.265 ± 0.08	1.479ValMet: 1.479 ± 0.043	2.842ValAsn: 2.842 ± 0.058	2.38ValPro: 2.38 ± 0.054	1.962ValGln: 1.962 ± 0.051	2.541ValArg: 2.541 ± 0.058	4.085ValSer: 4.085 ± 0.073	3.152ValThr: 3.152 ± 0.069	4.088ValVal: 4.088 ± 0.084	0.562ValTrp: 0.562 ± 0.026	1.823ValTyr: 1.823 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.706TrpAla: 0.706 ± 0.032	0.145TrpCys: 0.145 ± 0.012	0.495TrpAsp: 0.495 ± 0.021	0.49TrpGlu: 0.49 ± 0.024	0.588TrpPhe: 0.588 ± 0.025	0.676TrpGly: 0.676 ± 0.026	0.358TrpHis: 0.358 ± 0.021	0.79TrpIle: 0.79 ± 0.035	0.516TrpLys: 0.516 ± 0.024	1.609TrpLeu: 1.609 ± 0.05	0.295TrpMet: 0.295 ± 0.017	0.426TrpAsn: 0.426 ± 0.018	0.491TrpPro: 0.491 ± 0.024	0.799TrpGln: 0.799 ± 0.028	0.602TrpArg: 0.602 ± 0.027	0.648TrpSer: 0.648 ± 0.029	0.445TrpThr: 0.445 ± 0.02	0.736TrpVal: 0.736 ± 0.03	0.145TrpTrp: 0.145 ± 0.012	0.408TrpTyr: 0.408 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.419TyrAla: 2.419 ± 0.054	0.515TyrCys: 0.515 ± 0.022	1.658TyrAsp: 1.658 ± 0.071	1.802TyrGlu: 1.802 ± 0.049	1.821TyrPhe: 1.821 ± 0.048	2.146TyrGly: 2.146 ± 0.051	0.933TyrHis: 0.933 ± 0.035	1.931TyrIle: 1.931 ± 0.044	1.643TyrLys: 1.643 ± 0.041	4.166TyrLeu: 4.166 ± 0.071	0.574TyrMet: 0.574 ± 0.025	1.368TyrAsn: 1.368 ± 0.045	1.621TyrPro: 1.621 ± 0.047	2.019TyrGln: 2.019 ± 0.05	1.819TyrArg: 1.819 ± 0.049	2.194TyrSer: 2.194 ± 0.051	1.563TyrThr: 1.563 ± 0.036	1.836TyrVal: 1.836 ± 0.045	0.51TyrTrp: 0.51 ± 0.024	1.355TyrTyr: 1.355 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2989 proteins (985229 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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