Amino acid dipepetide frequency for Shewanella sp. P1-14-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.801AlaAla: 7.801 ± 0.11	0.958AlaCys: 0.958 ± 0.029	5.2AlaAsp: 5.2 ± 0.069	5.728AlaGlu: 5.728 ± 0.078	3.325AlaPhe: 3.325 ± 0.062	5.844AlaGly: 5.844 ± 0.087	1.595AlaHis: 1.595 ± 0.036	6.28AlaIle: 6.28 ± 0.08	5.313AlaLys: 5.313 ± 0.073	9.281AlaLeu: 9.281 ± 0.099	2.594AlaMet: 2.594 ± 0.049	4.179AlaAsn: 4.179 ± 0.059	2.875AlaPro: 2.875 ± 0.053	3.914AlaGln: 3.914 ± 0.066	3.148AlaArg: 3.148 ± 0.05	5.824AlaSer: 5.824 ± 0.065	4.606AlaThr: 4.606 ± 0.068	5.587AlaVal: 5.587 ± 0.074	0.873AlaTrp: 0.873 ± 0.027	2.394AlaTyr: 2.394 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.774CysAla: 0.774 ± 0.021	0.164CysCys: 0.164 ± 0.011	0.555CysAsp: 0.555 ± 0.022	0.615CysGlu: 0.615 ± 0.022	0.475CysPhe: 0.475 ± 0.019	0.783CysGly: 0.783 ± 0.023	0.465CysHis: 0.465 ± 0.035	0.626CysIle: 0.626 ± 0.024	0.435CysLys: 0.435 ± 0.02	0.947CysLeu: 0.947 ± 0.025	0.217CysMet: 0.217 ± 0.012	0.377CysAsn: 0.377 ± 0.017	0.442CysPro: 0.442 ± 0.02	0.499CysGln: 0.499 ± 0.019	0.402CysArg: 0.402 ± 0.015	0.72CysSer: 0.72 ± 0.023	0.448CysThr: 0.448 ± 0.019	0.645CysVal: 0.645 ± 0.02	0.137CysTrp: 0.137 ± 0.012	0.335CysTyr: 0.335 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.839AspAla: 4.839 ± 0.08	0.549AspCys: 0.549 ± 0.021	3.375AspAsp: 3.375 ± 0.058	3.936AspGlu: 3.936 ± 0.053	2.608AspPhe: 2.608 ± 0.047	3.998AspGly: 3.998 ± 0.088	1.009AspHis: 1.009 ± 0.033	4.524AspIle: 4.524 ± 0.068	3.419AspLys: 3.419 ± 0.051	5.123AspLeu: 5.123 ± 0.063	1.497AspMet: 1.497 ± 0.037	3.102AspAsn: 3.102 ± 0.063	2.086AspPro: 2.086 ± 0.039	1.741AspGln: 1.741 ± 0.037	2.021AspArg: 2.021 ± 0.042	3.735AspSer: 3.735 ± 0.063	3.204AspThr: 3.204 ± 0.06	3.911AspVal: 3.911 ± 0.064	0.889AspTrp: 0.889 ± 0.026	2.139AspTyr: 2.139 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.957GluAla: 4.957 ± 0.073	0.458GluCys: 0.458 ± 0.021	2.916GluAsp: 2.916 ± 0.058	3.149GluGlu: 3.149 ± 0.052	2.488GluPhe: 2.488 ± 0.044	3.39GluGly: 3.39 ± 0.054	1.535GluHis: 1.535 ± 0.03	3.62GluIle: 3.62 ± 0.05	3.335GluLys: 3.335 ± 0.06	6.961GluLeu: 6.961 ± 0.084	1.647GluMet: 1.647 ± 0.031	2.631GluAsn: 2.631 ± 0.043	1.953GluPro: 1.953 ± 0.041	4.262GluGln: 4.262 ± 0.058	2.827GluArg: 2.827 ± 0.05	3.736GluSer: 3.736 ± 0.061	3.246GluThr: 3.246 ± 0.054	4.16GluVal: 4.16 ± 0.057	0.652GluTrp: 0.652 ± 0.023	1.822GluTyr: 1.822 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.608PheAla: 3.608 ± 0.056	0.461PheCys: 0.461 ± 0.018	2.96PheAsp: 2.96 ± 0.047	2.701PheGlu: 2.701 ± 0.043	1.703PhePhe: 1.703 ± 0.041	3.113PheGly: 3.113 ± 0.055	0.771PheHis: 0.771 ± 0.022	3.037PheIle: 3.037 ± 0.051	2.051PheLys: 2.051 ± 0.042	3.169PheLeu: 3.169 ± 0.05	1.064PheMet: 1.064 ± 0.031	2.388PheAsn: 2.388 ± 0.044	1.376PhePro: 1.376 ± 0.036	1.204PheGln: 1.204 ± 0.028	1.282PheArg: 1.282 ± 0.032	3.537PheSer: 3.537 ± 0.049	2.46PheThr: 2.46 ± 0.046	2.729PheVal: 2.729 ± 0.043	0.525PheTrp: 0.525 ± 0.021	1.431PheTyr: 1.431 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.152GlyAla: 5.152 ± 0.076	0.871GlyCys: 0.871 ± 0.028	3.713GlyAsp: 3.713 ± 0.06	4.169GlyGlu: 4.169 ± 0.054	3.312GlyPhe: 3.312 ± 0.06	4.5GlyGly: 4.5 ± 0.07	1.581GlyHis: 1.581 ± 0.038	4.629GlyIle: 4.629 ± 0.06	3.789GlyLys: 3.789 ± 0.056	6.823GlyLeu: 6.823 ± 0.075	1.97GlyMet: 1.97 ± 0.039	2.788GlyAsn: 2.788 ± 0.062	1.606GlyPro: 1.606 ± 0.036	2.914GlyGln: 2.914 ± 0.047	2.728GlyArg: 2.728 ± 0.05	4.031GlySer: 4.031 ± 0.066	3.42GlyThr: 3.42 ± 0.059	5.057GlyVal: 5.057 ± 0.061	0.861GlyTrp: 0.861 ± 0.026	2.609GlyTyr: 2.609 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.582HisAla: 1.582 ± 0.036	0.325HisCys: 0.325 ± 0.015	1.133HisAsp: 1.133 ± 0.025	1.072HisGlu: 1.072 ± 0.029	1.105HisPhe: 1.105 ± 0.025	1.57HisGly: 1.57 ± 0.042	0.713HisHis: 0.713 ± 0.024	1.498HisIle: 1.498 ± 0.036	1.049HisLys: 1.049 ± 0.027	2.186HisLeu: 2.186 ± 0.042	0.51HisMet: 0.51 ± 0.021	0.949HisAsn: 0.949 ± 0.025	1.104HisPro: 1.104 ± 0.027	1.438HisGln: 1.438 ± 0.035	0.944HisArg: 0.944 ± 0.026	1.445HisSer: 1.445 ± 0.031	1.082HisThr: 1.082 ± 0.033	1.282HisVal: 1.282 ± 0.031	0.372HisTrp: 0.372 ± 0.018	0.894HisTyr: 0.894 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.709IleAla: 6.709 ± 0.084	0.7IleCys: 0.7 ± 0.022	4.608IleAsp: 4.608 ± 0.071	4.826IleGlu: 4.826 ± 0.061	2.187IlePhe: 2.187 ± 0.04	4.739IleGly: 4.739 ± 0.062	1.228IleHis: 1.228 ± 0.032	3.995IleIle: 3.995 ± 0.061	3.612IleLys: 3.612 ± 0.066	5.172IleLeu: 5.172 ± 0.068	1.346IleMet: 1.346 ± 0.032	3.813IleAsn: 3.813 ± 0.059	2.545IlePro: 2.545 ± 0.046	2.297IleGln: 2.297 ± 0.045	2.486IleArg: 2.486 ± 0.046	5.043IleSer: 5.043 ± 0.067	3.954IleThr: 3.954 ± 0.068	4.081IleVal: 4.081 ± 0.059	0.674IleTrp: 0.674 ± 0.024	1.79IleTyr: 1.79 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.879LysAla: 4.879 ± 0.068	0.332LysCys: 0.332 ± 0.022	2.692LysAsp: 2.692 ± 0.045	2.771LysGlu: 2.771 ± 0.054	1.645LysPhe: 1.645 ± 0.034	3.249LysGly: 3.249 ± 0.057	1.312LysHis: 1.312 ± 0.036	2.908LysIle: 2.908 ± 0.045	2.65LysLys: 2.65 ± 0.049	5.484LysLeu: 5.484 ± 0.073	1.468LysMet: 1.468 ± 0.032	2.123LysAsn: 2.123 ± 0.044	2.467LysPro: 2.467 ± 0.047	3.419LysGln: 3.419 ± 0.06	2.508LysArg: 2.508 ± 0.043	3.352LysSer: 3.352 ± 0.056	2.89LysThr: 2.89 ± 0.047	3.922LysVal: 3.922 ± 0.063	0.561LysTrp: 0.561 ± 0.02	1.432LysTyr: 1.432 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	9.927LeuAla: 9.927 ± 0.099	1.034LeuCys: 1.034 ± 0.029	5.646LeuAsp: 5.646 ± 0.064	5.415LeuGlu: 5.415 ± 0.067	4.23LeuPhe: 4.23 ± 0.064	6.41LeuGly: 6.41 ± 0.079	1.926LeuHis: 1.926 ± 0.036	6.362LeuIle: 6.362 ± 0.075	5.061LeuLys: 5.061 ± 0.074	10.379LeuLeu: 10.379 ± 0.132	2.745LeuMet: 2.745 ± 0.051	4.806LeuAsn: 4.806 ± 0.066	4.533LeuPro: 4.533 ± 0.06	3.693LeuGln: 3.693 ± 0.058	3.721LeuArg: 3.721 ± 0.053	8.095LeuSer: 8.095 ± 0.098	6.724LeuThr: 6.724 ± 0.078	6.819LeuVal: 6.819 ± 0.077	1.034LeuTrp: 1.034 ± 0.029	2.6LeuTyr: 2.6 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.573MetAla: 2.573 ± 0.048	0.207MetCys: 0.207 ± 0.012	1.249MetAsp: 1.249 ± 0.03	1.197MetGlu: 1.197 ± 0.029	0.909MetPhe: 0.909 ± 0.025	1.736MetGly: 1.736 ± 0.04	0.522MetHis: 0.522 ± 0.02	1.446MetIle: 1.446 ± 0.034	1.515MetLys: 1.515 ± 0.034	2.875MetLeu: 2.875 ± 0.049	0.848MetMet: 0.848 ± 0.022	1.154MetAsn: 1.154 ± 0.03	1.265MetPro: 1.265 ± 0.033	1.14MetGln: 1.14 ± 0.029	1.097MetArg: 1.097 ± 0.028	2.082MetSer: 2.082 ± 0.032	1.757MetThr: 1.757 ± 0.035	1.831MetVal: 1.831 ± 0.038	0.245MetTrp: 0.245 ± 0.013	0.588MetTyr: 0.588 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.794AsnAla: 3.794 ± 0.053	0.466AsnCys: 0.466 ± 0.021	2.826AsnAsp: 2.826 ± 0.07	2.705AsnGlu: 2.705 ± 0.05	1.652AsnPhe: 1.652 ± 0.037	3.242AsnGly: 3.242 ± 0.055	1.059AsnHis: 1.059 ± 0.031	3.159AsnIle: 3.159 ± 0.049	2.548AsnLys: 2.548 ± 0.048	4.124AsnLeu: 4.124 ± 0.058	1.116AsnMet: 1.116 ± 0.026	2.372AsnAsn: 2.372 ± 0.043	2.147AsnPro: 2.147 ± 0.036	2.651AsnGln: 2.651 ± 0.053	1.936AsnArg: 1.936 ± 0.037	2.956AsnSer: 2.956 ± 0.054	2.65AsnThr: 2.65 ± 0.05	2.986AsnVal: 2.986 ± 0.051	0.625AsnTrp: 0.625 ± 0.021	1.44AsnTyr: 1.44 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.082ProAla: 3.082 ± 0.055	0.291ProCys: 0.291 ± 0.017	2.32ProAsp: 2.32 ± 0.045	3.0ProGlu: 3.0 ± 0.054	1.694ProPhe: 1.694 ± 0.034	2.147ProGly: 2.147 ± 0.041	0.871ProHis: 0.871 ± 0.026	2.663ProIle: 2.663 ± 0.047	2.049ProLys: 2.049 ± 0.041	4.027ProLeu: 4.027 ± 0.061	0.998ProMet: 0.998 ± 0.029	1.766ProAsn: 1.766 ± 0.035	0.986ProPro: 0.986 ± 0.029	1.779ProGln: 1.779 ± 0.038	1.139ProArg: 1.139 ± 0.03	2.47ProSer: 2.47 ± 0.039	2.168ProThr: 2.168 ± 0.047	2.845ProVal: 2.845 ± 0.052	0.499ProTrp: 0.499 ± 0.022	1.217ProTyr: 1.217 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.699GlnAla: 4.699 ± 0.075	0.443GlnCys: 0.443 ± 0.018	2.176GlnAsp: 2.176 ± 0.044	2.135GlnGlu: 2.135 ± 0.046	2.072GlnPhe: 2.072 ± 0.039	3.074GlnGly: 3.074 ± 0.051	1.401GlnHis: 1.401 ± 0.036	2.722GlnIle: 2.722 ± 0.048	2.101GlnLys: 2.101 ± 0.04	5.686GlnLeu: 5.686 ± 0.08	1.169GlnMet: 1.169 ± 0.029	1.711GlnAsn: 1.711 ± 0.033	1.689GlnPro: 1.689 ± 0.038	3.984GlnGln: 3.984 ± 0.089	2.12GlnArg: 2.12 ± 0.042	3.189GlnSer: 3.189 ± 0.053	2.607GlnThr: 2.607 ± 0.046	3.395GlnVal: 3.395 ± 0.05	0.721GlnTrp: 0.721 ± 0.026	1.667GlnTyr: 1.667 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.913ArgAla: 2.913 ± 0.05	0.395ArgCys: 0.395 ± 0.017	2.181ArgAsp: 2.181 ± 0.04	2.39ArgGlu: 2.39 ± 0.047	2.067ArgPhe: 2.067 ± 0.042	2.354ArgGly: 2.354 ± 0.043	1.029ArgHis: 1.029 ± 0.029	2.724ArgIle: 2.724 ± 0.053	2.042ArgLys: 2.042 ± 0.042	4.41ArgLeu: 4.41 ± 0.065	1.045ArgMet: 1.045 ± 0.028	1.749ArgAsn: 1.749 ± 0.035	1.37ArgPro: 1.37 ± 0.032	2.079ArgGln: 2.079 ± 0.038	1.956ArgArg: 1.956 ± 0.046	2.35ArgSer: 2.35 ± 0.043	1.896ArgThr: 1.896 ± 0.034	2.793ArgVal: 2.793 ± 0.043	0.553ArgTrp: 0.553 ± 0.021	1.696ArgTyr: 1.696 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.896SerAla: 5.896 ± 0.068	0.652SerCys: 0.652 ± 0.027	3.981SerAsp: 3.981 ± 0.062	4.034SerGlu: 4.034 ± 0.057	3.104SerPhe: 3.104 ± 0.049	4.829SerGly: 4.829 ± 0.064	1.672SerHis: 1.672 ± 0.031	4.556SerIle: 4.556 ± 0.061	3.283SerLys: 3.283 ± 0.055	7.383SerLeu: 7.383 ± 0.087	1.848SerMet: 1.848 ± 0.036	3.034SerAsn: 3.034 ± 0.057	2.617SerPro: 2.617 ± 0.045	3.455SerGln: 3.455 ± 0.06	2.776SerArg: 2.776 ± 0.048	4.651SerSer: 4.651 ± 0.068	3.533SerThr: 3.533 ± 0.056	4.764SerVal: 4.764 ± 0.064	0.83SerTrp: 0.83 ± 0.025	2.129SerTyr: 2.129 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.854ThrAla: 4.854 ± 0.068	0.52ThrCys: 0.52 ± 0.021	3.483ThrAsp: 3.483 ± 0.057	3.553ThrGlu: 3.553 ± 0.054	2.154ThrPhe: 2.154 ± 0.041	4.048ThrGly: 4.048 ± 0.063	1.232ThrHis: 1.232 ± 0.032	3.54ThrIle: 3.54 ± 0.062	2.449ThrLys: 2.449 ± 0.041	5.997ThrLeu: 5.997 ± 0.071	1.215ThrMet: 1.215 ± 0.031	2.329ThrAsn: 2.329 ± 0.049	2.701ThrPro: 2.701 ± 0.049	2.897ThrGln: 2.897 ± 0.043	2.139ThrArg: 2.139 ± 0.04	3.728ThrSer: 3.728 ± 0.062	3.059ThrThr: 3.059 ± 0.052	4.007ThrVal: 4.007 ± 0.067	0.615ThrTrp: 0.615 ± 0.021	1.518ThrTyr: 1.518 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.133ValAla: 6.133 ± 0.079	0.73ValCys: 0.73 ± 0.022	4.291ValAsp: 4.291 ± 0.054	4.315ValGlu: 4.315 ± 0.058	2.74ValPhe: 2.74 ± 0.046	4.487ValGly: 4.487 ± 0.06	1.176ValHis: 1.176 ± 0.031	5.032ValIle: 5.032 ± 0.075	3.518ValLys: 3.518 ± 0.056	6.35ValLeu: 6.35 ± 0.073	1.93ValMet: 1.93 ± 0.036	3.505ValAsn: 3.505 ± 0.058	2.476ValPro: 2.476 ± 0.037	2.187ValGln: 2.187 ± 0.04	2.453ValArg: 2.453 ± 0.045	5.143ValSer: 5.143 ± 0.073	4.346ValThr: 4.346 ± 0.07	4.939ValVal: 4.939 ± 0.069	0.66ValTrp: 0.66 ± 0.023	1.868ValTyr: 1.868 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.801TrpAla: 0.801 ± 0.024	0.137TrpCys: 0.137 ± 0.01	0.648TrpAsp: 0.648 ± 0.027	0.492TrpGlu: 0.492 ± 0.019	0.6TrpPhe: 0.6 ± 0.024	0.796TrpGly: 0.796 ± 0.029	0.372TrpHis: 0.372 ± 0.019	0.674TrpIle: 0.674 ± 0.024	0.472TrpLys: 0.472 ± 0.018	1.531TrpLeu: 1.531 ± 0.037	0.339TrpMet: 0.339 ± 0.015	0.437TrpAsn: 0.437 ± 0.018	0.447TrpPro: 0.447 ± 0.019	1.006TrpGln: 1.006 ± 0.028	0.633TrpArg: 0.633 ± 0.019	0.743TrpSer: 0.743 ± 0.024	0.502TrpThr: 0.502 ± 0.019	0.787TrpVal: 0.787 ± 0.026	0.184TrpTrp: 0.184 ± 0.013	0.373TrpTyr: 0.373 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.343TyrAla: 2.343 ± 0.042	0.37TyrCys: 0.37 ± 0.014	1.751TyrAsp: 1.751 ± 0.042	1.543TyrGlu: 1.543 ± 0.037	1.503TyrPhe: 1.503 ± 0.033	2.211TyrGly: 2.211 ± 0.047	0.786TyrHis: 0.786 ± 0.026	1.809TyrIle: 1.809 ± 0.035	1.374TyrLys: 1.374 ± 0.032	3.252TyrLeu: 3.252 ± 0.053	0.668TyrMet: 0.668 ± 0.022	1.242TyrAsn: 1.242 ± 0.035	1.326TyrPro: 1.326 ± 0.029	2.203TyrGln: 2.203 ± 0.043	1.672TyrArg: 1.672 ± 0.034	2.197TyrSer: 2.197 ± 0.043	1.488TyrThr: 1.488 ± 0.037	1.738TyrVal: 1.738 ± 0.04	0.464TyrTrp: 0.464 ± 0.019	1.086TyrTyr: 1.086 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4159 proteins (1398972 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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