Amino acid dipepetide frequency for Lates calcarifer birnavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.825AlaAla: 11.825 ± 0.853
0.514AlaCys: 0.514 ± 0.336
4.113AlaAsp: 4.113 ± 0.397
6.684AlaGlu: 6.684 ± 0.216
3.599AlaPhe: 3.599 ± 0.704
4.627AlaGly: 4.627 ± 0.796
1.542AlaHis: 1.542 ± 1.009
5.141AlaIle: 5.141 ± 0.305
4.113AlaLys: 4.113 ± 0.368
11.825AlaLeu: 11.825 ± 2.204
2.571AlaMet: 2.571 ± 1.376
2.057AlaAsn: 2.057 ± 0.948
7.198AlaPro: 7.198 ± 1.649
5.141AlaGln: 5.141 ± 0.305
3.085AlaArg: 3.085 ± 0.488
7.198AlaSer: 7.198 ± 0.121
7.198AlaThr: 7.198 ± 0.885
4.627AlaVal: 4.627 ± 0.032
1.542AlaTrp: 1.542 ± 0.52
4.113AlaTyr: 4.113 ± 0.368
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.514CysAsp: 0.514 ± 0.336
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.542CysGly: 1.542 ± 0.244
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.542CysLeu: 1.542 ± 0.244
1.028CysMet: 1.028 ± 0.672
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.514CysGln: 0.514 ± 0.428
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.514CysThr: 0.514 ± 0.336
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.085AspAla: 3.085 ± 0.276
0.0AspCys: 0.0 ± 0.0
2.571AspAsp: 2.571 ± 0.612
4.627AspGlu: 4.627 ± 1.497
1.028AspPhe: 1.028 ± 0.092
2.057AspGly: 2.057 ± 0.948
1.028AspHis: 1.028 ± 0.672
3.085AspIle: 3.085 ± 0.488
3.085AspLys: 3.085 ± 1.253
4.113AspLeu: 4.113 ± 1.132
0.0AspMet: 0.0 ± 0.0
1.542AspAsn: 1.542 ± 0.244
2.057AspPro: 2.057 ± 0.58
2.057AspGln: 2.057 ± 0.184
3.085AspArg: 3.085 ± 1.04
3.085AspSer: 3.085 ± 0.276
7.198AspThr: 7.198 ± 3.701
3.085AspVal: 3.085 ± 0.488
2.571AspTrp: 2.571 ± 0.152
2.571AspTyr: 2.571 ± 0.917
0.0AspXaa: 0.0 ± 0.0
Glu
9.254GluAla: 9.254 ± 3.885
0.514GluCys: 0.514 ± 0.428
2.571GluAsp: 2.571 ± 0.152
3.599GluGlu: 3.599 ± 1.589
2.571GluPhe: 2.571 ± 0.612
3.599GluGly: 3.599 ± 0.825
1.028GluHis: 1.028 ± 0.856
2.571GluIle: 2.571 ± 0.917
3.085GluLys: 3.085 ± 1.805
5.141GluLeu: 5.141 ± 0.305
1.542GluMet: 1.542 ± 0.244
3.085GluAsn: 3.085 ± 0.276
1.028GluPro: 1.028 ± 0.672
1.542GluGln: 1.542 ± 0.52
2.571GluArg: 2.571 ± 0.612
4.113GluSer: 4.113 ± 0.397
3.085GluThr: 3.085 ± 0.488
3.085GluVal: 3.085 ± 0.488
0.514GluTrp: 0.514 ± 0.336
0.514GluTyr: 0.514 ± 0.428
0.0GluXaa: 0.0 ± 0.0
Phe
1.028PheAla: 1.028 ± 0.672
0.0PheCys: 0.0 ± 0.0
1.028PheAsp: 1.028 ± 0.672
0.514PheGlu: 0.514 ± 0.428
0.514PhePhe: 0.514 ± 0.336
3.085PheGly: 3.085 ± 1.253
0.514PheHis: 0.514 ± 0.336
0.514PheIle: 0.514 ± 0.336
2.571PheLys: 2.571 ± 0.612
4.113PheLeu: 4.113 ± 1.132
1.542PheMet: 1.542 ± 0.52
3.085PheAsn: 3.085 ± 1.805
3.599PhePro: 3.599 ± 0.825
1.028PheGln: 1.028 ± 0.092
2.571PheArg: 2.571 ± 0.152
1.028PheSer: 1.028 ± 0.856
2.571PheThr: 2.571 ± 1.681
0.514PheVal: 0.514 ± 0.336
0.514PheTrp: 0.514 ± 0.428
0.514PheTyr: 0.514 ± 0.336
0.0PheXaa: 0.0 ± 0.0
Gly
6.17GlyAla: 6.17 ± 1.741
1.028GlyCys: 1.028 ± 0.672
5.656GlyAsp: 5.656 ± 0.124
5.141GlyGlu: 5.141 ± 0.305
3.599GlyPhe: 3.599 ± 1.589
5.656GlyGly: 5.656 ± 0.124
0.514GlyHis: 0.514 ± 0.336
2.057GlyIle: 2.057 ± 0.184
3.599GlyLys: 3.599 ± 0.704
7.198GlyLeu: 7.198 ± 0.644
1.028GlyMet: 1.028 ± 0.092
1.542GlyAsn: 1.542 ± 0.244
2.057GlyPro: 2.057 ± 0.58
3.085GlyGln: 3.085 ± 0.276
5.141GlyArg: 5.141 ± 0.305
5.656GlySer: 5.656 ± 1.405
6.17GlyThr: 6.17 ± 1.741
4.113GlyVal: 4.113 ± 0.368
3.085GlyTrp: 3.085 ± 1.805
2.057GlyTyr: 2.057 ± 0.948
0.0GlyXaa: 0.0 ± 0.0
His
1.542HisAla: 1.542 ± 0.52
0.0HisCys: 0.0 ± 0.0
0.514HisAsp: 0.514 ± 0.336
0.0HisGlu: 0.0 ± 0.0
0.514HisPhe: 0.514 ± 0.428
1.028HisGly: 1.028 ± 0.092
0.514HisHis: 0.514 ± 0.336
0.0HisIle: 0.0 ± 0.0
1.028HisLys: 1.028 ± 0.092
1.542HisLeu: 1.542 ± 0.244
1.028HisMet: 1.028 ± 0.672
1.542HisAsn: 1.542 ± 1.009
0.514HisPro: 0.514 ± 0.336
1.028HisGln: 1.028 ± 0.092
1.028HisArg: 1.028 ± 0.672
0.0HisSer: 0.0 ± 0.0
1.028HisThr: 1.028 ± 0.672
1.542HisVal: 1.542 ± 0.52
0.0HisTrp: 0.0 ± 0.0
0.514HisTyr: 0.514 ± 0.336
0.0HisXaa: 0.0 ± 0.0
Ile
3.599IleAla: 3.599 ± 0.06
0.0IleCys: 0.0 ± 0.0
2.057IleAsp: 2.057 ± 0.184
2.571IleGlu: 2.571 ± 0.612
2.057IlePhe: 2.057 ± 0.58
4.113IleGly: 4.113 ± 0.397
0.514IleHis: 0.514 ± 0.336
1.028IleIle: 1.028 ± 0.672
3.085IleLys: 3.085 ± 0.276
3.599IleLeu: 3.599 ± 0.06
1.542IleMet: 1.542 ± 0.396
1.542IleAsn: 1.542 ± 0.52
4.113IlePro: 4.113 ± 0.368
2.057IleGln: 2.057 ± 0.58
1.028IleArg: 1.028 ± 0.092
3.085IleSer: 3.085 ± 0.276
3.085IleThr: 3.085 ± 2.017
3.599IleVal: 3.599 ± 0.825
1.028IleTrp: 1.028 ± 0.856
2.057IleTyr: 2.057 ± 0.948
0.0IleXaa: 0.0 ± 0.0
Lys
3.085LysAla: 3.085 ± 0.276
0.0LysCys: 0.0 ± 0.0
3.085LysAsp: 3.085 ± 1.04
5.656LysGlu: 5.656 ± 1.652
1.028LysPhe: 1.028 ± 0.672
4.113LysGly: 4.113 ± 1.896
0.0LysHis: 0.0 ± 0.0
3.085LysIle: 3.085 ± 0.488
2.057LysLys: 2.057 ± 0.58
6.17LysLeu: 6.17 ± 0.977
2.571LysMet: 2.571 ± 1.172
3.599LysAsn: 3.599 ± 0.704
4.113LysPro: 4.113 ± 0.368
3.085LysGln: 3.085 ± 1.805
1.542LysArg: 1.542 ± 0.52
5.656LysSer: 5.656 ± 0.641
3.085LysThr: 3.085 ± 2.569
3.599LysVal: 3.599 ± 2.353
0.514LysTrp: 0.514 ± 0.336
0.514LysTyr: 0.514 ± 0.336
0.0LysXaa: 0.0 ± 0.0
Leu
10.283LeuAla: 10.283 ± 0.155
0.514LeuCys: 0.514 ± 0.336
6.684LeuAsp: 6.684 ± 0.98
5.141LeuGlu: 5.141 ± 3.517
1.542LeuPhe: 1.542 ± 0.52
4.113LeuGly: 4.113 ± 0.397
0.514LeuHis: 0.514 ± 0.428
5.141LeuIle: 5.141 ± 0.305
8.226LeuLys: 8.226 ± 3.029
7.198LeuLeu: 7.198 ± 3.701
2.571LeuMet: 2.571 ± 0.917
5.141LeuAsn: 5.141 ± 1.069
9.254LeuPro: 9.254 ± 0.063
5.141LeuGln: 5.141 ± 0.46
4.113LeuArg: 4.113 ± 0.397
7.198LeuSer: 7.198 ± 0.644
6.684LeuThr: 6.684 ± 0.216
3.599LeuVal: 3.599 ± 0.06
0.0LeuTrp: 0.0 ± 0.0
3.085LeuTyr: 3.085 ± 1.253
0.0LeuXaa: 0.0 ± 0.0
Met
4.113MetAla: 4.113 ± 1.132
0.0MetCys: 0.0 ± 0.0
1.028MetAsp: 1.028 ± 0.856
1.028MetGlu: 1.028 ± 0.672
0.514MetPhe: 0.514 ± 0.336
1.028MetGly: 1.028 ± 0.092
0.514MetHis: 0.514 ± 0.428
0.514MetIle: 0.514 ± 0.336
1.542MetLys: 1.542 ± 0.244
2.571MetLeu: 2.571 ± 1.376
0.514MetMet: 0.514 ± 0.428
1.542MetAsn: 1.542 ± 0.52
0.514MetPro: 0.514 ± 0.336
1.542MetGln: 1.542 ± 0.52
1.542MetArg: 1.542 ± 0.52
0.514MetSer: 0.514 ± 0.428
3.599MetThr: 3.599 ± 0.06
1.028MetVal: 1.028 ± 0.856
0.514MetTrp: 0.514 ± 0.336
0.514MetTyr: 0.514 ± 0.428
0.0MetXaa: 0.0 ± 0.0
Asn
5.141AsnAla: 5.141 ± 1.988
0.0AsnCys: 0.0 ± 0.0
1.028AsnAsp: 1.028 ± 0.672
1.542AsnGlu: 1.542 ± 0.52
2.057AsnPhe: 2.057 ± 0.58
5.141AsnGly: 5.141 ± 1.833
1.028AsnHis: 1.028 ± 0.092
5.141AsnIle: 5.141 ± 1.069
3.085AsnLys: 3.085 ± 1.805
3.599AsnLeu: 3.599 ± 1.589
1.542AsnMet: 1.542 ± 1.284
1.542AsnAsn: 1.542 ± 0.244
5.656AsnPro: 5.656 ± 1.652
1.542AsnGln: 1.542 ± 0.244
1.028AsnArg: 1.028 ± 0.092
3.085AsnSer: 3.085 ± 0.488
1.542AsnThr: 1.542 ± 1.284
1.028AsnVal: 1.028 ± 0.092
0.0AsnTrp: 0.0 ± 0.0
0.514AsnTyr: 0.514 ± 0.336
0.0AsnXaa: 0.0 ± 0.0
Pro
5.656ProAla: 5.656 ± 1.652
0.514ProCys: 0.514 ± 0.336
3.599ProAsp: 3.599 ± 0.704
5.141ProGlu: 5.141 ± 0.46
2.057ProPhe: 2.057 ± 0.184
5.656ProGly: 5.656 ± 1.405
1.542ProHis: 1.542 ± 0.244
2.571ProIle: 2.571 ± 1.376
3.085ProLys: 3.085 ± 0.488
4.113ProLeu: 4.113 ± 0.397
1.028ProMet: 1.028 ± 0.092
5.141ProAsn: 5.141 ± 1.833
3.599ProPro: 3.599 ± 0.06
2.057ProGln: 2.057 ± 0.58
4.627ProArg: 4.627 ± 0.796
4.113ProSer: 4.113 ± 1.161
7.198ProThr: 7.198 ± 1.649
4.627ProVal: 4.627 ± 0.733
0.514ProTrp: 0.514 ± 0.428
2.057ProTyr: 2.057 ± 0.58
0.0ProXaa: 0.0 ± 0.0
Gln
8.74GlnAla: 8.74 ± 1.894
0.0GlnCys: 0.0 ± 0.0
3.599GlnAsp: 3.599 ± 0.704
1.542GlnGlu: 1.542 ± 0.244
1.542GlnPhe: 1.542 ± 0.52
2.057GlnGly: 2.057 ± 0.948
0.0GlnHis: 0.0 ± 0.0
2.057GlnIle: 2.057 ± 0.184
1.028GlnLys: 1.028 ± 0.856
1.542GlnLeu: 1.542 ± 0.52
1.028GlnMet: 1.028 ± 0.856
1.028GlnAsn: 1.028 ± 0.092
4.113GlnPro: 4.113 ± 0.368
2.571GlnGln: 2.571 ± 0.612
1.542GlnArg: 1.542 ± 0.244
1.542GlnSer: 1.542 ± 0.52
3.085GlnThr: 3.085 ± 0.488
2.057GlnVal: 2.057 ± 1.345
0.514GlnTrp: 0.514 ± 0.336
1.028GlnTyr: 1.028 ± 0.092
0.0GlnXaa: 0.0 ± 0.0
Arg
3.085ArgAla: 3.085 ± 1.253
0.0ArgCys: 0.0 ± 0.0
3.085ArgAsp: 3.085 ± 0.488
1.542ArgGlu: 1.542 ± 0.244
1.028ArgPhe: 1.028 ± 0.092
4.113ArgGly: 4.113 ± 0.397
1.028ArgHis: 1.028 ± 0.672
1.028ArgIle: 1.028 ± 0.856
3.085ArgLys: 3.085 ± 0.276
2.571ArgLeu: 2.571 ± 0.152
3.085ArgMet: 3.085 ± 0.276
4.627ArgAsn: 4.627 ± 1.56
4.113ArgPro: 4.113 ± 1.161
0.0ArgGln: 0.0 ± 0.0
2.057ArgArg: 2.057 ± 0.184
3.085ArgSer: 3.085 ± 2.569
1.028ArgThr: 1.028 ± 0.092
1.542ArgVal: 1.542 ± 0.244
1.028ArgTrp: 1.028 ± 0.092
1.542ArgTyr: 1.542 ± 0.52
0.0ArgXaa: 0.0 ± 0.0
Ser
7.198SerAla: 7.198 ± 1.408
1.542SerCys: 1.542 ± 0.52
1.542SerAsp: 1.542 ± 0.244
3.599SerGlu: 3.599 ± 0.06
1.028SerPhe: 1.028 ± 0.672
6.684SerGly: 6.684 ± 0.549
1.028SerHis: 1.028 ± 0.092
2.571SerIle: 2.571 ± 0.612
6.684SerLys: 6.684 ± 0.549
8.74SerLeu: 8.74 ± 1.164
0.514SerMet: 0.514 ± 0.428
2.057SerAsn: 2.057 ± 0.58
5.656SerPro: 5.656 ± 2.169
2.057SerGln: 2.057 ± 1.345
2.571SerArg: 2.571 ± 0.612
6.17SerSer: 6.17 ± 0.213
4.627SerThr: 4.627 ± 0.733
2.571SerVal: 2.571 ± 0.917
1.542SerTrp: 1.542 ± 0.52
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
4.113ThrAla: 4.113 ± 0.397
0.514ThrCys: 0.514 ± 0.336
3.085ThrAsp: 3.085 ± 0.488
2.571ThrGlu: 2.571 ± 1.376
2.571ThrPhe: 2.571 ± 1.376
6.684ThrGly: 6.684 ± 2.077
2.571ThrHis: 2.571 ± 0.917
6.684ThrIle: 6.684 ± 0.216
4.113ThrLys: 4.113 ± 0.368
7.712ThrLeu: 7.712 ± 1.072
1.028ThrMet: 1.028 ± 0.856
2.057ThrAsn: 2.057 ± 0.948
5.656ThrPro: 5.656 ± 0.641
2.571ThrGln: 2.571 ± 0.152
2.571ThrArg: 2.571 ± 0.152
6.17ThrSer: 6.17 ± 3.27
10.283ThrThr: 10.283 ± 2.902
6.17ThrVal: 6.17 ± 1.741
0.514ThrTrp: 0.514 ± 0.428
4.113ThrTyr: 4.113 ± 1.161
0.0ThrXaa: 0.0 ± 0.0
Val
6.684ValAla: 6.684 ± 2.842
0.0ValCys: 0.0 ± 0.0
3.599ValAsp: 3.599 ± 0.06
2.571ValGlu: 2.571 ± 0.152
1.028ValPhe: 1.028 ± 0.672
4.627ValGly: 4.627 ± 0.796
0.514ValHis: 0.514 ± 0.336
0.0ValIle: 0.0 ± 0.0
2.057ValLys: 2.057 ± 0.58
8.74ValLeu: 8.74 ± 1.894
0.0ValMet: 0.0 ± 0.0
1.542ValAsn: 1.542 ± 1.284
2.057ValPro: 2.057 ± 0.948
2.571ValGln: 2.571 ± 0.917
0.514ValArg: 0.514 ± 0.428
3.085ValSer: 3.085 ± 0.488
7.198ValThr: 7.198 ± 1.649
4.113ValVal: 4.113 ± 0.397
0.514ValTrp: 0.514 ± 0.336
2.057ValTyr: 2.057 ± 1.345
0.0ValXaa: 0.0 ± 0.0
Trp
2.571TrpAla: 2.571 ± 0.152
0.0TrpCys: 0.0 ± 0.0
1.028TrpAsp: 1.028 ± 0.092
0.0TrpGlu: 0.0 ± 0.0
1.028TrpPhe: 1.028 ± 0.856
1.028TrpGly: 1.028 ± 0.092
0.0TrpHis: 0.0 ± 0.0
1.028TrpIle: 1.028 ± 0.092
0.0TrpLys: 0.0 ± 0.0
1.542TrpLeu: 1.542 ± 0.52
0.0TrpMet: 0.0 ± 0.0
0.514TrpAsn: 0.514 ± 0.336
1.028TrpPro: 1.028 ± 0.856
0.514TrpGln: 0.514 ± 0.428
0.0TrpArg: 0.0 ± 0.0
1.542TrpSer: 1.542 ± 0.52
1.028TrpThr: 1.028 ± 0.092
2.057TrpVal: 2.057 ± 0.184
0.514TrpTrp: 0.514 ± 0.336
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.542TyrAla: 1.542 ± 0.244
0.514TyrCys: 0.514 ± 0.336
1.542TyrAsp: 1.542 ± 0.52
1.542TyrGlu: 1.542 ± 1.009
1.542TyrPhe: 1.542 ± 1.009
3.599TyrGly: 3.599 ± 0.06
0.514TyrHis: 0.514 ± 0.428
2.057TyrIle: 2.057 ± 0.184
1.028TyrLys: 1.028 ± 0.672
2.571TyrLeu: 2.571 ± 1.376
0.0TyrMet: 0.0 ± 0.0
2.057TyrAsn: 2.057 ± 1.345
2.571TyrPro: 2.571 ± 0.612
0.514TyrGln: 0.514 ± 0.428
2.057TyrArg: 2.057 ± 0.58
2.057TyrSer: 2.057 ± 0.58
1.542TyrThr: 1.542 ± 0.244
0.514TyrVal: 0.514 ± 0.336
0.0TyrTrp: 0.0 ± 0.0
1.028TyrTyr: 1.028 ± 0.856
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1946 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski