Amino acid dipepetide frequency for Acinetobacter indicus CIP 110367

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.53AlaAla: 8.53 ± 0.136
0.955AlaCys: 0.955 ± 0.033
4.678AlaAsp: 4.678 ± 0.087
6.264AlaGlu: 6.264 ± 0.103
3.338AlaPhe: 3.338 ± 0.068
6.177AlaGly: 6.177 ± 0.107
2.067AlaHis: 2.067 ± 0.048
5.919AlaIle: 5.919 ± 0.09
4.879AlaLys: 4.879 ± 0.087
10.256AlaLeu: 10.256 ± 0.112
2.555AlaMet: 2.555 ± 0.053
3.175AlaAsn: 3.175 ± 0.068
3.328AlaPro: 3.328 ± 0.063
5.453AlaGln: 5.453 ± 0.092
3.976AlaArg: 3.976 ± 0.058
4.925AlaSer: 4.925 ± 0.09
4.48AlaThr: 4.48 ± 0.073
6.04AlaVal: 6.04 ± 0.108
1.11AlaTrp: 1.11 ± 0.034
2.772AlaTyr: 2.772 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.839CysAla: 0.839 ± 0.033
0.17CysCys: 0.17 ± 0.015
0.468CysAsp: 0.468 ± 0.025
0.563CysGlu: 0.563 ± 0.025
0.478CysPhe: 0.478 ± 0.025
0.836CysGly: 0.836 ± 0.035
0.286CysHis: 0.286 ± 0.016
0.652CysIle: 0.652 ± 0.026
0.363CysLys: 0.363 ± 0.021
1.075CysLeu: 1.075 ± 0.038
0.221CysMet: 0.221 ± 0.017
0.323CysAsn: 0.323 ± 0.017
0.449CysPro: 0.449 ± 0.021
0.499CysGln: 0.499 ± 0.024
0.466CysArg: 0.466 ± 0.026
0.604CysSer: 0.604 ± 0.028
0.417CysThr: 0.417 ± 0.024
0.643CysVal: 0.643 ± 0.03
0.096CysTrp: 0.096 ± 0.01
0.306CysTyr: 0.306 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.743AspAla: 4.743 ± 0.081
0.488AspCys: 0.488 ± 0.022
2.577AspAsp: 2.577 ± 0.066
3.418AspGlu: 3.418 ± 0.066
2.336AspPhe: 2.336 ± 0.057
3.124AspGly: 3.124 ± 0.07
1.287AspHis: 1.287 ± 0.037
3.406AspIle: 3.406 ± 0.066
2.308AspLys: 2.308 ± 0.045
5.693AspLeu: 5.693 ± 0.079
1.21AspMet: 1.21 ± 0.039
1.759AspAsn: 1.759 ± 0.045
2.129AspPro: 2.129 ± 0.051
2.864AspGln: 2.864 ± 0.053
2.443AspArg: 2.443 ± 0.055
2.682AspSer: 2.682 ± 0.054
2.327AspThr: 2.327 ± 0.047
3.577AspVal: 3.577 ± 0.069
0.842AspTrp: 0.842 ± 0.034
2.042AspTyr: 2.042 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
5.166GluAla: 5.166 ± 0.096
0.412GluCys: 0.412 ± 0.02
2.874GluAsp: 2.874 ± 0.053
3.259GluGlu: 3.259 ± 0.065
2.373GluPhe: 2.373 ± 0.056
3.247GluGly: 3.247 ± 0.071
1.723GluHis: 1.723 ± 0.048
4.188GluIle: 4.188 ± 0.067
3.601GluLys: 3.601 ± 0.079
6.556GluLeu: 6.556 ± 0.089
1.577GluMet: 1.577 ± 0.044
2.593GluAsn: 2.593 ± 0.065
1.9GluPro: 1.9 ± 0.05
4.875GluGln: 4.875 ± 0.086
3.262GluArg: 3.262 ± 0.07
2.83GluSer: 2.83 ± 0.059
2.856GluThr: 2.856 ± 0.056
3.889GluVal: 3.889 ± 0.074
0.763GluTrp: 0.763 ± 0.032
1.731GluTyr: 1.731 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.725PheAla: 3.725 ± 0.066
0.512PheCys: 0.512 ± 0.025
2.584PheAsp: 2.584 ± 0.059
2.607PheGlu: 2.607 ± 0.055
1.768PhePhe: 1.768 ± 0.051
3.034PheGly: 3.034 ± 0.054
0.889PheHis: 0.889 ± 0.033
2.88PheIle: 2.88 ± 0.061
2.328PheLys: 2.328 ± 0.053
3.797PheLeu: 3.797 ± 0.089
1.097PheMet: 1.097 ± 0.04
2.005PheAsn: 2.005 ± 0.051
1.457PhePro: 1.457 ± 0.04
1.805PheGln: 1.805 ± 0.046
1.536PheArg: 1.536 ± 0.037
2.859PheSer: 2.859 ± 0.056
1.812PheThr: 1.812 ± 0.05
2.547PheVal: 2.547 ± 0.056
0.592PheTrp: 0.592 ± 0.027
1.512PheTyr: 1.512 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
5.139GlyAla: 5.139 ± 0.081
0.815GlyCys: 0.815 ± 0.03
2.893GlyAsp: 2.893 ± 0.065
3.71GlyGlu: 3.71 ± 0.069
3.055GlyPhe: 3.055 ± 0.067
4.415GlyGly: 4.415 ± 0.088
1.656GlyHis: 1.656 ± 0.046
4.646GlyIle: 4.646 ± 0.089
3.518GlyLys: 3.518 ± 0.06
7.363GlyLeu: 7.363 ± 0.108
1.899GlyMet: 1.899 ± 0.048
2.289GlyAsn: 2.289 ± 0.056
1.575GlyPro: 1.575 ± 0.041
3.437GlyGln: 3.437 ± 0.063
3.116GlyArg: 3.116 ± 0.07
3.672GlySer: 3.672 ± 0.074
3.248GlyThr: 3.248 ± 0.07
4.759GlyVal: 4.759 ± 0.092
0.917GlyTrp: 0.917 ± 0.033
2.419GlyTyr: 2.419 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.076HisAla: 2.076 ± 0.046
0.301HisCys: 0.301 ± 0.019
1.182HisAsp: 1.182 ± 0.037
1.29HisGlu: 1.29 ± 0.036
1.236HisPhe: 1.236 ± 0.04
1.654HisGly: 1.654 ± 0.043
0.777HisHis: 0.777 ± 0.036
1.586HisIle: 1.586 ± 0.045
0.967HisLys: 0.967 ± 0.033
2.731HisLeu: 2.731 ± 0.053
0.542HisMet: 0.542 ± 0.027
0.878HisAsn: 0.878 ± 0.037
1.519HisPro: 1.519 ± 0.047
1.522HisGln: 1.522 ± 0.051
1.13HisArg: 1.13 ± 0.039
1.474HisSer: 1.474 ± 0.038
1.12HisThr: 1.12 ± 0.033
1.433HisVal: 1.433 ± 0.04
0.423HisTrp: 0.423 ± 0.019
1.034HisTyr: 1.034 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.379IleAla: 6.379 ± 0.084
0.699IleCys: 0.699 ± 0.03
3.823IleAsp: 3.823 ± 0.077
4.4IleGlu: 4.4 ± 0.072
2.55IlePhe: 2.55 ± 0.065
4.51IleGly: 4.51 ± 0.085
1.53IleHis: 1.53 ± 0.04
3.732IleIle: 3.732 ± 0.079
3.006IleLys: 3.006 ± 0.055
6.091IleLeu: 6.091 ± 0.091
1.357IleMet: 1.357 ± 0.042
2.593IleAsn: 2.593 ± 0.062
2.911IlePro: 2.911 ± 0.059
3.889IleGln: 3.889 ± 0.074
3.211IleArg: 3.211 ± 0.056
4.061IleSer: 4.061 ± 0.068
2.973IleThr: 2.973 ± 0.057
4.032IleVal: 4.032 ± 0.065
0.757IleTrp: 0.757 ± 0.032
2.015IleTyr: 2.015 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
4.827LysAla: 4.827 ± 0.09
0.347LysCys: 0.347 ± 0.021
2.696LysAsp: 2.696 ± 0.056
2.78LysGlu: 2.78 ± 0.063
1.862LysPhe: 1.862 ± 0.044
2.918LysGly: 2.918 ± 0.064
1.217LysHis: 1.217 ± 0.039
3.487LysIle: 3.487 ± 0.063
3.121LysLys: 3.121 ± 0.075
5.099LysLeu: 5.099 ± 0.081
1.401LysMet: 1.401 ± 0.038
2.452LysAsn: 2.452 ± 0.063
2.199LysPro: 2.199 ± 0.054
3.185LysGln: 3.185 ± 0.066
2.692LysArg: 2.692 ± 0.058
2.814LysSer: 2.814 ± 0.059
2.931LysThr: 2.931 ± 0.063
3.627LysVal: 3.627 ± 0.062
0.58LysTrp: 0.58 ± 0.024
1.59LysTyr: 1.59 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
10.144LeuAla: 10.144 ± 0.121
1.126LeuCys: 1.126 ± 0.036
5.792LeuAsp: 5.792 ± 0.08
6.176LeuGlu: 6.176 ± 0.093
4.208LeuPhe: 4.208 ± 0.101
7.215LeuGly: 7.215 ± 0.107
2.308LeuHis: 2.308 ± 0.05
6.792LeuIle: 6.792 ± 0.11
6.507LeuLys: 6.507 ± 0.079
10.461LeuLeu: 10.461 ± 0.162
2.908LeuMet: 2.908 ± 0.065
5.312LeuAsn: 5.312 ± 0.088
4.801LeuPro: 4.801 ± 0.08
5.322LeuGln: 5.322 ± 0.129
4.61LeuArg: 4.61 ± 0.074
7.63LeuSer: 7.63 ± 0.101
5.533LeuThr: 5.533 ± 0.079
6.442LeuVal: 6.442 ± 0.091
1.298LeuTrp: 1.298 ± 0.046
2.86LeuTyr: 2.86 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.344MetAla: 2.344 ± 0.047
0.189MetCys: 0.189 ± 0.013
1.15MetAsp: 1.15 ± 0.038
0.994MetGlu: 0.994 ± 0.033
0.858MetPhe: 0.858 ± 0.034
1.753MetGly: 1.753 ± 0.045
0.624MetHis: 0.624 ± 0.026
1.606MetIle: 1.606 ± 0.042
1.391MetLys: 1.391 ± 0.041
2.797MetLeu: 2.797 ± 0.054
0.799MetMet: 0.799 ± 0.032
1.284MetAsn: 1.284 ± 0.037
1.221MetPro: 1.221 ± 0.04
1.554MetGln: 1.554 ± 0.046
1.169MetArg: 1.169 ± 0.04
1.943MetSer: 1.943 ± 0.048
1.535MetThr: 1.535 ± 0.04
1.606MetVal: 1.606 ± 0.048
0.226MetTrp: 0.226 ± 0.016
0.552MetTyr: 0.552 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.465AsnAla: 3.465 ± 0.062
0.351AsnCys: 0.351 ± 0.02
1.968AsnAsp: 1.968 ± 0.05
2.22AsnGlu: 2.22 ± 0.052
1.684AsnPhe: 1.684 ± 0.048
2.486AsnGly: 2.486 ± 0.069
0.936AsnHis: 0.936 ± 0.033
2.848AsnIle: 2.848 ± 0.063
1.985AsnLys: 1.985 ± 0.052
4.248AsnLeu: 4.248 ± 0.078
0.887AsnMet: 0.887 ± 0.027
1.722AsnAsn: 1.722 ± 0.054
2.267AsnPro: 2.267 ± 0.055
2.389AsnGln: 2.389 ± 0.063
1.919AsnArg: 1.919 ± 0.047
2.44AsnSer: 2.44 ± 0.053
2.35AsnThr: 2.35 ± 0.047
2.433AsnVal: 2.433 ± 0.057
0.542AsnTrp: 0.542 ± 0.027
1.431AsnTyr: 1.431 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.893ProAla: 3.893 ± 0.084
0.303ProCys: 0.303 ± 0.017
2.352ProAsp: 2.352 ± 0.05
3.655ProGlu: 3.655 ± 0.061
1.717ProPhe: 1.717 ± 0.04
1.928ProGly: 1.928 ± 0.044
0.995ProHis: 0.995 ± 0.032
2.255ProIle: 2.255 ± 0.048
2.245ProLys: 2.245 ± 0.05
4.262ProLeu: 4.262 ± 0.069
1.01ProMet: 1.01 ± 0.036
1.848ProAsn: 1.848 ± 0.049
1.216ProPro: 1.216 ± 0.042
2.151ProGln: 2.151 ± 0.051
1.615ProArg: 1.615 ± 0.047
2.305ProSer: 2.305 ± 0.046
2.173ProThr: 2.173 ± 0.047
3.39ProVal: 3.39 ± 0.068
0.486ProTrp: 0.486 ± 0.022
1.346ProTyr: 1.346 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
5.85GlnAla: 5.85 ± 0.101
0.45GlnCys: 0.45 ± 0.026
2.703GlnAsp: 2.703 ± 0.055
2.744GlnGlu: 2.744 ± 0.066
2.271GlnPhe: 2.271 ± 0.054
3.311GlnGly: 3.311 ± 0.062
2.105GlnHis: 2.105 ± 0.065
3.557GlnIle: 3.557 ± 0.063
2.845GlnLys: 2.845 ± 0.06
6.73GlnLeu: 6.73 ± 0.118
1.38GlnMet: 1.38 ± 0.037
2.182GlnAsn: 2.182 ± 0.057
2.639GlnPro: 2.639 ± 0.059
5.392GlnGln: 5.392 ± 0.189
3.034GlnArg: 3.034 ± 0.063
2.913GlnSer: 2.913 ± 0.066
2.756GlnThr: 2.756 ± 0.054
3.742GlnVal: 3.742 ± 0.07
0.73GlnTrp: 0.73 ± 0.029
1.844GlnTyr: 1.844 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
3.708ArgAla: 3.708 ± 0.074
0.405ArgCys: 0.405 ± 0.018
2.334ArgAsp: 2.334 ± 0.057
2.935ArgGlu: 2.935 ± 0.058
2.216ArgPhe: 2.216 ± 0.05
2.614ArgGly: 2.614 ± 0.056
1.222ArgHis: 1.222 ± 0.034
3.167ArgIle: 3.167 ± 0.06
2.47ArgLys: 2.47 ± 0.063
5.377ArgLeu: 5.377 ± 0.088
1.256ArgMet: 1.256 ± 0.038
1.795ArgAsn: 1.795 ± 0.045
1.946ArgPro: 1.946 ± 0.045
2.858ArgGln: 2.858 ± 0.06
2.44ArgArg: 2.44 ± 0.063
2.55ArgSer: 2.55 ± 0.054
2.162ArgThr: 2.162 ± 0.046
3.018ArgVal: 3.018 ± 0.056
0.653ArgTrp: 0.653 ± 0.029
1.959ArgTyr: 1.959 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
5.218SerAla: 5.218 ± 0.08
0.577SerCys: 0.577 ± 0.028
2.863SerAsp: 2.863 ± 0.054
3.152SerGlu: 3.152 ± 0.063
2.732SerPhe: 2.732 ± 0.056
4.152SerGly: 4.152 ± 0.075
1.464SerHis: 1.464 ± 0.046
3.767SerIle: 3.767 ± 0.067
2.966SerLys: 2.966 ± 0.056
6.524SerLeu: 6.524 ± 0.088
1.568SerMet: 1.568 ± 0.042
2.46SerAsn: 2.46 ± 0.061
2.349SerPro: 2.349 ± 0.05
2.919SerGln: 2.919 ± 0.068
2.788SerArg: 2.788 ± 0.057
3.974SerSer: 3.974 ± 0.085
3.261SerThr: 3.261 ± 0.074
3.646SerVal: 3.646 ± 0.067
0.725SerTrp: 0.725 ± 0.034
1.959SerTyr: 1.959 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
5.043ThrAla: 5.043 ± 0.096
0.45ThrCys: 0.45 ± 0.024
2.565ThrAsp: 2.565 ± 0.061
3.121ThrGlu: 3.121 ± 0.067
1.888ThrPhe: 1.888 ± 0.043
3.84ThrGly: 3.84 ± 0.07
1.215ThrHis: 1.215 ± 0.036
3.022ThrIle: 3.022 ± 0.063
1.934ThrLys: 1.934 ± 0.047
5.919ThrLeu: 5.919 ± 0.093
0.978ThrMet: 0.978 ± 0.037
1.59ThrAsn: 1.59 ± 0.046
2.747ThrPro: 2.747 ± 0.057
2.755ThrGln: 2.755 ± 0.061
2.246ThrArg: 2.246 ± 0.061
2.661ThrSer: 2.661 ± 0.052
2.888ThrThr: 2.888 ± 0.065
3.609ThrVal: 3.609 ± 0.072
0.572ThrTrp: 0.572 ± 0.026
1.399ThrTyr: 1.399 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
6.044ValAla: 6.044 ± 0.088
0.689ValCys: 0.689 ± 0.027
3.57ValAsp: 3.57 ± 0.067
4.302ValGlu: 4.302 ± 0.074
2.59ValPhe: 2.59 ± 0.056
4.462ValGly: 4.462 ± 0.085
1.447ValHis: 1.447 ± 0.041
4.3ValIle: 4.3 ± 0.071
3.308ValLys: 3.308 ± 0.064
7.133ValLeu: 7.133 ± 0.099
1.877ValMet: 1.877 ± 0.049
2.631ValAsn: 2.631 ± 0.05
2.626ValPro: 2.626 ± 0.062
3.294ValGln: 3.294 ± 0.06
2.942ValArg: 2.942 ± 0.058
3.974ValSer: 3.974 ± 0.069
3.478ValThr: 3.478 ± 0.071
4.751ValVal: 4.751 ± 0.09
0.77ValTrp: 0.77 ± 0.032
1.846ValTyr: 1.846 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.887TrpAla: 0.887 ± 0.035
0.134TrpCys: 0.134 ± 0.015
0.563TrpAsp: 0.563 ± 0.03
0.494TrpGlu: 0.494 ± 0.023
0.631TrpPhe: 0.631 ± 0.031
0.718TrpGly: 0.718 ± 0.033
0.356TrpHis: 0.356 ± 0.021
0.9TrpIle: 0.9 ± 0.033
0.628TrpLys: 0.628 ± 0.028
1.677TrpLeu: 1.677 ± 0.054
0.466TrpMet: 0.466 ± 0.024
0.555TrpAsn: 0.555 ± 0.027
0.398TrpPro: 0.398 ± 0.019
0.921TrpGln: 0.921 ± 0.03
0.615TrpArg: 0.615 ± 0.027
0.793TrpSer: 0.793 ± 0.028
0.574TrpThr: 0.574 ± 0.025
0.868TrpVal: 0.868 ± 0.031
0.143TrpTrp: 0.143 ± 0.012
0.396TrpTyr: 0.396 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.856TyrAla: 2.856 ± 0.053
0.383TyrCys: 0.383 ± 0.02
1.619TyrAsp: 1.619 ± 0.042
1.591TyrGlu: 1.591 ± 0.042
1.557TyrPhe: 1.557 ± 0.043
2.149TyrGly: 2.149 ± 0.052
0.771TyrHis: 0.771 ± 0.028
1.806TyrIle: 1.806 ± 0.043
1.453TyrLys: 1.453 ± 0.045
3.657TyrLeu: 3.657 ± 0.072
0.61TyrMet: 0.61 ± 0.027
1.126TyrAsn: 1.126 ± 0.038
1.468TyrPro: 1.468 ± 0.043
2.094TyrGln: 2.094 ± 0.052
1.876TyrArg: 1.876 ± 0.041
1.957TyrSer: 1.957 ± 0.054
1.57TyrThr: 1.57 ± 0.039
1.981TyrVal: 1.981 ± 0.046
0.491TyrTrp: 0.491 ± 0.023
1.032TyrTyr: 1.032 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2967 proteins (905149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski